blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2847230

EP2847230 - HETEROMULTIMER CONSTRUCTS OF IMMUNOGLOBULIN HEAVY CHAINS WITH MUTATIONS IN THE FC DOMAIN [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.06.2021
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  10.07.2020
FormerGrant of patent is intended
Status updated on  08.12.2019
FormerExamination is in progress
Status updated on  01.09.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT
published on 09.10.2024 [2024/41]
Applicant(s)For all designated states
Zymeworks Inc.
540-1385 West 8th Avenue
Vancouver, British Columbia V6H 3V9 / CA
[2020/33]
Former [2016/01]For all designated states
Zymeworks Inc.
540-1385 West 8th Avenue
Vancouver, British Colombia V6H 3V9 / CA
Former [2015/12]For all designated states
Zymeworks, Inc.
540-1385 West 8th Avenue
Vancouver, British Columbia V6H 3V9 / CA
Inventor(s)01 / SPRETER VON KREUDENSTEIN, Thomas
540-1385 West 8th Avenue
Vancouver British Columbia V6H 9V9 / CA
02 / ESCOBAR-CABRERA, Eric
540-1385 West 8th Avenue
Burnaby British Columbia V6H 9V9 / CA
03 / NG, Gordon YiuKon
6531 Yew Street
Vancouver British Columbia V6P 2N8 / CA
04 / DIXIT, Surjit Bhimarao
540-1385 West 8th Avenue
Vancouver British Columbia V6H 9V9 / CA
05 / LARIO, Paula Irene
201 - 2080 East Kent Avenue South
Vancouver British Columbia V5X 2Y2 / CA
06 / POON, David Kai Yuen
540-1385 West 8th Avenue
Vancouver British Columbia V6H 9V9 / CA
 [2020/33]
Former [2015/12]01 / SPRETER VON KREUDENSTEIN, Thomas
1007-1330 Harwood Street
Vancouver British Columbia V6E 1S8 / CA
02 / ESCOBAR-CABRERA, Eric
8562 Woodridge Place
Burnaby British Columbia V5A 4B3 / CA
03 / NG, Gordon YiuKon
1535 West 64th Avenue
Vancouver British Columbia V6P 2N8 / CA
04 / DIXIT, Surjit Bhimarao
11651 Kingfisher Drive, 51
Richmond British Columbia V7E 3N5 / CA
05 / LARIO, Paula Irene
201 - 2080 East Kent Avenue South
Vancouver British Columbia V5X 2Y2 / CA
06 / POON, David Kai Yuen
9230 Railway Avenue
Richmond British Columbia V7E 2B6 / CA
Representative(s)Elkington and Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
[2020/33]
Former [2015/12]Wichmann, Hendrik
Wuesthoff & Wuesthoff Schweigerstrasse 2
81541 München / DE
Application number, filing date13788302.110.05.2013
[2020/33]
WO2013CA00471
Priority number, dateUS201261645555P10.05.2012         Original published format: US 201261645555 P
[2015/12]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013166594
Date:14.11.2013
Language:EN
[2013/46]
Type: A1 Application with search report 
No.:EP2847230
Date:18.03.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 14.11.2013 takes the place of the publication of the European patent application.
[2015/12]
Type: B1 Patent specification 
No.:EP2847230
Date:12.08.2020
Language:EN
[2020/33]
Search report(s)International search report - published on:CA14.11.2013
(Supplementary) European search report - dispatched on:EP18.11.2015
ClassificationIPC:C07K16/46, A61K39/395, A61P35/00, A61P37/02, C07K16/12, C07K16/24, C07K16/28, C07K16/30
[2015/12]
CPC:
C07K16/32 (EP,US); A61P35/00 (EP); A61P37/02 (EP);
A61P43/00 (EP); C07K16/283 (US); C07K16/2863 (EP,US);
C07K16/468 (EP,US); C07K2317/31 (EP,US); C07K2317/526 (EP,US);
C07K2317/569 (EP,US); C07K2317/64 (EP,US); C07K2318/20 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/12]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:HETEROMULTIMERKONSTRUKTE AUS SCHWEREN IMMUNOGLOBULINKETTEN MIT MUTATIONEN IN DER FC-DOMÄNE[2015/12]
English:HETEROMULTIMER CONSTRUCTS OF IMMUNOGLOBULIN HEAVY CHAINS WITH MUTATIONS IN THE FC DOMAIN[2015/12]
French:CONSTRUCTIONS HÉTÉROMULTIMÈRES DE CHAÎNES LOURDES D'IMMUNOGLOBULINES COMPRENANT DES MUTATIONS DANS LE DOMAINE FC[2015/12]
Entry into regional phase28.11.2014National basic fee paid 
28.11.2014Search fee paid 
28.11.2014Designation fee(s) paid 
28.11.2014Examination fee paid 
Examination procedure28.11.2014Examination requested  [2015/12]
13.06.2016Amendment by applicant (claims and/or description)
05.09.2017Despatch of a communication from the examining division (Time limit: M02)
13.11.2017Reply to a communication from the examining division
13.02.2018Despatch of a communication from the examining division (Time limit: M06)
16.07.2018Reply to a communication from the examining division
10.04.2019Despatch of a communication from the examining division (Time limit: M02)
19.06.2019Reply to a communication from the examining division
07.01.2020Communication of intention to grant the patent
14.05.2020Fee for grant paid
14.05.2020Fee for publishing/printing paid
14.05.2020Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  05.09.2017
Opposition(s)14.05.2021No opposition filed within time limit [2021/29]
Fees paidRenewal fee
27.05.2015Renewal fee patent year 03
27.05.2016Renewal fee patent year 04
30.05.2017Renewal fee patent year 05
29.05.2018Renewal fee patent year 06
