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Extract from the Register of European Patents

EP About this file: EP2807186

EP2807186 - VACCINES AGAINST CLOSTRIDIUM DIFFICILE COMPRISING RECOMBINANT TOXINS [Right-click to bookmark this link]
StatusExamination is in progress
Status updated on  18.11.2016
Database last updated on 19.07.2024
Most recent event   Tooltip12.01.2024New entry: Renewal fee paid 
Applicant(s)For all designated states
Merck Sharp & Dohme LLC
126 East Lincoln Avenue
Rahway, New Jersey 07065 / US
For all designated states
Intervet International B.V.
Wim de Körverstraat 35
5831 AN Boxmeer / NL
[2022/42]
Former [2014/49]For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
For all designated states
Intervet International B.V.
Wim de Körverstraat 35
5831 AN Boxmeer / NL
Inventor(s)01 / HEINRICHS, Jon Henry
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
02 / BODMER, Jean-Luc
4 Abbott Lane, Unit 1
Concord Massachusetts 01742 / US
03 / SECORE, Susan Lynn
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
04 / GOERKE, Aaron Rudy
1 DNA Way
Mail Stop 43A
South San Francisco California 94080-4990 / US
05 / CARO-AGUILAR, Ivette
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
06 / GENTILE, Marie-Pierre
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
07 / HORTON, Melanie S.
770 Sumneytown Pike
West Point Pennsylvania19486 / US
08 / MIEZEIEWSKI, Matthew Ryan
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
09 / SKINNER, Julie M.
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
10 / SONDERMEIJER, Paulus Jacobus Antonius
Wim de Korverstraat 35
5381 AN Boxmeer / NL
11 / SUBRAMANIAN, Shyamsundar
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
12 / van der HEIJDEN-LIEFKENS, Karin Huberdina Antonia
Wimde Korverstraat 35
5831 AN Boxmeer / NL
13 / WANG, Su
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
14 / XIE, Jinfu
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
15 / XOCONOSTLE, Rachel Flora
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
16 / ZORMAN, Julie
770 Sumneytown Pike
West Point Pennsylvania 19486 / US
 [2014/49]
Representative(s)Merck Sharp & Dohme LLC
120 Moorgate
London EC2M 6UR / GB
[N/P]
Former [2014/49]Böhles, Elena, et al
Merck Sharp & Dohme Limited
Hertford Road
Hoddesdon, Herts EN11 9BU / GB
Application number, filing date13740509.825.01.2013
WO2013US23189
Priority number, dateUS201261591631P27.01.2012         Original published format: US 201261591631 P
US201261596419P08.02.2012         Original published format: US 201261596419 P
US201261703754P20.09.2012         Original published format: US 201261703754 P
[2014/49]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013112867
Date:01.08.2013
Language:EN
[2013/31]
Type: A1 Application with search report 
No.:EP2807186
Date:03.12.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 01.08.2013 takes the place of the publication of the European patent application.
[2014/49]
Search report(s)International search report - published on:US01.08.2013
(Supplementary) European search report - dispatched on:EP05.01.2016
ClassificationIPC:C07K14/33, A61K39/08, A61K39/00, A61K38/00, C12N9/10, C12N9/52
[2016/04]
CPC:
C12N9/1051 (EP,US); C07K14/33 (EP,CN,US); A61K39/08 (EP,CN,US);
A61P31/04 (EP); A61P37/04 (EP); C12N9/1077 (EP,US);
C12N9/52 (EP,US); A61K2039/55505 (EP,CN,US); A61K2039/55577 (EP,CN,US);
A61K38/00 (EP,CN,US) (-)
Former IPC [2014/49]C07K14/33
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/49]
Extension statesBA27.08.2014
ME27.08.2014
TitleGerman:IMPFSTOFFE GEGEN CLOSTRIDIUM DIFFICILE MIT REKOMBINANTEN TOXINEN[2014/49]
English:VACCINES AGAINST CLOSTRIDIUM DIFFICILE COMPRISING RECOMBINANT TOXINS[2014/49]
French:VACCINS CONTRE CLOSTRIDIUM DIFFICILE COMPRENANT DES TOXINES RECOMBINANTES[2014/49]
Entry into regional phase27.08.2014National basic fee paid 
27.08.2014Search fee paid 
27.08.2014Designation fee(s) paid 
27.08.2014Examination fee paid 
