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EP About this file: EP2662390

EP2662390 - Interferon alpha receptor 1 antibodies and their uses [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  08.06.2018
Database last updated on 26.06.2024
FormerThe patent has been granted
Status updated on  30.06.2017
FormerGrant of patent is intended
Status updated on  19.02.2017
Most recent event   Tooltip08.06.2018No opposition filed within time limitpublished on 11.07.2018  [2018/28]
Applicant(s)For all designated states
E. R. Squibb & Sons, L.L.C.
Route 206 and Province Line Road
Princeton, NJ 08540 / US
[2015/03]
Former [2013/46]For all designated states
Medarex, L.L.C.
Route 206 and Province Line Road
Princeton, NJ 08540 / US
Inventor(s)01 / Cardarelli, Josephine M.
126 Leslie Drive
San Carlos, CA 94070 / US
02 / Witte, Alison
6325 E Evans Creek Road
Rogue River, OR 97537-9605 / US
03 / Srinivasan, Mohan
1044 Arlington Lane
San Jose, CA 95129 / US
 [2013/46]
Representative(s)Reitstötter Kinzebach
Patentanwälte
Sternwartstraße 4
81679 München / DE
[N/P]
Former [2017/31]Reitstötter Kinzebach
Patentanwälte
Sternwartstrasse 4
81679 München / DE
Former [2013/46]Reitstötter - Kinzebach
Patentanwälte Sternwartstrasse 4
81679 München / DE
Application number, filing date13162333.220.06.2005
[2013/46]
Priority number, dateUS20040581747P21.06.2004         Original published format: US 581747 P
[2013/46]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2662390
Date:13.11.2013
Language:EN
[2013/46]
Type: B1 Patent specification 
No.:EP2662390
Date:02.08.2017
Language:EN
[2017/31]
Search report(s)(Supplementary) European search report - dispatched on:EP14.10.2013
ClassificationIPC:C07K16/28
[2013/46]
CPC:
C07K16/2866 (EP,KR,RU,US); A61K47/6801 (RU); A61P1/00 (EP);
A61P1/04 (EP); A61P13/12 (EP); A61P17/02 (EP);
A61P17/06 (EP); A61P17/16 (EP); A61P19/02 (EP);
A61P19/04 (EP); A61P25/00 (EP); A61P25/28 (EP);
A61P29/00 (EP); A61P3/10 (EP); A61P31/18 (EP);
A61P35/00 (EP); A61P37/00 (EP); A61P37/02 (EP);
A61P37/06 (EP); A61P43/00 (EP); A61P5/14 (EP);
A61P5/48 (EP); C07K2317/21 (EP,KR,US); C07K2317/31 (KR,US);
C07K2317/56 (EP,KR,US); C07K2317/565 (EP,KR,US); C07K2317/74 (EP,KR,US);
C07K2317/76 (EP,KR,US); C07K2317/92 (EP,KR,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/31]
Former [2013/46]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Interferon-Alpha-Rezeptor-1-Antikörper und deren Verwendungen[2013/46]
English:Interferon alpha receptor 1 antibodies and their uses[2013/46]
French:Anticorps du récepteur 1 de l'interféron alpha et leurs utilisations[2013/46]
Examination procedure13.05.2014Examination requested  [2014/26]
04.12.2015Despatch of a communication from the examining division (Time limit: M04)
11.04.2016Reply to a communication from the examining division
30.01.2017Cancellation of oral proceeding that was planned for 31.01.2017
31.01.2017Date of oral proceedings (cancelled)
20.02.2017Communication of intention to grant the patent
19.06.2017Fee for grant paid
19.06.2017Fee for publishing/printing paid
