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Extract from the Register of European Patents

EP About this file: EP2845862

EP2845862 - METHOD FOR INCUBATING PLURIPOTENT STEM CELLS AND POLYPEPTIDE TO BE USED THEREFOR [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.09.2019
Database last updated on 15.06.2024
FormerThe patent has been granted
Status updated on  19.10.2018
FormerGrant of patent is intended
Status updated on  24.07.2018
FormerExamination is in progress
Status updated on  25.11.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
FUJIFILM Corporation
26-30, Nishiazabu 2-chome
Minato-ku
Tokyo 106-8620 / JP
[N/P]
Former [2015/11]For all designated states
FUJIFILM Corporation
26-30, Nishiazabu 2-chome Minato-ku
Tokyo 106-8620 / JP
Inventor(s)01 / MURAKAMI, Yuta
c/o FUJIFILM Corporation
577 Ushijima
Kaisei-machi
Ashigarakami-gun Kanagawa 258-8577 / JP
02 / IWATA, Rie
c/o FUJIFILM Corporation
577 Ushijima
Kaisei-machi
Ashigarakami-gun Kanagawa 258-8577 / JP
03 / IWAKI, Yoshihide
c/o FUJIFILM Corporation
577 Ushijima
Kaisei-machi
Ashigarakami-gun Kanagawa 258-8577 / JP
04 / SASAKI, Tasuku
c/o FUJIFILM Corporation
577Ushijima
Kaisei-machi
Ashigarakami-gun Kanagawa 258-8577 / JP
 [2015/11]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2015/11]
Application number, filing date13784603.624.04.2013
[2018/47]
WO2013JP62122
Priority number, dateJP2012010481601.05.2012         Original published format: JP 2012104816
[2015/11]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013164970
Date:07.11.2013
Language:JA
[2013/45]
Type: A1 Application with search report 
No.:EP2845862
Date:11.03.2015
Language:EN
[2015/11]
Type: B1 Patent specification 
No.:EP2845862
Date:21.11.2018
Language:EN
[2018/47]
Search report(s)International search report - published on:JP07.11.2013
(Supplementary) European search report - dispatched on:EP20.10.2015
ClassificationIPC:C12N5/00, C07K14/00, C07K14/47, C12N5/074, C07K14/78
[2018/30]
CPC:
C12N5/0696 (EP,CN,US); C07K14/78 (EP,CN,US); C12N5/0068 (US);
C07K14/001 (US); C07K14/47 (EP,US); C12N5/0607 (US);
C12N2533/50 (EP,US); C12N2533/52 (EP,CN,US); C12N2537/00 (US) (-)
Former IPC [2015/47]C07K14/00, C12M1/00, C12N5/073, C12N5/0735, C12N5/074, C12N5/10, C07K14/78, C07K14/47
Former IPC [2015/11]C07K14/00, C12M1/00, C12N5/073, C12N5/0735, C12N5/074, C12N5/10
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/11]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR INKUBATION PLURIPOTENTER STAMMZELLEN UND POLYPEPTIDE ZUR VERWENDUNG DAFÜR[2015/11]
English:METHOD FOR INCUBATING PLURIPOTENT STEM CELLS AND POLYPEPTIDE TO BE USED THEREFOR[2015/11]
French:PROCÉDÉ D'INCUBATION DE CELLULES SOUCHES PLURIPOTENTES ET POLYPEPTIDE À UTILISER À CET EFFET[2015/11]
Entry into regional phase31.10.2014Translation filed 
31.10.2014National basic fee paid 
31.10.2014Search fee paid 
31.10.2014Designation fee(s) paid 
31.10.2014Examination fee paid 
Examination procedure31.10.2014Examination requested  [2015/11]
12.05.2016Amendment by applicant (claims and/or description)
23.11.2016Despatch of a communication from the examining division (Time limit: M04)
29.03.2017Reply to a communication from the examining division
10.11.2017Despatch of a communication from the examining division (Time limit: M04)
11.01.2018Reply to a communication from the examining division
25.07.2018Communication of intention to grant the patent
10.10.2018Fee for grant paid
10.10.2018Fee for publishing/printing paid
10.10.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.11.2016
Opposition(s)22.08.2019No opposition filed within time limit [2019/44]
Fees paidRenewal fee
27.04.2015Renewal fee patent year 03
30.03.2016Renewal fee patent year 04
10.04.2017Renewal fee patent year 05
11.04.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU24.04.2013
AL21.11.2018
