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Extract from the Register of European Patents

EP About this file: EP2875124

EP2875124 - CELL CULTURE OF CORNEAL ENDOTHELIAL CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.02.2020
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  22.02.2019
FormerGrant of patent is intended
Status updated on  30.09.2018
FormerExamination is in progress
Status updated on  20.01.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Singapore Health Services Pte Ltd
31 Third Hospital Avenue
03-03 Bowyer Block C
Singapore 168753 / SG
[2015/22]
Inventor(s)01 / TAN, Donald
c/o Singapore Eye Research Institute
11 Third Hospital Avenue
SNEC Building Level 5
Singapore 168751 / SG
02 / MEHTA, Jodhbir
c/o Singapore Eye Research Institute
11 Third Hospital Avenue
SNEC Building Level 5
Singapore 168751 / SG
03 / PEH, Swee Lim Gary
c/o Singapore Eye Research Institute
11 Third Hospital Avenue
SNEC Building Level 5
Singapore 168751 / SG
 [2015/22]
Representative(s)Ward, David Ian, et al
Marks & Clerk LLP
Alpha Tower
Suffolk Street
Queensway
Birmingham B1 1TT / GB
[N/P]
Former [2019/13]Bailey, Jennifer Ann, et al
Marks & Clerk LLP
Alpha Tower
Suffolk Street Queensway
Birmingham B1 1TT / GB
Former [2015/22]Fleck, Barbara
Marks & Clerk LLP
62-68 Hills Road
Cambridge CB2 1LA / GB
Application number, filing date13820042.318.07.2013
[2019/13]
WO2013SG00298
Priority number, dateSG2012000541318.07.2012         Original published format: SG 201205413
[2015/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014014419
Date:23.01.2014
Language:EN
[2014/04]
Type: A1 Application with search report 
No.:EP2875124
Date:27.05.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 23.01.2014 takes the place of the publication of the European patent application.
[2015/22]
Type: B1 Patent specification 
No.:EP2875124
Date:27.03.2019
Language:EN
[2019/13]
Search report(s)International search report - published on:AU23.01.2014
(Supplementary) European search report - dispatched on:EP30.11.2015
ClassificationIPC:C12N5/071, C12N5/02, C12N5/079
[2016/01]
CPC:
C12N5/0621 (EP,US); C12N2500/24 (US); C12N2500/25 (EP,US);
C12N2500/30 (US); C12N2500/32 (EP,US); C12N2500/34 (US);
C12N2500/38 (EP,US); C12N2500/62 (EP,US); C12N2500/72 (US);
C12N2500/80 (US); C12N2501/06 (US); C12N2501/10 (US);
C12N2501/31 (EP,US); C12N2501/33 (US); C12N2501/39 (EP,US) (-)
Former IPC [2015/22]C12N5/071, C12N5/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/22]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ZELLKULTUR AUS HORNHAUTENDOTHELZELLEN[2015/22]
English:CELL CULTURE OF CORNEAL ENDOTHELIAL CELLS[2015/22]
French:CULTURE CELLULAIRE DE CELLULES ENDOTHÉLIALES DE LA CORNÉE[2015/22]
Entry into regional phase30.01.2015National basic fee paid 
30.01.2015Search fee paid 
30.01.2015Designation fee(s) paid 
30.01.2015Examination fee paid 
Examination procedure30.01.2015Examination requested  [2015/22]
27.06.2016Amendment by applicant (claims and/or description)
19.01.2017Despatch of a communication from the examining division (Time limit: M04)
26.05.2017Reply to a communication from the examining division
20.11.2017Despatch of a communication from the examining division (Time limit: M04)
23.03.2018Reply to a communication from the examining division
01.10.2018Communication of intention to grant the patent
11.02.2019Fee for grant paid
11.02.2019Fee for publishing/printing paid
11.02.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  19.01.2017
Opposition(s)03.01.2020No opposition filed within time limit [2020/11]
Fees paidRenewal fee
10.07.2015Renewal fee patent year 03
11.07.2016Renewal fee patent year 04
25.07.2017Renewal fee patent year 05
11.07.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.07.2013
AL27.03.2019
AT27.03.2019
CY27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
MK27.03.2019
MT27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IE18.07.2019
LU18.07.2019
IS27.07.2019
PT27.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
[2022/31]
Former [2021/34]HU18.07.2013
AL27.03.2019
AT27.03.2019
CY27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
MT27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IE18.07.2019
LU18.07.2019
IS27.07.2019
PT27.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
Former [2021/32]HU18.07.2013
AL27.03.2019
AT27.03.2019
CY27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IE18.07.2019
LU18.07.2019
IS27.07.2019
PT27.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
Former [2021/26]AL27.03.2019
AT27.03.2019
CY27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IE18.07.2019
LU18.07.2019
IS27.07.2019
PT27.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
Former [2020/36]AL27.03.2019
AT27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IE18.07.2019
LU18.07.2019
IS27.07.2019
PT27.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
Former [2020/25]AL27.03.2019
AT27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
LU18.07.2019
IS27.07.2019
PT27.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
Former [2020/17]AL27.03.2019
AT27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/14]AL27.03.2019
AT27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/13]AL27.03.2019
AT27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/09]AL27.03.2019
AT27.03.2019
CZ27.03.2019
DK27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/04]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/03]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
PT27.07.2019
Former [2019/52]AL27.03.2019
CZ27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
PT27.07.2019
Former [2019/49]AL27.03.2019
CZ27.03.2019
EE27.03.2019
ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
PT27.07.2019
Former [2019/48]ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
RS27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
PT27.07.2019
Former [2019/47]ES27.03.2019
FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
RS27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
Former [2019/39]FI27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
RS27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
Former [2019/38]FI27.03.2019
LT27.03.2019
BG27.06.2019
NO27.06.2019
GR28.06.2019
Former [2019/37]FI27.03.2019
LT27.03.2019
NO27.06.2019
GR28.06.2019
Former [2019/33]FI27.03.2019
LT27.03.2019
NO27.06.2019
Documents cited:Search[X]US4959319  (SKELNIK DEBRA L [US], et al) [X] 1-15 * column 9, paragraph 2; claim 1 *;
 [Y]WO2008103191  (TISSUETECH INC [US], et al) [Y] 1-15* examples 1,2 *;
 [X]  - G.S. PEH, "Comparison of Five Culture Media for the Isolation and Propagation of Human Corneal Endothelial Cells -- Peh et al. 52 (6): 6595 -- ARVO Meeting Abstracts", ARVO MEETING ABSTRACTS, (20110501), vol. 52, XP055184398 [X] 1-15 * the whole document *
 [X]  - JÜRGEN BEDNARZ ET AL, "Effect of three different media on serum free culture of donor corneas and isolated human corneal endothelial cells", BR J OPHTHALMOL, (20010101), vol. 85, pages 1416 - 1420, XP055184400 [X] 1-15 * page 1417, column 1, paragraph 2 *
 [Y]  - ENGELMANN K ET AL, "Growth of human corneal endothelial cells in a serum-reduced medium", CORNEA: THE JOURNAL OF CORNEA AND EXTERNAL DISEASE, LIPPINCOTT WILLIAMS & WILKINS, US, (19950101), vol. 14, no. 1, ISSN 0277-3740, pages 62 - 70, XP009172449 [Y] 1-15 * figures 3,8 *

