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Extract from the Register of European Patents

EP About this file: EP2801366

EP2801366 - Improved apo E analogs and methods for their use [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  01.04.2016
Database last updated on 15.06.2024
Most recent event   Tooltip01.04.2016Application deemed to be withdrawnpublished on 04.05.2016  [2016/18]
Applicant(s)For all designated states
Cognosci, Inc.
2 Davis Drive
Research Triangle Park, NC 27709-2076 / US
[2014/46]
Inventor(s)01 / Vitek, Michael P.
2 Davies Drive
Research Triangle Park, NC 27709-2076 / US
02 / McKenna, Suzanne E.
2 Davies Drive
Research Triangle Park, NC 27709-2076 / US
03 / Self, Christopher R.
32 Natalie Drive
West Caldwell, New Jersey 07006 / US
 [2014/46]
Representative(s)Tollervey, Rebecca Marie, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[N/P]
Former [2014/46]Tollervey, Rebecca Marie, et al
Mewburn Ellis LLP 33 Gutter Lane London
EC2V 8AS / GB
Application number, filing date13179863.902.09.2005
[2014/46]
Priority number, dateUS20040606506P02.09.2004         Original published format: US 606506 P
US20040606507P02.09.2004         Original published format: US 606507 P
US20040608148P09.09.2004         Original published format: US 608148 P
[2014/46]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2801366
Date:12.11.2014
Language:EN
[2014/46]
Type: A3 Search report 
No.:EP2801366
Date:29.04.2015
Language:EN
[2015/18]
Search report(s)(Supplementary) European search report - dispatched on:EP27.03.2015
ClassificationIPC:A61K38/00
[2014/46]
CPC:
A61K38/1709 (EP,US); A61P1/00 (EP); A61P1/02 (EP);
A61P1/04 (EP); A61P11/04 (EP); A61P13/10 (EP);
A61P17/02 (EP); A61P17/06 (EP); A61P17/16 (EP);
A61P19/02 (EP); A61P25/00 (EP); A61P25/02 (EP);
A61P25/28 (EP); A61P29/00 (EP); A61P31/04 (EP);
A61P37/02 (EP); A61P39/00 (EP); A61P43/00 (EP);
A61P9/00 (EP); A61P9/10 (EP); C07K14/775 (EP,US);
Y02A50/30 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2014/46]
TitleGerman:Verbesserte ApoE-Analoga und Verwendungsverfahren dafür[2014/46]
English:Improved apo E analogs and methods for their use[2014/46]
French:Analogues apo E améliorés et leurs procédés d'utilisation[2014/46]
Examination procedure09.08.2013Examination requested  [2014/46]
04.03.2014Loss of particular rights, legal effect: Claims
09.04.2014Despatch of communication of loss of particular rights: Claims {1}
30.10.2015Application deemed to be withdrawn, date of legal effect  [2016/18]
07.12.2015Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2016/18]
Parent application(s)   TooltipEP05802697.2  / EP1796708
Fees paidRenewal fee
18.11.2013Renewal fee patent year 03
18.11.2013Renewal fee patent year 04
18.11.2013Renewal fee patent year 05
18.11.2013Renewal fee patent year 06
18.11.2013Renewal fee patent year 07
18.11.2013Renewal fee patent year 08
28.10.2013Renewal fee patent year 09
29.09.2014Renewal fee patent year 10
28.09.2015Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO03026479  (COGNOSCI INC [US], et al) [Y] 1-14 * the whole document *;
 [Y]US2003077641  (LASKOWITZ DANIEL T [US], et al) [Y] 1-14 * the whole document *;
 [E]WO2006029028  (COGNOSCI INC [US], et al) [E] 1-14 * the whole document *;
 [Y]  - LYNCH JOHN R ET AL, "APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 5 DEC 2003, (20031205), vol. 278, no. 49, ISSN 0021-9258, pages 48529 - 48533, XP002528634 [Y] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1074/JBC.M306923200
 [Y]  - AONO M ET AL, "Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.", NEUROSCIENCE 2003, (2003), vol. 116, no. 2, ISSN 0306-4522, pages 437 - 445, XP002528635 [Y] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0306-4522(02)00709-1
 [Y]  - FENG-QIAO LI ET AL, "Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, (20030901), vol. 318, no. 3, doi:10.1124/JPET.106.103671, ISSN 0022-3565, pages 956 - 965, XP008129906 [Y] 1,9,13 * the whole document *

DOI:   http://dx.doi.org/10.1124/jpet.106.103671
 [IP]  - D. T. LASKOWITZ ET AL, "Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease", ACTA NEUROLOGICA SCANDINAVICA, (20060801), vol. 114, no. s185, doi:10.1111/j.1600-0404.2006.00680.x, ISSN 0001-6314, pages 15 - 20, XP055008689 [IP] 1 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1600-0404.2006.00680.x
 [Y]  - LASKOWITZ D T ET AL, "Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides", EXPERIMENTAL NEUROLOGY, ACADEMIC PRESS, NEW YORK, NY, US, (20010101), vol. 167, no. 1, doi:10.1006/EXNR.2001.7541, ISSN 0014-4886, pages 74 - 85, XP002363220 [Y] 1 * the whole document *

DOI:   http://dx.doi.org/10.1006/exnr.2001.7541
by applicantUS4902505
 US5017566
 US5567682
 US5604198
 US5686416
 US2003105027
 US6762169
    - LYNCH ET AL., J. BIOL. CHEM., (2003), vol. 278, no. 4, pages 48529 - 33
    - PROC. NATL. ACAD. SCI. USA, (1994), vol. 91, pages 7144 - 7118
    - "Drug Transport and targeting", OH ET AL., Membrane Transporters as Drug Targets, PLENUM PRESS, (1999), pages 59 - 88
    - MIX ET AL., J NEUROIMMUNOL., (2004), vol. 151, no. 1-2, pages 158 - 70
    - ANDERSON ET AL., ANN. NEUROL., (2004), vol. 55, no. 5, pages 654 - 9
    - MULT. SCLER., (2004), vol. 10, no. 2, pages 158 - 64
    - ALBERTS ET AL., STROKE, (1996), vol. 27, page 183
    - AMADOR ET AL., "Serum lactate dehydrogenase activity: an analytical assessment of current assays", CLIN. CHEM., (1963), vol. 9, pages 391 - 4
    - AONO M.; LEE Y.; GRANT, E.R.; ZIVIN, R.A.; PEARLSTEIN, R.D.; WARNER, D.S.; BENNETT, E.R.; LASKOWITZ, D.T., "Apolipoprotein E protects against NMDA excitotoxicity", NEUROBIOL. DIS., (2002), vol. 11, pages 214 - 20
    - AONO, M.; BENNETT, E.R.; KIM, K.S.; LYNCH, J.R.; MYERS, J.; PEARLSTEIN, R.D.; WARNER, D.S.; LASKOWITZ, D.T., "Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures", NEUROSCIENCE, (2003), vol. 116, pages 437 - 45
    - ASOH, S.; OHSAWA, I.; MORI, T.; KATSURA, K.; HIRAIDE, T.; KATAYAMA, Y.; KIMURA, M.; OZAKI, D.; YAMAGATA, K.; OHTA, S, "Protection against ischemic brain injury by protein therapeutics", PNAS, (2002), vol. 99, pages 17107 - 17112
    - AVILA ET AL., J BIOL. CHEM., (1982), vol. 257, page 5900
