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Extract from the Register of European Patents

EP About this file: EP2906249

EP2906249 - SYNTHESIS AND INTERMEDIATES OF PYRROLOBENZODIAZEPINE DERIVATIVES FOR CONJUGATION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.05.2019
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  25.05.2018
FormerGrant of patent is intended
Status updated on  18.05.2018
FormerExamination is in progress
Status updated on  04.05.2018
FormerGrant of patent is intended
Status updated on  14.01.2018
FormerExamination is in progress
Status updated on  02.12.2016
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY, HU, MK		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
MedImmune Limited
Milstein Building Granta Park Cambridge
CB21 6GH / GB
[2015/43]
Former [2015/34]For all designated states
Spirogen Sàrl
Rue Saint-Pierre2
1003 Lausanne / CH
Inventor(s)01 / HOWARD, Philip Wilson
Spirogen Limited The QMB Innovation Centre
42 New Road
Londo Greater London E1 2AX / GB
 [2015/34]
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[N/P]
Former [2015/34]Watson, Robert James, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
Application number, filing date13783501.311.10.2013
[2015/34]
WO2013EP71234
Priority number, dateUS201261713083P12.10.2012         Original published format: US 201261713083 P
[2015/34]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014057072
Date:17.04.2014
Language:EN
[2014/16]
Type: A1 Application with search report 
No.:EP2906249
Date:19.08.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 17.04.2014 takes the place of the publication of the European patent application.
[2015/34]
Type: B1 Patent specification 
No.:EP2906249
Date:27.06.2018
Language:EN
[2018/26]
Search report(s)International search report - published on:EP17.04.2014
ClassificationIPC:A61K47/65, C07D487/04, C07D519/00, C07K5/078, C07K5/065, C07K5/062
[2018/03]
CPC:
C07D487/04 (EP,US); A61K47/65 (EP,US); C07D519/00 (EP,US);
C07K5/06043 (EP,US); C07K5/06052 (EP,US); C07K5/06078 (EP,US);
C07K5/06139 (EP,US) (-)
Former IPC [2015/34]A61K47/48, C07D487/04, C07D519/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/34]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:SYNTHESE UND ZWISCHENPRODUKTE PYRROLOBENZODIAZEPINDERIVATEN ZUR KONJUGATION[2015/34]
English:SYNTHESIS AND INTERMEDIATES OF PYRROLOBENZODIAZEPINE DERIVATIVES FOR CONJUGATION[2015/34]
French:SYNTHÈSE ET INTERMÉDIAIRES DE DÉRIVÉS DE PYRROLOBENZODIAZÉPINE POUR CONJUGAISON[2015/34]
Entry into regional phase01.05.2015National basic fee paid 
01.05.2015Designation fee(s) paid 
01.05.2015Examination fee paid 
Examination procedure01.05.2015Amendment by applicant (claims and/or description)
01.05.2015Examination requested  [2015/34]
01.12.2016Despatch of a communication from the examining division (Time limit: M06)
23.05.2017Reply to a communication from the examining division
15.01.2018Communication of intention to grant the patent
03.05.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
03.05.2018Fee for grant paid
03.05.2018Fee for publishing/printing paid
17.05.2018Information about intention to grant a patent
17.05.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  01.12.2016
Opposition(s)28.03.2019No opposition filed within time limit [2019/23]
Fees paidRenewal fee
26.10.2015Renewal fee patent year 03
24.10.2016Renewal fee patent year 04
25.10.2017Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU11.10.2013
AL27.06.2018
AT27.06.2018
CY27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
MK27.06.2018
NL27.06.2018
PL27.06.2018
PT27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
TR27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IE11.10.2018
LU11.10.2018
MT11.10.2018
IS27.10.2018
BE31.10.2018
[2020/31]
Former [2020/28]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
PT27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
TR27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IE11.10.2018
LU11.10.2018
MT11.10.2018
IS27.10.2018
BE31.10.2018
Former [2020/16]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
TR27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IE11.10.2018
LU11.10.2018
MT11.10.2018
IS27.10.2018
BE31.10.2018
Former [2020/08]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IE11.10.2018
LU11.10.2018
MT11.10.2018
IS27.10.2018
BE31.10.2018
Former [2019/51]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IE11.10.2018
LU11.10.2018
IS27.10.2018
