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Extract from the Register of European Patents

EP About this file: EP2849744

EP2849744 - PHARMACEUTICAL COMPOSITION COMPRISING (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO [3,4,B]INDOL]-4-AMINE AND DULOXETINE [Right-click to bookmark this link]
Former [2015/13]PHARMACEUTICAL COMPOSITION COMPRISING (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO [3,4,B]INDOL]-4-AMINE AND ANTIDEPRESSANTS
[2017/26]
StatusNo opposition filed within time limit
Status updated on  28.09.2018
Database last updated on 15.06.2024
FormerThe patent has been granted
Status updated on  20.10.2017
FormerGrant of patent is intended
Status updated on  15.06.2017
FormerExamination is in progress
Status updated on  09.11.2016
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL
published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Grünenthal GmbH
Zieglerstrasse 6
52078 Aachen / DE
[2015/13]
Inventor(s)01 / FROSCH, Stefanie
Beckerstrasse 49
52078 Aachen / DE
02 / LINZ, Klaus
Nachtigallengrund 5
53359 Rheinbach / DE
03 / CHRISTOPH, Thomas
Schilderstrasse 42
52080 Aachen / DE
 [2015/13]
Application number, filing date13723003.316.05.2013
[2017/47]
WO2013EP01464
Priority number, dateEP2012000393718.05.2012         Original published format: EP 12003937
[2015/13]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013170965
Date:21.11.2013
Language:EN
[2013/47]
Type: A1 Application with search report 
No.:EP2849744
Date:25.03.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 21.11.2013 takes the place of the publication of the European patent application.
[2015/13]
Type: B1 Patent specification 
No.:EP2849744
Date:22.11.2017
Language:EN
[2017/47]
Search report(s)International search report - published on:EP21.11.2013
ClassificationIPC:A61K31/407, A61K31/381, A61K31/5375, A61K45/06, A61P29/00, A61P25/08, A61P25/24, A61P25/22
[2015/13]
CPC:
A61K31/407 (EP,CN,US); A61K31/381 (EP,CN,US); A61K31/5375 (EP,CN,US);
A61K45/06 (EP,CN,US); A61P21/00 (EP); A61P25/00 (EP);
A61P25/04 (EP); A61P25/08 (EP); A61P25/22 (EP);
A61P25/24 (EP); A61P29/00 (EP); A61P43/00 (EP) (-)
C-Set:
A61K31/381, A61K2300/00 (US,CN,EP);
A61K31/407, A61K2300/00 (CN,EP,US);
A61K31/5375, A61K2300/00 (US,CN,EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/13]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:PHARMAZEUTISCHE ZUSAMMENSETZUNG MIT (1R,4R)-6'-FLUOR-N,N-DIMENTHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXAN-1,1'-PYRANO[3,4,B]INDO]-4-AMIN UND DULOXETIN[2017/26]
English:PHARMACEUTICAL COMPOSITION COMPRISING (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO [3,4,B]INDOL]-4-AMINE AND DULOXETINE[2017/26]
French:COMPOSITION PHARMACEUTIQUE COMPRENANT DE LA (1R,4R)-6'-FLUORO-N,N-DIMÉTHYL-4-PHÉNYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4,B]INDOL]-4-AMINE ET DE LA DULOXETINE[2017/26]
Former [2015/13]PHARMAZEUTISCHE ZUSAMMENSETZUNG MIT (1R,4R)-6'-FLUOR-N,N-DIMENTHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXAN-1,1'-PYRANO[3,4,B]INDO]-4-AMIN UND ANTIDEPRESSIVA
Former [2015/13]PHARMACEUTICAL COMPOSITION COMPRISING (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO [3,4,B]INDOL]-4-AMINE AND ANTIDEPRESSANTS
Former [2015/13]COMPOSITION PHARMACEUTIQUE COMPRENANT DE LA (1R,4R)-6'-FLUORO-N,N-DIMÉTHYL-4-PHÉNYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4,B]INDOL]-4-AMINE ET DES ANTIDÉPRESSEURS
Entry into regional phase18.12.2014National basic fee paid 
18.12.2014Designation fee(s) paid 
18.12.2014Examination fee paid 
Examination procedure18.12.2014Examination requested  [2015/13]
17.06.2015Amendment by applicant (claims and/or description)
15.07.2016Despatch of a communication from the examining division (Time limit: M04)
04.11.2016Reply to a communication from the examining division
13.06.2017Communication of intention to grant the patent
12.10.2017Fee for grant paid
12.10.2017Fee for publishing/printing paid
12.10.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.07.2016
Opposition(s)23.08.2018No opposition filed within time limit [2018/44]
Fees paidRenewal fee
12.05.2015Renewal fee patent year 03
10.05.2016Renewal fee patent year 04
10.05.2017Renewal fee patent year 05
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL22.11.2017
MK22.11.2017
SM22.11.2017
[2020/34]
Former [2020/31]MK22.11.2017
SM22.11.2017
Former [2018/40]SM22.11.2017
Cited inInternational search[Y]WO2005066183  (GRUENENTHAL GMBH [DE], et al) [Y] 1-15 * claims 1, 18 *;
 [Y]US2007004795  (SESHA RAMESH [US]) [Y] 1-15 * the whole document *;
 [YD]US2008125475  (LINZ KLAUS [DE], et al) [YD] 1-15 * paragraph [0113]; claims 5, 21-22, 32, 34-37; compound A4 *;
 [Y]US2008261984  (HUGHES BERNADETTE [GB], et al) [Y] 1-15* the whole document *;
 [YD]US2011319440  (HINZE CLAUDIA [DE], et al) [YD] 1-15 * claims 20-22; compound 25 *
by applicantUS4389393
 US4612008
 US4765989
 US4783337
 US5330761
 US5399362
 US5455046
 US5472711
 WO2004043967
 WO2008040481
    - Textbook of Drug Design and Discovery, TAYLOR AND FRANCIS, (2002), pages 410 - 458
    - PAIN, (1992), vol. 50, pages 355 - 63
    - SCHR6DER ET AL., EUR J PAIN, (2010), vol. 14, page 814
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.