19.06.2017Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP05787743.3  / EP1781705
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20050787743) is  25.03.2011
Opposition(s)03.05.2018No opposition filed within time limit [2018/28]
Fees paidRenewal fee
04.04.2013Renewal fee patent year 03
04.04.2013Renewal fee patent year 04
04.04.2013Renewal fee patent year 05
04.04.2013Renewal fee patent year 06
04.04.2013Renewal fee patent year 07
04.04.2013Renewal fee patent year 08
10.06.2013Renewal fee patent year 09
12.06.2014Renewal fee patent year 10
10.06.2015Renewal fee patent year 11
10.06.2016Renewal fee patent year 12
16.06.2017Renewal fee patent year 13
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XI]US6713609  (CHUNTHARAPAI ANAN [US], et al) [X] 1-4,6-14,16-18 * columns 49,50,53; table 2 * [I] 15;
 [XP]WO2004094473  (MEDAREX INC [US], et al) [XP] 1-4,6-14,16-18 * page 36; example 1 *;
 [XP]WO2004093908  (MEDAREX INC [US], et al) [XP] 1-4,6-14,16-18 * page 32 - page 37; claims 1-8 *;
 [X]  - GOLDMAN L A ET AL, "Characterization of antihuman IFNAR-1 monoclonal antibodies: Epitope localization and functional analysis", JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, MARY ANN LIEBERT, NEW YORK, NY, US, (19990101), vol. 19, no. 1, ISSN 1079-9907, pages 15 - 26, XP002307845 [X] 1-4,6-14,16-18 * abstract *
 [X]  - BENOIT P ET AL, "A MONOCLONAL ANTIBODY TO RECOMBINANT HUMAN IFN-ALPHA RECEPTOR INHIBITS BIOLOGIC ACTIVITY OF SEVERAL SPECIES OF HUMAN IFN-ALPHA, IFN-BETA, AND IFN-ONIEGA. DETECTION OF HETEROGENEITY OF THE CELLULAR TYPE I IFN RECEPTOR", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (19930201), vol. 150, no. 3, ISSN 0022-1767, pages 707 - 716, XP002025928 [X] 1-4,6-14,16-18 * page 709, column r, paragraph penultimate - page 710, column l, paragraph 3 *
 [A]  - WINTER G ET AL, "ANTIBODY-BASED THERAPY, HUMANIZED ANTIBODIES", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, (19930501), vol. 14, no. 5, doi:10.1016/0165-6147(93)90197-R, ISSN 0165-6147, pages 139 - 143, XP001205172 [A] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1016/0165-6147(93)90197-R
Examination   - JI LU ET AL., "Structure-function study of the extracellular domain of the human IFN-alpha receptor (hIFNAR1) using blocking monoclonal antibodies: The role of domains 1 and 2", THE JOURNAL OF IMMUNOLOGY, (1998), vol. 160, pages 1782 - 1788, XP055018579
    - SIGRID BEIBOER ET AL., "Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent", J. MOL. BIOL., (2000), vol. 296, pages 833 - 849, XP000944326

DOI:   http://dx.doi.org/10.1006/jmbi.2000.3512
    - A. KLIMKA ET AL, "Human anti-CD30 recombinant antibodies by guided phage antibody selection using cell panning", BRITISH JOURNAL OF CANCER, (2000), vol. 83, no. 2, pages 252 - 260, XP001021661

DOI:   http://dx.doi.org/10.1054/bjoc.2000.1226
    - LI PENG ET AL, "Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody", MABS, (201503), vol. 7, no. 2, pages 428 - 439
by applicantUS4399216
 US4439196
 US4447233
 US4447224
 US4475196
 US4486194
 US4487603
 US4522811
 EP0154316
 US4596556
 US4634665
