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Extract from the Register of European Patents

EP About this file: EP2830637

EP2830637 - COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES ASSOCIATED WITH OXIDATIVE STRESS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.06.2025
Database last updated on 11.04.2026
FormerThe patent has been granted
Status updated on  19.07.2024
FormerGrant of patent is intended
Status updated on  19.03.2024
FormerExamination is in progress
Status updated on  03.02.2017
Most recent event   Tooltip23.01.2026Lapse of the patent in a contracting state
New state(s): BE, CH, IE		published on 25.02.2026  [2026/09]
Applicant(s)For all designated states
Epion Therapeutics, Inc.
1500 District Ave
Burlington, MA 01803 / US
[2023/46]
Former [2015/06]For all designated states
CXL Ophthalmics, LLC
4354 Manchester Avenue
Encinitas, California 92024 / US
Inventor(s)01 / RUBINFELD, Roy, S.
6401 Fallen Oak Court
Bethesda, MD 20817 / US
02 / HARTMAN, Raymond, A.
3003 Azahar Street
Carlsbad, CA 92009 / US
03 / FELDMAN, Sandy, T.
P.O. Box 2530
Del Mar, CA 92014 / US
 [2015/06]
Representative(s)Dehns
10 Old Bailey
London EC4M 7NG / GB
[N/P]
Former [2024/34]Dehns
St. Bride's House
10 Salisbury Square
London EC4Y 8JD / GB
Former [2015/06]Jennings, Tara Romaine
FRKelly
27 Clyde Road
Dublin 4 / IE
Application number, filing date13768403.128.03.2013
[2024/34]
WO2013US34467
Priority number, dateUS201261617501P29.03.2012         Original published format: US 201261617501 P
[2015/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013149075
Date:03.10.2013
Language:EN
[2013/40]
Type: A1 Application with search report 
No.:EP2830637
Date:04.02.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 03.10.2013 takes the place of the publication of the European patent application.
[2015/06]
Type: B1 Patent specification 
No.:EP2830637
Date:21.08.2024
Language:EN
[2024/34]
Search report(s)International search report - published on:KR03.10.2013
(Supplementary) European search report - dispatched on:EP12.02.2016
ClassificationIPC:A61K33/18, A61K38/44, A61K9/08, A61K9/14, A61K9/06, A61P27/02, A61K31/525, A61P17/14
[2024/15]
CPC:
A61K33/18 (EP,US); A61K31/525 (EP,US); A61K38/44 (EP,US);
A61K9/0014 (EP,US); A61K9/0048 (EP,US); A61K9/08 (EP,US);
A61L26/0066 (EP,US); A61P17/00 (EP); A61P17/14 (EP);
A61P27/02 (EP); C12Y111/01006 (EP,US); A61L2300/106 (EP,US);
A61L2300/254 (EP,US) (-)
Former IPC [2015/47]A61K33/18, A61K38/44, A61K9/08, A61K9/14, A61K9/06, A61P27/02
Former IPC [2015/06]A61K33/36, A61K33/18, A61K33/14, A61K9/08, A61K9/14, A61P17/14, A61P17/00, A61K9/06
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/06]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG ODER PRÄVENTION VON ERKRANKUNGEN IM ZUSAMMENHANG MIT OXIDATIVEM STRESS[2015/06]
English:COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES ASSOCIATED WITH OXIDATIVE STRESS[2015/06]
French:COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT OU DE PRÉVENTION DE MALADIES ASSOCIÉES AU STRESS OXYDATIF[2015/06]
Entry into regional phase29.10.2014National basic fee paid 
29.10.2014Search fee paid 
29.10.2014Designation fee(s) paid 
29.10.2014Examination fee paid 
Examination procedure29.10.2014Examination requested  [2015/06]
22.08.2016Amendment by applicant (claims and/or description)
07.02.2017Despatch of a communication from the examining division (Time limit: M04)
04.04.2017Reply to a communication from the examining division
09.05.2018Date of oral proceedings
29.05.2018Despatch of communication that the application is refused, reason: substantive examination {1}
29.05.2018Minutes of oral proceedings despatched
13.04.2019Observations by third parties
16.03.2021Despatch of a communication from the examining division (Time limit: M06)
19.10.2021Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
31.12.2021Reply to a communication from the examining division
25.07.2023Despatch of a communication from the examining division (Time limit: M04)
28.11.2023Reply to a communication from the examining division
20.03.2024Communication of intention to grant the patent
16.07.2024Fee for grant paid
16.07.2024Fee for publishing/printing paid
16.07.2024Receipt of the translation of the claim(s)
Appeal following examination29.07.2018Appeal received No.  T2534/18
02.10.2018Statement of grounds filed
24.11.2020Result of appeal procedure: continuation of examination procedure
