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Extract from the Register of European Patents

EP About this file: EP2877599

EP2877599 - METHODS AND COMPOSITIONS FOR DETERMINING RESISTANCE TO ANDROGEN RECEPTOR THERAPY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  28.08.2020
Database last updated on 03.10.2024
FormerThe patent has been granted
Status updated on  20.09.2019
FormerGrant of patent is intended
Status updated on  29.04.2019
FormerExamination is in progress
Status updated on  25.07.2017
Most recent event   Tooltip28.08.2020No opposition filed within time limitpublished on 30.09.2020  [2020/40]
Applicant(s)For all designated states
Aragon Pharmaceuticals, Inc.
10990 Wilshire Blvd. Suite 300
Los Angeles, CA 90024 / US
[2020/01]
Former [2015/23]For all designated states
Aragon Pharmaceuticals, Inc.
12780 El Camino Real, Suite 301
San Diego, CA 92130 / US
Inventor(s)01 / JOSEPH, James David
10242 Lone Bluff Drive
San Diego, CA 92127 / US
02 / HAGER, Jeffrey H.
13381 Benchley Road
San Diego, CA 92130 / US
03 / SENSINTAFFAR, John, Lee
12777 Casa Avenida
Poway, CA 92064 / US
04 / LU, Nhin
3635 Ash Street
Unit 4
San Diego, CA 92126 / US
05 / QIAN, Jing
9456 Compass Point Drive
South 8
San Diego, CA 92126 / US
06 / SMITH, Nicholas, D.
1204 Beryl Street
San Diego, CA 92109 / US
 [2019/43]
Former [2015/23]01 / JOSEPH, James, David
10242 Lone Bluff Drive
San Diego, CA 92127 / US
02 / HAGER, Jeffrey H.
13381 Benchley Road
San Diego, CA 92130 / US
03 / SENSINTAFFAR, John, Lee
12777 Casa Avenida
Poway, CA 92064 / US
04 / LU, Nhin
3635 Ash Street
Unit 4
San Diego, CA 92126 / US
05 / QIAN, Jing
9456 Compass Point Drive
South 8
San Diego, CA 92126 / US
06 / SMITH, Nicholas, D.
1204 Beryl Street
San Diego, CA 92109 / US
Representative(s)McGuire, Gillian Margaret
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2019/43]
Former [2015/23]Phillips, Gillian Margaret
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Application number, filing date13745973.126.07.2013
[2019/43]
WO2013US52395
Priority number, dateUS201261676842P27.07.2012         Original published format: US 201261676842 P
US201361783763P14.03.2013         Original published format: US 201361783763 P
US201361829123P30.05.2013         Original published format: US 201361829123 P
[2015/23]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014018926
Date:30.01.2014
Language:EN
[2014/05]
Type: A1 Application with search report 
No.:EP2877599
Date:03.06.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 30.01.2014 takes the place of the publication of the European patent application.
[2015/23]
Type: B1 Patent specification 
No.:EP2877599
Date:23.10.2019
Language:EN
[2019/43]
Search report(s)International search report - published on:EP30.01.2014
ClassificationIPC:C12Q1/6886
[2019/19]
CPC:
A61K31/4166 (EP,IL,US); A61K31/4184 (IL,US); C12Q1/6886 (EP,IL,KR,US);
C12Q1/6888 (CN,IL); C07K19/00 (EA); A61K31/00 (CN,IL);
A61K31/4164 (KR); A61K31/4439 (EP,IL,US); A61K38/09 (EP,IL,US);
A61K45/06 (EP,IL,US); A61P1/16 (EP,IL); A61P13/08 (EP,IL);
A61P13/10 (EP,IL); A61P15/00 (EP,IL); A61P29/00 (EP,IL);
A61P35/00 (EP,IL); A61P43/00 (EP,IL); C07K14/72 (EA);
C07K14/721 (EP,CN,IL,KR,US); C07K16/28 (KR); C07K16/2869 (CN,IL,US);
C12N15/63 (EA); C12N5/10 (EA); C12Q1/6869 (KR);
C12Q1/6897 (IL,US); G01N33/543 (EA); G01N33/57492 (IL,US);
C12Q2600/106 (EP,IL,KR,US); C12Q2600/136 (IL,US); C12Q2600/156 (IL,US);
C12Q2600/158 (IL,US); C12Q2600/16 (IL,US); G01N2333/723 (IL,US) (-)
C-Set:
A61K31/00, A61K2300/00 (CN);
A61K31/4166, A61K2300/00 (EP,US);
A61K31/4439, A61K2300/00 (US,EP)
Former IPC [2015/23]C12Q1/68, A61K31/00, C07K14/72, C07K16/28
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/23]
Extension statesBA24.02.2015
ME24.02.2015
TitleGerman:VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BESTIMMUNG DER RESISTENZ GEGEN EINE ANDROGENREZEPTORTHERAPIE[2015/23]
English:METHODS AND COMPOSITIONS FOR DETERMINING RESISTANCE TO ANDROGEN RECEPTOR THERAPY[2015/23]
French:MÉTHODES ET COMPOSITIONS POUR DÉTERMINER LA RÉSISTANCE À UNE THÉRAPIE DU RÉCEPTEUR DES ANDROGÈNES[2015/23]
Entry into regional phase24.02.2015National basic fee paid 
24.02.2015Designation fee(s) paid 
24.02.2015Examination fee paid 
Examination procedure24.02.2015Examination requested  [2015/23]
14.10.2015Amendment by applicant (claims and/or description)
14.01.2016Despatch of a communication from the examining division (Time limit: M06)
15.07.2016Reply to a communication from the examining division
13.07.2017Despatch of a communication from the examining division (Time limit: M04)
21.11.2017Reply to a communication from the examining division
03.05.2018Despatch of a communication from the examining division (Time limit: M04)
12.09.2018Reply to a communication from the examining division
30.04.2019Communication of intention to grant the patent
10.09.2019Fee for grant paid
10.09.2019Fee for publishing/printing paid
10.09.2019Receipt of the translation of the claim(s)
Divisional application(s)EP19204705.8  / EP3653733
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.01.2016
Opposition(s)24.07.2020No opposition filed within time limit [2020/40]
Fees paidRenewal fee
10.07.2015Renewal fee patent year 03
11.07.2016Renewal fee patent year 04
12.07.2017Renewal fee patent year 05
11.07.2018Renewal fee patent year 06
15.07.2019Renewal fee patent year 07
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Cited inInternational search[A]WO0166599  (SCHERING AG [DE], et al) [A] 1-76,91-114 * the whole document *;
 [I]EP2065474  (SIEMENS HEALTHCARE DIAGNOSTICS [DE]) [I] 1-76,91-114 * the whole document *;
 [X]US2010068802  (QIU YUN [US], et al) [X] 102* the whole document *;
 [X]  - TAKAYOSHI D ET AL, "Establishment and characterization of monoclonal antibody against androgen receptor", JOURNAL OF STEROID BIOCHEMISTRY, PERGAMON PRESS PLC, GB, vol. 33, no. 5, doi:10.1016/0022-4731(89)90231-8, ISSN 0022-4731, (19891101), pages 845 - 851, (19891101), XP025204824 [X] 102,103 * the whole document *

