EP2867360 - DESIGNED ANKYRIN REPEAT PROTEINS BINDING TO PLATELET-DERIVED GROWTH FACTOR [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 13.03.2020 Database last updated on 17.07.2024 | |
Former | The patent has been granted Status updated on 05.04.2019 | ||
Former | Grant of patent is intended Status updated on 02.08.2018 | ||
Former | Examination is in progress Status updated on 02.01.2017 | Most recent event Tooltip | 01.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 03.08.2022 [2022/31] | Applicant(s) | For all designated states Molecular Partners AG Wagistrasse 14 8952 Schlieren / CH | [2015/19] | Inventor(s) | 01 /
BAUMANN, Michael Agnesstrasse 8 CH-8406 Winterthur / CH | [2015/19] | Representative(s) | Latscha Schöllhorn Partner AG Grellingerstrasse 60 4052 Basel / CH | [2019/19] |
Former [2015/19] | Latscha Schöllhorn Partner AG Austrasse 24 4051 Basel / CH | Application number, filing date | 13731809.3 | 27.06.2013 | [2019/19] | WO2013EP63488 | Priority number, date | EP20120174020 | 28.06.2012 Original published format: EP 12174020 | [2015/19] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2014001442 | Date: | 03.01.2014 | Language: | EN | [2014/01] | Type: | A1 Application with search report | No.: | EP2867360 | Date: | 06.05.2015 | Language: | EN | The application published by WIPO in one of the EPO official languages on 03.01.2014 takes the place of the publication of the European patent application. | [2015/19] | Type: | B1 Patent specification | No.: | EP2867360 | Date: | 08.05.2019 | Language: | EN | [2019/19] | Search report(s) | International search report - published on: | EP | 03.01.2014 | Classification | IPC: | C12N15/10, C07K14/49, C07K14/71, G01N33/68 | [2015/19] | CPC: |
C07K14/49 (EP,KR,US);
C07K14/001 (KR,US);
A61P27/02 (EP,KR);
A61P27/10 (EP);
A61P35/00 (KR);
A61P9/14 (KR);
C07K14/47 (KR,US);
C07K14/71 (EP,KR,US);
A61K38/00 (KR);
C07K2318/20 (EP,KR,US)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/19] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | VON BLUTPLÄTTCHEN ABSTAMMENDER WACHSTUMSFAKTOR (PDGF)-BINDENDE, KONSTRUIERTE ANKYRIN-REPEAT-PROTEINE | [2018/34] | English: | DESIGNED ANKYRIN REPEAT PROTEINS BINDING TO PLATELET-DERIVED GROWTH FACTOR | [2015/19] | French: | LIAISON DE PROTÉINES DE RÉPÉTITION ANKYRINE SUR MESURE AU FACTEUR DE CROISSANCE DÉRIVÉ DES PLAQUETTES (PDGF) | [2018/34] |
Former [2015/19] | DESIGNIERTE ANKYRIN-VERSTÄRKUNGSPROTEINE ZUR BINDUNG AN EINEN AUS THROMBOZYTEN GEWONNENEN WACHSTUMSFAKTOR | ||
Former [2015/19] | CONCEPTION DE PROTÉINES À MOTIFS ANKYRINE RÉPÉTÉS LIÉES AU FACTEUR DE CROISSANCE DÉRIVÉ DES PLAQUETTES | Entry into regional phase | 27.01.2015 | National basic fee paid | 27.01.2015 | Designation fee(s) paid | 27.01.2015 | Examination fee paid | Examination procedure | 27.01.2015 | Examination requested [2015/19] | 08.10.2015 | Amendment by applicant (claims and/or description) | 21.03.2016 | Despatch of a communication from the examining division (Time limit: M06) | 27.09.2016 | Reply to a communication from the examining division | 22.12.2016 | Despatch of a communication from the examining division (Time limit: M06) | 20.06.2017 | Reply to a communication from the examining division | 17.07.2017 | Despatch of a communication from the examining division (Time limit: M06) | 30.04.2018 | Reply to a communication from the examining division | 03.08.2018 | Communication of intention to grant the patent | 21.01.2019 | Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time | 25.03.2019 | Fee for grant paid | 25.03.2019 | Fee for publishing/printing paid | 25.03.2019 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 21.03.2016 | Opposition(s) | 11.02.2020 | No opposition filed within time limit [2020/16] | Request for further processing for: | The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent | 25.03.2019 | Request for further processing filed | 25.03.2019 | Full payment received (date of receipt of payment) Request granted | 03.04.2019 | Decision despatched | 25.03.2019 | Request for further processing filed | 25.03.2019 | Full payment received (date of receipt of payment) Request granted | 03.04.2019 | Decision despatched | The application is deemed to be withdrawn due to failure to reply to the examination report | 30.04.2018 | Request for further processing filed | 30.04.2018 | Full payment received (date of receipt of payment) Request granted | 16.05.2018 | Decision despatched | Fees paid | Renewal fee | 19.06.2015 | Renewal fee patent year 03 | 27.06.2016 | Renewal fee patent year 04 | 27.06.2017 | Renewal fee patent year 05 | 27.06.2018 | Renewal fee patent year 06 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 27.06.2013 | AL | 08.05.2019 | AT | 08.05.2019 | CY | 08.05.2019 | CZ | 08.05.2019 | DK | 08.05.2019 | EE | 08.05.2019 | ES | 08.05.2019 | FI | 08.05.2019 | HR | 08.05.2019 | IT | 08.05.2019 | LT | 08.05.2019 | LV | 08.05.2019 | MC | 08.05.2019 | MK | 08.05.2019 | MT | 08.05.2019 | NL | 08.05.2019 | PL | 08.05.2019 | RO | 08.05.2019 | RS | 08.05.2019 | SE | 08.05.2019 | SI | 08.05.2019 | SK | 08.05.2019 | SM | 08.05.2019 | TR | 08.05.2019 | IE | 27.06.2019 | LU | 27.06.2019 | BE | 30.06.2019 | BG | 08.08.2019 | NO | 08.08.2019 | GR | 09.08.2019 | IS | 08.09.2019 | PT | 08.09.2019 | [2022/31] |
Former [2021/34] | HU | 27.06.2013 | |
AL | 08.05.2019 | ||
AT | 08.05.2019 | ||
CY | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
MC | 08.05.2019 | ||
MT | 08.05.2019 | ||
NL | 08.05.2019 | ||
PL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SI | 08.05.2019 | ||
SK | 08.05.2019 | ||
SM | 08.05.2019 | ||
TR | 08.05.2019 | ||
IE | 27.06.2019 | ||
LU | 27.06.2019 | ||
BE | 30.06.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
IS | 08.09.2019 | ||
PT | 08.09.2019 | ||
Former [2021/32] | HU | 27.06.2013 | |
AL | 08.05.2019 | ||
AT | 08.05.2019 | ||
CY | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
MC | 08.05.2019 | ||
NL | 08.05.2019 | ||
PL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SI | 08.05.2019 | ||
SK | 08.05.2019 | ||
SM | 08.05.2019 | ||
TR | 08.05.2019 | ||
IE | 27.06.2019 | ||
LU | 27.06.2019 | ||
BE | 30.06.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
IS | 08.09.2019 | ||
PT | 08.09.2019 | ||
Former [2021/31] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CY | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
MC | 08.05.2019 | ||
NL | 08.05.2019 | ||
PL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SI | 08.05.2019 | ||
SK | 08.05.2019 | ||
SM | 08.05.2019 | ||
TR | 08.05.2019 | ||
IE | 27.06.2019 | ||
LU | 27.06.2019 | ||
BE | 30.06.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
IS | 08.09.2019 | ||
PT | 08.09.2019 | ||
Former [2021/26] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CY | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
MC | 08.05.2019 | ||
NL | 08.05.2019 | ||
PL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SI | 08.05.2019 | ||
SK | 08.05.2019 | ||
SM | 08.05.2019 | ||
TR | 08.05.2019 | ||