    - BALARAM; GURUNATH, "Incorporation of a potentially helix breaking D- Phe-Pro sequence into the center of a right handed 16 residue peptide helix", BIOCHEM. BIOPHYS. RES. COMMUN., (1994), vol. 202, no. 1, page 241
    - BARABOI, V. A.; BELOSHISKII, P. V.; KRASIUK, A. N.; KORKACH, V. I., "Oxygen dependent processes in the irradiated organisms", FIZIOL. ZH., (1994), vol. 40, pages 116 - 128
    - BART ET AL., "Regional cerebral blood flow in apolipoprotein E deficient mice and wildtype mice during focal cerebral ischemia", NEUROREPORT, (1998), vol. 9, pages 2615 - 2620
    - BELLOSTA ET AL., "Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth", J BIOL. CHEM., (1995), vol. 270, pages 27063 - 27071
    - BEN-NATHAN D; PADGETT DA; LORIA RM, "Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity", J MED MICROBIOL., (199905), vol. 48, no. 5, pages 425 - 31
    - BENVENISTE EN, "Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis", J MOL MED., (1997), vol. 75, no. 3, pages 165 - 73
    - BOLIN ET AL., "Peptide and peptide mimetic inhibitors of antigen presentation by HLA- DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures", J. MED. CHEM., (2000), vol. 43, pages 2135 - 48
    - BACSKAI ET AL., "The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors", PROC. NATL. ACAD. SCI., (2000), vol. 97, pages 11551 - 11556
    - BARGER; HARMON, NATURE, (1997), vol. 388, page 878
    - BART ET AL., "Regional cerebral blood flow in apolipoprotein E deficient vs wildtype mice undergoing middle cerebral artery occlusion", NEUROREPORT, (1998), vol. 11, pages 2615 - 2620
    - BELL ET AL., "Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS", J. NEUROCYTOL., (1994), vol. 23, no. 10, pages 605 - 13
    - BERLINER ET AL., CIRCULATION, (1995), vol. 91, page 2488
    - BI ET AL., "Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists", NEUROSCIENCE, (2002), vol. 112, no. 4, pages 827 - 40
    - BI ET AL., "N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease", J. NEUROL. SCI., (2002), vol. 200, no. 1-2, pages 11 - 8
    - BIAKOV, V. M.; STEPANOV, S.V., "Mechanism of primary radiobiologic action", RADIAT. BIOL. RADIOECOL., (1997), vol. 37, pages 469 - 474
    - BOCCHINI, V. R.; MAZZOLLA, R.; BARLUZZI, E.; BLASI, P.; SICK; H. KETTENMANN, "An immortalized cell line expresses properties of activated microglial cells", J. NEUROSCI. RES., (1992), vol. 31, pages 616 - 621
    - BOGOYEVITCH, M. A.; KENDRICK, T.S.; NG, D.C.H.; BARR, R.K., "Taking the cell by stealth or storm? Protein transduction domains (PTDs) as versatile vectors for delivery", DNA AND CELL BIOLOGY, (2002), vol. 21, pages 879 - 894
    - BOLTON, S.J.; JONES, D.N.C.; DARKER, J.G.; EGGLESTON, D.S.; HUNTER, J.; WALSH, F.S., "Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain", EUROPEAN JOURNAL OF NEUROSCIENCE, (2000), vol. 12, pages 2847 - 2855
    - BRAIN INJURY FACT SHEET, (2002), URL: http://www.biausa.org/word.files.to.pdf/good.pdfs/2002FactSheetBrainInjury.pdf
    - BREITNER ET AL., NEUROBIOL. AGING, (1995), vol. 16, page 523
    - BRODERICK ET AL., "Apolipoprotein E phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke", ANN. NEUROL., (2001), vol. 49, pages 736 - 744
    - CAO, G.; W. PEI, H.; GE, Q.; LIANG, Y.; LUO, F. R.; SHARP, A.; LU, R.; RAN, S. H.; GRAHAM; CHEN, J., "In vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against Ischemic Brain Injury and Neuronal Apoptosis", SOCIETY OFNEUROSCIENCE, (2002), vol. 22, pages 5423 - 5431
    - CADY, "Understanding opioid tolerance in cancer pain", ONCOL. NURS. FORUM, (2001), vol. 28, no. 10, pages 1561 - 8
    - CALABRESI, "Considerations in the treatment of relapsing-remitting multiple sclerosis", NEUROLOGY, (2002), vol. 58, no. 8, pages 10 - 22
    - CHAPMAN ET AL., "Preliminary observations on APOE epsilon 4 allele and progression of disability in multiple sclerosis", ARCH. NEUROL., (1999), vol. 56, pages 1484 - 1487
    - CHAPMAN J; VINOKUROV S; ACHIRON A; KARUSSIS DM; MITOSEK-SZEWCZYK K; BIRNBAUM M; MICHAELSON DM; KORCZYN AD, "APOE genotype is a major predictor of long-term progression of disability in MS", NEUROLOGY, (2001), vol. 56, no. 3, pages 312 - 6
    - CHEN ET AL., "Motor and cognitive deficits in apolipoprotein-E deficient mice after closed head injury", NEUROSCIENCE, (1997), vol. 80, pages 1255 - 1262
    - CHEN ET AL., "N-acyl-L-phenylalanine derivatives as potent VLA-4 antagonists that mimic a cyclic peptide conformation", BIOORG. MED. CHEM. LETT., (2002), vol. 12, pages 137 - 40
    - CHENSUE ET AL., AM. J. PATHOL., (1991), vol. 138, pages 395 - 402
    - CHIANG CS; HONG JH; STALDER A; SUN JR; WITHERS HR; MCBRIDE WH, "Delayed molecular responses to brain irradiation", INT J RADIAT BIOL., (1997), vol. 72, no. L, pages 45 - 53
    - COLEMAN N; BUMP E; KRAMER R, "Chemical modifiers of cancer treatment", J CLIN ONCOL, (1988), vol. 6, pages 709 - 733
    - CLIFFORD, "AIDS dementia", MED. CLIN. NORTH AM., (2002), vol. 86, no. 3, pages 537 - 50
    - COHEN ET AL., "Interaction oflactoferrin and lipopolysaccharide (LPS): effects on the antioxidant property of lactoferrin and the ability of LPS to prime human neutrophils for enhanced superoxide formation", J. INFECT. DIS., (1992), vol. 166, pages 1375 - 1378
    - CONNOLLY ET AL., STROKE, (1996), vol. 27, page 174
    - CLODI; YOUNES, "Reed-Stemberg cells and the TNF family of receptors/ligands", LEUK. LYMPHOMA, (1997), vol. 27, pages 195 - 205
    - COLTON, C.A.; BROWN, C.M.; COOK, D.; NEEDHAM, L.K.; XU, Q.; CZAPIGA, M.; SAUNDERS, A.M.; SCHMECHEL, D.E.; RASHEED, K.; VITEK, M.P., "APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress", NEUROBIOLOGY OFAGING, (2002), vol. 23, pages 777 - 85
    - CORDER ET AL., "Gene doses of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families", SCIENCE, (1993), vol. 261, pages 921 - 923
    - CRAWFORD FC; VANDERPLOEG RD; FREEMAN MJ; SINGH S; WAISMAN M; MICHAELS L; ABDULLAH L; WARDEN D; LIPSKY R; SALAZAR A, "APOE genotype influences acquisition and recall following traumatic brain injury", NEUROLOGY, (2002), vol. 58, no. 7, pages 1115 - 8
    - DAIL ET AL., "Responses to cortical injury: II. Widespread depression of the activity of an enzyme in cortex remote from a focal injury", BRAIN RES., (1981), vol. 211, pages 79 - 89
