blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2932274

EP2932274 - METHOD FOR THE DIAGNOSIS OF METACHROMATIC LEUKODYSTROPHY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  20.11.2020
Database last updated on 18.05.2024
FormerThe patent has been granted
Status updated on  13.12.2019
FormerGrant of patent is intended
Status updated on  05.08.2019
FormerExamination is in progress
Status updated on  13.01.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Centogene GmbH
Am Strande 7
18055 Rostock / DE
[2020/41]
Former [2020/37]For all designated states
Centogene GmbH
Am Strande 7
18055§ Rostock / DE
Former [2018/19]For all designated states
Centogene AG
Am Strande 7
18055 Rostock / DE
Former [2017/27]For all designated states
Centogene AG
Schillingallee 68
18057 Rostock / DE
Former [2015/43]For all designated states
Centogene AG
Schillingallee 68
18057 Rostock / DE
For all designated states
Pharm Analyt Labor GmbH
Ferdinand-Pichler-Gasse 2
2500 Baden / AT
Inventor(s)01 / ROLFS, Arndt
Leibnizstrasse 58
10629 Berlin / DE
02 / MASCHER, Hermann
Gregor-Mendelstr. 11/2/28
2514 Traiskirchen / AT
 [2020/03]
Former [2015/43]01 / ROLFS, Arndt
Kleiststrasse 21
14163 Berlin / DE
02 / MASCHER, Hermann
Gregor-Mendelstr. 11/2/28
2514 Traiskirchen / AT
Representative(s)Bohmann, Armin K.
Bohmann
Anwaltssozietät
Nymphenburger Straße 1
80335 München / DE
[2015/43]
Application number, filing date13815378.811.12.2013
[2015/43]
WO2013EP03750
Priority number, dateEP2012000825711.12.2012         Original published format: EP 12008257
EP2012000829312.12.2012         Original published format: EP 12008293
EP2013000145421.03.2013         Original published format: EP 13001454
[2015/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014090404
Date:19.06.2014
Language:EN
[2014/25]
Type: A1 Application with search report 
No.:EP2932274
Date:21.10.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 19.06.2014 takes the place of the publication of the European patent application.
[2015/43]
Type: B1 Patent specification 
No.:EP2932274
Date:15.01.2020
Language:EN
[2020/03]
Search report(s)International search report - published on:EP19.06.2014
ClassificationIPC:G01N33/68
[2015/43]
CPC:
G01N33/6893 (EP,US); G01N2800/04 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/43]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR DIAGNOSE DER METACHROMATISCHEN LEUKODYSTROPHIE[2018/51]
English:METHOD FOR THE DIAGNOSIS OF METACHROMATIC LEUKODYSTROPHY[2015/43]
French:PROCÉDÉ POUR LE DIAGNOSTIC DE LA LEUCODYSTROPHIE MÉTACHROMATIQUE[2015/43]
Former [2015/43]VERFAHREN ZUR DIAGNOSE VON METACHROMATISCHER LEUKODYSTROPHIE
Entry into regional phase15.05.2015National basic fee paid 
15.05.2015Designation fee(s) paid 
15.05.2015Examination fee paid 
Examination procedure03.07.2014Request for preliminary examination filed
International Preliminary Examining Authority: EP
15.05.2015Amendment by applicant (claims and/or description)
15.05.2015Examination requested  [2015/43]
15.03.2016Despatch of a communication from the examining division (Time limit: M06)
26.10.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
03.01.2017Reply to a communication from the examining division
08.02.2017Despatch of a communication from the examining division (Time limit: M06)
18.08.2017Reply to a communication from the examining division
13.10.2017Despatch of a communication from the examining division (Time limit: M06)
23.04.2018Reply to a communication from the examining division
06.06.2018Despatch of a communication from the examining division (Time limit: M04)
16.10.2018Reply to a communication from the examining division
22.11.2018Despatch of a communication from the examining division (Time limit: M06)
03.06.2019Reply to a communication from the examining division
06.08.2019Communication of intention to grant the patent
05.12.2019Fee for grant paid
05.12.2019Fee for publishing/printing paid
05.12.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.03.2016
Opposition(s)16.10.2020No opposition filed within time limit [2020/52]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
03.01.2017Request for further processing filed
03.01.2017Full payment received (date of receipt of payment)
Request granted
20.01.2017Decision despatched
Fees paidRenewal fee