28.05.2019Renewal fee patent year 07
27.05.2020Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU10.05.2013
AL12.08.2020
AT12.08.2020
CY12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
MK12.08.2020
MT12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
TR12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
PT14.12.2020
IE10.05.2021
LU10.05.2021
[2024/41]
Former [2024/29]HU10.05.2013
AL12.08.2020
AT12.08.2020
CY12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
MK12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
TR12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
PT14.12.2020
IE10.05.2021
LU10.05.2021
Former [2024/22]HU10.05.2013
AL12.08.2020
AT12.08.2020
CY12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
MK12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
PT14.12.2020
IE10.05.2021
LU10.05.2021
Former [2023/30]HU10.05.2013
AL12.08.2020
AT12.08.2020
CY12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
PT14.12.2020
IE10.05.2021
LU10.05.2021
Former [2023/27]HU10.05.2013
AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
PT14.12.2020
IE10.05.2021
LU10.05.2021
Former [2023/20]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
PT14.12.2020
IE10.05.2021
LU10.05.2021
Former [2022/21]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
IE10.05.2021
LU10.05.2021
Former [2022/09]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
LU10.05.2021
Former [2022/07]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/36]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/28]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/25]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/24]AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/23]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/22]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/20]DK12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RS12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/12]FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RS12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/10]FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
PL12.08.2020
RS12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/09]FI12.08.2020
LT12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
Former [2021/08]FI12.08.2020
LT12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
Former [2021/07]FI12.08.2020
LT12.08.2020
NO12.11.2020
Documents cited:Search[IY]US2011008345  (ASHMAN CLAIRE [GB], et al) [I] 1-20 * table 40 * * table 37 * [Y] 8;
 [Y]WO2011063348  (AMGEN INC [US], et al) [Y] 8 * page 17; table 2 *;
 [E]WO2013063702  (ZYMEWORKS INC [CA]) [E] 1 * page 2 *;
 [A]  - DEMAREST S J ET AL, "Optimization of the Antibody CH3 Domain by Residue Frequency Analysis of IgG Sequences", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, (20040102), vol. 335, no. 1, doi:10.1016/J.JMB.2003.10.040, ISSN 0022-2836, pages 41 - 48, XP004476444 [A] 1-20 * figure 1; table 1 *

DOI:   http://dx.doi.org/10.1016/j.jmb.2003.10.040
 [A]  - ALTINTAS ISIL ET AL, "Targeting epidermal growth factor receptor in tumors: From conventional monoclonal antibodies via heavy chain-only antibodies to nanobodies", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, (20111028), vol. 45, no. 4, doi:10.1016/J.EJPS.2011.10.015, ISSN 0928-0987, pages 399 - 407, XP028887665 [A] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.ejps.2011.10.015
 [A]  - K. GUNASEKARAN ET AL, "Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects: APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG", JOURNAL OF BIOLOGICAL CHEMISTRY, (20100618), vol. 285, no. 25, doi:10.1074/jbc.M110.117382, ISSN 0021-9258, pages 19637 - 19646, XP055001947 [A] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.M110.117382
International search[YP]WO2012058768  (ZYMEWORKS INC [CA], et al);
 [XP]WO2013002362  (CHUGAI PHARMACEUTICAL CO LTD [JP], et al);
ExaminationWO2006064136
 WO2009089004
by applicantEP0003089
 US4347935
 US4474893
 WO8605807
 US4676980
 US4714681
 WO8901036
 EP0307434
 EP0367166
 US4925648
 EP0368684
 WO9100360
 EP0413622
 WO9106570
 EP0439095
 WO9205793
 US5112946
 WO9208802
 US5122464
 WO9220373
 US5223409
 WO9315199
 WO9315200
 WO9316185
 WO9317715
 WO9321232
 WO9404690
 US5322798
 US5336603
 US5341215
 US5349053
 US5359046
 US5447851
 US5464581
 US5474981
 US5483469
 WO9604388
 US5571894
 US5573920
 US5587458
 US5601819
 US5602039
 US5605793
 US5622929
 US5643796
 WO9734631
 US5807715
 US5811238
 US5830721
 US5834252
 US5837458
 WO0061739
 US6211477
 WO0129246
 US6268125
 US6289286
 WO0177137
 US6373577
 WO0231140
 WO0230954
 EP1229125
 WO02070007
 US2003115614
 US6602684
 WO03075957
 US2003190311
 WO2004029207
 US6737056
 WO2004068820
 WO2005018629
 US2005064514
 WO2006003388
 WO2006030220
 US20020113929
 US20020277370
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.