AT21.11.2018
CY21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
MK21.11.2018
MT21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
TR21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
IE24.04.2019
LU24.04.2019
BE30.04.2019
CH30.04.2019
LI30.04.2019
[2022/31]
Former [2021/34]HU24.04.2013
AL21.11.2018
AT21.11.2018
CY21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
MT21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
TR21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
IE24.04.2019
LU24.04.2019
BE30.04.2019
CH30.04.2019
LI30.04.2019
Former [2021/32]HU24.04.2013
AL21.11.2018
AT21.11.2018
CY21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
TR21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
IE24.04.2019
LU24.04.2019
BE30.04.2019
CH30.04.2019
LI30.04.2019
Former [2021/26]AL21.11.2018
AT21.11.2018
CY21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
TR21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
IE24.04.2019
LU24.04.2019
BE30.04.2019
CH30.04.2019
LI30.04.2019
Former [2020/21]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
TR21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
IE24.04.2019
LU24.04.2019
BE30.04.2019
CH30.04.2019
LI30.04.2019
Former [2020/17]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
TR21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
LU24.04.2019
BE30.04.2019
CH30.04.2019
LI30.04.2019
Former [2020/11]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
LU24.04.2019
BE30.04.2019
CH30.04.2019
LI30.04.2019
Former [2020/04]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
LU24.04.2019
Former [2020/02]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
MC21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
Former [2019/50]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SI21.11.2018
SK21.11.2018
SM21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
Former [2019/40]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SK21.11.2018
SM21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
Former [2019/37]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
EE21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
PL21.11.2018
RO21.11.2018
RS21.11.2018
SE21.11.2018
SM21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
Former [2019/35]AL21.11.2018
AT21.11.2018
CZ21.11.2018
DK21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
PL21.11.2018
RS21.11.2018
SE21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
Former [2019/34]AL21.11.2018
AT21.11.2018
DK21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
IT21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
RS21.11.2018
SE21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
Former [2019/26]AL21.11.2018
AT21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
RS21.11.2018
SE21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
PT21.03.2019
Former [2019/25]AT21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
RS21.11.2018
SE21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
Former [2019/24]AT21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
SE21.11.2018
BG21.02.2019
NO21.02.2019
GR22.02.2019
IS21.03.2019
Former [2019/23]AT21.11.2018
ES21.11.2018
FI21.11.2018
HR21.11.2018
LT21.11.2018
LV21.11.2018
NL21.11.2018
BG21.02.2019
NO21.02.2019
IS21.03.2019
Former [2019/22]FI21.11.2018
LT21.11.2018
BG21.02.2019
NO21.02.2019
IS21.03.2019
Former [2019/21]FI21.11.2018
LT21.11.2018
NO21.02.2019
IS21.03.2019
Former [2019/20]LT21.11.2018
NO21.02.2019
Documents cited:Search[Y]WO2012032169  (UNIV BRISTOL [GB], et al) [Y] 1-19 * figure 4; claims 7-8 *;
 [X]  - JOSEPH R KLIM ET AL, "A defined glycosaminoglycan-binding substratum for human pluripotent stem cells", NATURE METHODS, (20101201), vol. 7, no. 12, doi:10.1038/nmeth.1532, ISSN 1548-7091, pages 989 - 994, XP055061190 [X] 1-19 * page 992, column 2 *

