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Extract from the Register of European Patents

EP About this file: EP2822386

EP2822386 - FOLATE RECEPTOR ALPHA BINDING LIGANDS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.03.2022
Database last updated on 14.09.2024
FormerThe patent has been granted
Status updated on  03.04.2021
FormerGrant of patent is intended
Status updated on  15.11.2020
FormerExamination is in progress
Status updated on  04.06.2019
FormerRequest for examination was made
Status updated on  16.12.2016
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024 [2024/41]
Applicant(s)For all designated states
Purdue Research Foundation
The Convergence Center
101 Foundry Drive, Suite 2500
West Lafayette, IN 47906 / US
[2021/17]
Former [2019/11]For all designated states
Purdue Research Foundation
Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906 / US
Former [2019/10]For all designated states
Purdue Research Foundation
1801 Newman Road
West Lafayette, IN 47906 / US
Former [2015/03]For all designated states
Purdue Research Foundation
1281 Win Hentschel Boulevard
West Lafayette, IN 47096-4182 / US
Inventor(s)01 / LOW, Philip Stewart
5850 Farm Ridge Road
West Lafayette, Indiana 47906 / US
02 / VAITILINGAM, Balasubramanian
3825 Fox Run Drive, Apt. 1344
Blue Ash, OH 45236 / US
03 / CHELVAM, Venkatesh
425 South River Road Apt. 35
West Lafayette, Indiana 47906 / US
 [2015/37]
Former [2015/03]01 / LOW, Philip Stewart
5850 Farm Ridge Road
West Lafayette, Indiana 47906 / US
02 / VAITILINGAM, Balasubramanian
204 Airport Road Apt. 13
West Lafayette, Indiana 47906 / US
03 / CHELVAM, Venkatesh
425 South River Road Apt. 35
West Lafayette, Indiana 47906 / US
Representative(s)Grünecker Patent- und Rechtsanwälte PartG mbB
Leopoldstraße 4
80802 München / DE
[2021/18]
Former [2015/03]Grünecker, Kinkeldey, Stockmair & Schwanhäusser
Leopoldstrasse 4
80802 München / DE
Application number, filing date13754418.528.02.2013
[2021/18]
WO2013US28277
Priority number, dateUS201261605113P29.02.2012         Original published format: US 201261605113 P
[2015/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013130776
Date:06.09.2013
Language:EN
[2013/36]
Type: A1 Application with search report 
No.:EP2822386
Date:14.01.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 06.09.2013 takes the place of the publication of the European patent application.
[2015/03]
Type: B1 Patent specification 
No.:EP2822386
Date:05.05.2021
Language:EN
[2021/18]
Search report(s)International search report - published on:US06.09.2013
(Supplementary) European search report - dispatched on:EP21.12.2015
ClassificationIPC:A61K38/06, A61K31/475, A61K47/54, A61K47/55, A61P35/00
[2020/45]
CPC:
A61K38/06 (EP,US); A61K31/475 (EP,US); A61K47/545 (EP,US);
A61K47/551 (EP,US); A61K49/0052 (US); A61K51/0459 (US);
A61P35/00 (EP) (-)
Former IPC [2016/03]A01N43/54, A61K47/48, A61K31/06, A61K49/00, A61K38/06, A61K51/04, A61K31/475, A61P35/00
Former IPC [2015/03]A01N43/54
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/03]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:FOLATREZEPTOR-ALPHA-BINDENDE LIGANDEN[2015/03]
English:FOLATE RECEPTOR ALPHA BINDING LIGANDS[2015/03]
French:LIGANDS DE LIAISON AU RÉCEPTEUR ALPHA DE FOLATES[2015/03]
Entry into regional phase29.09.2014National basic fee paid 
29.09.2014Search fee paid 
29.09.2014Designation fee(s) paid 
29.09.2014Examination fee paid 
Examination procedure29.09.2014Examination requested  [2015/03]
21.07.2016Amendment by applicant (claims and/or description)
07.06.2019Despatch of a communication from the examining division (Time limit: M06)
17.12.2019Reply to a communication from the examining division
31.01.2020Despatch of a communication from the examining division (Time limit: M04)
10.06.2020Reply to a communication from the examining division
16.11.2020Communication of intention to grant the patent
26.03.2021Fee for grant paid
26.03.2021Fee for publishing/printing paid
26.03.2021Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.06.2019
Opposition(s)08.02.2022No opposition filed within time limit [2022/15]
Fees paidRenewal fee
25.02.2015Renewal fee patent year 03
26.02.2016Renewal fee patent year 04
27.02.2017Renewal fee patent year 05
27.02.2018Renewal fee patent year 06
27.02.2019Renewal fee patent year 07
27.02.2020Renewal fee patent year 08
25.02.2021Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.02.2013
AL05.05.2021
AT05.05.2021
CY05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
IT05.05.2021
LT05.05.2021
LV05.05.2021
MC05.05.2021
MK05.05.2021
MT05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SI05.05.2021
SK05.05.2021
SM05.05.2021
TR05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
[2024/41]
Former [2024/29]HU28.02.2013
AL05.05.2021
AT05.05.2021
CY05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
IT05.05.2021
LT05.05.2021
LV05.05.2021
MC05.05.2021
MK05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SI05.05.2021
SK05.05.2021
SM05.05.2021
TR05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2024/22]HU28.02.2013
AL05.05.2021
AT05.05.2021
CY05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
IT05.05.2021
LT05.05.2021
LV05.05.2021
MC05.05.2021
MK05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SI05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2024/20]HU28.02.2013
AL05.05.2021
AT05.05.2021
CY05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
IT05.05.2021
LT05.05.2021
LV05.05.2021
MC05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SI05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2024/18]HU28.02.2013
AL05.05.2021
AT05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
IT05.05.2021
LT05.05.2021
LV05.05.2021
MC05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SI05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/44]AL05.05.2021
AT05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
IT05.05.2021
LT05.05.2021
LV05.05.2021
MC05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SI05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/36]AL05.05.2021
AT05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
IT05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SI05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/29]AL05.05.2021
AT05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SI05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/26]AL05.05.2021
AT05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/23]AT05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/10]AT05.05.2021
CZ05.05.2021
DK05.05.2021
EE05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
PT06.09.2021
IS22.12.2021
Former [2022/09]AT05.05.2021
CZ05.05.2021
DK05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RO05.05.2021
RS05.05.2021
SE05.05.2021
SK05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/08]AT05.05.2021
CZ05.05.2021
DK05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RS05.05.2021
SE05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/07]AT05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RS05.05.2021
SE05.05.2021
SM05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2022/04]AT05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
NL05.05.2021
PL05.05.2021
RS05.05.2021
SE05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2021/52]AT05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
PL05.05.2021
RS05.05.2021
SE05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2021/51]AT05.05.2021
ES05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
RS05.05.2021
SE05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
IS05.09.2021
PT06.09.2021
Former [2021/50]AT05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
SE05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
PT06.09.2021
Former [2021/49]AT05.05.2021
FI05.05.2021
HR05.05.2021
LT05.05.2021
LV05.05.2021
SE05.05.2021
BG05.08.2021
NO05.08.2021
GR06.08.2021
Former [2021/47]AT05.05.2021
FI05.05.2021
LT05.05.2021
BG05.08.2021
Former [2021/46]AT05.05.2021
FI05.05.2021
LT05.05.2021
Documents cited:Search[XY]WO2005080431  (MORPHOTEK INC [US], et al) [X] 1,2 * abstract * * claims 1,8 * [Y] 1-4,6-15;
 [XY]EP1900752  (DOMPE PHA R MA SPA RES & MFG [IT], et al) [X] 1,2 * abstract * * claims 1,15 * [Y] 1-4,6-15;
 [XY]WO2010033733  (ENDOCYTE INC [US], et al) [X] 1-4,8-10,12,15 * abstract * * claims 1,16,18,20 * [Y] 1-4,6-15;
 [XY]WO2010040854  (MERCK EPROVA AG [CH], et al) [X] 1-4,9-13 * abstract * * page 21; compounds VII,VIII * * page 23; compounds IX,X * * claims 12-18 * [Y] 1-4,6-15;
 [XY]WO2007022493  (ENDOCYTE INC [US], et al) [X] 1,2 * abstract * * claim - * [Y] 1-4,6-15;
 [XY]WO2011069116  (ENDOCYTE INC [US], et al) [X] 1,2 * abstract * * claim - * [Y] 1-4,6-15;
 [Y]WO2010102238  (PURDUE RESEARCH FOUNDATION [US], et al) [Y] 1-4,6-15 * abstract * * claim - *;
 [XY]  - ANGELA COLIVA ET AL, "90Y Labeling of monoclonal antibody MOv18 and preclinical validation for radioimmunotherapy of human ovarian carcinomas", CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER, BERLIN, DE, (20051201), vol. 54, no. 12, doi:10.1007/S00262-005-0693-2, ISSN 1432-0851, pages 1200 - 1213, XP019333088 [X] 1,2 * abstract * [Y] 1-4,6-15