 WO8704462
 WO8800052
 US4790824
 WO8901036
 US4816567
 EP0338841
 US4881175
 US4941880
 US4946778
 US4954617
 EP0401384
 US5013653
 US5064413
 US5091513
 WO9203918
 US5132405
 US5179017
 WO9312227
 US5223409
 US5225539
 US5258498
 US5260203
 WO9410332
 US5312335
 WO9425585
 US5374548
 WO9429351
 US5383851
 US5399163
 US5399331
 US5403484
 US5416016
 US5427908
 US5455030
 US5476996
 US5476786
 US5482858
 US5530101
 US5545806
 US5545807
 US5569825
 US5571698
 US5580717
 US5585089
 WO9713852
 US5624821
 US5625126
 US5625825
 US5633425
 US5648260
 US5661016
 US5677425
 US5693762
 US5698767
 US5714350
 WO9824884
 US5770429
 US5789650
 US5814318
 US5869046
 US5874299
 US5877397
 US5885793
 US5888511
 US5939598
 WO9945962
 US5969108
 WO9954342
 US6075181
 WO0042072
 US6114598
 US6121022
 US6150584
 US6162963
 US6165745
 US6172197
 US6180370
 WO0109187
 US6194551
 WO0114424
 US6277375
 EP1176195
 US6350861
 WO0243478
 US2002160974
 WO02092780
 US6521404
 US6544731
 US6555313
 WO03035835
 US6582915
 US6593081
 US2003153043
 WO03074679
    - HARDY ET AL., BLOOD, (2001), vol. 97, page 473
    - CUTRONE; LANGER, J. BIOL. CHEM, (2001), vol. 276, page 17140
    - WEISSMANN; WEBER, PROG. NUCL. ACID RES. MOL. BIOL., (1986), vol. 33, pages 251 - 300
    - STREULI ET AL., PROC. NATL. ACAD. SCI. USA, (1981), vol. 78, page 2848
    - AGNET M. ET AL., Interferon 5 th ed., ACADEMIC PRESS, (1983), pages 1 - 22
    - UZE, CELL, (1990), vol. 60, page 225
    - NOVICK ET AL., CELL, (1994), vol. 77, page 391
    - COOK ET AL., J. BIOL. CHEM., (1996), vol. 271, page 13448
    - LEWERENZ ET AL., J. MOL. BIOL., (1998), vol. 282, page 585
    - HALLER ET AL., J. EXP. MED., (1981), vol. 154, page 199
    - LINDENMANN ET AL., METHODS ENZYMOL., (1981), vol. 78, page 181
    - BRINKMANN ET AL., J. EXP. MED., (1993), vol. 178, page 1655
    - FINKELMAN ET AL., J. EXP. MED., (1991), vol. 174, page 1179
    - SANTINI ET AL., J. EXP. MED., (2000), vol. 191, page 1777
    - TOUGH ET AL., SCIENCE, (1996), vol. 272, page 1947
    - LUFT ET AL., J. IMMUNOL., (1998), vol. 161, page 1947
    - LUFT ET AL., INT. IMMUNOL., (2002), vol. 14, page 367
    - RADVANYI ET AL., SCAND. J. IMMUNOL., (1999), vol. 50, page 499
    - FOULIS ET AL., LANCET, (1987), vol. 2, page 1423
    - HOOKS ET AL., ARTHRITIS RHEUM., (1982), vol. 25, page 396
    - HERTZOG ET AL., CLIN. IMMUNOL. IMMUNOPATHOL., (1988), vol. 48, page 192
    - HOPKINS; MEAGER, CLIN. EXP. IMMUNOL., (1988), vol. 73, page 88
    - ARVIN; MILLER, ARTHRITIS RHEUM., (1984), vol. 27, page 582
    - WARD ET AL., NATURE, (1989), vol. 341, pages 544 - 546
    - BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426
    - HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883
    - E. MEYERS; W. MILLER, COMPUT. APPL. BIOSCI., (1988), vol. 4, pages 11 - 17
    - NEEDLEMAN; WUNSCH, J. MOL. BIOL., (1970), vol. 48, pages 444 - 453
    - ALTSCHUL ET AL., J. MOL. BIOL., (1990), vol. 215, pages 403 - 10
    - ALTSCHUL ET AL., NUCLEIC ACIDS RES., (1997), vol. 25, no. 17, pages 3389 - 3402
    - RIECHMANN, L ET AL., NATURE, (1998), vol. 332, pages 323 - 327