DOI:   http://dx.doi.org/10.1038/nmeth.1532
 [X]  - GUOKAI CHEN ET AL, "Chemically defined conditions for human iPSC derivation and culture", NATURE METHODS, (20110501), vol. 8, no. 5, doi:10.1038/nmeth.1593, ISSN 1548-7091, pages 424 - 429, XP055092759 [X] 1-19 * page 425, column 2, paragraph 2; figure 3 *

DOI:   http://dx.doi.org/10.1038/nmeth.1593
 [Y]  - PROWSE A B J ET AL, "Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 31, no. 32, ISSN 0142-9612, (20101101), pages 8281 - 8288, (20100802), XP027259533 [Y] 1-19 * table 1 *
 [Y]  - KERRY J. MANTON ET AL, "A Chimeric Vitronectin: IGF-I Protein Supports Feeder-Cell-Free and Serum-Free Culture of Human Embryonic Stem Cells", STEM CELLS AND DEVELOPMENT, (20100901), vol. 19, no. 9, doi:10.1089/scd.2009.0504, ISSN 1547-3287, pages 1297 - 1305, XP055010532 [Y] 1-19 * page 292, column 2; figure 2 *

DOI:   http://dx.doi.org/10.1089/scd.2009.0504
 [Y]  - CHANDRAMOULI R CHILLAKURI ET AL, "Heparin binding domain in vitronectin is required for oligomerization and thus enhances integrin mediated cell adhesion and spreading", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 584, no. 15, doi:10.1016/J.FEBSLET.2010.06.023, ISSN 0014-5793, (20100614), pages 3287 - 3291, (20100619), XP028340487 [Y] 1-19 * page 3290, column 1; figure 1a *

DOI:   http://dx.doi.org/10.1016/j.febslet.2010.06.023
 [Y]  - SCHLEICHER IRIS ET AL, "SURFACE MODIFICATION BY COMPLEXES OF VITRONECTIN AND GROWTH FACTORS FOR SERUM-FREE CULTURE OF HUMAN OSTEOBLASTS", TISSUE ENGINEERING, LARCHMONT, NY, US, (20051101), vol. 11, no. 11-12, doi:10.1089/TEN.2005.11.1688, ISSN 1076-3279, pages 1688 - 1698, XP009072079 [Y] 1-19 * page 1690 *

DOI:   http://dx.doi.org/10.1089/ten.2005.11.1688
International search[A]JP2010537626  (QUEENSLAND UNIVERSITY OF TECHNOLOGY);
 [X]  - CHEN GUOKAI ET AL., "Chemically defined conditions for human iPSC derivation and culture", NATURE METHODS, (2011), vol. 8, no. 5, pages 424 - 429, XP055092759

DOI:   http://dx.doi.org/10.1038/nmeth.1593
 [X]  - PROWSE B.J. ANDREW ET AL., "Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media", BIOMATERIALS, (2010), vol. 31, pages 8281 - 8288, XP027259533
 [A]  - MELKOUMIAN ZARA ET AL., "Synthetic peptide- acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells", NATURE BIOTECHNOLOGY, (2010), vol. 28, no. 6, pages 606 - 612, XP002636474

DOI:   http://dx.doi.org/10.1038/NBT.1629
 [A]  - KLIM R. JOSEPH ET AL., "A defined glycosaminoglycan-binding substratum for human pluripotent stem cells", NATURE METHODS, (2010), vol. 7, no. 12, pages 989 - 994, XP055061190

DOI:   http://dx.doi.org/10.1038/nmeth.1532
by applicantJP2001017183
 JP2010029186
 JP2012502664
 JP2012104816
    - NATURE BIOTECHNOLOGY, (2001), vol. 19, pages 971 - 974
    - BIOMATERIALS, (201011), vol. 31, no. 32, pages 8281 - 8218
    - NATURE BIOTECHNOLOGY, (2010), vol. 28, no. 6, pages 606 - 610
    - KYTE J.; DOOLITTLE R. F., J. MOL. BIOL, (1982), vol. 157, pages 105 - 132
    - NATURE, (20070719), vol. 448, pages 313 - 317
    - CELL, (20060825), vol. 126, no. 4, pages 663 - 676
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.