DOI:   http://dx.doi.org/10.1097/00003226-199501000-00011
 [Y]  - GARY S. L. PEH ET AL, "Cultivation of Human Corneal Endothelial Cells Isolated from Paired Donor Corneas", PLOS ONE, (20111216), vol. 6, no. 12, doi:10.1371/journal.pone.0028310, page e28310, XP055184403 [Y] 1-15 * figure 1; tables 1,2 *

DOI:   http://dx.doi.org/10.1371/journal.pone.0028310
 [Y]  - GARY S. L. PEH ET AL, "Human Corneal Endothelial Cell Expansion for Corneal Endothelium Transplantation: An Overview", TRANSPLANTATION, (20110401), vol. 91, no. 8, doi:10.1097/TP.0b013e3182111f01, ISSN 0041-1337, pages 811 - 819, XP055192483 [Y] 1-15 * page 813, paragraph last *

DOI:   http://dx.doi.org/10.1097/TP.0b013e3182111f01
International search[X]  - PEH, G.S. ET AL., "Comparison of Five Culture Media for the Isolation and Propagation of Human Corneal Endothelial Cells", 2011 ANNUAL MEETING OF THE ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY: ARVO 2011 VISIONARY GENOMICS, FORT LAUDERDALE, FLORDIA, USA, (20110501), XP055184398
 [X]  - BEDNARZ, J. ET AL., "Effect of three different media on serum free culture of donor corneas and isolated human corneal endothelial cells", BRITISH JOURNAL OF OPHTHALMOLOGY, (2001), vol. 85, pages 1416 - 1420, XP055184400
 [X]  - SOLVIK, U.0. ET AL., "Human serum-induced expression of e-selectin on porcine aortic endothelial cells in vitro is totally complement mediated", TRANSPLANTATION, (2001), vol. 72, pages 1967 - 1973, XP001069663

DOI:   http://dx.doi.org/10.1097/00007890-200112270-00017
 [XP]  - PEH, G.S.L. ET AL., "Optimization of human corneal endothelial cell culture: density dependency of successful cultures in vitro", BMC RESEARCH NOTES, (2013), vol. 6, page 176, XP021151541

DOI:   http://dx.doi.org/10.1186/1756-0500-6-176
 [A]  - PEH, G.S.L. ET AL., "Cultivation of Human Corneal Endothelial Cells Isolated from Paired Donor Corneas", PLOSONE, (2011), vol. 6, page E28310, XP055184403

DOI:   http://dx.doi.org/10.1371/journal.pone.0028310
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