    - JONES, P. ET AL., NATURE, (1986), vol. 321, pages 522 - 525
    - QUEEN, C. ET AL., PROC. NATL. ACAD. SEE. US.A., (1989), vol. 86, pages 10029 - 10033
    - TOMLINSON, I. M. ET AL., "The Repertoire of Human Germline VH Sequences Reveals about Fifty Groups of VH Segments with Different Hypervariable Loops", J. MOL. BIOL., (1992), vol. 227, pages 776 - 798
    - COX, J. P. L. ET AL., "A Directory of Human Germ-line VH Segments Reveals a Strong Bias in their Usage", EUR. J. IMMUNOL., (1994), vol. 24, pages 827 - 836
    - SHIELDS, R.L. ET AL., J. BIOL. CHEM., (2001), vol. 276, pages 6591 - 6604
    - SHIELDS, R.L. ET AL., J. BIOL. CHEM., (2002), vol. 277, pages 26733 - 26740
    - UMANA ET AL., NAT. BIOTECH., (1999), vol. 17, pages 176 - 180
    - MCCAFFERTY ET AL., NATURE, (1990), vol. 348, pages 552 - 554
    - KOHLER; MILSTEIN, NATURE, (1975), vol. 256, page 495
    - LONBERG ET AL., NATURE, (1994), vol. 368, no. 6474, pages 856 - 859
    - LONBERG, N., Handbook of Experimental Pharmacology, (1994), vol. 113, pages 49 - 101
    - LONBERG, N.; HUSZAR, D., INTERN. REV. IMMUNOL., (1995), vol. 13, pages 65 - 93
    - HARDING, F.; LONBERG, N., ANN. N.Y. ACAD. SCI., (1995), vol. 764, pages 536 - 546
    - TAYLOR, L. ET AL., NUCLEIC ACIDS RESEARCH, (1992), vol. 20, pages 6287 - 6295
    - CHEN, J. ET AL., INTERNATIONAL IMMUNOLOGY, (1993), vol. 5, pages 647 - 656
    - TUAILLON ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 3720 - 3724
    - CHOI ET AL., NATURE GENETICS, (1993), vol. 4, pages 117 - 123
    - CHEN, J. ET AL., EMBO J., (1993), vol. 12, pages 821 - 830
    - TUAILLON ET AL., J IMMUNOL., (1994), vol. 152, pages 2912 - 2920
    - TAYLOR, L. ET AL., INTERNATIONAL IMMUNOLOGY, (1994), vol. 6, pages 579 - 591
    - FISHWILD, D. ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 845 - 851
    - TOMIZUKA ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, pages 722 - 727
    - KUROIWA ET AL., NATURE BIOTECHNOLOGY, (2002), vol. 20, pages 889 - 894
    - LONBERG, N. ET AL., NATURE, (1994), vol. 368, no. 6474, pages 856 - 859
    - MORRISON, S., SCIENCE, (1985), vol. 229, page 1202
    - GOEDDEL, Gene Expression Technology. Methods in Enzymology, ACADEMIC PRESS, (1990), vol. 185
    - TAKEBE, Y. ET AL., MOL. CELL. BIOL., (1988), vol. 8, pages 466 - 472
    - BOSS, M. A.; WOOD, C. R., IMMUNOLOGY TODAY, (1985), vol. 6, pages 12 - 13
    - URLAUB; CHASIN, PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, pages 4216 - 4220
    - R. J. KAUFINAN; P. A. SHARP, MOL. BIOL., (1982), vol. 159, pages 601 - 621
    - SAITO, G. ET AL., ADV. DRUG DELIV. REV., (2003), vol. 55, pages 199 - 215
    - TRAIL, P.A. ET AL., CANCER IMMUNOL. IMMUNOTHER., (2003), vol. 52, pages 328 - 337
    - PAYNE, G., CANCER CELL, (2003), vol. 3, pages 207 - 212
    - ALLEN, T.M., NAT. REV. CANCER, (2002), vol. 2, pages 750 - 763
    - PASTAN, 1.; KREITMAN, R. J., CURR. OPIN. INVESTIG. DRUGS, (2002), vol. 3, pages 1089 - 1091
    - SENTER, P.D.; SPRINGER, C.J., ADV. DRUG DELIV. REV., (2001), vol. 53, pages 247 - 264
