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Extract from the Register of European Patents

EP About this file: EP2872680

EP2872680 - DNA-ENCODED LIBRARIES HAVING ENCODING OLIGONUCLEOTIDE LINKAGES NOT READABLE BY POLYMERASES [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  03.02.2023
Database last updated on 03.04.2025
FormerThe patent has been granted
Status updated on  02.03.2018
FormerGrant of patent is intended
Status updated on  29.10.2017
FormerExamination is in progress
Status updated on  18.11.2016
Most recent event   Tooltip03.02.2023Revocation of patentpublished on 08.03.2023  [2023/10]
03.02.2023New entry: Despatch of communication that patent is revoked 
Applicant(s)For all designated states
X-Chem, Inc.
100 Beaver Street, Suite 101
Waltham, Massachusetts 02453 / US
[2015/21]
Inventor(s)01 / KEEFE, Anthony, D.
9 Bellis Circle Apt. 6
Cambridge, MA 02140 / US
02 / LITOVCHICK, Alexander
468 Dutton Road
Sudbury, MA 01776 / US
03 / CLARK, Matthew, A.
36 Clelland Road
Lexington, MA 02421 / US
 [2015/21]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2015/21]Bösl, Raphael Konrad
Isenbruck Bösl Hörschler LLP
Patentanwälte
Prinzregentenstraße 68
81675 München / DE
Application number, filing date13816635.012.07.2013
[2018/14]
WO2013US50303
Priority number, dateUS201261671406P13.07.2012         Original published format: US 201261671406 P
[2015/21]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014012010
Date:16.01.2014
Language:EN
[2014/03]
Type: A1 Application with search report 
No.:EP2872680
Date:20.05.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 16.01.2014 takes the place of the publication of the European patent application.
[2015/21]
Type: B1 Patent specification 
No.:EP2872680
Date:04.04.2018
Language:EN
[2018/14]
Search report(s)International search report - published on:US16.01.2014
(Supplementary) European search report - dispatched on:EP05.01.2016
ClassificationIPC:C12N15/10, C40B40/06
[2016/04]
CPC:
C12N15/1065 (EP,EA,IL,KR,US); C12N15/1044 (EP,EA,IL,KR,US); C12N15/1068 (EP,EA,IL,KR,US);
C12Q1/6869 (EA,IL,KR,US); C40B40/06 (EA,IL,KR); C40B50/00 (EA,IL)
C-Set:
C12N15/1044, C12Q2563/179, C12Q2565/514 (EP,US);
C12N15/1065, C12Q2563/179, C12Q2565/514 (US,EP);
C12N15/1068, C12Q2563/179, C12Q2565/514 (US,EP)
Former IPC [2015/21]C40B40/06
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/21]
Extension statesBA30.01.2015
ME30.01.2015
TitleGerman:DNA-CODIERTE BIBLIOTHEKEN MIT FÜR POLYMERASEN NICHT LESBAREN OLIGONUKLEOTID-CODIERUNGSBINDUNGEN[2015/21]
English:DNA-ENCODED LIBRARIES HAVING ENCODING OLIGONUCLEOTIDE LINKAGES NOT READABLE BY POLYMERASES[2015/21]
French:BANQUES ENCODÉES PAR L'ADN POSSÉDANT DES LIAISONS OLIGONUCLÉOTIDIQUES CODANTES NE POUVANT ÊTRE LUES PAR LES POLYMÉRASES[2015/21]
Entry into regional phase30.01.2015National basic fee paid 
30.01.2015Search fee paid 
30.01.2015Designation fee(s) paid 
30.01.2015Examination fee paid 
Examination procedure30.01.2015Examination requested  [2015/21]
22.07.2016Amendment by applicant (claims and/or description)
16.11.2016Despatch of a communication from the examining division (Time limit: M04)
09.03.2017Reply to a communication from the examining division
28.04.2017Observations by third parties
23.05.2017Despatch of a communication from the examining division (Time limit: M04)
02.10.2017Reply to a communication from the examining division
30.10.2017Communication of intention to grant the patent
26.02.2018Fee for grant paid
26.02.2018Fee for publishing/printing paid
26.02.2018Receipt of the translation of the claim(s)
Divisional application(s)EP18158509.2  / EP3392338
EP20211472.4  / EP3851529
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  16.11.2016
Opposition(s)Opponent(s)01  04.01.2019    ADMISSIBLE
Nuevolution A/S
Rønnegade 8
2100 Copenhagen / DK
Opponent's representative
Aamand, Jesper L.
Jesper Levin A/S
Jægersborg Allé 93
2820 Gentofte / DK
 [2019/07]
16.01.2019Invitation to proprietor to file observations on the notice of opposition
24.05.2019Reply of patent proprietor to notice(s) of opposition
06.03.2020Date of oral proceedings
07.04.2020Despatch of interlocutory decision in opposition
07.04.2020Despatch of minutes of oral proceedings
12.01.2023Despatch of communication that the patent will be revoked
22.01.2023Legal effect of revocation of patent [2023/10]
Appeal following opposition16.06.2020Appeal received No.  T1436/20
17.08.2020Statement of grounds filed
15.12.2022Result of appeal procedure: REVOCATION OF PATENT AT PROPRIETOR'S REQUEST
12.01.2023Despatch of the decision of the Board of Appeal
16.06.2020Appeal received No.  T1436/20
14.08.2020Statement of grounds filed
15.12.2022Result of appeal procedure: REVOCATION OF PATENT AT PROPRIETOR'S REQUEST
