blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2843046

EP2843046 - PRACTICAL METHOD FOR ENZYMATICALLY SYNTHESIZING CYCLIC DI-GMP [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.06.2018
Database last updated on 07.10.2024
FormerThe patent has been granted
Status updated on  23.06.2017
FormerGrant of patent is intended
Status updated on  21.03.2017
FormerExamination is in progress
Status updated on  20.01.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
YAMASA CORPORATION
10-1, Araoicho 2-chome Choshi-shi
Chiba 288-0056 / JP
[2015/10]
Inventor(s)01 / TANABE, Kaori
c/o Yamasa Corporation
10-1 Araoicho 2-chome
Choshi-shi Chiba 288-0056 / JP
02 / ISHIGE, Kazuya
c/o Yamasa Corporation
10-1 Araoicho 2-chome
Choshi-shi Chiba 288-0056 / JP
 [2015/10]
Representative(s)Harrison IP Limited
3 Ebor House
Millfield Lane
Nether Poppleton
York YO26 6QY / GB
[N/P]
Former [2017/30]Harrison IP Ltd.
3 Ebor House
London Ebor Business Park
Millfield Lane
Nether Poppleton York YO26 6QY / GB
Former [2015/10]O'Neill, Michelle
Harrison IP
1st Floor, Box Tree House
Northminster Business Park
Northfield Lane
York, YO26 6QU / GB
Application number, filing date13755675.926.02.2013
[2017/30]
WO2013JP55018
Priority number, dateJP2012004368829.02.2012         Original published format: JP 2012043688
[2015/10]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013129427
Date:06.09.2013
Language:JA
[2013/36]
Type: A1 Application with search report 
No.:EP2843046
Date:04.03.2015
Language:EN
[2015/10]
Type: B1 Patent specification 
No.:EP2843046
Date:26.07.2017
Language:EN
[2017/30]
Search report(s)International search report - published on:JP06.09.2013
(Supplementary) European search report - dispatched on:EP16.12.2015
ClassificationIPC:C12N15/09, C12N1/15, C12N1/19, C12N1/21, C12N5/10, C12N9/12, C12P19/32
[2015/10]
CPC:
C12N9/1241 (EP,US); C12N15/62 (EP,US); C12P19/36 (EP,US);
C12Y207/07065 (EP,US); C07K2319/00 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/10]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:PRAKTISCHES VERFAHREN ZUR ENZYMATISCHEN SYNTHESE VON CYCLISCHEM DI-GMP[2015/10]
English:PRACTICAL METHOD FOR ENZYMATICALLY SYNTHESIZING CYCLIC DI-GMP[2015/10]
French:PROCÉDÉ PRATIQUE DE SYNTHÈSE DE DI-GMP CYCLIQUE PAR VOIE ENZYMATIQUE[2015/10]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase11.09.2014Translation filed 
11.09.2014National basic fee paid 
11.09.2014Search fee paid 
11.09.2014Designation fee(s) paid 
11.09.2014Examination fee paid 
Examination procedure11.09.2014Examination requested  [2015/10]
05.07.2016Amendment by applicant (claims and/or description)
10.10.2016Despatch of a communication from the examining division (Time limit: M04)
17.01.2017Reply to a communication from the examining division
22.03.2017Communication of intention to grant the patent
14.06.2017Fee for grant paid
14.06.2017Fee for publishing/printing paid
14.06.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.10.2016
Opposition(s)30.04.2018No opposition filed within time limit [2018/27]
Fees paidRenewal fee
07.01.2015Renewal fee patent year 03
18.01.2016Renewal fee patent year 04
30.11.2016Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.02.2013
AL26.07.2017
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
PT26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
IE26.02.2018
LU26.02.2018
MT26.02.2018
BE28.02.2018
CH28.02.2018
LI28.02.2018
[2020/34]
Former [2020/31]HU26.02.2013
AT26.07.2017
CY26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
MK26.07.2017
NL26.07.2017
PL26.07.2017
PT26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
IE26.02.2018
LU26.02.2018
MT26.02.2018
BE28.02.2018
CH28.02.2018
LI28.02.2018
Former [2020/30]HU26.02.2013
AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
PT26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
IE26.02.2018
LU26.02.2018
MT26.02.2018
BE28.02.2018
CH28.02.2018
LI28.02.2018
Former [2020/28]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
PT26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
IE26.02.2018
LU26.02.2018
MT26.02.2018
BE28.02.2018
CH28.02.2018
LI28.02.2018
Former [2020/15]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
TR26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
IE26.02.2018
LU26.02.2018
MT26.02.2018
BE28.02.2018
CH28.02.2018
LI28.02.2018
Former [2020/08]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
IE26.02.2018
LU26.02.2018
MT26.02.2018
BE28.02.2018
CH28.02.2018
LI28.02.2018
Former [2019/12]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
IE26.02.2018
LU26.02.2018
BE28.02.2018
CH28.02.2018
LI28.02.2018
Former [2019/09]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
IE26.02.2018
LU26.02.2018
CH28.02.2018
LI28.02.2018
Former [2018/52]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
LU26.02.2018
CH28.02.2018
LI28.02.2018
Former [2018/44]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
MC26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/39]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SI26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/25]AT26.07.2017
CZ26.07.2017
DK26.07.2017
EE26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
IT26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RO26.07.2017
RS26.07.2017
SE26.07.2017
SK26.07.2017
SM26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/21]AT26.07.2017
CZ26.07.2017
DK26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/12]AT26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
LV26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/11]AT26.07.2017
ES26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
NL26.07.2017
PL26.07.2017
RS26.07.2017
SE26.07.2017
BG26.10.2017
NO26.10.2017
GR27.10.2017
IS26.11.2017
Former [2018/10]AT26.07.2017
FI26.07.2017
HR26.07.2017
LT26.07.2017
NL26.07.2017
RS26.07.2017
SE26.07.2017
NO26.10.2017
Former [2018/09]FI26.07.2017
LT26.07.2017
NL26.07.2017
SE26.07.2017
NO26.10.2017
Former [2018/08]FI26.07.2017
LT26.07.2017
NL26.07.2017
NO26.10.2017
Former [2018/07]LT26.07.2017
NO26.10.2017
Documents cited:Search[X]  - VOLKER SPEHR ET AL, "Large-Scale Production of the Immunomodulator c-di-GMP from GMP and ATP by an Enzymatic Cascade", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY ; PART A: ENZYME ENGINEERING AND BIOTECHNOLOGY, HUMANA PRESS INC, NEW YORK, (20110628), vol. 165, no. 3 - 4, doi:10.1007/S12010-011-9294-Z, ISSN 1559-0291, pages 761 - 775, XP019973318 [X] 2-4,6-10 * abstract * * page 762, paragraph 5 - page 764, paragraph 2 * * page 767 *