02.12.2015Renewal fee patent year 03
29.11.2016Renewal fee patent year 04
27.10.2017Renewal fee patent year 05
03.12.2018Renewal fee patent year 06
08.10.2019Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU11.12.2013
AL15.01.2020
AT15.01.2020
CY15.01.2020
CZ15.01.2020
DK15.01.2020
EE15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
IT15.01.2020
LT15.01.2020
LV15.01.2020
MC15.01.2020
MK15.01.2020
MT15.01.2020
NL15.01.2020
PL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SI15.01.2020
SK15.01.2020
SM15.01.2020
TR15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
[2022/31]
Former [2022/30]HU11.12.2013
AL15.01.2020
AT15.01.2020
CY15.01.2020
CZ15.01.2020
DK15.01.2020
EE15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
IT15.01.2020
LT15.01.2020
LV15.01.2020
MC15.01.2020
MT15.01.2020
NL15.01.2020
PL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SI15.01.2020
SK15.01.2020
SM15.01.2020
TR15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2022/27]HU11.12.2013
AT15.01.2020
CY15.01.2020
CZ15.01.2020
DK15.01.2020
EE15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
IT15.01.2020
LT15.01.2020
LV15.01.2020
MC15.01.2020
MT15.01.2020
NL15.01.2020
PL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SI15.01.2020
SK15.01.2020
SM15.01.2020
TR15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2022/26]AT15.01.2020
CZ15.01.2020
DK15.01.2020
EE15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
IT15.01.2020
LT15.01.2020
LV15.01.2020
MC15.01.2020
NL15.01.2020
PL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SI15.01.2020
SK15.01.2020
SM15.01.2020
TR15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2021/40]AT15.01.2020
CZ15.01.2020
DK15.01.2020
EE15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
IT15.01.2020
LT15.01.2020
LV15.01.2020
MC15.01.2020
NL15.01.2020
PL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SI15.01.2020
SK15.01.2020
SM15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2021/10]AT15.01.2020
CZ15.01.2020
DK15.01.2020
EE15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
IT15.01.2020
LT15.01.2020
LV15.01.2020
NL15.01.2020
PL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SI15.01.2020
SK15.01.2020
SM15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2020/50]CZ15.01.2020
DK15.01.2020
EE15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
LT15.01.2020
LV15.01.2020
NL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SK15.01.2020
SM15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2020/49]CZ15.01.2020
DK15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
LT15.01.2020
LV15.01.2020
NL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SK15.01.2020
SM15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2020/48]DK15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
LT15.01.2020
LV15.01.2020
NL15.01.2020
RO15.01.2020
RS15.01.2020
SE15.01.2020
SM15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2020/47]DK15.01.2020
ES15.01.2020
FI15.01.2020
HR15.01.2020
LT15.01.2020
LV15.01.2020
NL15.01.2020
RS15.01.2020
SE15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2020/40]FI15.01.2020
HR15.01.2020
LV15.01.2020
NL15.01.2020
RS15.01.2020
SE15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
IS15.05.2020
PT07.06.2020
Former [2020/39]FI15.01.2020
HR15.01.2020
LV15.01.2020
NL15.01.2020
RS15.01.2020
SE15.01.2020
BG15.04.2020
NO15.04.2020
GR16.04.2020
PT07.06.2020
Former [2020/38]FI15.01.2020
HR15.01.2020
LV15.01.2020
NL15.01.2020
RS15.01.2020
SE15.01.2020
NO15.04.2020
GR16.04.2020
PT07.06.2020
Former [2020/37]FI15.01.2020
HR15.01.2020
LV15.01.2020
NL15.01.2020
RS15.01.2020
SE15.01.2020
NO15.04.2020
PT07.06.2020
Former [2020/36]FI15.01.2020
NL15.01.2020
RS15.01.2020
NO15.04.2020
PT07.06.2020
Former [2020/35]FI15.01.2020
NL15.01.2020
NO15.04.2020
Former [2020/33]NL15.01.2020
Cited inInternational search[A]  - CHRISTOPHER R ET AL, "Serum arylsulfatase A assay in metachromatic leukodystrophy: An experience in a neuropsychiatric set-up", INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY 1995 IN, (1995), vol. 10, no. 2, ISSN 0970-1915, pages 89 - 92, XP008161838 [A] 1-20 * the whole document * * In particular: Title; Abstract; Materials and methods section; Table 1; Discussion, 1st paragraph and last paragraph. *