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.02.2017
Opposition(s)22.05.2025No opposition filed within time limit [2025/31]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
31.12.2021Request for further processing filed
31.12.2021Full payment received (date of receipt of payment)
Request granted
12.01.2022Decision despatched
Fees paidRenewal fee
27.08.2015Renewal fee patent year 03
31.03.2016Renewal fee patent year 04
27.03.2017Renewal fee patent year 05
27.03.2018Renewal fee patent year 06
27.03.2019Renewal fee patent year 07
27.03.2020Renewal fee patent year 08
12.03.2021Renewal fee patent year 09
20.09.2022Renewal fee patent year 10
27.02.2023Renewal fee patent year 11
15.02.2024Renewal fee patent year 12
Penalty fee
Additional fee for renewal fee
31.03.201503   M06   Fee paid on   27.08.2015
31.03.202210   M06   Fee paid on   20.09.2022
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT21.08.2024
BG21.08.2024
CZ21.08.2024
DK21.08.2024
EE21.08.2024
FI21.08.2024
HR21.08.2024
LV21.08.2024
MC21.08.2024
PL21.08.2024
RO21.08.2024
SE21.08.2024
SK21.08.2024
SM21.08.2024
NO21.11.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
IE28.03.2025
LU28.03.2025
BE31.03.2025
CH31.03.2025
[2026/09]
Former [2025/52]AT21.08.2024
BG21.08.2024
CZ21.08.2024
DK21.08.2024
EE21.08.2024
FI21.08.2024
HR21.08.2024
LV21.08.2024
MC21.08.2024
PL21.08.2024
RO21.08.2024
SE21.08.2024
SK21.08.2024
SM21.08.2024
NO21.11.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
LU28.03.2025
Former [2025/47]AT21.08.2024
BG21.08.2024
CZ21.08.2024
DK21.08.2024
EE21.08.2024
FI21.08.2024
HR21.08.2024
LV21.08.2024
MC21.08.2024
PL21.08.2024
RO21.08.2024
SE21.08.2024
SK21.08.2024
SM21.08.2024
NO21.11.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
Former [2025/42]AT21.08.2024
BG21.08.2024
CZ21.08.2024
DK21.08.2024
EE21.08.2024
FI21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
RO21.08.2024
SE21.08.2024
SK21.08.2024
SM21.08.2024
NO21.11.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
Former [2025/23]AT21.08.2024
BG21.08.2024
CZ21.08.2024
DK21.08.2024
EE21.08.2024
FI21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
RO21.08.2024
SK21.08.2024
SM21.08.2024
NO21.11.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
Former [2025/22]AT21.08.2024
BG21.08.2024
DK21.08.2024
EE21.08.2024
FI21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
RO21.08.2024
SM21.08.2024
NO21.11.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
Former [2025/21]AT21.08.2024
BG21.08.2024
DK21.08.2024
FI21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
RO21.08.2024
SM21.08.2024
NO21.11.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
Former [2025/10]AT21.08.2024
BG21.08.2024
FI21.08.2024
HR21.08.2024
LV21.08.2024
PL21.08.2024
NO21.11.2024
RS21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
Former [2025/09]AT21.08.2024
BG21.08.2024
FI21.08.2024
LV21.08.2024
PL21.08.2024
NO21.11.2024
GR22.11.2024
IS21.12.2024
PT23.12.2024
Former [2025/08]FI21.08.2024
PL21.08.2024
NO21.11.2024
GR22.11.2024
PT23.12.2024
Documents cited:Search[Y] US2007207116  (BROWN DAVID C et al.) [Y] 1-13 * claim 1 * * paragraphs [0012] , [0 14] *
 [Y] US2006275278  (CHOY CAMUS K M et al.) [Y] 1-13 * claims 1,4, 15, 16 *
 [Y] WO2007020673  (TUBILUX PHARMA S P A et al.) [Y] 1-13 * claims 1-8 * * page 11, paragraph 2 *
 [X] WO2008005059  (FRIO TECHNOLOGIES INC et al.) [X] 1-3,6,8-10 * claims 1, 9 *
 [XY] US7186417  (SIEGEL GREGG et al.) [X] 1-3,6-10,13 * column 1, lines 50-52 * * column 4, lines 48-55 * * examples 2,4 *[Y] 1-13
 [X] US2005152993  (DE OLIVEIRA MARIANA et al.) [X] 1-3,6-10 * claim 3 *
 [XY] WO03068247  (UNIMED PHARMA SPOL SR O et al.) [X] 1-10,13 * page 8, paragraph 2 * * claims 1-6 * * example 1 *[Y] 1-13
 [X] US6248335  (DUAN YONGJUN et al.) [X] 1-5,8-10 * claims 1,2,4,5 * * examples 5,6 *
 [XPI] WO2012047307  (CURVERIGHT LLC et al.) [XP] 1-3,9-11 * claims 95-97, 107-111 * * paragraphs [0107] - [0108] *[I] 11-15
 [E] WO2013148896  (CXL OPHTHALMICS LLC et al.) [E] 1-14 * claims 1,4,6,12-14,17,19,26,27 *
 [XY]   HORWATH-WINTER J ET AL: "Iodide iontophoresis as a treatment for dry eye syndrome.", THE BRITISH JOURNAL OF OPHTHALMOLOGY JAN 2005, vol. 89, no. 1, January 2005 (2005-01-01), pages 40 - 44, XP055219143, ISSN: 0007-1161 [X] 1-5,8-10,13 * abstract * * page 40, column 2, paragraphs 2-4 * * page 41, column 1, paragraph 4 *[Y] 1-13