DOI:   http://dx.doi.org/10.1007/s12010-011-9294-z
 [X]  - CHAO-YU YANG ET AL, "The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)2 at the active site", ACTA CRYSTALLOGRAPHICA, SECTION D (BIOLOGICAL CRYSTALLOGRAPHY) MUNKSGAARD INTERNATIONAL PUBLISHERS DENMARK, (201112), vol. D67, no. 12, ISSN 0907-4449, pages 997 - 1008, XP002751482 [X] 2,3,6-10 * the whole document *

DOI:   http://dx.doi.org/10.1107/S090744491104039X
 [X]  - "SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) {ECO:0000313|EMBL:ACV61677.1};", UniProt, (20091103), Database accession no. C8W213, URL: EBI, XP002751483 [X] 2,3,6,7,10 * sequence . *
 [A]  - SESHASAYEE ASWIN S N ET AL, "Comparative genomics of cyclic-di-GMP signalling in bacteria: post-translational regulation and catalytic activity", NUCLEIC ACIDS RESEARCH, (201010), vol. 38, no. 18, ISSN 0305-1048, pages 5970 - 5981, XP002751484 [A] 1-10 * abstract *

DOI:   http://dx.doi.org/10.1093/nar/gkq382
 [XP]  - KOROVASHKINA A S ET AL, "Enzymatic synthesis of c-di-GMP using inclusion bodies ofThermotoga maritimafull-length diguanylate cyclase", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20121226), vol. 164, no. 2, doi:10.1016/J.JBIOTEC.2012.12.006, ISSN 0168-1656, pages 276 - 280, XP028990888 [XP] 2,3,6-10 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.jbiotec.2012.12.006
International search[Y]WO2010101526  (UNIV NANYANG [SG], et al);
 [Y]  - KAORI TANABE ET AL, "GTP Kyokyu-kei o Kyoyaku saseta Kokoritsu na cyclic di-GMP no Koso Gosei", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY 2011 NENDO TAIKAI KOEN YOSHISHU, (20110305), page 119, XP008174466
 [Y]  - LUCAS S. ET AL, "GEOBACILLUS SP. Y412MC52, COMPLETE GENOME", GENBANK, (20111121), Database accession no. CP002442.1, XP055174847
 [Y]  - RAO F. ET AL, "Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase.", ANAL.BIOCHEM., (20090615), vol. 389, no. 2, pages 138 - 42, XP026088901

DOI:   http://dx.doi.org/10.1016/j.ab.2009.03.031
 [Y]  - CHRISTEN B. ET AL, "Allosteric control of cyclic di-GMP signaling.", J.BIOL.CHEM., (20061020), vol. 281, no. 42, pages 32015 - 32024, XP002527910

DOI:   http://dx.doi.org/10.1074/JBC.M603589200
 [XP]  - KAZUYA ISHIGE, "Cyclic di-GMP Ryosanka Gijutsu no Kaihatsu", BIOSCIENCE & INDUSTRY, (20121101), vol. 70, no. 6, pages 466 - 467, XP008174493
by applicantWO2010066666
 WO2010101526
 WO03100056
 WO2006080313
    - ANALYTICAL BIOCHEMISTRY, (2009), vol. 389, pages 138 - 142
    - ABSTRACTS OF PRESENTATIONS AT THE ANNUAL MEETING OF THE JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, (2011), page 119
    - NUCLEIC ACIDS RES., (20040810), vol. 32, no. 14, page E115
    - MARK ET AL., PROC NATL ACAD SCI U S A., (198409), vol. 81, no. 18, pages 5662 - 5666
    - ZOLLER ET AL., NUCLEIC ACIDS RES., (19821025), vol. 10, no. 20, pages 6487 - 6500
    - WANG ET AL., SCIENCE, (19840629), vol. 224, no. 4656, pages 1431 - 1433
    - GENE, (19890415), vol. 77, no. 1, pages 51 - 9
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.