    - DENICOURT, C.; DOWDY, S.F., "Protein transduction technology offers novel therapeutic approach for brain ischemia", TRENDS IN PHARMACOLOGICAL SCIENCES, (2003), vol. 24, pages 216 - 218
    - DIETZ, G.P.H; KILIC, E.; BAHR, M., "Inhibition of neuronal apoptosis in vitro and in vivo Using TAT-mediated protein transduction", MOLECULAR AND CELLULAR NEUROSCIENCE, (2002), vol. 21, pages 29 - 37
    - DE BONT N; NETEA MG; DEMACKER PN; VERSCHUEREN I; KULLBERG BJ; VAN DIJK KW; VAN DER MEER JW; STALENHOEF AF, "Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection", J LIPID RES., (199904), vol. 40, no. 4, pages 680 - 5
    - DISCALA ET AL., "Children hospitalized for traumatic brain injury: transition to postacute care", J. HEAD TRAUMA REHABIL., (1997), vol. 12, no. 2, pages 1 - 10
    - DOIG, "Recent Advances in helix-coil theory", BIOPHYS. CHEM., (2002), vol. 101-102, page 281
    - DOIG ET AL., "Determination of free energies of N-capping in alpha helices by modification of the Lifson-Roig helix-coil theory to include N- and C- capping", BIOCHEMISTRY, (1994), vol. 33, no. 11, page 3396
    - DOIG; BALDWIN, "N- and C- capping preferences for all 20 amino acids in alpha-helical peptides", PROTEIN SCI., (1993), vol. 4, no. 7, page 1325
    - DHIB-JALBUT, "Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis", NEUROLOGY, (2002), vol. 58, no. 8, pages 3 - 9
    - DOBLE, "The role of excitotoxicity in neurodegenerative disease: implications for therapy", PHARMACOL. THER., (1999), vol. 81, no. 3, pages 163 - 221
    - DRAGARIC, 1. G.; DRAGARIC, Z. D., The radiation chemistry of water, ACADEMIC PRESS, (1971), page 256
    - DUNLOP ET AL., "HIV dementia and apolipoprotein E", ACTA NEUROL. SCAND., (1997), vol. 95, no. 5, pages 315 - 8
    - DYER ET AL., J BIOL. CHEM., (1991), vol. 266, page 15009
    - ERNST ET AL., "Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion", ANGEW CHEM. INT. ED. ENGL., (2002), vol. 41, pages 278 - 81
    - EDGINGTON; CURTISS, CANCER RES., (1981), vol. 41, page 3786
    - ENG LF; GHIRNIKAR RS; LEE YL, "Inflammation in EAE: role of chemokine/cytokine expression by resident and infiltrating cells", NEUROCHEM RES., (1996), vol. 21, no. 4, pages 511 - 25
    - FAZEKAS F; STRASSER-FUCHS S; KOLLEGGER H; BERGER T; KRISTOFERITSCH W; SCHMIDT H; ENZINGER C; SCHIEFERMEIER M; SCHWARZ C; KORNEK B, "Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis", NEUROLOGY, (2001), vol. 57, no. 5, pages 853 - 7
    - FEINSTEIN DL; GALEA E; GAVRILYUK V; BROSNAN CF; WHITACRE CC; DUMITRESCU- OZIMEK L; LANDRETH GE; PERSHADSINGH HA; WEINBERG G; HENEK, "Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis", ANN NEUROL., (2002), vol. 51, no. 6, pages 694 - 702
    - FEENEY ET AL., "Responses to cortical injury: I. Methodology and local effects of contusions in the rat", BRAIN RES., (1981), vol. 211, pages 67 - 77
    - FISHER, P. M.; E. KRAUSZ.; D. P. LANE., "Cellular delivery of impermeable effector molecules in the form of conjugates with peptides capable of mediating membrane translocation", BIOCONJUGATE CHEMISTRY, (2001), vol. 12, pages 825 - 841
    - FIKE JR; CANN CE; TUROWSKI K; HIGGINS RJ; CHAN AS; PHILLIPS TL; DAVIS RL., "Radiation dose response of normal brain", INT J RADIAT ONCOL BIOL PHYS., (1988), vol. 14, no. L, pages 63 - 70
    - FLEGEL WA; BAUMSTARK MW; WEINSTOCK C; BERG A; NORTHOFFH, "Prevention of endotoxin-induced monokine release by human low- and high-density lipoproteins and by apolipoprotein A-I", INFECT IMMUN., (1993), vol. 61, no. 12, pages 5140 - 6
    - FLEMING ET AL., "Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins", EXP. NEUROL., (1996), vol. 138, pages 252 - 260
    - FRIEDMAN, "Apolipoprotein E-epsilon 4 genotype predicts a poor outcome in survivors of traumatic brain injury", NEUROLOGY, (1999), vol. 52, pages 244 - 248
    - FOTOUHI ET AL., "The design and synthesis of potent cyclic peptide VCAM- VLA-4 antagonists incorporating an achiral Asp-Pro mimetic", BIOORG. MED. CHEM. LETT., (2000), vol. 10, pages 1171 - 3
    - FUTAKI, S., "Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms", INTERNATIONAL JOURNAL OFPHARMACEUTICS, (2002), vol. 245, pages 1 - 7
    - FARBER ET AL., "Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity", MOL. PSYCHIATRY, (2002), vol. 7, no. 7, pages 726 - 33
    - FAZIO ET AL., PROC. NATL. ACAD. SCI., (1997), vol. 94, page 4647
    - FLAHERTY ET AL., "Regulation of tau phosphorylation in microtubule fractions by apolipoprotein E", J. NEUROSCI. RES., (1999), vol. 56, no. 3, pages 271 - 4
    - GARCIA-ECHEVERRIA, C.; JIANG, L.; RAMSEY, T.M.; SHARMA, S.K.; CHEN, Y.-N. P, "A new Antennapedia-derived vector for intracellular delivery of exogenous compounds", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2001), vol. 11, pages 1363 - 1366
    - GARCIA-ECHEVERRIA, C.; RUETZ, S., "p-Homolysine oligomers: a new class of Trojan carriers", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2003), vol. 13, pages 247 - 251
    - GAFFIN SL; WELLS M; JORDAN JP, "Anti-lipopolysaccharide toxin therapy for whole body X-irradiation overdose", BR J RADIOL., (1985), vol. 58, no. 693, pages 881 - 4
    - GIRINSKY TA; M PALLARDY; E COMOY; T. BENASSI; R ROGER; G GANEM; JM COSSET; G SOCIE; H MAGDELENAT, "Peripheral blood corticotropin-releasing factor, adrenocorticotropic hormone and cytokine (interleukin beta, interleukin 6, tumor necrosis factor alpha) levels after high- and low-dose total-body irradiation in humans", RADIAT RES., (1994), vol. 139, pages 360 - 363
    - GALLO ET AL., "Potential role of apolipoprotein-E in fibrillogenesis", AM. J. PATHOL., (1994), vol. 145, pages 526 - 530
    - GOTSCHALL ET AL., "Comparison of three measures of injury severity in children with traumatic brain injury", J. NEUROTRAUMA, (1995), vol. 12, pages 611 - 619
    - GRUBBS ET AL., "Ring-closing metathesis of olefinic peptides: Design, Synthesis, and Structural characterization of macrocyclic helical peptide", J. ORG. CHEM., (2001), vol. 66, page 5291
    - GUTMAN ET AL., "Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor", J NEUROSCI., (1997), vol. 17, pages 6114 - 6121
    - GEHRMENN ET AL., "Microglia: intrinsic immuneffector cell of the brain", BRAIN RES. BRAIN RES. REV, (1995), vol. 20, no. 3, pages 269 - 87
