blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2692354

EP2692354 - Means for treating heart disease [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  27.03.2015
Database last updated on 26.07.2024
Most recent event   Tooltip27.03.2015Application deemed to be withdrawnpublished on 29.04.2015  [2015/18]
Applicant(s)For all designated states
Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch
Berlin-Buch
Robert-Rössle-Strasse 10
13092 Berlin / DE
[N/P]
Former [2014/06]For all designated states
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Berlin-Buch, Robert-Rössle-Strasse 10
13092 Berlin / DE
Inventor(s)01 / Gotthardt, Michael.
Wichert Str. 39
10439 Berlin / DE
02 / Freiberg, Fabian.
Olga-Benario-Prestes- Str. 3
10407 Berlin / DE
 [2014/06]
Representative(s)Hoppe, Georg Johannes
Darani Anwaltskanzlei
Hohenzollerndamm 117
14199 Berlin / DE
[N/P]
Former [2014/06]Hoppe, Georg Johannes
darani Anwaltskanzlei Beuckestrasse 20
14163 Berlin / DE
Application number, filing date13164109.417.04.2013
[2014/06]
Priority number, dateEP2012017929503.08.2012         Original published format: EP 12179295
[2014/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2692354
Date:05.02.2014
Language:EN
[2014/06]
Search report(s)(Supplementary) European search report - dispatched on:EP24.06.2013
ClassificationIPC:A61K38/17, A61K48/00, C07K16/28, C12N15/113, G01N33/53
[2014/06]
CPC:
C07K14/705 (EP,US); A61K31/7088 (EP,US); A61K38/17 (EP,US);
A61K38/177 (EP,US); A61K38/39 (EP,US); A61K39/3955 (US);
A61K45/06 (US); A61K47/68 (US); A61K48/005 (EP,US);
A61P9/10 (EP,US); C07K16/28 (EP,US); C12N15/1138 (EP,US);
G01N33/6887 (EP,US); C07K14/78 (US); C07K2319/30 (EP,US);
C12N2310/11 (EP,US); C12N2310/14 (EP,US); C12N2310/3233 (EP,US);
C12N2320/31 (US); G01N2800/324 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/06]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:Mittel zur Behandlung einer Herzerkrankung[2014/06]
English:Means for treating heart disease[2014/06]
French:Moyens pour traiter une maladie cardiaque[2014/06]
Examination procedure06.08.2014Application deemed to be withdrawn, date of legal effect  [2015/18]
09.10.2014Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2015/18]
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]US2008248502  (YAMAGUCHI KEIKO [JP], et al) [X] 1,2,6,7,9 * abstract * * paragraphs [0001] , [0013]; example 5 *;
 [X]WO2009053104  (CHARITE UNIVERSITAETSMEDIZIN [DE], et al) [X] 1,2,6,7 * page 3, line 23 - line 24 * * page 5, line 4 - line 9; example 6 *;
 [X]WO2012064307  (MAHMUT BILGIC [TR]) [X] 1-3,5-8 * abstract *;
 [X]US2011160236  (SEREBRUANY VICTOR L [US]) [X] 1-3,5-8 * paragraphs [0009] , [0023] *;
 [X]WO03057195  (ATHPHARMA LTD [IE], et al) [X] 1-3,5-8 * paragraph [0027] *;
 [X]WO2011078712  (DAFIANTE FARMACEUTICA S A [PT], et al) [X] 1-3,5-8 * abstract *;
 [XP]EP2517697  (DEFIANTE FARMACEUTICA SA [PT]) [XP] 1-3,5-8 * paragraph [0023] *;
 [A]DE102009019460  (KRANKENHAUSBETR SGESELLSCHAFT [DE]) [A] 1-9 * paragraph [0029]; examples 1-5 *;
 [X]  - YANAGAWA B ET AL, "Soluble recombinant coxsackievirus and adenovirus receptor abrogates coxsackievirus b3-mediated pancreatitis and myocarditis in mice", JOURNAL OF INFECTIOUS DISEASES, UNIVERSITY OF CHICAGO PRESS, CHICAGO, IL, (20040415), vol. 189, no. 8, doi:10.1086/382598, ISSN 0022-1899, pages 1431 - 1439, XP002362527 [X] 1,2,6,7 * abstract *

DOI:   http://dx.doi.org/10.1086/382598
 [X]  - PINKERT SANDRA ET AL, "Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor.", CIRCULATION, (20091208), vol. 120, no. 23, ISSN 1524-4539, page 26PP, XP002698211 [X] 1,2,6,7 * abstract *

DOI:   http://dx.doi.org/10.1161/CIRCULATIONAHA.108.845339
 [X]  - CARUSO LAURA ET AL, "Cardiomyocyte-targeted overexpression of the coxsackie-adenovirus receptor causes a cardiomyopathy in association with beta-catenin signaling", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, (201006), vol. 48, no. 6, ISSN 0022-2828, pages 1194 - 1205, XP002698212 [X] 1-9 * abstract * * "Discussion" particularly the final paragraph *