DOI:   http://dx.doi.org/10.1007/BF02871008
 [A]  - GRIFFITHS P A ET AL, "Plasma acid hydrolases in normal adults and children, and in patients with some lysosomal storage diseases", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 90, no. 2, doi:10.1016/0009-8981(78)90514-4, ISSN 0009-8981, (19781201), pages 129 - 141, (19781201), XP024784849 [A] 1-20 * the whole document * * In particular: Title; Summary; Materials and methods section; Table IV; p. 138, l. 10 - p. 139, l. 35. *

DOI:   http://dx.doi.org/10.1016/0009-8981(78)90514-4
 [X]  - "The development of an UPLC-MS/MS method for determination of lysoglobotriaosylceramide (lysoGb3) and (lyso)-sulfatide in body fluids and tissues from patients with Fabry disease and metachromatic leukodystrophy (MLD)", The development of an UPLC-MS/MS method for determination of lysoglobotriaosylceramide (lysoGb3) and (lyso)-sulfatide in body fluids and tissues from patients with Fabry disease and metachromatic leukodystrophy (MLD), (20110301), XP055061021 [X] 1-20 * Pages 21-54. * * In particular: Sections 2.2, 2.4 and 2.5 *
 [Y]  - TODA K ET AL, "Accumulation of lysosulfatide (sulfogalactosylsphingosine) in tissues of a boy with metachromatic leukodystrophy", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 159, no. 2, doi:10.1016/0006-291X(89)90037-5, ISSN 0006-291X, (19890315), pages 605 - 611, (19890315), XP024836620 [Y] 1-20 * the whole document * * In particular: Title; Abstract; Materials and methods section. *

DOI:   http://dx.doi.org/10.1016/0006-291X(89)90037-5
 [Y]  - ROSENGREN B ET AL, "Lysosulfatide (galactosylsphingosine-3-O-sulfate) from metachromatic leukodystrophy and normal human brain.", JOURNAL OF NEUROCHEMISTRY APR 1989, (198904), vol. 52, no. 4, ISSN 0022-3042, pages 1035 - 1041, XP055070555 [Y] 1-20 * the whole document * * In particular: Title; Abstract; Materials and methods section. *

DOI:   http://dx.doi.org/10.1111/j.1471-4159.1989.tb01844.x
ExaminationEP2533051
 EP2743700
by applicant   - "Metachromatic leukodystrophy", VON FIGURA; SCRIVER CR ET AL., The Metabolic and Molecular Bases of Inherited Disease
    - C.E. HOLLAK ET AL., J. CLIN. INVEST., (1994), vol. 93, pages 1288 - 1292
    - R.G. BOOT ET AL., BLOOD, (2004), vol. 103, pages 33 - 39
    - GROENER ET AL., BIOCHIM BIOPHYS ACTA, (200801), vol. 1781, no. 1-2, pages 72 - 8
    - ROSENGREN B; FREDMAN P; MÅNSSON JE; SVENNERHOLM L., J NEUROCHEM., (198904), vol. 52, no. 4, pages 1035 - 41
    - GROENER ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, (2007), vol. 1781, no. 2908, pages 72 - 78
    - TODA K. ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1989), vol. 159, no. 2, pages 605 - 611
    - J.E.M. GROENER ET AL., CLIN.CHERN., (2007), vol. 53, pages 742 - 747
    - T. TAKETOMI ET AL., J. BIOCHEM., (1996), vol. 120, pages 573 - 579
    - GREEN, J.R., Statistical Treatment of Experimental Data, ELSEVIER, (1977), page 210 FF
    - SEEMAN, N. C., J. AM. CHEM. SOC., (1995), vol. 117, pages 1194 - 1200
    - N.C. SEEMAN, BIOCHEMISTRY, (1995), vol. 34, pages 673 - 682
    - N.C. SEEMAN, "Structural Domains of DNA Mesojunctions", BIOCHEMISTRY, (1995), vol. 34, pages 920 - 929
    - N.C. SEEMAN, THE CHEMICAL INTELLIGENCER, (1995), vol. 1, no. 3, pages 38 - 47
    - N.C. SEEMAN, JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, (1995), pages 2249 - 2250
    - DELONG E.R.; DELONG D.M.; CLARKE-PEARSON D.L., BIOMETRICS, (1988), vol. 44, pages 837 - 45
    - METZ C.E., SEMIN NUCL MED, (1978), vol. 8, pages 283 - 98
    - ZWEIG M.H.; CAMPBELL G., CLIN CHEM, (1993), vol. 39, pages 561 - 77
    - GIESELMANN, PROC. NATAL. ACAD. SCI USA, (1989), vol. 86, no. 23, pages 9436 - 40
    - BARONICA, COLL ANTROPOL., (201101), vol. 35, no. 1, pages 11 - 6
    - RICKETTES, AM J MED GENET., (1996), vol. 67, no. 4, pages 387 - 92
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.