IE | 27.06.2019 | ||
LU | 27.06.2019 | ||
BE | 30.06.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2020/25] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
MC | 08.05.2019 | ||
NL | 08.05.2019 | ||
PL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SI | 08.05.2019 | ||
SK | 08.05.2019 | ||
SM | 08.05.2019 | ||
TR | 08.05.2019 | ||
IE | 27.06.2019 | ||
LU | 27.06.2019 | ||
BE | 30.06.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2020/21] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
MC | 08.05.2019 | ||
NL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SK | 08.05.2019 | ||
SM | 08.05.2019 | ||
TR | 08.05.2019 | ||
IE | 27.06.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2020/17] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
MC | 08.05.2019 | ||
NL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SK | 08.05.2019 | ||
SM | 08.05.2019 | ||
TR | 08.05.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2020/14] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
MC | 08.05.2019 | ||
NL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SK | 08.05.2019 | ||
SM | 08.05.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2020/12] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
IT | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
NL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SK | 08.05.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2020/11] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
EE | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
NL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
SK | 08.05.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2020/10] | AL | 08.05.2019 | |
AT | 08.05.2019 | ||
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
NL | 08.05.2019 | ||
RO | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2020/09] | AL | 08.05.2019 | |
CZ | 08.05.2019 | ||
DK | 08.05.2019 | ||
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
NL | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2019/51] | AL | 08.05.2019 | |
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
NL | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
BG | 08.08.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2019/50] | AL | 08.05.2019 | |
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
LT | 08.05.2019 | ||
LV | 08.05.2019 | ||
NL | 08.05.2019 | ||
RS | 08.05.2019 | ||
SE | 08.05.2019 | ||
NO | 08.08.2019 | ||
GR | 09.08.2019 | ||
PT | 08.09.2019 | ||
Former [2019/49] | AL | 08.05.2019 | |
ES | 08.05.2019 | ||
FI | 08.05.2019 | ||
HR | 08.05.2019 | ||
LT | 08.05.2019 | ||
NL | 08.05.2019 | ||
SE | 08.05.2019 | ||
NO | 08.08.2019 | ||
PT | 08.09.2019 | ||
Former [2019/48] | ES | 08.05.2019 | |
FI | 08.05.2019 | ||
LT | 08.05.2019 | ||
SE | 08.05.2019 | ||
NO | 08.08.2019 | ||
PT | 08.09.2019 | ||
Former [2019/47] | ES | 08.05.2019 | |
FI | 08.05.2019 | ||
LT | 08.05.2019 | ||
NO | 08.08.2019 | Cited in | International search | [XD]WO0220565 (UNIV ZUERICH [CH], et al) [XD] 1-7,9-19,21,23,24 * the whole document *; | [X]WO2006050984 (SCHERING AG [DE], et al) [X] 1-7,9-19,21,23,24 * example 7; claim - *; | [X]WO2006129828 (CANON KK [JP], et al) [X] 1-7,9-19,21,23,24 * claim -; sequence 6 *; | [XY]WO2009068649 (GLAXO GROUP LTD [GB], et al) [X] 1-7,9-19,21,23,24 * pages 28,35,36; claims 14, 15; sequence 128 * * pages 24,25; example - * [Y] 1-7,9-19,21,23,24; | [XD]WO2011135067 (MOLECULAR PARTNERS AG [CH], et al) [XD] 1-7,9-19,21,23,24 * the whole document *; | [XD] - BINZ H KASPAR ET AL, "High-affinity binders selected from designed ankyrin repeat protein libraries", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20040418), vol. 22, no. 5, doi:10.1038/NBT962, ISSN 1087-0156, pages 575 - 582, XP002343919 [XD] 1-7,9-19,21,23,24 * the whole document * DOI: http://dx.doi.org/10.1038/nbt962 | [XD] - STUMPP M T ET AL, "DARPins: A new generation of protein therapeutics", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 13, no. 15-16, doi:10.1016/J.DRUDIS.2008.04.013, ISSN 1359-6446, (20080801), pages 695 - 701, (20080711), XP023440383 [XD] 1-7,9-19,21,23,24 * the whole document * DOI: http://dx.doi.org/10.1016/j.drudis.2008.04.013 | [Y] - SHEN ET AL, "An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (20070510), vol. 357, no. 4, doi:10.1016/J.BBRC.2007.04.075, ISSN 0006-291X, pages 1142 - 1147, XP022106979 [Y] 1-7,9-19,21,23,24 * the whole document * DOI: http://dx.doi.org/10.1016/j.bbrc.2007.04.075 | [Y] - HONGCHAO SHAN ET AL, "Inhibitory effect of soluble platelet-derived growth factor receptor [beta] on intraosseous growth of breast cancer cells in nude mice", CANCER SCIENCE, (20110804), vol. 102, no. 10, doi:10.1111/j.1349-7006.2011.02026.x, ISSN 1347-9032, pages 1904 - 1910, XP055035691 [Y] 1-7,9-19,21,23,24 * the whole document * DOI: http://dx.doi.org/10.1111/j.1349-7006.2011.02026.x | [XP] - PETER-CHRISTIAN KLÖHN ET AL, "IBC's 23nd Annual Antibody Engineering, 10th Annual Antibody Therapeutics International Conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CA", MABS, (20121203), vol. 5, no. 2, doi:10.4161/mabs.23655, ISSN 1942-0862, pages 178 - 201, XP055070468 [XP] 1-3,24-26 * page 195, column R * DOI: http://dx.doi.org/10.4161/mabs.23655 | [XP] - Leonardzehr, "Molecular Partners continues to validate DARPin platform", (20120911), BioTuesdays, URL: http://biotuesdays.com/2012/09/11/molecular-partners-continues-to-validate-darpin-platform/, (20130829), XP002711999 [XP] 1-3,24-26 * page 2 * | by applicant | WO9002809 | WO9308278 | WO9310214 | WO9834120 | WO9848008 | WO0032823 | WO0220565 | WO2005020972 | WO2007006665 | WO2007103515 | WO2008155134 | WO2010060748 | US2011207668 | WO2011135067 | WO2012069654 | US2013116197 | - ANDRAE, J.; GALLINI, R.; BETSHOLTZ, C., GENES DEV., (2008), vol. 22, pages 1276 - 1312 | - JO, N.; MAILHOS, C.; JU, M.; CHEUNG, E.; BRADLEY, J.; NISHIJIMA, K.; ROBINSON, G.S.; ADAMIS, A.P.; SHIMA, D.T., AM. J. PATHOL., (2006), vol. 168, no. 6, pages 2036 - 2053 | - BINZ, H.K.; AMSTUTZ, P.; P UCKTHUN, A., NAT. BIOTECHNOL., (2005), vol. 23, pages 1257 - 1268 | - BINZ, H.K.; AMSTUTZ, P.; KOHL, A.; STUMPP, M.T.; BRIAND, C.; FORRER, P.; GRÜTTER, M.G.; P UCKTHUN, A., NAT. BIOTECHNOL., (2004), vol. 22, pages 575 - 582 | - STUMPP, M.T.; BINZ, H.K; AMSTUTZ, P., DRUG DISCOV. TODAY, (2008), vol. 13, pages 695 - 701 | - FORRER, P.; STUMPP, M.T.; BINZ, H.K.; P UCKTHUN, A., FEBS LETTERS, (2003), vol. 539, pages 2 - 6 | - BINZ, H.K. ET AL., J. MOL. BIOL., (2003), vol. 332, pages 489 - 503 | - FORRER, P. ET AL., FEBS LETTERS, (2003), vol. 539, pages 2 - 6 | - TANAKA, N.; NAKANISHI, M; KUSAKABE, Y; GOTO, Y.; KITADE, Y; NAKAMURA, K.T., EMBO J., (2004), vol. 23, no. 30, pages 3929 - 3938 | - HANES, J.; P UCKTHUN, A., PNAS, (1997), vol. 94, pages 4937 - 42 | - ZAHND, C.; AMSTUTZ, P.; P UCKTHUN, A., NAT. METHODS, (2007), vol. 4, pages 69 - 79 | - TAKAHASHI, K.; SAISHIN, Y.; SAISHIN, Y.; KING, A.G.; LEVIN, R.; CAMPOCHIARO, P.A., ARCH. OPHTHALMOL., (2009), vol. 127, no. 4, pages 494 - 499 |