DOI:   http://dx.doi.org/10.1016/0022-4731(89)90231-8
 [A]  - C. E. BOHL ET AL, "Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design", JOURNAL OF BIOLOGICAL CHEMISTRY, (20070316), vol. 282, no. 18, doi:10.1074/jbc.M611711200, ISSN 0021-9258, pages 13648 - 13655, XP055080870 [A] 1-76,91-114 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.M611711200
 [I]  - XING HUO ET AL, "Quantitative structure-activity relationship analysis of a novel series of chemicals antagonizing WT and MT AR", CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, (20110701), vol. 107, no. 2, doi:10.1016/j.chemolab.2011.04.013, ISSN 0169-7439, pages 283 - 289, XP055081203 [I] 1-76,91-114 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.chemolab.2011.04.013
 [XP]  - M. KORPAL ET AL, "An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)", CANCER DISCOVERY, (20130710), vol. 3, no. 9, doi:10.1158/2159-8290.CD-13-0142, ISSN 2159-8274, pages 1030 - 1043, XP055080863 [XP] 1-76,91-114 * the whole document *

DOI:   http://dx.doi.org/10.1158/2159-8290.CD-13-0142
 [XP]  - J. D. JOSEPH ET AL, "A Clinically Relevant Androgen Receptor Mutation Confers Resistance to Second-Generation Antiandrogens Enzalutamide and ARN-509", CANCER DISCOVERY, (20130618), vol. 3, no. 9, doi:10.1158/2159-8290.CD-13-0226, ISSN 2159-8274, pages 1020 - 1029, XP055080859 [XP] 1-76,91-114 * the whole document *

DOI:   http://dx.doi.org/10.1158/2159-8290.CD-13-0226
 [A]  - HAAPALA K ET AL, "Androgen receptor alterations in prostate cancer relapsed during a combined androgen blockade by orchiectomy and bicalutamide", LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, THE UNITED STATES AND CANADIAN ACADEMY OF PALHOLOGY, INC, (20011201), vol. 81, no. 12, ISSN 0023-6837, pages 1647 - 1651, XP002382327 [A] 1-76,91-114 * the whole document *
 [XP]  - BALBAS MINNA D ET AL, "Overcoming mutation-based resistance to antiandrogens with rational drug design.", ELIFE 2013, (2013), vol. 2, ISSN 2050-084X, page e00499, XP009173001 [XP] 1-76,91-114 * the whole document *

DOI:   http://dx.doi.org/10.7554/eLife.00499
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