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EP About this file: EP2841559

EP2841559 - GLYCOENGINEERED OUTER MEMBRANE VESICLES AND USE THEREOF AS VACCINES [Right-click to bookmark this link]
Status	The application has been refused Status updated on 25.10.2017 Database last updated on 27.07.2024
Former	Examination is in progress Status updated on 14.12.2016
Most recent event Tooltip	09.02.2018	Refusal of application	published on 14.03.2018 [2018/11]
Applicant(s)	For all designated states The Governors of the University of Alberta 4000 Enterprise Square 10230 Jasper Avenue Edmonton, Alberta T5J 4P6 / CA
	[2015/10]
Inventor(s)	01 / FELDMAN, Mario 6167 Stinson Way Edmonton, Alberta T6R 0K3 / CA
	02 / PRICE, Nancy 3043 116th Street Edmonton, Alberta T6J 3T2 / CA
	03 / GARCIA-QUINTANILLA, Fatima C/Atanasio Barron 14 Portal 4 5A E-41003 Seville / ES
	04 / IELMINI, Maria Veronica Tinogasta 2801 Buenos Aires C1417EHI / AR
	[2015/10]
Representative(s)	Turner, Rhiannon Rosalind, et al Greaves Brewster LLP Copa House Station Road Cheddar, BS27 3AH / GB
	[N/P]
Former [2015/10]	Script IP Limited Turnpike House 18 Bridge Street Frome BA11 1BB / GB
Application number, filing date	13782478.5	26.04.2013
	WO2013CA50322
Priority number, date	US201261639340P	27.04.2012 Original published format: US 201261639340 P
	[2015/10]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2013159234
	Date:	31.10.2013
	Language:	EN
	[2013/44]
	Type:	A1 Application with search report
	No.:	EP2841559
	Date:	04.03.2015
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 31.10.2013 takes the place of the publication of the European patent application.
	[2015/10]
Search report(s)	International search report - published on:	CA	31.10.2013
	(Supplementary) European search report - dispatched on:	EP	12.11.2015
Classification	IPC:	C12N1/21, A61K39/02, A61K39/116, A61P31/04, A61P37/04, C12N15/52, C12N15/63, C12P19/00, C12P21/00, A61K39/09, C12P19/04, C12N15/70, A61K39/00	[2015/51]
	CPC:	A61K39/092 (EP,US); A61K39/0208 (EP,US); A61P31/04 (EP); A61P37/04 (EP); C12N15/52 (EP,US); C12N15/70 (US); (+) C12P19/04 (EP,US); A61K2039/55555 (EP,US); A61K2039/6018 (US); Y02A50/30 (EP) (-)
	Former IPC [2015/10]	C12N1/21, A61K39/02, A61K39/116, A61P31/04, A61P37/04, C12N15/52, C12N15/63, C12P19/00, C12P21/00
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/10]
Title	German:	MITTELS GLYCOENGINEERING HERGESTELLTE AUSSENMEMBRANVESIKEL UND VERWENDUNG DAVON ALS IMPFSTOFFE	[2015/10]
	English:	GLYCOENGINEERED OUTER MEMBRANE VESICLES AND USE THEREOF AS VACCINES	[2015/10]
	French:	VÉSICULES DE MEMBRANE EXTERNE GLYCOMODIFIÉES ET LEUR UTILISATION COMME VACCINS	[2015/10]
Entry into regional phase	27.11.2014	National basic fee paid
	27.11.2014	Search fee paid
	27.11.2014	Designation fee(s) paid
	27.11.2014	Examination fee paid
Examination procedure	27.11.2014	Examination requested [2015/10]
	27.05.2016	Amendment by applicant (claims and/or description)
	07.06.2016	Observations by third parties
	17.08.2016	Despatch of a communication from the examining division (Time limit: M04)
	13.12.2016	Reply to a communication from the examining division
	28.09.2017	Cancellation of oral proceeding that was planned for 06.10.2017
