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Extract from the Register of European Patents

EP About this file: EP2746402

EP2746402 - Method of prognosis of Alzheimers disease and substrates for use therein [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  06.03.2015
Database last updated on 11.09.2024
Most recent event   Tooltip06.03.2015Refusal of applicationpublished on 08.04.2015  [2015/15]
Applicant(s)For all designated states
Academisch Medisch Centrum
Bureau Kennistransfer AMC TKs0-136
(De Rode Luifel)
Meibergdreef 9
1105 AZ Amsterdam / NL
[2014/26]
Representative(s)de Pauw, Elmar Sebastian David
Schenklaan 5
2497 AV Den Haag / NL
[N/P]
Former [2014/26]de Pauw, Elmar Sebastian David
Bureau Kennistransfer AMC
TKs0-136 (De Rode Luifel)
Meibergdreef 9
1105 AZ Amsterdam / NL
Application number, filing date13158742.012.03.2013
[2014/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2746402
Date:25.06.2014
Language:EN
[2014/26]
Search report(s)(Supplementary) European search report - dispatched on:EP18.09.2013
ClassificationIPC:C12Q1/37, C07K7/00
[2014/26]
CPC:
C12Q1/37 (EP); C07K2319/50 (EP); C07K2319/60 (EP);
G01N2800/2821 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/26]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:Verfahren zur Prognose von Morbus Alzheimer und Substrate zur Verwendung darin[2014/26]
English:Method of prognosis of Alzheimers disease and substrates for use therein[2014/26]
French:Procédé de pronostic de la maladie d'Alzheimer et substrats pour utilisation associée[2014/26]
Examination procedure12.03.2013Examination requested  [2014/26]
22.10.2014Despatch of communication that the application is refused, reason: Examination on filing A.90(5) [2015/15]
01.11.2014Application refused, date of legal effect [2015/15]
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
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 [X]US2005164319  (FOURIE ANNE M [US], et al) [X] 1-5,8 * abstract * * sequence 33 *;
 [YD]EP1674580  (HOFFMANN LA ROCHE [CH]) [YD] 1-9,11-15 * the whole document * * in particular * * paragraphs [0006] , [0056] - [0058] *;
 [Y]US2011092445  (BARGHORN STEFAN [DE], et al) [Y] 2,7 * abstract * * sequence 970 *;
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 [I]  - PEREZ ADRIANA ET AL, "Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains", NEUROCHEMICAL RESEARCH, (200002), vol. 25, no. 2, ISSN 0364-3190, pages 247 - 255, XP055078943 [I] 10 * abstract * * page 251, column 2, paragraph 1 - page 252, column 1, paragraph 1 * * page 253, paragraph bridging columns 1 and 2 *
 [Y]  - COOK DAVID G ET AL, "Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele", AMERICAN JOURNAL OF PATHOLOGY; [10640], AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY, US, (20030101), vol. 162, no. 1, ISSN 0002-9440, pages 313 - 319, XP009172465 [Y] 10 * abstract * * page 314, column 1, paragraph 2 - column 2, paragraph 1 * * page 315, column 1, paragraph 3 *

DOI:   http://dx.doi.org/10.1016/S0002-9440(10)63822-9
 [A]  - SUQING WANG ET AL, "Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain", JOURNAL OF NEUROCHEMISTRY, (20101030), vol. 115, no. 1, doi:10.1111/j.1471-4159.2010.06899.x, ISSN 0022-3042, pages 47 - 57, XP055078957 [A] 10 * abstract * * page 52, column 2, paragraph 2 * * page 54, column 1, paragraph 3 *

DOI:   http://dx.doi.org/10.1111/j.1471-4159.2010.06899.x
 [A]  - MINERS JAMES SCOTT ET AL, "Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS AND WILKINS, NEW YORK, NY, (20090801), vol. 68, no. 8, ISSN 0022-3069, pages 902 - 914, XP009172454 [A] 10 * abstract * * page 903, column 1, paragraph 2 * * page 910, column 2, paragraph 3 *

DOI:   http://dx.doi.org/10.1097/NEN.0b013e3181afe475
by applicantEP1674580
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