Extract from the Register of European Patents

EP About this file: EP2807263

EP2807263 - PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  12.03.2021
Database last updated on 01.04.2026
FormerGrant of patent is intended
Status updated on  08.06.2020
FormerExamination is in progress
Status updated on  24.02.2017
Most recent event   Tooltip12.03.2021Application deemed to be withdrawnpublished on 14.04.2021  [2021/15]
Applicant(s)For all designated states
Leo Laboratories Limited
285 Cashel Road
Crumlin
Dublin 12 / IE
[2014/49]
Inventor(s)01 / LIANG, Xifu
c/o LEO Pharma A/S
Industriparken 55
DK-2750 Ballerup / DK
02 / HÖGBERG, Thomas
c/o LEO Pharma A/S
Industriparken 55
DK-2750 Ballerup / DK
03 / GRUE-SØRENSEN, Gunnar
Thyrasvej 3
DK-4000 Roskilde / DK
04 / MOODY, Thomas, S.
c/o Almac Group Ltd
Almac House
20 Seagoe Industrial Estate
Craigavon BT63 5QD / GB
05 / ROWAN, Andrew, S.
c/o Almac Group Ltd
Almac House
20 Seagoe Industrial Estate
Craigavon BT63 5QD / GB
 [2014/49]
Representative(s)Leo Pharma A/S
Industrieparken 55
2750 Ballerup / DK
[N/P]
Former [2014/49]Jensen, Dorte Kold
Leo Pharma A/S
Patents
Industriparken 55
2750 Ballerup / DK
Application number, filing date13713756.825.01.2013
WO2013EP51431
Priority number, dateUS201261590544P25.01.2012         Original published format: US 201261590544 P
US201261669657P09.07.2012         Original published format: US 201261669657 P
[2014/49]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013110753
Date:01.08.2013
Language:EN
[2013/31]
Type: A1 Application with search report 
No.:EP2807263
Date:03.12.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 01.08.2013 takes the place of the publication of the European patent application.
[2014/49]
Search report(s)International search report - published on:EP01.08.2013
ClassificationIPC:C12P15/00, C12P5/00, C12P7/62, C07C69/08
[2014/49]
CPC:
C12P15/00 (EP,US); C12P7/62 (US); C12Y301/01003 (EP,US);
Y02P20/52 (US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/49]
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON INGENOL-3-ANGELATE[2014/49]
English:PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE[2014/49]
French:PROCÉDÉ DE PRÉPARATION D'INGÉNOL-3-ANGÉLATE[2014/49]
Entry into regional phase25.08.2014National basic fee paid 
25.08.2014Designation fee(s) paid 
25.08.2014Examination fee paid 
Examination procedure21.08.2014Amendment by applicant (claims and/or description)
25.08.2014Examination requested  [2014/49]
24.02.2017Despatch of a communication from the examining division (Time limit: M04)
22.06.2017Reply to a communication from the examining division
31.05.2019Despatch of a communication from the examining division (Time limit: M06)
06.03.2020Reply to a communication from the examining division
09.06.2020Communication of intention to grant the patent
20.10.2020Application deemed to be withdrawn, date of legal effect  [2021/15]
25.11.2020Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2021/15]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.02.2017
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
06.03.2020Request for further processing filed
06.03.2020Full payment received (date of receipt of payment)
Request granted
19.03.2020Decision despatched
Fees paidRenewal fee
27.01.2015Renewal fee patent year 03
27.01.2016Renewal fee patent year 04
27.01.2017Renewal fee patent year 05
29.01.2018Renewal fee patent year 06
28.01.2019Renewal fee patent year 07
27.01.2020Renewal fee patent year 08
Penalty fee
Additional fee for renewal fee
31.01.202109   M06   Not yet paid
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Cited inInternational search[XP] WO2012010172  (LEO PHARMA AS et al.) [XP] 1-4,17,18,26,27,34,35 * page 14, lines 1-10; claims 1-12 * * page 19, lines 16-18 * * page 28, lines 23-29 * * page 30, lines 19-26 * * page 32, lines 12-15 *
 [X]   TENG R W ET AL: "Regioselective acylation of 3-O-angeloylingenol by Candida antarctica Lipase B", FITOTERAPIA, IDB HOLDING, MILAN, IT, vol. 80, no. 4, 1 June 2009 (2009-06-01), pages 233 - 236, XP026085874, ISSN: 0367-326X, [retrieved on 20090208], DOI: 10.1016/J.FITOTE.2009.02.001 [X] 1,34,35 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.fitote.2009.02.001
 [Y]   KIO A. ABO ET AL: "Ingenol esters from the pro-inflammatory fraction of Euphorbia kamerunica", PHYTOCHEMISTRY, vol. 21, no. 3, 1982, pages 725 - 726, XP055006203, ISSN: 0031-9422, DOI: 10.1016/0031-9422(82)83174-9 [Y] 1,34,35 * page 726 *

DOI:   http://dx.doi.org/10.1016/0031-9422(82)83174-9
 [A]   OPFERKUCH H J ET AL: "Zur Chemie des Ingenols, I Ingenol und einige 8einer Derivate", ZEITSCHRIFT FUER NATURFORSCHUNG. TEIL B, ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, VERLAG DER ZEITSCHRIFT FUER NATURFORSCHUNG, TUEBINGEN, DE, vol. 36b, 2 March 1981 (1981-03-02), pages 878 - 887, XP008142492, ISSN: 0340-5087 [A] 1,34,35 * page 879 - column r * * page 881 *
 [Y]   B.SORG ET AL.: "Zur Chemie des Ingenols, II, Ester des Ingenols und des Delta-7.8-Isoingenols", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B:ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, VERLAG DER ZEITSCHRIFT FUR NATURFORSCHUNG. TUBINGEN, DE, vol. 37b, 3 February 1982 (1982-02-03), pages 748 - 756, XP008142493, ISSN: 0932-0776 [Y] 1,34,35 * page 754 - column r *
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