    - GIULIAN ET AL., J. NEUROSCIENCE, (1996), vol. 16, page 3139
    - GRIFFIN ET AL., J NEUROPATH. EXP. NEUROL., (1995), vol. 54, page 276
    - GRUBBS R.H.; BLACKWELL H.E.; SADOWSKY J.D.; HOWARD R.J.; SAMPSON J.N.; CHAO J.A.; STEINMETZ W.E.; O'LEARY D.J., "Ring-closing metathesis of olefinic peptides: Design, Synthesis, and Structural characterization ofmacrocyclic helical peptides", J.ORG.CHEM., (2001), vol. 66, page 5291
    - HALL, EJ., Radiobiology for the Radiologist, 5th edition,, LIPPINCOTT WILLIAMS AND WILKINS, (2000), page 138
    - HAMM ET AL., "The Rotarod Test: An Evaluation Of Its Effectiveness In Assessing Motor Deficits Following Traumatic Brain Injury", J NEUROTRAUMA, (1994), vol. 11, pages 187 - 196
    - HAMILTON ET AL., "Design and application of an alpha helix mimetic scaffold based on an Oligoamide-foldamer strategy: Antagonism of the Bak BH3/Bcl-xL complex", ANGEW. CHEM. INT. ED., (2003), vol. 42, no. 5, page 535
    - HAMILTON ET AL., "Design of a protein surface antagonist based on alpha-helix mimicry: Inhibition of gp41 assembly and viral fusion", ANGEW. CHEM. INT. ED., (2002), vol. 41, no. 2, page 278
    - HAMILTON ET AL., "Towards proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha helix", J AMER. CHEM. SOC., (2001), vol. 123, page 5382
    - HAYEK ET AL., "Increased plasma and lipoprotein lipid peroxidation in apo E- deficient mice", BIOCHEM. BIOPHYS. RES. COMMUN., (1994), vol. 201, pages 1567 - 1574
    - HEBER-KATZ E, "The ups and downs ofEAE", INT REV IMMUNOL., (1993), vol. 9, no. 4, pages 277 - 85
    - HEMMER B; ARCHELOS JJ; HARTUNG HP, "New concepts in the immunopathogenesis of multiple sclerosis", NAT REV NEUROSCI., (2002), vol. 3, no. 4, pages 291 - 301
    - HILL GR; CRAWFORD JM; COOKE KR; BRINSON YS; PAN L; FERRARA JL, "Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines", BLOOD, (1997), vol. 90, no. 8, pages 3204 - 13
    - HILL RP; H-P RODEMANN; JH HENDRY; SA ROBERTS; M. S. ANSCHER, "Normal tissue radiobiology: From the laboratory to the clinic", INT. J. RADIATION ONCOLOGY BIOL. PHYS., (2001), vol. 49, pages 353 - 365
    - HONG JH; CHIANG CS; CAMPBELL IL; SUN JR; WITHERS HR; MCBRIDE WH, "Induction of acute phase gene expression by brain irradiation", INT J RADIAT ONCOL BIOL PHYS, (19951015), vol. 33, no. 3, pages 619 - 26
    - HIRSCHMANN ET AL., "Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic", J MED. CHEM., (1996), vol. 39, pages 2441 - 2448
    - HOLTZMAN ET AL., "Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line", PROC. NATL. ACAD. SCI. U. S. A., (1995), vol. 92, pages 9480 - 9484
    - HORSBURGH ET AL., "Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia", NEUROREPORT, (1999), vol. 10, pages 837 - 841
    - HORSBURGH ET AL., "Intraventricular infusion of apolipoprotein E ameliorates acute neuronal damage after global cerebral ischemia in mice", J. CEREBRAL BLOOD FLOW METAB., (2000), vol. 20, pages 458 - 462
    - HANSSON, BASIC RES. CARDIOL., (1994), vol. 89, no. 1, page 41
    - HARRIS ET AL., HEPATOL., (1998), vol. 27, pages 1341 - 48
    - HARRIS ET AL., J. CLIN. INVEST., (1993), vol. 91, pages 1028 - 34
    - HARRIS HW; GRUNFELD C; FEINGOLD KR; RAPP JH., "Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mic", J CLIN INVEST., (1990), vol. 86, no. 3, pages 696 - 702
    - HAUGHEY ET AL., "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity", J. NEUROCHEM., (2001), vol. 78, no. 3, pages 457 - 67
    - HENDERSON ET AL., MICROBIOL. REV., (1996), vol. 60, pages 316 - 34
    - HOLTZMAN ET AL., "Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line", PROC. NATL. ACAD. SCI., (1995), vol. 92, pages 9480 - 9484
    - HENSLEY, ML.; LM SCHUCHTER; C LINDLEY; NL MEROPOL; GI COHEN; G BRODER; WJ GRADISHAR; DM GREEN; RJ LANGDON; RB MITCHELL, "DG Pfister for the American Society of Clinical Oncology. 1999. American Society of Clinical Oncology Clinical Practice Guidelines for the Use of Chemotherapy and Radiotherapy Protectants.", J CLIN. ONCOL., vol. 17, pages 3333 - 3355
    - HIGUCHI, Y; GA NELSON; M VAZQUEZ; DT LASKOWITZ; JM SLATER; RD PEARLSTEIN, "Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation", J. RADIAT. RES., (2002), vol. 43, pages S219 - S224
    - HUANG ET AL., "Apolipoprotein E fragments present in Alzheimer's Disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons", PROC. NATL. ACAD. SCI. USA, (2001), vol. 91, pages 11183 - 11186
    - HUETTINGER ET AL., "Characteristics of chylomicron remnant uptake into rat liver", CLIN. BIOCHEM., (1988), vol. 21, no. 2, pages 87 - 92
    - INNERARITY, J BIOL. CHEM., (1979), vol. 254, pages 4186 - 4190
    - INNERARITY ET AL., "The receptor-binding domain of human apolipoprotein E: binding of apolipoprotein E fragments", J. BIOL. CHEM., (1983), vol. 258, pages 12341 - 47
    - JORDAN ET AL., "Apolipoprotein E epsilon-4 associated with chronic traumatic brain injury in boxing", JAM. MED. ASSOC., (1997), vol. 278, pages 136 - 140
    - JONES ET AL., "Attenuation of acute morphine withdrawal in the neonatal rat by the competitive NMDA receptor antagonist LY2359592002", NEUROPSYCHOPHARMACOLOGY, (2002), vol. 26, no. 3, pages 301 - 10
    - JORDAN ET AL., "Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures", J NEUROSCI., (1998), vol. 18, pages 195 - 204
    - JOSEPH, JA; S ERAT; BM RABIN, "CNS effects of heavy particle irradiation in space: behavioral implications", ADV. SPACE RES., (1998), vol. 22, pages 209 - 216
    - KARLE, "Controls exerted by the Aib residue: Helix formation and Helix reversal", BIOPOLYMERS, (2001), vol. 60, no. 5, page 351
    - KARLE; BALARAM, "Structural characteristics of alpha helical peptide molecules containing Aib residues", BIOCHEMISTRY, (1990), vol. 29, no. 29, page 6747
    - KILIC, Ü.; KILIC, E.; DIETZ, G.P.H.; BAHR, M., "Intravenous TAT-GDNF is protective after focal cerebral ischemia in mice", STROKE, (2003), vol. 34, pages 1304 - 1310
    - KNOUFF ET AL., "ApoE structure determines VLDL clearance and atherosclerosis risk in mice", J. CLIN. INVEST., (1999), vol. 103, pages 1579 - 86
    - KRAUS ET AL., "Brain injuries among infants, children, adolescents and young adults", AJDC, (1990), vol. 144, pages 684 - 691
    - KIM ET AL., "Human apolipoprotein E receptor 2", J. BIOL CHEM., (1996), vol. 271, pages 8373 - 8380