	06.10.2017	Date of oral proceedings (cancelled)
	26.10.2017	Despatch of communication that the application is refused, reason: substantive examination [2018/11]
	05.11.2017	Application refused, date of legal effect [2018/11]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 17.08.2016
Fees paid	Renewal fee
	27.04.2015	Renewal fee patent year 03
	11.04.2016	Renewal fee patent year 04
	10.04.2017	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[XI]WO2009104074 (GLYCOVAXYN AG [CH], et al) [X] 1-3,9,10 * abstract, p. 3 line 14 - p. 5 line 25, p. 13 line 12 - p. 22 line 4, examples 1-10, claims 1-29 * [I] 4-8,11-15;
		[XI]US2011274720 (WACKER MICHAEL [CH], et al) [X] 1-3,5-7,9,10 * abstract, p. 5 paragraph [0027] - p. 6 paragraph [0038], examples 1-9 and claims * [I] 4,8,11-15;
		[XA] - FARIDMOAYER A ET AL, "Extreme substrate promiscuity of the Neisseria oligosaccharyl transferase involved in protein O-glycosylation", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, (20081212), vol. 283, no. 50, doi:10.1074/JBC.M807113200, ISSN 0021-9258, pages 34596 - 34604, XP002616754 [X] 1,3-5,7,9,10 * abstract, p. 34599 right-hand column second full paragraphp. 34601 right-hand column first paragraph, p. 34603 right-hand column last paragraph, Fig. 2-6 * [A] 2,6,8,11-15 DOI: http://dx.doi.org/10.1074/JBC.M807113200
		[XA] - MARIO F FELDMAN ET AL, "Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 102, no. 8, doi:10.1073/PNAS.0500044102, ISSN 0027-8424, (20050222), pages 3016 - 3021, (20050209), XP009121034 [X] 1,2,4,5,7,9,10 * abstract, p. 3018 left-hand column first full paragraph - 3rd full paragraph, p. 3018 right-hand column last paragraph - p. 3021 left-hand column line 20, p. 3021 right-hand column second full paragraph, Fig. 1-5 * [A] 3,6,8,11-15 DOI: http://dx.doi.org/10.1073/pnas.0500044102
		[XA] - GRANT E. HENDERSON ET AL, "Site-Specific Modification of Recombinant Proteins: A Novel Platform for Modifying Glycoproteins Expressed in E. coli", BIOCONJUGATE CHEMISTRY., US, (20110518), vol. 22, no. 5, doi:10.1021/bc100510g, ISSN 1043-1802, pages 903 - 912, XP055225248 [X] 1,3,8-10 * abstract, p. 906 left-hand column first-full paragraph - p. 908 left-hand column second full paragraph, paragraqph bridging p. 908 and 909, Fig. 2-4 and Tables 3-4 * [A] 2,4-7,11-15 DOI: http://dx.doi.org/10.1021/bc100510g
		[XA] - C. GEBHART ET AL, "Characterization of exogenous bacterial oligosaccharyltransferases in Escherichia coli reveals the potential for O-linked protein glycosylation in Vibrio cholerae and Burkholderia thailandensis", GLYCOBIOLOGY, (20120305), vol. 22, no. 7, doi:10.1093/glycob/cws059, ISSN 0959-6658, pages 962 - 974, XP055176525 [X] 1,3-5,7,9,10 * abstract, p. 963 right-hand column second full paragraph - p. 968 left-hand column line 9, paragraph bridging p. 971 to p. 972 and p. 972 left-hand column first full paragraph, Fig. 1- 6 and Table I * [A] 2,6,8,11-15 DOI: http://dx.doi.org/10.1093/glycob/cws059
