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Extract from the Register of European Patents

EP About this file: EP2819749

EP2819749 - AUTISM-ASSOCIATED BIOMARKERS AND USES THEREOF [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 01.02.2019 Database last updated on 30.10.2024
Former	Request for examination was made Status updated on 16.12.2016
Most recent event Tooltip	01.02.2019	Application deemed to be withdrawn	published on 06.03.2019 [2019/10]
Applicant(s)	For all designated states The Trustees of Columbia University in the City of New York 412 Low Memorial Library 535 West 116th Street New York, NY 10027 / US
	[N/P]
Former [2015/02]	For all designated states The Trustees of Columbia University in the City of New York 412 Low Memorial Library 535 West 116th Street New York, New York 10027 / US
Inventor(s)	01 / HORNIG, Mady 8 Spruce Street Apt. 22a New York, NY 10038 / US
	02 / LIPKIN, W., Ian 45 West 105th Street New York, NY 10032 / US
	[2015/02]
Representative(s)	Barker Brettell LLP 100 Hagley Road Edgbaston Birmingham B16 8QQ / GB
	[N/P]
Former [2015/02]	Lawrence, John Barker Brettell LLP 100 Hagley Road Edgbaston Birmingham B16 8QQ / GB
Application number, filing date	13754386.4	01.03.2013
	WO2013US28589
Priority number, date	US201261605567P	01.03.2012 Original published format: US 201261605567 P
	[2015/02]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2013130953
	Date:	06.09.2013
	Language:	EN
	[2013/36]
	Type:	A2 Application without search report
	No.:	EP2819749
	Date:	07.01.2015
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 06.09.2013 takes the place of the publication of the European patent application.
	[2015/02]
Search report(s)	International search report - published on:	US	16.10.2014
	(Supplementary) European search report - dispatched on:	EP	03.02.2016
Classification	IPC:	A61P25/00, A61K45/06, A61K31/7088, C07K16/18, A61K38/17, A61K31/593, A61K39/395, C12Q1/68, G01N33/68, A61N5/06	[2016/09]
	CPC:	C12Q1/6883 (EP,US); G01N33/6896 (US); A61K31/593 (EP,US); A61K38/1722 (EP,US); A61K38/19 (US); A61K39/3955 (US); (+) A61K45/06 (EP,US); A61N5/062 (US); A61P25/00 (EP); C07K16/18 (US); C12Q2600/106 (EP,US); C12Q2600/112 (US); C12Q2600/158 (EP,US); G01N2800/2814 (US) (-)
	C-Set:	A61K31/593, A61K2300/00 (EP,US)
	Former IPC [2015/02]	A61P25/00
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/02]
Title	German:	BIOMARKER FÜR AUTISMUS UND VERWENDUNGEN DAVON	[2015/02]
	English:	AUTISM-ASSOCIATED BIOMARKERS AND USES THEREOF	[2015/02]
	French:	BIOMARQUEURS ASSOCIÉS À L'AUTISME ET LEURS UTILISATIONS	[2015/02]
Entry into regional phase	23.07.2014	National basic fee paid
	23.07.2014	Search fee paid
	23.07.2014	Designation fee(s) paid
	23.07.2014	Examination fee paid
Examination procedure	23.07.2014	Examination requested [2015/02]
	25.08.2016	Amendment by applicant (claims and/or description)
	02.10.2018	Application deemed to be withdrawn, date of legal effect [2019/10]
	26.10.2018	Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time [2019/10]
Fees paid	Renewal fee
	27.03.2015	Renewal fee patent year 03
	29.03.2016	Renewal fee patent year 04
	10.03.2017	Renewal fee patent year 05
	Penalty fee
	Additional fee for renewal fee
	31.03.2018	06 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[XI]US2003036638 (JOERGENSEN CHARLOTTE SVAERKE [DK], et al) [X] 2-5,13,14 * claims 13-21 * * page 92; example 3 * [I] 21;
		[X]US2004156826 (DANGOND FERNANDO [US], et al) [X] 2-5,13,14 * paragraphs [0010] , [0 23] , [0024] , [0025] , [0043] , [0034] , [0 51] - [0055] - [0061] - [0064] - [0065] , [0067] , [0070] , [0071] * * Probe M11321;; table 2 *;
		[X]US2004224877 (PIRIE-SHEPHERD STEVEN [US], et al) [X] 17-19 * paragraphs [0009] - [0011] - [0036] , [0 67]; claims 1, 12,19 *;