    - KLOPMAN; SEDYKH, "An MCASE approach to the search of a cure for Parkinson's Disease", BMC PHARMACOL., (2002), vol. 2, no. 1, page 8
    - KOLKER ET AL., "NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria", EUR. J. NEUROSCI., (2002), vol. 16, no. 1, pages 21 - 8
    - KOPPELHUS, U.; AWASTHI, S.K.; ZACHAR, V.; HOLST H.U.; EBBSEN, P.; NIELSON, P.E., "Cell-dependent differential cellular uptake ofPNA, peptides, and PNA-peptide conjugates", ANTISENSE NUCLEIC ACID DRUG DEV, (2002), vol. 12, pages 51 - 63
    - KOTLINSKA, "NMDA antagonists inhibit the development of ethanol dependence in rats", POL. J PHARMACOL., (2001), vol. 53, no. 1, pages 47 - 50
    - KRIEGER; HERZ, "Structures and functions ofmultiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP", ANN. REV. BIOCHEM., (1994), vol. 63, pages 601 - 37
    - KUDO ET AL., "Absence of direct antioxidant effects from volatile anesthetics in mixed neuronal-glial culture", ANESTHESIOLOGY, (2001), vol. 94, pages 303 - 312
    - LASKOWITZ ET AL., "Altered immune responses in apolipoprotein E deficient mice", J. LIPID RES., (2000), vol. 41, pages 613 - 620
    - LASKOWITZ ET AL., "Apolipoprotein E and the CNS response to injury", J. CEREBRAL BLOOD FLOW METAB., (1998), vol. 18, pages 465 - 471
    - LASKOWITZ; ROSES, "Apolipoprotein E: an expanding role in the neurobiology of disease", ALZHEIMER'S REPORTS, (1998), vol. 1, pages 5 - 12
    - LASKOWITZ ET AL., "Downregulation of microglia activation by apolipoprotein-E and apoE-mimetic peptides", EXPT. NEUROL., (2001), vol. 167, pages 74 - 85
    - LASKOWITZ ET AL., "Apolipoprotein E deficient mice have increased susceptibility to focal cerebral ischemia", J. CEREB. BLOOD FLOW METAB., (1997), vol. 17, pages 753 - 758
    - LASKOWITZ ET AL., "Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric-oxide production", NEUROREPORT, (1997), vol. 9, pages 615 - 618
    - LASKOWITZ ET AL., "Apolipoprotein E suppresses glial cell secretion of TNFa", JNEUROIMMUNOLOGY, (1997), vol. 76, pages 70 - 74
    - LIEFERT, J.A.; WHITTON, J.L., "Translocatory proteins'' and ''protein transduction domains'': a critical analysis of their biological effects and the underlying mechanisms", MOLECULAR THERAPY, (2003), vol. 8, pages 13 - 19
    - LINDSAY, M.A., "Peptide-mediated cell delivery: application in protein target validation", CURRENT OPINIONS IN PHARMACOLOGY, (2002), vol. 2, pages 587 - 594
    - LO, E.H.; SINGHAL, A.B.; TORCHLIN, V.P.; ABBOTT, N.J., "Drug delivery to damaged brain", BRAIN RESEARCH REVIEWS, (2001), vol. 38, pages 140 - 148
    - LOMNITSKI, L.; CHAPMAN, S.; HOCHMAN, A.; KOHEN, R.; SHOHAMI, E.; CHEN, Y.; TREMBOVLER, V.; MICHAELSON, D.M., "Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury", BIOCHIM BIOPHYS ACTA, (1999), vol. 1453, pages 359 - 68
    - LENDON ET AL., "No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo", EURO. J. NEUROSCI., (2000), vol. 12, pages 2235 - 2242
    - LIGHTHALL, "Controlled cortical impact: a new experimental brain injury model", J NEUROTRAUMA, (1988), vol. 5, pages 1 - 15
    - LINTON ET AL., "Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation", J. CLIN. INVEST., (1991), pages 270 - 81
    - LINTON ET AL., SCIENCE, (1995), vol. 267, page 1034
    - LINTON ET AL., "Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation. V", CLIN. INVEST., (1997), pages 270 - 281
    - LIU ET AL., "Synthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry", J MED. CHEM., (2000), vol. 43, pages 3827 - 3831
    - LUCOTTE GL; FRENCH MS, "Confirmation of a gene for multiple sclerosis (MS) to chromosome region 19ql3.3", GENET COUNS., (2002), vol. 13, no. 2, pages 133 - 8
    - LYNCH ET AL., "Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response", J. NEUROIMMUNOLOGY, (2001), vol. 114, pages 107 - 113
    - LYNCH ET AL., "Apolipoprotein E affects the Central Nervous System Resonse to Injury and the Development of Cerebral Edema", ANN. NEUROL., (2002), vol. 51, pages 113 - 7
    - LALAZAR ET AL., "Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions", J BIOL. CHEM., (1998), vol. 263, pages 3542 - 3545
    - LE; LIPTON, "Potential and current use ofN-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging", DRUGS AGING, (2001), vol. 18, no. 10, pages 717 - 24
    - LENDON ET AL., "No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo", EURO. J. NEUROSCI, (2000), vol. 12, pages 2235 - 2242
    - LYNN, W. A.; J. COHEN, "Adjunctive therapy for septic shock: a review of experimental approaches", CLIN. INFECT. DIS., (1995), vol. 20, pages 143 - 158
    - LOVESTONE ET AL., "Apolipoprotein E gene and Alzheimer's disease: is tau the link?", BIOCHEM. SOC. SYMP., (2001), pages 111 - 20
    - LUNDBERG, M; JOHANSSON, "Positively charged DNA-binding proteins cause apparent cell membrane translocation", BIOCHEM, VIOPHYS RES COMM, (2002), vol. 291, pages 367 - 371
    - MAI, J.C.; SHEN, H.; WATKINS, S.C.; CHENG, T.; ROBBINS, P.D., "Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2002), vol. 277, pages 30208 - 30218
    - MANDELL LR; STEINHERZ P; FUKS Z, "Delayed central nervous system (CNS) radiation in childhood CNS acute lymphoblastic leukemia. Results of a pilot trial", CANCER, (19900801), vol. 66, no. 3, pages 447 - 50
    - MASTERMAN T; ZHANG Z; HELLGREN D; SALTER H; ANVRET M; LILIUS L; LANNFELT L; HILLERT J, "APOE genotypes and disease severity in multiple sclerosis", MULT SCLER., (2002), vol. 8, no. 2, pages 98 - 103
    - MATTHEWS; BEAL, "Increased 3-nitrotyrosine in brains of Apo E-deficient mice", BRAIN RES., (1996), vol. 718, pages 181 - 184
    - MCARRON ET AL., "The apolipoprotein E epsilon4 allele and outcome in cerebrovascular disease", STROKE, (1998), vol. 29, pages 1882 - 1887
    - MISRA ET AL., "Apolipoprotein E and mimetic peptide initiate a calcium- dependent signaling response in macrophages", JLEUKOCYTE BIOL., (2001), vol. 70, pages 677 - 683
    - MITCHELL; SMITH, "D-amino acid residues in peptide and proteins", PROTEINS, (2003), vol. 50, no. 4, page 563
    - MIYATA; SMITH, "Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides", NAT. GENET., (1996), vol. 14, pages 55 - 61