12.01.2023Despatch of the decision of the Board of Appeal
Fees paidRenewal fee
27.07.2015Renewal fee patent year 03
27.07.2016Renewal fee patent year 04
27.07.2017Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU12.07.2013
AL04.04.2018
CY04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
MK04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SI04.04.2018
SK04.04.2018
SM04.04.2018
TR04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
LU12.07.2018
MT12.07.2018
BE31.07.2018
IS04.08.2018
PT06.08.2018
[2020/33]
Former [2020/31]HU12.07.2013
AL04.04.2018
CY04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
MK04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SI04.04.2018
SK04.04.2018
SM04.04.2018
TR04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
LU12.07.2018
MT12.07.2018
BE31.07.2018
PT06.08.2018
Former [2020/28]HU12.07.2013
AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SI04.04.2018
SK04.04.2018
SM04.04.2018
TR04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
LU12.07.2018
MT12.07.2018
BE31.07.2018
PT06.08.2018
Former [2020/16]AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SI04.04.2018
SK04.04.2018
SM04.04.2018
TR04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
LU12.07.2018
MT12.07.2018
BE31.07.2018
PT06.08.2018
Former [2020/08]AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SI04.04.2018
SK04.04.2018
SM04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
LU12.07.2018
MT12.07.2018
BE31.07.2018
PT06.08.2018
Former [2019/26]AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SI04.04.2018
SK04.04.2018
SM04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
LU12.07.2018
BE31.07.2018
PT06.08.2018
Former [2019/24]AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SK04.04.2018
SM04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
LU12.07.2018
BE31.07.2018
PT06.08.2018
Former [2019/17]AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SK04.04.2018
SM04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
LU12.07.2018
PT06.08.2018
Former [2019/15]AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
MC04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SK04.04.2018
SM04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
PT06.08.2018
Former [2019/11]AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SK04.04.2018
SM04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
PT06.08.2018
Former [2019/10]AL04.04.2018
CZ04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
NL04.04.2018
PL04.04.2018
RO04.04.2018
RS04.04.2018
SE04.04.2018
SK04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
PT06.08.2018
Former [2019/09]AL04.04.2018
EE04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
NL04.04.2018
PL04.04.2018
RS04.04.2018
SE04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
PT06.08.2018
Former [2019/03]AL04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
NL04.04.2018
PL04.04.2018
RS04.04.2018
SE04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
PT06.08.2018
Former [2018/52]AL04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
NL04.04.2018
PL04.04.2018
RS04.04.2018
SE04.04.2018
BG04.07.2018
NO04.07.2018
GR05.07.2018
Former [2018/51]AL04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
LV04.04.2018
NL04.04.2018
PL04.04.2018
RS04.04.2018
SE04.04.2018
BG04.07.2018
NO04.07.2018
Former [2018/50]AL04.04.2018
FI04.04.2018
HR04.04.2018
LT04.04.2018
NL04.04.2018
PL04.04.2018
SE04.04.2018
BG04.07.2018
NO04.07.2018
Former [2018/49]AL04.04.2018
FI04.04.2018
LT04.04.2018
NL04.04.2018
PL04.04.2018
SE04.04.2018
BG04.07.2018
NO04.07.2018
Former [2018/47]AL04.04.2018
FI04.04.2018
LT04.04.2018
NL04.04.2018
NO04.07.2018
Former [2018/46]AL04.04.2018
LT04.04.2018
NL04.04.2018
NO04.07.2018
Former [2018/43]NL04.04.2018
Documents cited:Search[A]WO2005058479  (PRAECIS PHARM INC [US], et al) [A] 1-16 * the whole document *;
 [A]WO2007062664  (NUEVOLUTION AS [DK], et al) [A] 1-16 * the whole document *;
 [A]WO2009077173  (PHILOCHEM AG [CH], et al) [A] 1-16 * the whole document *;
 [A]WO2010094036  (CHEM INC X [US], et al) [A] 1-16 * the whole document *;
 [XP]WO2013036810  (CHEM INC X [US], et al) [XP] 1-14,16 * the whole document *;
 [T]WO2015091207  (PHILOCHEM AG [CH]) [T] 1-16* the whole document *
International search[A]US2011136697  (MORGAN BARRY [US], et al);
 [A]WO2011127933  (NUEVOLUTION AS [DK], et al);
 [Y]US2011262898  (DONG SHOULIAN [US], et al);
 [Y]US2012053091  (WAGNER RICHARD W [US])
ExaminationEP2216338
    - YOSHINAGA YOSHIMURA AND KENZO FUJIMOTO, "Ultrafast Reversible Photo-Cross-Linking Reaction: Toward in Situ DNA Manipulation", ORGANIC LETTERS , 14(23), 6012-6015 CODEN: ORLEF7; ISSN: 1523-7052,, vol. 10, no. 15, doi:10.1021/OL801112J, ISSN 1523-7060, (20080807), pages 3227 - 3230, (20080627), XP008134569

