blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2814587

EP2814587 - FC-RECEPTOR BASED AFFINITY CHROMATOGRAPHY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  08.03.2019
Database last updated on 05.08.2024
FormerThe patent has been granted
Status updated on  30.03.2018
FormerGrant of patent is intended
Status updated on  29.11.2017
FormerExamination is in progress
Status updated on  02.12.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
[2018/18]
Former [2014/52]For all designated states
F.Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
Inventor(s)01 / FALKENSTEIN, Roberto
Wastl-Witt-Strasse 5
80689 Muenchen / DE
02 / HERTENBERGER, Hubert
Muenchener Strasse 37a
82362 Weilheim / DE
03 / RUEGER, Petra
Auf der Leiten 4
82377 Penzberg / DE
04 / SCHLOTHAUER, Tilman
Sommerstrasse 3a
82377 Penzberg / DE
 [2014/52]
Representative(s)Burger, Alexander
Roche Diagnostics GmbH
Patentabteilung
Nonnenwald 2
82377 Penzberg / DE
[N/P]
Former [2014/52]Burger, Alexander
Roche Diagnostics GmbH Patent Department (LPP.....6164) P.O.Box 11 52
82372 Penzberg / DE
Application number, filing date13704599.314.02.2013
[2018/18]
WO2013EP52932
Priority number, dateEP2012015563015.02.2012         Original published format: EP 12155630
[2014/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013120929
Date:22.08.2013
Language:EN
[2013/34]
Type: A1 Application with search report 
No.:EP2814587
Date:24.12.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 22.08.2013 takes the place of the publication of the European patent application.
[2014/52]
Type: B1 Patent specification 
No.:EP2814587
Date:02.05.2018
Language:EN
[2018/18]
Search report(s)International search report - published on:EP22.08.2013
ClassificationIPC:B01D15/38, C07K1/22, C07K16/06
[2014/52]
CPC:
C07K1/22 (EP,RU,US); B01D15/168 (EP,RU,US); B01D15/3809 (EP,RU,US);
B01J20/289 (EP,RU,US); B01J20/3204 (EP,RU,US); B01J20/3206 (EP,RU,US);
B01J20/3219 (EP,RU,US); B01J20/3274 (EP,RU,US); B01J39/26 (RU,US);
C07K14/70535 (EP); C07K16/00 (EP); C07K16/065 (EP,RU,US);
C07K16/2866 (EP,RU,US); G01N33/6854 (RU,US); C07K2317/52 (EP);
C07K2317/72 (EP); C07K2317/94 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/52]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:AFFINITÄTSCHROMATOGRAPHIE AUF FC-REZEPTOR-BASIS[2014/52]
English:FC-RECEPTOR BASED AFFINITY CHROMATOGRAPHY[2014/52]
French:CHROMATOGRAPHIE D'AFFINITÉ FAISANT APPEL À DES RÉCEPTEURS FC[2014/52]
Entry into regional phase15.09.2014National basic fee paid 
15.09.2014Designation fee(s) paid 
15.09.2014Examination fee paid 
Examination procedure24.06.2014Amendment by applicant (claims and/or description)
15.09.2014Examination requested  [2014/52]
08.12.2015Despatch of a communication from the examining division (Time limit: M04)
24.02.2016Reply to a communication from the examining division
28.04.2016Despatch of a communication from the examining division (Time limit: M04)