DOI:   http://dx.doi.org/10.1016/j.yjmcc.2010.01.022
 [X]  - STELLA YUEN ET AL, "The coxsackie adenovirus receptor induces an inflammatory cardiomyopathy independent of viral infection", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS, GB, vol. 50, no. 5, doi:10.1016/J.YJMCC.2011.02.011, ISSN 0022-2828, (20110211), pages 826 - 840, (20110223), XP028189054 [X] 1-9 * abstract *

DOI:   http://dx.doi.org/10.1016/j.yjmcc.2011.02.011
 [X]  - SHI Y ET AL, "Cardiac Deletion of the Coxsackievirus-Adenovirus Receptor Abolishes Coxsackievirus B3 Infection and Prevents Myocarditis In Vivo", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 53, no. 14, doi:10.1016/J.JACC.2008.10.064, ISSN 0735-1097, (20090407), pages 1219 - 1226, (20090331), XP026080959 [X] 1-9 * abstract *

DOI:   http://dx.doi.org/10.1016/j.jacc.2008.10.064
by applicant   - THYGESEN ET AL., EUR HEART J., (2007), vol. 28, no. 20, pages 2525 - 38
    - HE, Y. ET AL., "Interaction of coxsackievirus B3 with the full-length coxsackievirus-adenovirus receptor", NAT. STRUCT. BIOL, (2001), vol. 8, pages 874 - 878
    - BEWLEY, M. C.; SPRINGER, K.; ZHANG, Y. B.; FREIMUTH, P.; FLANAGAN, J. M., "Structural analysis of the mechanism of adenovirus binding to its human cellular receptor", CAR. SCIENCE, (1999), vol. 286, pages 1579 - 1583
    - NOUTSIAS, M. ET AL., "Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections", CIRCULATION, (2001), vol. 104, pages 275 - 280
    - FECHNER, H. ET AL., "Induction of coxsackievirus-adenovirus- receptor expression during myocardial tissue formation and remodeling: identification of a cell-to-cell contact-dependent regulatory mechanism", CIRCULATION, (2003), vol. 107, pages 876 - 882
    - BERGELSON ET AL., "Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5", SCIENCE, (1997), vol. 275, doi:doi:10.1126/science.275.5304.1320, pages 1320 - 1323, XP002911142

DOI:   http://dx.doi.org/10.1126/science.275.5304.1320
    - TOMKO ET AL., "HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses", PROC NATL ACAD SCI USA, (1997), vol. 94, doi:doi:10.1073/pnas.94.7.3352, pages 3352 - 3356, XP002911143

DOI:   http://dx.doi.org/10.1073/pnas.94.7.3352
    - BERGELSON ET AL., "The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses", J VIROL, (1998), vol. 72, pages 415 - 419, XP002195888
    - FECHNER ET AL., "Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers", GENE THER, (1999), vol. 6, doi:doi:10.1038/sj.gt.3301030, pages 1520 - 1535, XP009006998

DOI:   http://dx.doi.org/10.1038/sj.gt.3301030
    - THOELEN ET AL., "Characterization of a cDNA encoding the bovine coxsackie and adenovirus receptor", BIOCHEM. BIOPHYS. RES. COMMUN, (2001), vol. 288, pages 805 - 808
    - PETRELLA ET AL., "A zebrafish coxsackievirus and adenovirus receptor homologue interacts with coxsackie B virus and adenovirus", J VIROL, (2002), vol. 76, pages 10503 - 10506
    - FISCHER ET AL., J MOL MED, (2009), vol. 87, no. 9, pages 879 - 8
    - PINKERT ET AL., CIRCULATION, (2009), vol. 120, pages 2358 - 2366
    - HE, Y. ET AL., "Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor", NAT. STRUCT. BIOL, (2001), vol. 8, pages 874 - 878
    - PINKERT ET AL., CIRCULATION, (2009), vol. 120, no. 23, pages 2358 - 66
    - WANG ET AL., J VIROL., (2011), vol. 85, no. 13, pages 6390 - 402
    - LISEWSKI ET AL., J EX MED, (2008), vol. 205, no. 10, pages 2369 - 2379
    - RASCHPERGER ET AL., DEV BIOL., (2008), vol. 313, no. 1, pages 455 - 64
    - DORNER ET AL., J BIOL CHEM., (2004), vol. 279, no. 18, pages 18497 - 503
    - AOURDI ET AL., NATURE, (2009), vol. 458, pages 1180 - 1184
    - LISEWSKI, U. ET AL., "The tight junction protein CAR regulates cardiac conduction and cell-cell communication", J EXP MED, (2008), vol. 205, pages 2369 - 79
    - WEINERT ET AL., J CELL BIOL., (20060522), vol. 173, no. 4, pages 559 - 570
    - MICHAEL ET AL., AM J PHYSIOL., (199512), vol. 269, pages H2147 - 54
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.