DOI:   http://dx.doi.org/10.1021/ol801112j
    - Yoshinaga Yoshimura ET AL, "Supporting Information Ultrafast Reversible Photocrosslinking Reaction: Toward in Situ DNA Manipulation", (20080101), URL: http://pubs.acs.org/doi/suppl/10.1021/ol801112j/suppl_file/ol801112j-file003.pdf, (20170509), XP055370688
    - HOEPFNER R W ET AL, "Amplified primer extension assay for psoralen photoproducts provides a sensitive assay for a (CG)6TA(CG)2(TG)8 Z-DNA torsionally tuned probe: preferential psoralen photobinding to one strand of a B-Z junction.", BIOCHEMISTRY 27 JUL 1993, (19930727), vol. 32, no. 29, ISSN 0006-2960, pages 7542 - 7548
    - TORNALETTI SILVIA ET AL, "Transcription arrest at an abasic site in the transcribed strand of template DNA.", CHEMICAL RESEARCH IN TOXICOLOGY SEP 2006, (200609), vol. 19, no. 9, ISSN 0893-228X, pages 1215 - 1220
    - DIMITRI ALEXANDRA ET AL, "Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase.", NUCLEIC ACIDS RESEARCH NOV 2008, (200811), vol. 36, no. 20, ISSN 1362-4962, pages 6459 - 6471
    - ENGELHART AARON E ET AL, "Nonenzymatic ligation of DNA with a reversible step and a final linkage that can be used in PCR.", CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY 29 MAY 2012, (20120529), vol. 13, no. 8, ISSN 1439-7633, pages 1121 - 1124
otherEP2216338
    - YOSHIMURA; FUJIMOTO, "Ultrafast Reversible Photo-Cross-Linking Reaction: Toward in Situ DNA Manipulation", Org. Lett., (20080807), vol. 10, no. 15, pages 3227 - 3230, XP008134569