07.09.2016Reply to a communication from the examining division
22.11.2016Despatch of a communication from the examining division (Time limit: M04)
20.03.2017Reply to a communication from the examining division
30.11.2017Communication of intention to grant the patent
23.03.2018Fee for grant paid
23.03.2018Fee for publishing/printing paid
23.03.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.12.2015
Opposition(s)05.02.2019No opposition filed within time limit [2019/15]
Fees paidRenewal fee
13.02.2015Renewal fee patent year 03
08.02.2016Renewal fee patent year 04
07.02.2017Renewal fee patent year 05
07.02.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU14.02.2013
AL02.05.2018
CY02.05.2018
CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
MC02.05.2018
MK02.05.2018
RS02.05.2018
SK02.05.2018
SM02.05.2018
BG02.08.2018
NO02.08.2018
IS02.09.2018
PT03.09.2018
[2022/31]
Former [2021/32]HU14.02.2013
AL02.05.2018
CY02.05.2018
CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
MC02.05.2018
RS02.05.2018
SK02.05.2018
SM02.05.2018
BG02.08.2018
NO02.08.2018
IS02.09.2018
PT03.09.2018
Former [2021/31]AL02.05.2018
CY02.05.2018
CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
MC02.05.2018
RS02.05.2018
SK02.05.2018
SM02.05.2018
BG02.08.2018
NO02.08.2018
IS02.09.2018
PT03.09.2018
Former [2021/26]AL02.05.2018
CY02.05.2018
CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
MC02.05.2018
RS02.05.2018
SK02.05.2018
SM02.05.2018
BG02.08.2018
NO02.08.2018
PT03.09.2018
Former [2020/29]AL02.05.2018
CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
MC02.05.2018
RS02.05.2018
SK02.05.2018
SM02.05.2018
BG02.08.2018
NO02.08.2018
PT03.09.2018
Former [2019/51]AL02.05.2018
CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
MC02.05.2018
RS02.05.2018
SK02.05.2018
SM02.05.2018
BG02.08.2018
NO02.08.2018
Former [2019/45]CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
MC02.05.2018
RS02.05.2018
SK02.05.2018
SM02.05.2018
BG02.08.2018
NO02.08.2018
Former [2019/12]CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
RS02.05.2018
SK02.05.2018
SM02.05.2018
BG02.08.2018
NO02.08.2018
Former [2019/10]CZ02.05.2018
DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
RS02.05.2018
SK02.05.2018
BG02.08.2018
NO02.08.2018
Former [2019/09]DK02.05.2018
EE02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
RS02.05.2018
BG02.08.2018
NO02.08.2018
Former [2019/08]DK02.05.2018
FI02.05.2018
LT02.05.2018
LV02.05.2018
RS02.05.2018
BG02.08.2018
NO02.08.2018
Former [2018/51]FI02.05.2018
LT02.05.2018
LV02.05.2018
RS02.05.2018
BG02.08.2018
NO02.08.2018
Former [2018/50]FI02.05.2018
LT02.05.2018
BG02.08.2018
NO02.08.2018
Former [2018/47]FI02.05.2018
LT02.05.2018
NO02.08.2018
Cited inInternational search[IDAY]WO2005047327  (BIOGEN IDEC INC [US], et al) [ID] 1-10,14-18 * the whole document, in particular page 26, lines 18-20; page 101, lines 3-13; examples 5 and 6; claims 44-50, 53-54 * [A] 12,19-36 [Y] 1,2,11,13,16,17;
 [AD]WO2010048313  (BIOGEN IDEC INC [US], et al) [AD] 1-36* the whole document *;
