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Extract from the Register of European Patents

EP About this file: EP2885425

EP2885425 - EXPRESSION OF PROTEIN-CODING AND NONCODING GENES AS PROGNOSTIC CLASSIFIERS IN EARLY STAGE LUNG CANCER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.06.2018
Database last updated on 12.06.2024
FormerThe patent has been granted
Status updated on  23.06.2017
FormerGrant of patent is intended
Status updated on  21.02.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services
6011 Executive Blvd. Suite 325
Rockville, MD 20852-3804 / US
[2015/26]
Inventor(s)01 / HARRIS, Curtis, C.
4720 Waverly Avenue
Garrett Park, MD 20896-0077 / US
02 / SCHETTER, Aaron, Joseph
19220 Wheatfield Drive
Germantown, MD 20876 / US
03 / OKAYAMA, Hirokazu
257 Congressional Lane
412
Rockville, MD 20852 / US
04 / AKAGI, Ichiro
15-8 Nisshinmachi
Aizu-wakamatsu 965-0861 / JP
 [2015/26]
Representative(s)Hiebl, Inge Elisabeth
Kraus & Weisert
Patentanwälte PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
[2015/26]
Application number, filing date13753973.020.08.2013
[2017/30]
WO2013US55746
Priority number, dateUS201261691118P20.08.2012         Original published format: US 201261691118 P
[2015/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014031609
Date:27.02.2014
Language:EN
[2014/09]
Type: A1 Application with search report 
No.:EP2885425
Date:24.06.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 27.02.2014 takes the place of the publication of the European patent application.
[2015/26]
Type: B1 Patent specification 
No.:EP2885425
Date:26.07.2017
Language:EN
[2017/30]
Search report(s)International search report - published on:EP27.02.2014
ClassificationIPC:C12Q1/68
[2015/26]
CPC:
C12Q1/6886 (EP,US); A61B6/032 (US); A61N5/10 (US);
A61P11/00 (EP); A61P35/00 (EP); C12Q2600/118 (US);
C12Q2600/158 (EP,US); C12Q2600/178 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/26]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:EXPRESSION VON PROTEINCODIERENDEN UND NICHTCODIERENDEN GENEN ALS PROGNOSTISCHEN KLASSIFIKATOREN FÜR LUNGENKREBS IM FRÜHSTADIUM[2015/26]
English:EXPRESSION OF PROTEIN-CODING AND NONCODING GENES AS PROGNOSTIC CLASSIFIERS IN EARLY STAGE LUNG CANCER[2015/26]
French:EXPRESSION DE GÈNES CODANT ET NON CODANT DES PROTÉINES EN TANT QUE CLASSIFICATEURS PRONOSTIQUES DANS UN CANCER DU POUMON À UN STADE PRÉCOCE[2015/26]
Entry into regional phase16.03.2015National basic fee paid 
16.03.2015Designation fee(s) paid 
16.03.2015Examination fee paid 
Examination procedure16.03.2015Amendment by applicant (claims and/or description)
16.03.2015Examination requested  [2015/26]
11.03.2016Despatch of a communication from the examining division (Time limit: M06)
21.09.2016Reply to a communication from the examining division
22.02.2017Communication of intention to grant the patent
13.06.2017Fee for grant paid
13.06.2017Fee for publishing/printing paid
13.06.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  11.03.2016
Opposition(s)30.04.2018No opposition filed within time limit [2018/27]
Fees paidRenewal fee
27.08.2015Renewal fee patent year 03
29.08.2016Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU20.08.2013
AL26.07.2017
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
PT26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
IE20.08.2017
LU20.08.2017
MT20.08.2017
BE31.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
[2020/34]
Former [2020/28]HU20.08.2013
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
PT26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
IE20.08.2017
LU20.08.2017
MT20.08.2017
BE31.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2020/15]HU20.08.2013
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
IE20.08.2017
LU20.08.2017
MT20.08.2017
BE31.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2019/51]HU20.08.2013
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
IE20.08.2017
LU20.08.2017
MT20.08.2017
BE31.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2019/47]HU20.08.2013
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
IE20.08.2017
LU20.08.2017
MT20.08.2017
BE31.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2019/31]HU20.08.2013
AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
IE20.08.2017
LU20.08.2017
MT20.08.2017
BE31.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/43]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
IE20.08.2017
LU20.08.2017
MT20.08.2017
BE31.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/39]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
IE20.08.2017
LU20.08.2017
BE31.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/34]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SK26.07.2017
SM26.07.2017
IE20.08.2017
LU20.08.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/24]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SK26.07.2017
SM26.07.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/21]AT26.07.2017
CZ26.07.2017
DK26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
CH31.08.2017
LI31.08.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/12]AT26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/11]AT26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/10]AT26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
NL26.07.2017
RS26.07.2017
SE26.07.2017
NO26.10.2017
Former [2018/09]FI26.07.2017
LT26.07.2017
NL26.07.2017
SE26.07.2017
NO26.10.2017
Former [2018/08]FI26.07.2017
LT26.07.2017
NL26.07.2017
NO26.10.2017
Former [2018/07]LT26.07.2017
NO26.10.2017
Cited inInternational search[XA]  - Affymetrix, "GeneChip® Human Genome Arrays", (2004), pages 1 - 4, URL: http://www.osa.sunysb.edu/udmf/ArraySheets/human_datasheet.pdf, (20131008), XP002714318 [X] 42-47 * the whole document * * figure Fig. 1 * [A] 1-41
 [YDA]  - J. SUBRAMANIAN ET AL, "Gene Expression-Based Prognostic Signatures in Lung Cancer: Ready for Clinical Use?", JNCI JOURNAL OF THE NATIONAL CANCER INSTITUTE, (20100407), vol. 102, no. 7, doi:10.1093/jnci/djq025, ISSN 0027-8874, pages 464 - 474, XP055073612 [YD] 1,2,5,6,9,10,13,14,17,18,21,22,25-47 * the whole document * * table 1 * [A] 3,4,7,8,11,12,15,16,19,20,23,24

DOI:   http://dx.doi.org/10.1093/jnci/djq025
 [YA]  - BAO-ZHU YUAN ET AL, "DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas", ONCOGENE, (20040219), vol. 23, no. 7, doi:10.1038/sj.onc.1207291, ISSN 0950-9232, pages 1405 - 1411, XP055082980 [Y] 1,2,5,6,9,10,13,14,17,18,21,22,25-47 * the whole document * [A] 3,4,7,8,11,12,15,16,19,20,23,24

DOI:   http://dx.doi.org/10.1038/sj.onc.1207291
 [YDA]  - M. SAITO ET AL, "The Association of MicroRNA Expression with Prognosis and Progression in Early-Stage, Non-Small Cell Lung Adenocarcinoma: A Retrospective Analysis of Three Cohorts", CLINICAL CANCER RESEARCH, (20110401), vol. 17, no. 7, doi:10.1158/1078-0432.CCR-10-2961, ISSN 1078-0432, pages 1875 - 1882, XP055082883 [YD] 1,2,5,6,9,10,13,14,17,18,21,22,25-47 * the whole document * [A] 3,4,7,8,11,12,15,16,19,20,23,24

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-10-2961
 [XP]  - I. AKAGI ET AL, "Combination of Protein Coding and Noncoding Gene Expression as a Robust Prognostic Classifier in Stage I Lung Adenocarcinoma", CANCER RESEARCH, (20130701), vol. 73, no. 13, doi:10.1158/0008-5472.CAN-13-0031, ISSN 0008-5472, pages 3821 - 3832, XP055082817 [XP] 1-47 * the whole document *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-13-0031
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.