DOI:   http://dx.doi.org/10.1021/ol801112j
    - YOSHIMURA; FUJIMOTO, "Ultrafast Reversible Photo-Cross-Linking Reaction: Toward in Situ DNA Manipulation /Supporting Information/", ORGANIC LETTERS, (20080807), vol. 10, no. 15, pages 1 - 20, XP055378529
    - HOEPFNER; SINDEN, "Amplified Primer Extension Assay for Psoralen Photoproducts Provides a Sensitive Assay for a (CG)6TA(CGh(TG)8 Z-DNA Torsionally Tuned Probe: Preferential Psoralen Photobinding to One Strand of a B-Z Junctiont", Biochemistry, (19930000), vol. 32, no. 29, pages 7542 - 7548, XP055378508
    - TORNALETTI et al., "Transcription Arrest at an Abasic Site in the Transcribed Strand of Template DNA", CHEMICAL RESEARCH IN TOXICOLOGY, (20060900), vol. 19, no. 9, pages 1215 - 1220, XP055378510

DOI:   http://dx.doi.org/10.1021/tx060103g
    - DIMITRI et al., "Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase", Nucleic Acids Res., (20081101), vol. 36, no. 20, pages 6459 - 6471, XP055378514

DOI:   http://dx.doi.org/10.1093/nar/gkn657
    - ENGELHART et al., "Nonenzymatic Ligation of DNA with a Reversible Step and a Final Linkage that Can Be Used in PCR", ChemBioChem., (20120529), vol. 13, pages 1121 - 1124, XP055378517

DOI:   http://dx.doi.org/10.1002/cbic.201200167
OppositionWO02103008
 WO2004013070
 WO2004039825
 WO2004056994
 WO2004083427
 WO2005058479
 WO2005090566
 WO2007062664
 US2007224607
 WO2010094036
 WO2013036810
 EP2216338
 WO2014012010
 EP2272856
    - KORE, A.R. et al., "Efficient synthesis of 3-cyanovinylcarbazole-1'-beta- deoxyriboside-5'-triphosphate: a reversible photo-cross-linking probe", Tetrahedron Lett., (20120530), vol. 53, no. 31, pages 4012 - 4014, XP028498814

DOI:   http://dx.doi.org/10.1016/j.tetlet.2012.05.114
    - YOSHIMURA, Y. et al., "Ultrafast Reversible Photo-Cross-Linking Reaction: Toward in Situ DNA Manipulation", Org. Lett., (20080000), vol. 10, no. 15, pages 3227 - 3230, XP008134569

DOI:   http://dx.doi.org/10.1021/ol801112j
    - YOSHIMURA, Y. et al., "Supporting Information for Ultrafast Reversible Photo-Cross-Linking Reaction: Toward in Situ DNA Manipulation", School of Materials Science, Japan, (20080000), pages 1 - 20, URL: http://pubs.acs.org, XP055547101
    - FUJIMOTO et al., "A light-Controlled Reversible DNA Photoligation via Carbazole-Tethered 5-Carboxyvinyluracil", Org. Lett., (20080000), vol. 10, no. 3, pages 397 - 400, XP008144747

DOI:   http://dx.doi.org/10.1021/ol7026784
    - QIU, Z. et al., "A Diazirine-Based Nucleoside Analogue for Efficient DNA Interstrand Photocross-Linking", J. Am. Chem. Soc., (20080000), vol. 130, no. 44, pages 14398 - 14399, XP055547104

DOI:   http://dx.doi.org/10.1021/ja805445j
    - EL-SAGHEER et al., "Click Nucleic Acid Ligation: Applications in Biology and Nanotechnology", Acc. Chem. Res., (20120322), vol. 45, no. 8, pages 1258 - 1267, XP055454304

DOI:   http://dx.doi.org/10.1021/ar200321n
    - XIONG, H. et al., "Cross-Linked DNA: Site-Selective ''Click'' Ligation in Duplexes with Bis-Azides and Stability Changes Caused by Internal Cross-Links. Biocon", Biochem., (20120000), vol. 23, no. 6, pages 1230 - 1243, XP055519081