DOI:   http://dx.doi.org/10.1007/s00262-005-0693-2
 [Y]  - K. M. MAZIARZ ET AL, "Complete Mapping of Divergent Amino Acids Responsible for Differential Ligand Binding of Folate Receptors and", JOURNAL OF BIOLOGICAL CHEMISTRY, (19990416), vol. 274, no. 16, doi:10.1074/jbc.274.16.11086, ISSN 0021-9258, pages 11086 - 11091, XP055146926 [Y] 1-4,6-15 * page 11086, column R, paragraph 3 *

DOI:   http://dx.doi.org/10.1074/jbc.274.16.11086
 [Y]  - XIN W ET AL, "Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 44, no. 9, doi:10.1016/0006-2952(92)90089-2, ISSN 0006-2952, (19921103), pages 1898 - 1901, (19921103), XP025567617 [Y] 1-4,6-15 * abstract * * page 1900; table 1 *

DOI:   http://dx.doi.org/10.1016/0006-2952(92)90089-2
 [T]  - B. VAITILINGAM ET AL, "A Folate Receptor- -Specific Ligand That Targets Cancer Tissue and Not Sites of Inflammation", THE JOURNAL OF NUCLEAR MEDICINE, US, (20120612), vol. 53, no. 7, doi:10.2967/jnumed.111.099390, ISSN 0161-5505, pages 1127 - 1134, XP055226614 [T] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.2967/jnumed.111.099390
International search[Y]WO02085908  (PURDUE RESEARCH FOUNDATION [US], et al);
 [Y]WO2010033733  (ENDOCYTE INC [US], et al);
 [Y]EP2258401  (ENDOCYTE INC [US]);
 [Y]  - BHATTACHARYA ET AL., "Folate receptor targeted, carboxymethyl chitosan functionalized iron oxide nanoparticles: a novel ultradispersed nanoconjugates for bimodal imaging", NANOSCALE, vol. 3, no. 4, (2011), pages 1653 - 1662, URL: http://www.ncbi.nlm.nih.gov/pubmed/21331392, XP055164355

DOI:   http://dx.doi.org/10.1039/c0nr00821d
by applicantUS5627165
    - PATHALK et al., "Enzymic protecting group techniques in organic synthesis", Stereosel. Biocatal., (20000000), pages 775 - 797
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.