 [IA]  - HUBER A H ET AL, "Crystallization and Stoichiometry of Binding of a Complex between a Rat Intestinal Fc Receptor and Fc", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 230, no. 3, doi:10.1006/JMBI.1993.1220, ISSN 0022-2836, (19930405), pages 1077 - 1083, (19930405), XP024009407 [I] 1,3-10 * the whole document, in particular abstract; page 1078, column 1, lines 34-37; page 1079, column 2, line 13 to page 1080, column 2, line 10; figure 3 * [A] 2,11-36

DOI:   http://dx.doi.org/10.1006/jmbi.1993.1220
 [Y]  - JOSIC D ET AL, "Analytical and preparative methods for purification of antibodies", FOOD TECHNOLOGY AND BIOTECHNOLOGY, SVEUCILISTE U ZAGREBU * PREHRAMBENO-BIOTEHNOLOSKI FAKULTET, CROATIA, (20010101), vol. 39, no. 3, ISSN 1330-9862, pages 215 - 226, XP002357256 [Y] 1,2,13,16,17 * the whole document, in particular page 221, column 2, lines 4-25; figure 10 *
 [Y]  - ROOPENIAN DERRY C ET AL, "FcRn: the neonatal Fc receptor comes of age", NATURE REVIEWS. IMMUNOLOGY, NATURE PUBLISHING GROUP, GB, (20070901), vol. 7, no. 9, doi:10.1038/NRI2155, ISSN 1474-1733, pages 715 - 725, XP002510057 [Y] 1,2,11,13,16,17 * the whole document, in particular page 715, column 2, lines 10-12; page 720, column 2, lines 8-19; figure 4 *

DOI:   http://dx.doi.org/10.1038/NRI2155
 [IY]  - PAN HAI ET AL, "Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn", PROTEIN SCIENCE, CAMBRIDGE UNIVERSITY PRESS, vol. 18, no. 2, doi:10.1002/PRO.45, ISSN 0961-8368, (20090201), pages 424 - 433, (20081229), XP009143092 [I] 12 * the whole document, in particular abstract; paragraph spanning pages 427 and 428; paragraph spanning pages 430 and 431; figure 4; table I * [Y] 1,2,13,16,17

DOI:   http://dx.doi.org/10.1002/pro.45
 [AD]  - GIOVANNI MAGISTRELLI ET AL, "Robust recombinant FcRn production in mammalian cells enabling oriented immobilization for IgG binding studies", JOURNAL OF IMMUNOLOGICAL METHODS, (20120101), vol. 375, no. 1-2, doi:10.1016/j.jim.2011.09.002, ISSN 0022-1759, pages 20 - 29, XP055032388 [AD] 1-36 * the whole document, in particular abstract; section 3.1 on page 23; paragraph spanning pages 25 and 26; figure 5 *

DOI:   http://dx.doi.org/10.1016/j.jim.2011.09.002
by applicantUS4676980
 US4737456
 US4816567
 EP0404097
 WO9301161
 US5208020
 WO9308829
 WO9316185
 WO9411026
 WO9429351
 US5416064
 US5500362
 EP0425235
 US5571894
 US5587458
 US5624821
 US5635483
 US5648260
 US5648237
 US5658570
 WO9730087
 US5712374
 US5714586
 US5731168
 US5739116
 US5750373
 US5767285
 US5770429
 US5770701
 US5770710
 US5773001
 US5780588
 US5789199
 US5821337
 US5840523
 WO9858964
 US5869046
 US5877296
 WO9922764
 US5959177
 WO9951642
 US6040498
 US6075181
 WO0061739
 US6150584
 US6171586
 US6194551
 WO0129246
 US6248516
 US6267958
 WO0231140
 US6417429
 US6420548
 US2002164328
 WO03011878
 US2003115614
 US6602684
 US2003157108
 US6630579
 WO03085119
 WO03084570
 WO03085107
 US2004093621
