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Extract from the Register of European Patents

EP About this file: EP2875125

EP2875125 - METHODS FOR PRODUCING CARTILAGE AND BONE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.08.2019
Database last updated on 11.09.2024
FormerThe patent has been granted
Status updated on  21.09.2018
FormerGrant of patent is intended
Status updated on  02.05.2018
FormerExamination is in progress
Status updated on  03.03.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Kuo, Alfred C.
3535 Lebon Drive
San Diego, CA 92122 / US
[2016/20]
Former [2015/22]For all designated states
The Regents of the University of California
1111 Franklin Street, 12th Floor
Oakland, CA 94607-5200 / US
For all designated states
Department of Veterans Affairs
Office of the General Counsel
Washington, DC 20420 / US
Inventor(s)01 / see applicant
...
 [2016/20]
Former [2015/44]01 / KUO, Alfred
500 Parnassus Avenue, MU
San Francisco, California 94143 / US
Former [2015/22]01 / KUO, Alfred
530 19th Avenue
San Francisco, California 94121 / US
Representative(s)Browne, Robin Forsythe, et al
Hepworth Browne
15 St Paul's Street
Leeds LS1 2JG / GB
[2015/22]
Application number, filing date13819300.818.07.2013
[2018/43]
WO2013US51022
Priority number, dateUS201261673903P20.07.2012         Original published format: US 201261673903 P
[2015/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014015109
Date:23.01.2014
Language:EN
[2014/04]
Type: A1 Application with search report 
No.:EP2875125
Date:27.05.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 23.01.2014 takes the place of the publication of the European patent application.
[2015/22]
Type: B1 Patent specification 
No.:EP2875125
Date:24.10.2018
Language:EN
[2018/43]
Search report(s)International search report - published on:KR23.01.2014
(Supplementary) European search report - dispatched on:EP31.03.2016
ClassificationIPC:C12N5/077, A61K35/32, A61F2/28
[2016/17]
CPC:
C12N5/0655 (EP,US); A61K35/32 (US); A61K35/00 (EP,US);
C12N2500/90 (EP,US); C12N2501/15 (EP,US); C12N2501/155 (EP,US);
C12N2501/37 (US) (-)
Former IPC [2015/22]C12N5/077, C12N5/071, A61K35/32, A61F2/28
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/22]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON KNORPEL UND KNOCHEN[2015/22]
English:METHODS FOR PRODUCING CARTILAGE AND BONE[2015/22]
French:PROCÉDÉS DE PRODUCTION DE CARTILAGE ET D'OS[2015/22]
Entry into regional phase16.02.2015National basic fee paid 
16.02.2015Search fee paid 
16.02.2015Designation fee(s) paid 
16.02.2015Examination fee paid 
Examination procedure16.02.2015Examination requested  [2015/22]
19.10.2016Amendment by applicant (claims and/or description)
01.03.2017Despatch of a communication from the examining division (Time limit: M04)
16.05.2017Reply to a communication from the examining division
03.05.2018Communication of intention to grant the patent
11.09.2018Fee for grant paid
11.09.2018Fee for publishing/printing paid
11.09.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  01.03.2017
Opposition(s)25.07.2019No opposition filed within time limit [2019/40]
Fees paidRenewal fee
10.07.2015Renewal fee patent year 03
11.07.2016Renewal fee patent year 04
12.07.2017Renewal fee patent year 05
27.07.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.07.2013
AL24.10.2018
AT24.10.2018
CY24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
MK24.10.2018
MT24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE18.07.2019
LU18.07.2019
[2022/31]
Former [2021/34]HU18.07.2013
AL24.10.2018
AT24.10.2018
CY24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
MT24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE18.07.2019
LU18.07.2019
Former [2021/32]HU18.07.2013
AL24.10.2018
AT24.10.2018
CY24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE18.07.2019
LU18.07.2019
Former [2021/26]AL24.10.2018
AT24.10.2018
CY24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE18.07.2019
LU18.07.2019
Former [2020/36]AL24.10.2018
AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE18.07.2019
LU18.07.2019
Former [2020/27]AL24.10.2018
AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
LU18.07.2019
Former [2020/17]AL24.10.2018
AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2020/14]AL24.10.2018
AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/50]AL24.10.2018
AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
SM24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/40]AL24.10.2018
AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SK24.10.2018
SM24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/37]AL24.10.2018
AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
RS24.10.2018
SE24.10.2018
SM24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/35]AL24.10.2018
AT24.10.2018
CZ24.10.2018
DK24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RS24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/34]AL24.10.2018
AT24.10.2018
DK24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RS24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/26]AL24.10.2018
AT24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RS24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/25]AT24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RS24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
Former [2019/24]AT24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
Former [2019/23]AT24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
BG24.01.2019
NO24.01.2019
IS24.02.2019
Former [2019/22]FI24.10.2018
LT24.10.2018
NL24.10.2018
PL24.10.2018
BG24.01.2019
NO24.01.2019
IS24.02.2019
Former [2019/21]FI24.10.2018
LT24.10.2018
NL24.10.2018
NO24.01.2019
IS24.02.2019
Former [2019/20]LT24.10.2018
NL24.10.2018
NO24.01.2019
Former [2019/17]NL24.10.2018
Documents cited:Search[X]US8017394  (ADKISSON IV HUSTON DAVIS [US], et al) [X] 1-3,6,7 * column 7 - column 8; claims 1-4 *;
 [X]  - NARCISI R ET AL, "TGF beta-1 administration during Ex vivo expansion of human Articular Chondrocytes in a Serum-Free Medium Redirects the Cell Phenotype Toward Hypertrophy", JOURNAL OF CELLULAR PHYSIOLOGY, (20111121), vol. 227, no. 9, pages 3282 - 3290, XP009188715 [X] 1-3,6,7 * page 3283 *
 [X]  - JOHNSTONE B ET AL, "IN VITRO CHONDROGENESIS OF BONE MARROW-DERIVED MESENCHYMAL PROGENITOR CELLS", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, (19980101), vol. 238, no. 1, doi:10.1006/EXCR.1997.3858, ISSN 0014-4827, pages 265 - 272, XP000881888 [X] 1 * page 270 *