    - MORRIS, "Developments of a water maze procedure for studying spatial learning in the rat", J NEUROSCI. METHODS, (1984), vol. 11, pages 47 - 60
    - MOSSMAN KL, "Frequent short-term oral complications of head and neck radiotherapy", EAR NOSE THROAT J., (1994), vol. 73, pages 316 - 320
    - MULLER ET AL., "Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel", BRAIN PATHOLOGY, (1998), vol. 8, pages 641 - 653
    - MATSUBARA ET AL., "Monoclonal antibodies against inflammatory mediators for the treatment of patients with sepsis", NIPPON RINSHO, (2002), vol. 60, no. 3, pages 578 - 84
    - MAYEUX ET AL., NEUROLOGY, (1995), vol. 45, page 555
    - MCGEER ET AL., GLIA, (1993), vol. 7, page 88
    - MCKENNA; MELZACK, "Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test", EXP. NEUROL., (2001), vol. 172, no. 1, pages 92 - 9
    - MELDRUM ET AL., "Excitatory amino acid neurotoxicity and neurodegenerative disease", TRENDS PHARMACOL. SCI., (1990), vol. 11, pages 379 - 387
    - MISRA ET AL., "The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor", J BIOL. CHEM., (1994), vol. 269, no. 28, pages 18303 - 6
    - MIYAZAWA ET AL., "Lactoferrin-lipopolysaccharide interactions. Effect of lactoferrin binding to monocyte/macrophage-differentiated HL-60 cells", 1 IMMUNOL., (1991), vol. 146, pages 723 - 729
    - MOULDER ET AL., "Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide", J. NEUROCHEM., (1999), vol. 72, pages 1069 - 1080
    - MYERS ET AL., "Helix propensities are identical in proteins and peptides", BIOCHEMISTRY, (1997), vol. 36, pages 10923 - 10929
    - MYTILINEOU ET AL., "L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro", J. NEUROCHEM., (1997), vol. 68, no. 1, pages 33 - 9
    - NAIR CK; DK PARIDA; TJ NOMURA, "Radioprotectors in radiotherapy", RADIAT RES (TOKYO)., (2001), vol. 42, no. L, pages 21 - 37
    - NETEA MG; DE BONT N; DEMACKER PN; KULLBERG BJ; JACOBS LE; VERVER-JANSEN TJ; STALENHOEF AF; VAN DER MEER JW., "Lipoprotein(a) inhibits lipopolysaccharide- induced tumor necrosis factor alpha production by human mononuclear cells", INFECT IMMUN, (1998), vol. 66, no. 5, pages 2365 - 7
    - NATHAN ET AL., "Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro", SCIENCE, (1994), vol. 264, pages 850 - 852
    - REPORT OF THE CONSENSUS DEVELOPMENT CONFERENCE ON THE REHABILITATION OF PERSONS WITH TRAUMATIC BRAIN INJURY, (1999), URL: http://www.nichd.nih.gov/publications/pubs/traumatic/NIH_Consensus_Statement.htm
    - NEWMAN ET AL., ANN.. THORAC. SURG., (1995), vol. 59, page 1326
    - NGUIMFACK, "Do the glutamate excitotoxicity theory and potential free radicals implication in schizophrenia aetiopathogenesis provide a new enlightenment to links between: genome, environment and biology in the determinism of that disorder?", ENCEPHALE, (2002), vol. 28, no. 2, pages 147 - 53
    - NICOLL ET AL., NAT. MED., (1995), vol. 1, page 135
    - NOVAK ET AL., "A new low density lipoprotein receptor homologue with 8 binding ligand repeats in brain of chicken and mouse", J. BIOL. CHEM., (1996), vol. 271, pages 11732 - 11736
    - OLSON ET AL., "Perspective: Concepts and Progress in the Development of Peptide Mimetics", J MED. CHEM., (1993), vol. 36, pages 3039 - 3049
    - OLSON ET AL., "Peptide Mimetics of Thyrotropin Releasing Hormone Based on a Cyclohexane Framework: Design, Synthesis, and Cognition-Enhancing Properties", J MED. CHEM, (1995), vol. 38, pages 2866 - 2879
    - ORNER ET AL., "Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix", J. AM. CHEM. SOC., (2001), vol. 123, pages 5382 - 3
    - PAUL; BOLTON, "Modulation of blood-brain barrier dysfunction and neurological deficits during acute experimental allergic encephalomyelitis by the N- methyl-D-aspartate receptor antagonist memantine", J PHARMACOL. EXP. THER., (2002), vol. 302, no. 1, pages 50 - 7
    - PEARLSTEIN, "Neuroprotective effects Of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration", J NEUROCHEM., (1998), vol. 70, pages 2012 - 2019
    - PENDER MP; WOLFE NP, "Prevention of autoimmune attack and disease progression in multiple sclerosis: current therapies and future prospects", INTERN MED J., (2002), vol. 32, no. 11, pages 554 - 63
    - PEREZ ET AL., "Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture", J. NEUROVIROL., (2001), vol. 7, no. 1, pages 1 - 10
    - PESCAROLO ET AL., "A retro-inverso peptide homologous to helix 1 of c-Myc is a potent and specific inhibitor of proliferation in different cellular systems", FASEB J., (2001), vol. 15, pages 31 - 3
    - PARKER TS; LEVINE DM; CHANG JC; LAXER J; COFFIN CC; RUBIN AL., "Reconstituted high-density lipoprotein neutralizes gram-negative bacterial lipopolysaccharides in human whole blood", INFECT IMMUN., (199501), vol. 63, no. L, pages 253 - 8
    - POIRIER, J., "Apolipoprotein E in animal models of CNS injury and Alzheimer's disease", TRENDS NEUROSCI., (1994), vol. 17, pages 525 - 530
    - PRADHAN, D. S.; NAIR, C. K. K.; SREENIVASAN, A., "Radiation injury repair and sensitization of microorganisms", PROC. IND. NATL. SCI. ACAD., (1973), vol. 39B, pages 516 - 530
    - REDLICH CA; GAO X; ROCKWELL S; KELLEY M; ELIAS JA., "IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury", J IMMUNOL., (1996), vol. 157, no. 4, pages 1705 - 10
    - RAO ET AL., "Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats", BRAIN RES., (2001), vol. 911, no. 1, pages 96 - 100
    - REGNER ET AL., "Neurochemical characterization of traumatic brain injury in humans", J. NEUROTRAUMA, (2001), vol. 18, no. 8, pages 783 - 92
    - RENSEN ET AL., "Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats in vivo", J CLIN. INVEST., (1997), vol. 99, no. 10, pages 2438 - 45
    - RICHARD, J.P.; MELIKOV, K.; VIVES, E.; RAMOS, C.; VERBEURE, B.; GAIT, M.J.; CHERNOMORDIK, L.V; LEBLEU, B, "Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2003), vol. 278, pages 585 - 590
    - ROUSSELLE, C; CLAIR, P.; LEFAUCONNIER, J.; KACZOREK, M.; SCHERRMANN, J.; TEMSAMANI, J, "New advances in the transport of doxorubicin through the blood- brain barrier by a peptide vector-mediated strategy", MOLECULAR PHARMACOLOGY, (2000), vol. 57, pages 679 - 686