		[XI]US2007003922 (AMARAL DAVID G [US], et al) [X] 11,12 * claims 14-26 * * paragraphs [0071] , [ 7582] , [0 88]; example 1 * [I] 8,9;
		[X] - FEI LI ET AL, "Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population", BMC MEDICAL GENETICS, BIOMED CENTRAL, LONDON, GB, (20110803), vol. 12, no. 1, doi:10.1186/1471-2350-12-103, ISSN 1471-2350, page 103, XP021105045 [X] 6,7,11,12,15,16 * abstract * * page 3, column r, paragraph l - page 4, column l, paragraph 1 * * table 2 * * page 4, column r, paragraph 4; table 4 * DOI: http://dx.doi.org/10.1186/1471-2350-12-103
		[X] - BRAUN A ET AL, "Sequence and organization of the human vitamin D-binding protein gene", BIOCHIMICA ET BIOPHYSICA ACTA . GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1216, no. 3, doi:10.1016/0167-4781(93)90005-X, ISSN 0167-4781, (19931214), pages 385 - 394, (19931214), XP023468099 [X] 15,16 * abstract * * page 385, column l, paragraph 1 - paragraph 2; tables I, III * DOI: http://dx.doi.org/10.1016/0167-4781(93)90005-X
		[X] - OSAWA M ET AL, "Epitope analysis of monoclonal antibodies to human GC globulin (vitamin D-binding protein)", BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, ACADEMIC PRESS, LONDON, GB, vol. 44, no. 2, doi:10.1080/15216549800201312, ISSN 1039-9712, (19980201), pages 293 - 303, (20080117), XP008122418 [X] 15,16 * abstract * * Materials and methods;; table 1 * DOI: http://dx.doi.org/10.1080/15216549800201312
		[X] - NOBUTO YAMAMOTO ET AL, "Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF)", JOURNAL OF MEDICAL VIROLOGY, (20090101), vol. 81, no. 1, doi:10.1002/jmv.21376, ISSN 0146-6615, pages 16 - 26, XP055010289 [X] 17,20 * abstract * * page 25, column l, paragraph l * DOI: http://dx.doi.org/10.1002/jmv.21376
	International search	[Y]US6268478 (ADAMS JOHN S [US]);
		[A]US2002055140 (YAMAMOTO NOBUTO [US]);
		[X]US2007003922 (AMARAL DAVID G [US], et al);
		[Y]WO2007137582 (ANTIBODYSHOP AS [DK], et al);
		[Y]US2009041793 (EGGINK LAURA L [US], et al);
		[X]US2009209501 (BISHOP CHARLES W [US], et al);
		[A]US2009221437 (HARKIN PAUL [IE], et al);
		[Y] - CANNELL ET AL., "On the Aetiology of Autism.", ACTA PÆDIATRICA, (2010), vol. 99, pages 1128 - 1130, XP055158998 DOI: http://dx.doi.org/10.1111/j.1651-2227.2010.01883.x
		[Y] - LEANDRO ET AL., "Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-y genes and its association with susceptibility to tuberculosis.", BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, (2009), vol. 42, pages 312 - 322, XP055158999 DOI: http://dx.doi.org/10.1590/S0100-879X2009000400002
		[Y] - SAYRE ET AL., "Reintroduction of a classic vitamin D ultraviolet source.", JOURNAL OF STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY, (20070212), vol. 103, no. 3-5, pages 686 - 688., XP022275133 DOI: http://dx.doi.org/10.1016/j.jsbmb.2006.12.062
		[A] - OSAWA ET AL., "Epitope Analysis of Monoclonal Antibodies to Human Gc Globulin (Vitamin D-Binding Protein)", BIOCHEMISTRY AND MOLECULAR BIOLOGY LINTEMATIONAL., (199802), vol. 44, no. 2, pages 293 - 303, XP008122418 DOI: http://dx.doi.org/10.1080/15216549800201312
		[A] - SAAF ET AL., "Severe vitamin D deficiency in pregnant women of Somali origin living in Sweden .", ACTA PEDIATRICA, (201104), vol. 100, no. 4, pages 612 - 614, XP055159004 DOI: http://dx.doi.org/10.1111/j.1651-2227.2011.02134.x
		[AP] - BRADSTREET ET AL., "Initial Observations of elevated Alpha-Acetylglucosaminidase Activity Associated with Autism and Observed Reductions from GC Protein-Macrophage Activating Factor Injections.", AUTISM INSIGHTS, (20121210), vol. 4, pages 31 - 38, XP055159005 DOI: http://dx.doi.org/10.4137/AUI.S10485

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