DOI:   http://dx.doi.org/10.1006/excr.1997.3858
 [X]  - JONG-MIN LEE ET AL, "PTHrP isoforms have differing effect on chondrogenic differentiation and hypertrophy of mesenchymal stem cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 421, no. 4, doi:10.1016/J.BBRC.2012.04.096, ISSN 0006-291X, (20120425), pages 819 - 824, (20120425), XP028489192 [X] 8-10,13-15 * page 820 *

DOI:   http://dx.doi.org/10.1016/j.bbrc.2012.04.096
 [A]  - LIU GUANGYAO ET AL, "Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, (20070701), vol. 282, no. 28, doi:10.1074/JBC.M608383200, ISSN 0021-9258, pages 20407 - 20415, XP002453794 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.M608383200
International search[A]US5846931  (HATTERSLEY GARY [US], et al);
 [A]US2003175257  (SONG SUN UK [KR], et al);
 [A]US2006148077  (THIES R S [US]);
 [X]US2011159070  (JIN SUNGHO [US], et al);
 [A]  - MEHLHORN, A. T. ET AL., "Differential effects of BMP-2 and TGF-betal on chondrogenic differentiation of adipose derived stem cells", CELL PROLIF., (200712), vol. 40, no. 6, pages 809 - 823, XP055184440

DOI:   http://dx.doi.org/10.1111/j.1365-2184.2007.00473.x
by applicantUS6150163
 US2003175257
 US7169610
 US2011159070
 US8017394
 US2011256109
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    - IWATA ET AL., BIOMATERIALS, (2012), vol. 444, page 454
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    - PELTTARI ET AL., ARTHRITIS RHEUM., (2006), vol. 54, no. 10, pages 3254 - 66
    - NARCISI R ET AL., "TGF beta-1 administration during Ex vivo expansion of human Articular Chondrocytes in a Serum-Free Medium Redirects the Cell Phenotype Toward Hypertrophy", JOURNAL OF CELLULAR PHYSIOLOGY, (20111121), vol. 227, no. 9, pages 3282 - 3290
    - "In Vitro Chondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells", JOHNSTONE B ET AL., Experimental Cell Research, ACADEMIC PRESS, (19980101), vol. 238, pages 265 - 272
    - JONG-MIN LEE ET AL., "PTHrP isoforms have differing effect on chondrogenic differentiation and hypertrophy of mesenchymal stem cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (20120425), vol. 421, no. 4, pages 819 - 824
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