    - ROUSSELLE, C.; SMIRNOVA, M.; CLAIR, P.; LEFAUCONNIER, J.; CHAVANIEU, A.; CALAS, B.; SCHERRMANN, J.; TEMSAMANI, J., "Enhanced delivery of doxorubicin into the brain via a peptide-vector-mediated strategy: saturation kinetics and specificity", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, (2001), vol. 296, pages 124 - 131
    - ROUSSELLE, C.; CLAIR, P.; SMIRNOVA, M.; KOLESNIKOV, Y.; PASTERNAK, G.W; GAC- BRETON, S.; REES, A.R.; SCHERRMANN, J.; TEMSAMANI, J., "Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated-strategy", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, (2003), vol. 36, pages 371 - 376
    - ROGERS ET AL., NEUROLOGY, (1993), vol. 43, page 1609
    - ROTHWELL; RELTON, CEREBROVASC. BRAIN METAB. REV., (1993), vol. 5, page 178
    - ROSELAAR SE; DAUGHERTY A., "Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo", J LIPID RES., (1998), vol. 39, no. 9, pages 1740 - 3
    - ROSES, AD; AM SAUNDERS, "ApoE, Alzheimer's disease, and recovery from brain stress", ANN. N.Y. ACAD. SCI., (1998), vol. 826, pages 200 - 212
    - SCHMIDT S; BARCELLOS LF; DESOMBRE K; RIMMLER JB; LINCOLN RR; BUCHER P; SAUNDERS AM; LAI E; MARTIN ER; VANCE JM, "Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis", AM J HUM GENET., vol. 70, no. 3, pages 708 - 17
    - SHENG ET AL., "Characterization of a recovery global ischemia model in the mouse", J NEUROSCI. METHODS, (1999), vol. 88, pages 103 - 109
    - SHENG ET AL., "Characterization of a recovery global ischemia model in the mouse", J. NEUROSCI. METHODS, (1999), vol. 88, pages 103 - 109
    - SHENG ET AL., "Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice", J CEREB. BLOOD FLOW METAB., (1998), vol. 18, pages 361 - 366
    - SHENG ET AL., "Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse", STROKE, (1999), vol. 30, pages 1118 - 1124
    - SCHOLES, G., "Radiation effects on DNA: The Silvanus Thomson memorial lecture", BR. J. RADIOL., (1983), vol. 56, pages 221 - 231
    - SCHUCHTER LM; GLICK J, "The Current status of WR-2721 (Amifostine): A chemotherapy and radiation therapy protector", BIOLOGIC THER CANCER, (1993), vol. 3, pages 1 - 10
    - SKELTON, R.W.; BUKACH, C.M.; LAURANCE, H.E.; THOMAS, K.G.; JACOBS, J.W., "Humans with traumatic brain injuries show place-learning deficits in computer- generated virtual space", J CLIN EXP NEUROPSYCHO, (2000), vol. 22, pages 157 - 75
    - SLOOTER ET AL., "Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation", J.AM. MED.ASSOC., (1997), vol. 277, pages 818 - 821
    - SMITH ET AL., "A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects", J NEUROTRAUMA, (1995), vol. 12, pages 169 - 78
    - SMITH ET AL., "An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 I Protease: Computational Analysis and X-Ray Structure of the Enzyme Complex", J MED. CHEM., (1997), vol. 40, pages 2440 - 2444
    - SMITH ET AL., "Design, Synthesis, and Evaluation of a Pyrrolinone-peptide Hybrid Ligand for the Class II MHC Protein HLA-DR1", J AM. CHEM. SOC., (1998), vol. 120, pages 12704 - 12705
    - SMITH ET AL., "Design, Synthesis and Evaluation of a Pyrrolinone-Based Matrix Metalloprotease Inhibitor", ORG. LETT., (2000), vol. 2, pages 3809 - 3812
    - STRITTMATTER ET AL., "Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease", PROC. NATL. ACAD. SCI. U. S. A., (1994), vol. 91, pages 11183 - 11186
    - STRITTMATTER ET AL., "Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease", PROC. NATL. ACAD. SCI. U. S. A., (1993), vol. 90, pages 1977 - 1981
    - SCHIEFER ET AL., "Riluzole prolongs survival time and alters nuclear inclusion formation in a transgenic mouse model of Huntington's disease", MOV. DISORD., (2002), vol. 17, no. 4, pages 748 - 57
    - SCHIEFERMEIER ET AL., "Apolipoprotein E polymorphism. Survival and neurological outcome after cardiopulmonary resuscitation", STROKE, (2000), vol. 21, pages 2068 - 2071
    - SCHWARZE, S.R.; HO, A.; VOCERO-AKBANI, A.; DOWDY, S.F., "In vivo transduction: delivery of a biologically active protein into the mouse", SCIENCE, (1999), vol. 285, pages 1569 - 1572
    - SCHWARZE, S.R.; DOWDY, S.F., "In vivo protein transduction: intracellular delivery of biologically active proteins, compounds, and DNA", TRENDS PHARMACOL SCI, (2000), vol. 21, pages 45 - 48
    - SELIGER ET AL., NEUROLOGY, (1997), page A213
    - SHENG ET AL., J. NEUROCHEM., (1994), vol. 63, page 1872
    - SHENG ET AL., "Apolipoprotein E deficiency worsens outcome from global ischemia in the mouse", STROKE, (1999), vol. 30, pages 1118 - 1123
    - SHENG, H.; D.T. LASKOWITZ; E. BENNETT; D.E. SCHMECHEL; R.D. BART; A.M. SAUNDERS; R.D. PEARLSTEIN; A.D. ROSES; D.S. WARNER, "Apolipoprotein E isoform- specific differences in outcome from focal ischemia in transgenic mice", J. CEREB. BLOOD FLOW METAB., (1998), vol. 18, pages 361 - 366
    - SHENG H; DT LASKOWITZ; RD PEARLSTEIN; DS WARNER, "Characterization of a recovery global ischemia model in the mouse", J NEUROSCI METHODS, (1999), vol. 88, pages 103 - 109
    - SHENG, H.; D.T. LASKOWITZ; G.B. MACKENSEN; M. KUDO; R.D. PEARLSTEIN; D.S. WARNER, "Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse", STROKE, (1999), vol. 30, pages 1118 - 1124
    - SHUKITT-HALE, B; G CASADESUS; JJ MCEWEN; BM RABIN; JA JOSEPH, "Spatial teaming and memory deficits induced by exposure to iron-56-particle radiation", RADIAT. RES., (2000), vol. 154, pages 28 - 33
    - SORBI ET AL., NEUROLOGY, (1996), vol. 46, page A307
    - SORBI ET AL., "ApoE as a prognostic factor for post-traumatic coma", NAT. MED., (1995), vol. 1, page 852
    - SOYKA ET AL., "NMDA receptor challenge with dextromethorphan - subjective response, neuroendocrinological findings and possible clinical implications", J NEURAL. TRANSM., (2000), vol. 107, no. 6, pages 701 - 14
    - STOLL; MUELLER, NEUROSCI. LETT., (1986), vol. 72, page 233
    - STOLL ET AL., GLIA, (1989), vol. 2, page 170
    - STRITTMATTER ET AL., "Apolipoprotein-e-epsilon-4 allele distributions in late- onset alzheimers disease and in other amyloid-forming diseases", PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 1977 - 81
    - SUZUKI. T.; FUTAKI, S.; NIWA, M.; TANAKA, S.; UEDO, K.; SUGIURA, Y., "Possible existence of common internalization mechanisms among Arginine-rich peptides", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2002), vol. 277, pages 2437 - 2443