 US6737056
 US2004110704
 US2004110282
 US2004109865
 US2004132140
 WO2004056312
 US2005014934
 US2005079574
 WO2005035586
 WO2005035778
 WO2005047327
 US2005119455
 US2005123546
 WO2005053742
 WO2005100402
 US2005260186
 US2005266000
 US6982321
 US2006025576
 WO2006031370
 WO2006029879
 WO2006044908
 US7041870
 US2006104968
 US7087409
 US7125978
 US7189826
 US2007061900
 US2007117126
 US2007160598
 US2007237764
 US2007292936
 US7332581
 US2008069820
 US7371826
 WO2008077546
 US2009002360
 US7498298
 WO2009041643
 US7521541
 US7527791
 WO2009080251
 WO2009080252
 WO2009080253
 WO2009080254
 WO2009089004
 WO2010048313
 WO2010112193
 WO2010115589
 WO2010136172
 WO2010145792
 WO2010145793
    - WARD, E.S.; OBER, R.J., ADVANCES IN IMMUNOLOGY, (2009), vol. 103, pages 77 - 115
    - GHETIE, V. ET AL., NAT. BIOTECHNOL., (1997), vol. 15, pages 637 - 640
    - ISRAEL, E.J., IMMUNOLOGY, (1996), vol. 89, pages 573 - 578
    - JUNGHANS, R.P.; ANDERSON, C.L., PROC. NATL. ACAD. SCI. USA, (1996), vol. 93, pages 5512 - 5516
    - AKILESH, S. ET AL., PROC. NATL. ACAD. SCI. USA, (2008), vol. 105, pages 967 - 972
    - DICKINSON, B.L. ET AL., J. CLIN. INVEST., (1999), vol. 104, pages 903 - 911
    - KIM, H. ET AL., INVEST. OPHTHALMOL. VIS. SCI., (2008), vol. 49, pages 2025 - 2029
    - SPIEKERMANN, G.M. ET AL., J. EXP. MED., (2002), vol. 196, pages 303 - 310
    - ZHU, X. ET AL., J. IMMUNOL., (2001), vol. 166, pages 3266 - 3276
    - ADAMSKI, F.M. ET AL., MOL. IMMUNOL., (2000), vol. 37, pages 435 - 444
    - AHOUSE, J.J. ET AL., J. IMMUNOL., (1993), vol. 151, pages 6076 - 6088
    - KACSKOVICS, I. ET AL., J. IMMUNOL., (2000), vol. 164, pages 1889 - 1897
    - KACSKOVICS, I. ET AL., DEV. COMP. IMMUNOL., (2006), vol. 30, pages 1203 - 1215
    - KANDIL, E. ET AL., J. IMMUNOL., (1995), vol. 154, pages 5907 - 5918
    - MAYER, B. ET AL., IMMUNOLOGY, (2002), vol. 107, pages 288 - 296
    - SCHNULLE, P.M.; HURLEY, W.L., VET. IMMUNOL. IMMUNOPATHOL., (2003), vol. 91, pages 227 - 231
    - SIMISTER, N.E.; MOSTOV, K.E., NATURE, (1989), vol. 337, pages 184 - 187
    - STORY, C.M. ET AL., J. EXP. MED., (1994), vol. 180, pages 2377 - 2381
    - OBER, R.J. ET AL., PROC. NATL. ACAD. SCI. USA, (2004), vol. 101, pages 11076 - 11081
    - OBER, R.J. ET AL., J. IMMUNOL., (2004), vol. 172, pages 2021 - 2029
    - PRABHAT, P. ET AL., PROC. NATL. ACAD. SCI. USA, (2007), vol. 104, pages 5889 - 5894
    - DALL'ACQUA, W.F. ET AL., J. BIOL. CHEM., (2006), vol. 281, pages 23514 - 23524
    - HINTON, P.R. ET AL., J. BIOL. CHEM., (2004), vol. 279, pages 6213 - 6216
    - HINTON, P.R. ET AL., J. IMMUNOL., (2006), vol. 176, pages 346 - 356
    - SHIELDS, R.L. ET AL., J. BIOL. CHEM., (2001), vol. 276, pages 6591 - 6604
    - KABAT, E.A. ET AL., Sequences of Proteins of Immunological Interest, NATIONAL INSTITUTES OF HEALTH, (1991), pages 91 - 3242
    - HUBER, A.H. ET AL., J. MOL. BIOL., (1993), vol. 230, pages 1077 - 1083
    - CHOTHIA, C.; LESK, A.M., J. MOL. BIOL., (1987), vol. 196, pages 901 - 917