DOI:   http://dx.doi.org/10.1021/bc300074k
    - XIONG, H. et al., "Stepwise ''Click'' Chemistry for the Template Independent Construction of a Broad Variety of Cross-Linked Oligonucleotides: Influence of Linker Length", J. Org. Chem., (20110000), vol. 76, no. 14, pages 5584 - 5597, XP055057427

DOI:   http://dx.doi.org/10.1021/jo2004988
    - PUJARI, S.S. et al., "Cross-Linked DNA Generated by ''Bis-click'' Reactions with Bis-functional Azides: Site Independent Ligation of Oligonucleotides via Nucleobase Alkynyl Chains", J. Org. Chem., (20100000), vol. 75, no. 24, pages 8693 - 8696, XP055031965

DOI:   http://dx.doi.org/10.1021/jo101809w
    - KOCALKA, P. et al., "Rapid and Efficient DNA Strand Cross-Linking by Click Chemistry", ChemBioChem., (20080000), vol. 9, no. 8, pages 1280 - 1285, XP055016982

DOI:   http://dx.doi.org/10.1002/cbic.200800006
    - NAKAMURA, S. et al., "Template Directed Reversible Photochemical Ligation of Oligodeoxynucleotides", Molecules, (20120000), vol. 17, no. 1, pages 163 - 178, XP055547116

DOI:   http://dx.doi.org/10.3390/molecules17010163
    - KLEINER, R.E. et al., "In Vitro Selection of a DNA-templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors", J. Am. Chem. Soc., (20100000), vol. 132, no. 33, pages 11779 - 11791, XP055142200

DOI:   http://dx.doi.org/10.1021/ja104903x
    - EFFIMOV, V.A. et al., "Cross-Linked Nucleic Acids: Formation, Structure, and Biological Function", Russian J. Bioorg. Chem., (20100000), vol. 36, no. 1, pages 49 - 72, XP055547120

DOI:   http://dx.doi.org/10.1134/S1068162010010061
    - BERGER J. et al., "Chemistry on Nucleic Acid Templates", Chemistry & Biodiversity, (20100000), vol. 7, pages 2581 - 2614, XP055547122

DOI:   http://dx.doi.org/10.1002/cbdv.201000108
    - "Crosslinking and Photoactivatable Reagents - Molecular Probes Handbook", ThermoFisher Scientific, (20100000), pages 171 - 188, XP055547125
    - CLARK, M.A. et al., "Design, synthesis and selection of DNA-encoded small- molecule libraries", Nature Chem. Biol., (20090000), vol. 5, no. 9, pages 647 - 654, XP002677464

DOI:   http://dx.doi.org/10.1038/NCHEMBIO.211
    - CLARK et al., "SUPPLEMENTARY METHODS FOR Design, synthesis and selection of DNA-encoded small-molecule libraries", Nature Chem. Biol., (20090000), pages 1 - 57, XP055547139
    - HOEPFNER, R.W. et al., "Amplified Primer Extension Assay for Psoralen Photoproducts Provides a Sensitive Assay for a (CG)6TA(CG)2(TG)8 Z-DNA Torsionally Tuned Probe: Preferential Psoralen Photobinding to One Strand of a B-Z Junction", Biochem., (19930000), vol. 32, no. 29, pages 7542 - 7548, XP055378508
    - TORNALETTI, S. et al., "Transcription Arrest at an Abasic Site in the Transcribed Strand of Template DNA", Chem. Res. Toxicol., (20060000), vol. 19, no. 9, pages 1215 - 1220, XP055378510

DOI:   http://dx.doi.org/10.1021/tx060103g
    - DIMITRI, A. et al., "Transcription elongation past 06-methylguaning by human RNA polymerase II and bacteriophage T7 RNA polymerase", Nucleic Acids Res., (20080000), vol. 36, no. 20, pages 6459 - 6471, XP055378514

DOI:   http://dx.doi.org/10.1093/nar/gkn657
    - ENGELHART, A.E. et al., "Nonenzymatic Ligation of DNA with a Reversible Step and a Final Linkage that Can Be Used in PCR", ChemBioChem ., (20120529), vol. 13, no. 8, pages 1121 - 1124, XP055378517

DOI:   http://dx.doi.org/10.1002/cbic.201200167
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