    - "Monoclonal Antibodies For Immunotargeting Of Drugs In Cancer Therapy", AMON ET AL., Monoclonal Antibodies And Cancer Therapy, ALAN R. LISS, INC., (1985), pages 243 - 56
    - "Antibodies For Drug Delivery", HELLSTROM ET AL., Controlled Drug Delivery, MARCEL DEKKER, INC., (1987), pages 623 - 53
    - "Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review", THORPE ET AL., Monoclonal Antibodies '84: Biological And Clinical Applications, (1985), pages 475 - 506
    - "Analysis, Results, And Future Prospective Of The Therapeutic Use Of Radiolabeled Antibody In Cancer Therapy", Monoclonal Antibodies For Cancer Detection And Therapy, ACADEMIC PRESS, (1985), pages 303 - 16
    - THORPE, "The Preparation And Cytotoxic Properties Of Antibody-Toxin Conjugates", IMMUNOL. REV., (1982), vol. 62, pages 119 - 58
    - GRAZIANO, R.F. ET AL., J. IMMUNOL, (1995), vol. 155, no. 10, pages 4996 - 5002
    - MORTON, H.C. ET AL., CRITICAL REVIEWS IN IMMUNOLOGY, (1996), vol. 16, pages 423 - 440
    - MONTEIRO, R.C. ET AL., J. IMMUNOL., (1992), vol. 148, page 1764
    - KARPOVSKY ET AL., J. EXP. MED., (1984), vol. 160, page 1686
    - LIU, MA ET AL., PROC. NATL. ACAD. SCI. USA, (1985), vol. 82, page 8648
    - PAULUS, BEHRING INS. MITT., (1985), vol. 78, pages 118 - 132
    - BRENNAN ET AL., SCIENCE, (1985), vol. 229, pages 81 - 83
    - GLENNIE ET AL., J. IMMUNOL., (1987), vol. 139, pages 2367 - 2375
    - BERGE, S.M. ET AL., J. PHARM. SCI., (1977), vol. 66, pages 1 - 19
    - V.V. RANADE, J. CLIN. PHARMACOL., (1989), vol. 29, page 685
    - UMEZAWA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1988), vol. 153, page 1038
    - P.G. BLOEMAN ET AL., FEBS LETT., (1995), vol. 357, page 140
    - M. OWAIS ET AL., ANTIMICROB. AGENTS CHEMOTHER., (1995), vol. 39, page 180
    - BRISCOE ET AL., AM. J. PHYSIOL., (1995), vol. 1233, page 134
    - SCHREIER ET AL., J. BIOL. CHEM., (1994), vol. 269, page 9090
    - K. KEINANEN; M.L. LAUKKANEN, FEBS LETT., (1994), vol. 346, page 123
    - J.J. KILLION; I.J. FIDLER, IMMUNOMETHODS, (1994), vol. 4, page 273
    - KIM ET AL., CLIN. EXP. IMMUNOL., (1987), vol. 70, pages 562 - 569
    - GARCIA-PORRUA ET AL., CLIN. EXP. RHEUMATOL., (1998), vol. 16, pages 107 - 108
    - FOULIS ET AL., LANCET, (1987), vol. 2, pages 1423 - 1427
    - WAGURI ET AL., DIABETES RES. CLIN. PRACT., (1994), vol. 23, pages 33 - 36
    - MONZANI ET AL., CLIN. EXP. MED., (2004), vol. 3, pages 199 - 210
    - PRUMMEL; LAURBERG, THYROID, (2003), vol. 13, pages 547 - 551
    - HERTZOG ET AL., CLIN. IMMUNOL. IMMUNOPATH., (1988), vol. 48, page 192
    - DESTEFANO ET AL., J. INFEC. DISEASE, (1982), vol. 146, page 451
    - VADHAN-RAJ ET AL., CANCER RES., (1986), vol. 46, page 417
    - TOVEY ET AL., J. LEUKOC. BIOL., (1996), vol. 59, pages 512 - 517
    - BENIZRI ET AL., J. INTERFERON CYTOKINE RES., (1998), vol. 18, pages 273 - 284
    - CHEN ET AL., EMBO J., (1993), vol. 12, pages 811 - 820
    - FISHWILD ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 845 - 851
 US20030465155
 US20030465058
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.