		[XAI] - A. C. FISHER ET AL, "Production of Secretory and Extracellular N-Linked Glycoproteins in Escherichia coli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (20101203), vol. 77, no. 3, doi:10.1128/AEM.01901-10, ISSN 0099-2240, pages 871 - 881, XP055142701 [X] 1,2,5,7,9-13 * abstract, p. 872 left-hand column first full paragraph - right-hand column first full paragraph, p. 874 left-hand column first full paragraph lines 13-19, p. 876 paragraph bridging the left- to the right-hand column - p. 879 right-hand column line 14, p. 880 the paragraph bridging the left- to the right-hand column, Fig. 2-6 * [A] 3,4,6,8 [I] 14,15 DOI: http://dx.doi.org/10.1128/AEM.01901-10
		[A] - D. J. CHEN ET AL, "Delivery of foreign antigens by engineered outer membrane vesicle vaccines", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20100216), vol. 107, no. 7, doi:10.1073/pnas.0805532107, ISSN 0027-8424, pages 3099 - 3104, XP055035314 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.0805532107
		[A] - CRISTIAN J A ASENSIO ET AL, "Outer membrane vesicles obtained fromTohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate", VACCINE, ELSEVIER LTD, GB, vol. 29, no. 8, doi:10.1016/J.VACCINE.2010.12.068, ISSN 0264-410X, (20101216), pages 1649 - 1656, (20101222), XP028139985 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/j.vaccine.2010.12.068
		[A] - V. S. TERRA ET AL, "Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design", JOURNAL OF MEDICAL MICROBIOLOGY, (20120419), vol. 61, no. Pt_7, doi:10.1099/jmm.0.039438-0, ISSN 0022-2615, pages 919 - 926, XP055107688 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1099/jmm.0.039438-0
		[A] - M. QUTYAN ET AL, "Glycosylation of Pilin and Nonpilin Protein Constructs by Pseudomonas aeruginosa 1244", JOURNAL OF BACTERIOLOGY, US, (20101115), vol. 192, no. 22, doi:10.1128/JB.00007-10, ISSN 0021-9193, pages 5972 - 5981, XP055225244 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1128/JB.00007-10
		[T] - WACKER MICHAEL ET AL, "Prevention of Staphylococcus aureus Infections by Glycoprotein Vaccines Synthesized in Escherichia coli", JOURNAL OF INFECTIOUS DISEASES. JID, UNIVERSITY OF CHICAGO PRESS, CHICAGO, IL, (20140501), vol. 209, ISSN 0022-1899, pages 1551 - 1561, XP009181722 DOI: http://dx.doi.org/10.1093/infdis/jit800
	International search	[A]WO2008093165 (UNIV ALBERTA [CA], et al);
		[X] - ASENSIO, C.J.A. ET AL., "Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate.", VACCINE, (20110211), vol. 29, no. 8, pages 1649 - 1656, XP028139985 DOI: http://dx.doi.org/10.1016/j.vaccine.2010.12.068
		[A] - FELDMAN, M.F. ET AL., "Engineering N-linked protein glycosylation with deverse O antigen lipopolysaccharide structures in Escherichia coli.", PNAS, (20050222), vol. 102, no. 8, pages 3016 - 3021, XP009121034 DOI: http://dx.doi.org/10.1073/pnas.0500044102
		[A] - CHEN, D.J. ET AL., "Delivery of foreign antigens by engineered outer membrane vesicle vaccines.", PNAS, (20100216), vol. 107, no. 7, pages 3099 - 3104, XP055035314 DOI: http://dx.doi.org/10.1073/pnas.0805532107
		[A] - GEBHART. C. ET AL., "Characterization of exogenous bacterial oligosaccharyltransferases in Escherichia coli reveals the potential for O-linked protein glycosylation in Vibrio cholerae and Burkhoderia thailandensis.", GLYCOBIOLOGY, (20120305), vol. 22, no. 7, pages 962 - 974, XP055176525 DOI: http://dx.doi.org/10.1093/glycob/cws059
	other	WO2010108682

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