    - TAKAHASHI, S; X-Z SUN; Y KUBOTA; N TAKAI; K NOJIMA, "Histological and elemental changes in rat brain after local irradiation with carbon ion beams", J. RADIAT. RES., (2002), vol. 43, pages 143 - 152
    - TAKESHIMA, K.; CHIKUSHI, A.; LEE, K.; YONEHARA, S.; MATSUZAKI, K., "Translocation of Analogues of the antimicrobial peptides magainin and buforin across human cell membranes", THE JOURNAL OFBIOLOGICAL CHEMISTRY, (2003), vol. 278, pages 1310 - 1315
    - TARDIFF ET AL., "Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center", ANN. THORAC. SURG., (1997), vol. 64, pages 715 - 20
    - TEASDALE ET AL., "Challenges in translating the efficacy of neuroprotective agents in experimental models into knowledge of clinical benefits in head injured patients", ACTA NEUROCHIR (WIEN, (1999), vol. 73, pages 111 - 6
    - TEASDALE ET AL., "Association of apolipoprotein E polymorphism with outcome after head injury", LANCET, (1997), vol. 350, pages 1069 - 1071
    - TESSEUR ET AL., "Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice", AM. J PATHOL., (2000), vol. 156, no. 3, pages 951 - 64
    - THORÉN, P.E.G.; PERSSON, D.; ISAKSON, P.; GOKSOR, M.; ONFELT, A.; NORDÉN, B, "Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (2003), vol. 307, pages 100 - 107
    - TOLAR ET AL., "Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate apoE neurotoxicity", J NEUROSCI., (1999), vol. 19, pages 7100 - 7110
    - TOLAR ET AL., "Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated", J. NEUROSCI., (1997), vol. 17, pages 5678 - 5686
    - TUNG, C.; WEISSLEDER, R., "Arginine containing peptides as delivery vectors", ADVANCED DRUG DELIVERY REVIEWS, (2002), vol. 55, pages 281 - 294
    - VAN LENTEN BJ; FOGELMAN AM; HABERLAND ME; EDWARDS PA., "The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide", PROC NATL ACAD SCI USA., (198604), vol. 83, no. 8, pages 2704 - 8
    - VAN OOSTEN M; RENSEN PC; VAN AMERSFOORT ES; VAN ECK M; VAN DAM AM; BREVE JJ; VOGEL T; PANET A; VAN BERKEL TJ; KUIPER J., "Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis", J BIOL CHEM., (20010323), vol. 276, no. 12, pages 8820 - 4
    - VEBER ET AL., "Molecular properties that influence the oral bioavailability of drug candidates", J.MED.CHEM., (2002), vol. 45, page 2615
    - VERDINE ET AL., "An all hydrocarbon cross-linking system for enhancing the helicity and metabolic stability of peptides", J AMER. CHEM. SOC., (2000), vol. 122, page 5891
    - VIJAYALAKSHMI ET AL., "Comparison of Helix stabilizing effects of a,a- Dialkyl Glycines with Linear and Cycloalkyl Side Chains", BIOPOLYMERS, (2000), vol. 53, no. 1, page 84
    - VIVES, E.; RICHARD, J.-P.; RISPAL, C.; LEBLEU, B., "TAT peptide internalization: seeking the mechanism of entry", CURRENT PROTEIN AND PEPTIDE SCIENCE, (2003), vol. 4, pages 125 - 132
    - VAN OOSTEN ET AL., "Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality", J. BIOL. CHEM., (2001), vol. 276, no. 12, pages 8820 - 24
    - VEINBERGS ET AL., "Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E", EXP. NEUROL., (2001), vol. 170, no. 1, pages 15 - 2
    - VON BERGEN ET AL., "Effect of intrathecal non-NMDA EAA receptor antagonist LY293558 in rats: a new class of drugs for spinal anesthesia", ANESTHESIOLOGY, (2002), vol. 97, no. 1, pages 177 - 82
    - WELLONS ET AL., "A comparison of strain-related susceptiblitiy in two murine recovery models of global cerebral ischemia", BRAIN RES., (2000), vol. 868, pages 14 - 21
    - WAAGE ET AL., J. EXP. MED., (1987), vol. 169, pages 333 - 38
    - WANG ET AL., "Apolipoprotein E (ApoE) peptide regulates tau phosphorylation via two different signaling pathways", J NEUROSCI. RES., (1998), vol. 51, pages 658 - 665
    - WANG ET AL., "Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide", J CELL. PHYSIOL., (1997), vol. 173, pages 73 - 83
    - WATANABE ET AL., INT. J CARDIOL., (1997), vol. 54, page 551
    - WEISBARGER ET AL., "The receptor-binding domain of human apolipoprotein E: monoclonal antibody inhibition of binding", J BIOL. CHEM., (1983), vol. 258, pages 12348 - 54
    - WEISGRABER ET AL., "Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site", J BIOL. CHEM., (1982), vol. 257, pages 2518 - 2521
    - WEISGRABER, "Apolipoprotein E: Structure-function relationships", ADV. PROTEIN CHEM., (1994), vol. 45, pages 249 - 302
    - WELLS MT; GAFFIN SL; JORDAAN JP., "Radiation induced gram negative bacteremia and endotoxemia in rabbits: modification by anti-lipopolysaccharide hyperimmune equine plasma", LIFE SCI., (19870629), vol. 40, no. 26, pages 2543 - 50
    - WELLS MT; GAFFIN SL; WESSELS BC; BROCK-UTNE JG; JORDAAN JP; VAN DEN ENDE J., "Anti-LPS antibodies reduce endotoxemia in whole body 60Co irradiated primates: a preliminary report", AVIAT SPACE ENVIRON MED., (199009), vol. 61, no. 9, pages 802 - 6
    - WENDER, P. A.; MITCHELL, D. J.; PATTABIRAMAN, K.; PELKEY, E. T.; STEINMAN, L.; ROTHBARD, J.B., "The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters", PROC. NATL. ACAD. SCI., (2000), vol. 97, pages 13003 - 13008
    - WETTEREAU ET AL., "Human apolipoprotein E3 is aqueaous solution. Evidence for two structural domains", J BIOL. CHEM., (1988), vol. 263, pages 6240 - 48
    - "Combined treatment of acute EAE in Lewis rats with TNF-binding protein and interleukin-1 receptor antagonist", EXP NEUROL., (1998), vol. 149, no. 2, pages 455 - 63
    - WISNIEWSKI ET AL., "Apolipoprotein E: a pathological chaperone in patients with cerebral and systemic amyloid", NEUROSCI. LET., (1992), vol. 135, pages 235 - 238
    - WRIGHT, L.R.; ROTHBARD, J.B.; WENDER, P.A., "Guanidinium rich peptide transporters and drug delivery", CURRENT PROTEIN AND PEPTIDE SCIENCE, (2003), vol. 4, pages 105 - 124
    - XU; LUO, "Relationship between changes ofN-methyl-D-aspartate receptor activity and brain edema after brain injury in rats", CHIN. J. TRAUMATOL., (2001), vol. 4, no. 3, pages 135 - 8
    - YE, D.; XU, D.; SINGER, A.U.; JULIANO, R.L., "Evaluation of strategies for the intracellular delivery of proteins", PHARMACEUTICAL RESEARCH, (2002), vol. 19, pages 1302 - 1309
    - ZANOTTI ET AL., "Cytokine modulation in sepsis and septic shock", EXPERT OPIN. INVESTIG. DRUGS, (2002), vol. 11, no. 8, pages 1061 - 75
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