DOI:   http://dx.doi.org/10.1136/bjo.2004.048314
 [XY]   SINGH Y P ET AL: "Clinical evaluation of sodium iodide in the treatment of various types of cataracts (A preliminary report)", JOURNAL OF THE INDIAN MEDICAL ASSOCIATION 1983 IN, vol. 81, no. 7-8, 1983, pages 119 - 121, XP009186526, ISSN: 0019-5847 [X] 1-3,8-10,13 * page 119, column 2, paragraphs 5, 8 * * page 120, column 2, paragraph 3 - page 121, column 1, paragraph 3 * * table 2 *[Y] 1-13
 [Y]   RIEGER GEBHARD: "Anti-oxidative capacity of various artificial tear preparations", GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, SPRINGER VERLAG, DE, vol. 239, March 2001 (2001-03-01), pages 222 - 226, XP003014992, ISSN: 0721-832X [Y] 1-13 * abstract * * table 3 * * page 225, column 1, paragraph 3 - column 2, paragraph 3 *
 [Y]   WINKLER R ET AL: "Effect of iodide on total antioxidant status of human serum.", CELL BIOCHEMISTRY AND FUNCTION JUN 2000, vol. 18, no. 2, June 2000 (2000-06-01), pages 143 - 146, XP002746014, ISSN: 0263-6484 [Y] 1-13 * abstract * * page 145, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1002/(SICI)1099-0844(200006)18:2<143::AID-CBF857>3.0.CO;2-#
International search[A] WO2011056477  (LU ZHE et al.) [A]
 [X]   RIEGER, G.: "Anti-oxidative capacity of various artificial tear preparations", GRAEFE'S ARCH. CLIN. EXP. OPHTHALMOL., vol. 239, 2001, pages 222 - 226, XP003014992 [X]
 [X]   SCHMUT, 0. ET AL.: "Iodide protection from UVB irradiation-induced degradation of hyaluronate and against UVB-damage of human conjunctival fibroblasts", GRAEFE'S ARCH. CLIN. EXP. OPHTHALMOL., vol. 242, 2004, pages 279 - 283, XP008166988 [X]

DOI:   http://dx.doi.org/10.1007/s00417-003-0829-z
 [X]   AGBOR, G. A. ET AL.: "Effect of iodine supplementation on antioxidant status of normal and alloxan monohydrate in toxicated rats", INT. J. PHARMACOL., vol. 7, no. 6, 2011, pages 726 - 731, XP055165243 [X]

DOI:   http://dx.doi.org/10.3923/ijp.2011.726.731
 [A]   RIEGER, G. ET AL.: "The effect of iodide iontophoresis on the antioxidative capacity of the tear fluid", GRAEFE'S ARCH. CLIN. EXP. OPHTHALMOL., vol. 248, 2010, pages 1639 - 1646, XP019848044 [A]

DOI:   http://dx.doi.org/10.1007/s00417-010-1416-8
ExaminationWO2011050164
by applicantWO2011050164
   REMINGTON: "The Science and Practice of Pharmacy", 1995, MACK PUBLISHING COMPANY [X]
   HOOVER, JOHN E.: "Remington's Pharmaceutical Sciences", 1975, MACK PUBLISHING CO. [X]
   "Pharmaceutical Dosage Forms", 1980, MARCEL DECKER [A]
   "Pharmaceutical Dosage Forms and Drug Delivery Systems", 1999, LIPPINCOTT WILLIAM & WILKINS
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.