    - ALMAGRO, J.C.; FRANSSON, J., FRONT. BIOSCI., (2008), vol. 13, pages 1619 - 1633
    - ELLMAN ET AL., METH. ENZYM., (1991), vol. 202, pages 301 - 336
    - NOREN ET AL., SCIENCE, (1989), vol. 244, page 182
    - KINDT, T.J. ET AL., Kuby Immunology, W.H. FREEMAN AND CO., (2007), page 91
    - PORTOLANO, S. ET AL., J. IMMUNOL., (1993), vol. 150, pages 880 - 887
    - CLACKSON, T. ET AL., NATURE, (1991), vol. 352, pages 624 - 628
    - WANG, W. ET AL., DRUG METAB. DISP., (2011), vol. 39, pages 1469 - 1477
    - DATTA-MANNAN, A. ET AL., DRUG METAB. DISP., (2012), vol. 40, pages 1545 - 1555
    - VAUGHN, D.E.; BJORKMAN, P.J., BIOCHEMISTRY, (1997), vol. 36, pages 9374 - 9380
    - RAGHAVAN, M. ET AL., PROC. NATL. ACAD. SCI. USA, (1995), vol. 92, pages 11200 - 11204
    - MARTIN, W.L.; BJORKMAN, P.J., BIOCHEMISTRY, (1999), vol. 38, pages 12639 - 12647
    - POLLASTRINI, J. ET AL., BIOCHEM., (2011), vol. 414, pages 88 - 98
    - GURBAXANI, B. ET AL., MOL. IMMUNOL., (2006), vol. 43, pages 1462 - 1473
    - GURBAXANI, B.M.; MORRISON, S.L., MOL. IMMUNOL., (2006), vol. 43, pages 1379 - 1389
    - GURBAXANI, B., CLIN. IMMUNOL., (2007), vol. 122, pages 121 - 124
    - YEUNG, Y.A. ET AL., J. IMMUNOL., (2009), vol. 182, pages 7663 - 7671
    - MARTIN, C.R. ET AL., ANALYTICAL CHEMISTRY-NEWS & FEATURES, (19980501), pages 322A - 327A
    - DALL'ACQUA, W.F. ET AL., J. IMMUNOL, vol. 169
    - MEDESAN, C. ET AL., EUR. J. IMMUNOL., (1996), vol. 26, page 2533
    - FIRAN, M. ET AL., INT. IMMUNOL., (2001), vol. 13, page 993
    - KIM, J.K. ET AL., EUR. J. IMMUNOL., (1994), vol. 24, page 542
    - KIM, J.K. ET AL., J. IMMUNOL., (1999), vol. 29, page 2819
    - FIRAN, M. ET AL., INT. IMMUNOL, (2001), vol. 13, page 993
    - YEUNG, Y.A. ET AL., J. IMMUNOL., (2009), vol. 182, pages 7667 - 7671
    - SPIEKERMAN, G.M. ET AL., J. EXP. MED., (2002), vol. 196, pages 303 - 310
    - PETKOVA, S.B. ET AL., INT. IMMUNOL., (2006), vol. 18, pages 1759 - 1769
    - ZALEVSKY, J. ET AL., NAT. BIOTECHNOL., (2010), vol. 28, pages 157 - 159
    - HUDSON, P.J. ET AL., NAT. MED., (2003), vol. 9, pages 129 - 134
    - PLUECKTHUN, A., The Pharmacology of Monoclonal Antibodies, SPRINGER-VERLAG, (1994), vol. 113, pages 269 - 315
    - HOLLIGER, P. ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448
    - MORRISON, S.L. ET AL., PROC. NATL. ACAD. SCI. USA, (1984), vol. 81, pages 6851 - 6855
    - RIECHMANN, I. ET AL., NATURE, (1988), vol. 332, pages 323 - 329
    - QUEEN, C. ET AL., PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 10029 - 10033
    - KASHMIRI, S.V. ET AL., METHODS, (2005), vol. 36, pages 25 - 34
    - PADLAN, E.A., MOL. IMMUNOL., (1991), vol. 28, pages 489 - 498
    - DALL'ACQUA, W.F. ET AL., METHODS, (2005), vol. 36, pages 43 - 60
    - OSBOURN, J. ET AL., METHODS, (2005), vol. 36, pages 61 - 68
    - KLIMKA, A. ET AL., BR. J. CANCER, (2000), vol. 83, pages 252 - 260