BE31.10.2018
Former [2019/48]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IE11.10.2018
LU11.10.2018
IS27.10.2018
BE31.10.2018
Former [2019/38]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
LU11.10.2018
IS27.10.2018
BE31.10.2018
Former [2019/37]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
LU11.10.2018
IS27.10.2018
Former [2019/30]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
LU11.10.2018
IS27.10.2018
Former [2019/28]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/26]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/12]AT27.06.2018
CZ27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/11]AT27.06.2018
CZ27.06.2018
EE27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/10]AT27.06.2018
CZ27.06.2018
EE27.06.2018
FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SK27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/09]EE27.06.2018
FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/08]FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/03]FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
Former [2018/52]FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
Former [2018/51]FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
Former [2018/50]FI27.06.2018
HR27.06.2018
LT27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
Former [2018/49]FI27.06.2018
LT27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
Former [2018/47]FI27.06.2018
LT27.06.2018
NO27.09.2018
Cited inInternational search[XP]WO2013041606  (SPIROGEN SARL [CH]) [XP] 1-25,34-56,58,59,66,67,69,70 * whole document, in particular schemes on pages 79 and 85; claims 48, 62-64; page 27, line 15 - page 28, line 16; page 43, line 13-23; page 44, line 28 - page 47, line 2; page 61, lines 20-24; page 63, line 13; page 67, line 1-13; page 68, lines 18-28 *;
 [XP]WO2013053873  (SPIROGEN SARL [CH], et al) [XP] 1-25,31-59,66,67 * whole document, in particular scheme on page 96; claims 8-10, 27-29; page 29, line 23 - 28; page 30, line 12 - page 31, line 4;page 48, lines 1-7; page 49, line 16 - page 51, line 18; page 66, line 20; page 74, lines 1-14; page 75, lines 24-29; *;
 [XP]WO2013055990  (SEATTLE GENETICS INC [US], et al) [XP] 1-15,26-30,35-56,58,59 * whole document, in particular scheme on page 72; page 44, lines 14-22; page 45, line 21 - page 47, line 19; page 48, line 38 - page 49, line 4 *;
 [XI]US2012184520  (YOSHIHARA KOUSEI [JP], et al) [X] 60,63 * preparation example 7 * [I] 61,62,64,65;
 [X]WO9524382  (SEARLE & CO [US], et al) [X] 60 * compound 49a *;
 [X]CN101492494  (UNIV ZHEJIANG [CN]) [X] 60 * scheme 3 *;
 [X]WO02102820  (NUEVOLUTION AS [DK], et al) [X] 60 * compound 2a *;
 [X]US2011077365  (YU GILBERT [PH], et al) [X] 60 * table 2, entry 7 *;
 [X]JP2008291207  (KYOWA HAKKO KIRIN CO LTD, et al) [X] 60 * compound II *;
 [AD]WO2011130616  (SPIROGEN LTD [GB], et al) [AD] 1-70 * the whole document *;
 [XP]WO2013150486  (COMMISSARIAT ENERGIE ATOMIQUE [FR]) [XP] 60 * compound 48 *;
 [XP]WO2013123282  (UNIV TOLEDO [US], et al) [XP] 60 * compound 5 *;
 [XI]  - ZHENLIN ZHONG ET AL, "A Colorimetric Sensing Ensemble for Heparin", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20020801), vol. 124, no. 31, doi:10.1021/ja020505k, ISSN 0002-7863, pages 9014 - 9015, XP055095600 [X] 60,61 * compounds 8,9 * [I] 62-65

DOI:   http://dx.doi.org/10.1021/ja020505k
 [X]  - ANGELL YU ET AL, "Ring Closure to beta-Turn Mimetics via Copper-Catalyzed Azide/alkyne Cycloaddition", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY [NOT]ETC. , US, vol. 70, no. 23, doi:10.1021/JO0516180, ISSN 0022-3263, (20050101), pages 9595 - 9598, (20051019), XP002679903 [X] 60 * compounds 3,4 *

DOI:   http://dx.doi.org/10.1021/JO0516180
 [XPI]  - MIN TENG ET AL, "Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design", JOURNAL OF MEDICINAL CHEMISTRY, (20130228), vol. 56, no. 4, doi:10.1021/jm301756m, ISSN 0022-2623, pages 1748 - 1760, XP055095104 [XP] 60,61 * compound 16 * [I] 62-65

DOI:   http://dx.doi.org/10.1021/jm301756m
ExaminationWO2009027707
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DOI:   http://dx.doi.org/10.1248/cpb.48.1270
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DOI:   http://dx.doi.org/10.1021/jo0106501
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 WO2010043880
 WO2011130613
 WO2011130616
 WO0012508
 WO2004043963
 WO2010043877
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 WO2012EP68506
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.