Examination procedure27.08.2014Examination requested  [2014/49]
20.07.2016Amendment by applicant (claims and/or description)
18.11.2016Despatch of a communication from the examining division (Time limit: M06)
05.05.2017Reply to a communication from the examining division
06.11.2017Despatch of a communication from the examining division (Time limit: M06)
16.05.2018Reply to a communication from the examining division
04.04.2019Despatch of a communication from the examining division (Time limit: M06)
15.01.2020Reply to a communication from the examining division
09.12.2020Despatch of a communication from the examining division (Time limit: M06)
09.07.2021Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
08.09.2021Reply to a communication from the examining division
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.11.2016
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
08.09.2021Request for further processing filed
08.09.2021Full payment received (date of receipt of payment)
Request granted
17.09.2021Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
15.01.2020Request for further processing filed
15.01.2020Full payment received (date of receipt of payment)
Request granted
27.01.2020Decision despatched
Fees paidRenewal fee
08.01.2015Renewal fee patent year 03
08.01.2016Renewal fee patent year 04
09.01.2017Renewal fee patent year 05
08.01.2018Renewal fee patent year 06
09.01.2019Renewal fee patent year 07
10.01.2020Renewal fee patent year 08
12.01.2021Renewal fee patent year 09
13.01.2022Renewal fee patent year 10
11.01.2023Renewal fee patent year 11
11.01.2024Renewal fee patent year 12
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Documents cited:Search[X]WO2010093801  (CEDARS SINAI MEDICAL CENTER [US], et al) [X] 26,29 * pages 4, 5, 17 - page 18; claim 13 *;
 [XI]  - Toxin From ET AL, "STRUCTURAL STUDIES ON ACTIN­ADP RIBOSYLATING BINARY A thesis submitted for the degree ofDoctor ofPhilosophy", (20100201), URL: http://opus.bath.ac.uk/24677/1/UnivBath_PhD_2010_A_Sundriyal.pdf, (20151218), XP055237657 [X] 20,25,36,39 * page 159 - page 11; figure 5.20 * [I] 21-24,27,28,30-35,38
 [A]  - Hossein Khademi ET AL, "THE ROLE OF CDT IN THE PATHOGENESIS OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE", (20110410), URL: http://rudar.ruc.dk/bitstream/1800/6614/1/Bachelor project final report.pdf, (20151218), XP055237659 [A] 20-36,38,39 * the whole document *
 [A]  - A. SUNDRIYAL ET AL, "Structural Basis for Substrate Recognition in the Enzymatic Component of ADP-ribosyltransferase Toxin CDTa from Clostridium difficile", JOURNAL OF BIOLOGICAL CHEMISTRY, US, (20091016), vol. 284, no. 42, doi:10.1074/jbc.M109.043018, ISSN 0021-9258, pages 28713 - 28719, XP055237661 [A] 20-36,38,39 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.M109.043018
 [AP]  - Jon H Heinrichs ET AL, "DESIGN, PRODUCTION AND PRE-CLINICAL EVALUATION OF A NOVEL TOXIN-BASED VACCINE FOR THE PREVENTION OF Clostridium difficile DISEASE", 4th INTERNATIONAL CLOSTRIDIUM DIFFICILE SYMPOSIUM, (20120920), page 30, URL: http://www.icds.si/icds-2012/docs/abstract_book.pdf, (20141029), XP055149657 [AP] 20-36,38,39 * the whole document *
International search[A]US6573003  (WILLIAMS JAMES A [US], et al);
 [Y]US2011053244  (OYLER GEORGE A [US], et al);
 [Y]WO2011068953  (UNIV TUFTS [US], et al);
 [YP]US2012269841  (SIDHU MANINDER K [US], et al);
 [YP]  - WANG ET AL., "A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection.", INFECT. IMMUN., (20120521), vol. 80, no. 8, pages 2678 - 2688, XP002730906

DOI:   http://dx.doi.org/10.1128/IAI.00215-12
by applicantWO9859053
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 WO2005058353
 US7226597
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 US7713535
 WO2011060431
 WO2011068953
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DOI:   http://dx.doi.org/10.1074/jbc.M109.043018
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.