    - SIMS, M.J. ET AL., J. IMMUNOL., (1993), vol. 151, pages 2296 - 2308
    - CARTER, P. ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 4285 - 4289
    - PRESTA, L.G. ET AL., J. IMMUNOL., (1993), vol. 151, pages 2623 - 2632
    - BACA, M. ET AL., J. BIOL. CHEM., (1997), vol. 272, pages 10678 - 10684
    - ROSOK, M.J. ET AL., J. BIOL. CHEM., (1996), vol. 271, pages 22611 - 22618
    - VAN DIJK, M.A.; VAN DE WINKEL, J.G., CURR. OPIN. PHARMACOL., (2001), vol. 5, pages 368 - 374
    - LONBERG, N., CURR. OPIN. IMMUNOL., (2008), vol. 20, pages 450 - 459
    - LONBERG, N., NAT. BIOTECH., (2005), vol. 23, pages 1117 - 1125
    - KOZBOR, D., J. IMMUNOL., (1984), vol. 133, pages 3001 - 3005
    - BRODEUR, B.R. ET AL., Monoclonal Antibody Production Techniques and Applications, MARCEL DEKKER, INC., (1987), pages 51 - 63
    - BOERNER, P. ET AL., J. IMMUNOL., (1991), vol. 147, pages 86 - 95
    - LI, J. ET AL., PROC. NATL. ACAD. SCI. USA, (2006), vol. 103, pages 3557 - 3562
    - NI, J., XIANDAI MIANYIXUE, (2006), vol. 26, pages 265 - 268
    - VOLLMERS, H.P.; BRANDLEIN, S., HISTOLOGY AND HISTOPATHOLOGY, (2005), vol. 20, pages 927 - 937
    - VOLLMERS, H.P.; BRANDLEIN, S., METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, (2005), vol. 27, pages 185 - 191
    - HOOGENBOOM, H.R. ET AL., METHODS IN MOLECULAR BIOLOGY, (2002), vol. 178, pages 1 - 37
    - MCCAFFERTY, J. ET AL., NATURE, (1990), vol. 348, pages 552 - 554
    - MARKS, J.D. ET AL., J. MOL. BIOL., (1992), vol. 222, pages 581 - 597
    - MARKS, J.D.; BRADBURY, A., METHODS IN MOLECULAR BIOLOGY, (2003), vol. 248, pages 161 - 175
    - SIDHU, S.S. ET AL., J. MOL. BIOL., (2004), vol. 338, pages 299 - 310
    - LEE, C.V. ET AL., J. MOL. BIOL., (2004), vol. 340, pages 1073 - 1093
    - FELLOUSE, F.A., PROC. NATL. ACAD. SCI. USA, (2004), vol. 101, pages 12467 - 12472
    - LEE, C.V. ET AL., J. IMMUNOL. METHODS, (2004), vol. 284, pages 119 - 132
    - WINTER, G. ET AL., ANN. REV. IMMUNOL., (1994), vol. 12, pages 433 - 455
    - GRIFFITHS, A.D. ET AL., EMBO J., (1993), vol. 12, pages 725 - 734
    - HOOGENBOOM, H.R.; WINTER, G., J. MOL. BIOL., (1992), vol. 227, pages 381 - 388
    - MILSTEIN, C.; CUELLO, A.C., NATURE, (1983), vol. 305, pages 537 - 540
    - TRAUNECKER, A. ET AL., EMBO J., (1991), vol. 10, pages 3655 - 3659
    - SCIENCE, (1985), vol. 229, pages 81 - 83
    - KOSTELNY, S.A. ET AL., J. IMMUNOL., (1992), vol. 148, pages 1547 - 1553
    - GRUBER, M. ET AL., J. IMMUNOL., (1994), vol. 152, pages 5368 - 5374
    - TUTT, A. ET AL., J. IMMUNOL., (1991), vol. 147, pages 60 - 69
    - CHOWDHURY, P.S., METHODS MOL. BIOL., (2008), vol. 207, pages 179 - 196
    - HOOGENBOOM, H.R.; 2002 ET AL., METHODS IN MOLECULAR BIOLOGY, vol. 178, pages 1 - 37
    - CUNNINGHAM, B.C.; WELLS, J.A., SCIENCE, (1989), vol. 244, pages 1081 - 1085
    - WRIGHT, A. A; MORRISON, S.L., TIBTECH, (1997), vol. 15, pages 26 - 32
    - OKAZAKI, A. ET AL., J. MOL. BIOL., (2004), vol. 336, pages 1239 - 1249
    - YAMANE-OHNUKI, N. ET AL., BIOTECH. BIOENG., (2004), vol. 87, pages 614 - 622
    - RIPKA, J. ET AL., ARCH. BIOCHEM. BIOPHYS., (1986), vol. 249, pages 533 - 545
    - KANDA, Y. ET AL., BIOTECHNOL. BIOENG., (2006), vol. 94, pages 680 - 688
    - RAVETCH, J.V.; KINET, J.P., ANNU. REV. IMMUNOL., (1991), vol. 9, pages 457 - 492
    - HELLSTROM, I. ET AL., PROC. NATL. ACAD. SCI. USA, (1986), vol. 83, pages 7059 - 7063
    - HELLSTROM, I. ET AL., PROC. NATL. ACAD. SCI. USA, (1985), vol. 82, pages 1499 - 1502
    - BRUGGEMANN, M. ET AL., J. EXP. MED., (1987), vol. 166, pages 1351 - 1361
    - CLYNES, R. ET AL., PROC. NATL. ACAD. SCI. USA, (1998), vol. 95, pages 652 - 656
    - GAZZANO-SANTORO, H. ET AL., J. IMMUNOL. METHODS, (1996), vol. 202, pages 163 - 171
    - CRAGG, M.S. ET AL., BLOOD, (2003), vol. 101, pages 1045 - 1052
    - CRAGG, M.S.; M.J. GLENNIE, BLOOD, (2004), vol. 103, pages 2738 - 2743
    - IDUSOGIE, E.E. ET AL., J. IMMUNOL., (2000), vol. 164, pages 4178 - 4184
    - GUYER, R.L. ET AL., J. IMMUNOL., (1976), vol. 117, pages 587 - 593
    - KIM, J.K. ET AL., J. IMMUNOL., (1994), vol. 24, pages 2429 - 2434
    - DUNCAN, A.R.; WINTER, G., NATURE, (1988), vol. 322, pages 738 - 740
    - KAM, N.W. ET AL., PROC. NATL. ACAD. SCI. USA, (2005), vol. 102, pages 11600 - 11605
    - KOHLER; MILSTEIN, NATURE, (1975), vol. 256, pages 495 - 497
    - OI ET AL., PROC. NATL. ACAD. SCI. USA, (1983), vol. 80, pages 6351 - 6355
    - CHARLTON, K.A., Methods in Molecular Biology, HUMANA PRESS, (2003), vol. 248, pages 245 - 254
    - GERNGROSS, T.U., NAT. BIOTECH., (2004), vol. 22, pages 1409 - 1414
    - LI, H. ET AL., NAT. BIOTECH., (2006), vol. 24, pages 210 - 215
    - GRAHAM, F.L. ET AL., J. GEN VIROL., (1977), vol. 36, pages 59 - 74
    - MATHER, J.P., BIOL. REPROD., (1980), vol. 23, pages 243 - 252
    - MATHER, J.P ET AL., ANNALS N.Y. ACAD. SCI., (1982), vol. 383, pages 44 - 68
    - URLAUB, G. ET AL., PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, pages 4216 - 4220
    - YAZAKI, P.; WU, A.M., Methods in Molecular Biology, HUMANA PRESS, (2004), vol. 248, pages 255 - 268
    - HINMAN, L.M. ET AL., CANCER RES., (1993), vol. 53, pages 3336 - 3342
    - LODE, H.N. ET AL., CANCER RES., (1998), vol. 58, pages 2925 - 2928
    - KRATZ, F. ET AL., CURR. MED. CHEM., (2006), vol. 13, pages 477 - 523
    - JEFFREY, S.C. ET AL., BIOORG. MED. CHEM. LETT., (2006), vol. 16, pages 358 - 362
    - TORGOV, M.Y. ET AL., BIOCONJUG. CHEM., (2005), vol. 16, pages 717 - 721
    - NAGY, A. ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, pages 829 - 834
    - DUBOWCHIK, G.M. ET AL., BIOORG. & MED. CHEM. LETTERS, (2002), vol. 12, pages 1529 - 1532
    - KING, H.D. ET AL., J. MED. CHEM., (2002), vol. 45, pages 4336 - 4343
    - VITETTA, E.S. ET AL., SCIENCE, (1987), vol. 238, pages 1098 - 1104
    - CHARI, R.V. ET AL., CANCER RES., (1992), vol. 52, pages 127 - 131
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.