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Extract from the Register of European Patents

EP About this file: EP2910564

EP2910564 - WEAKLY ACIDIC PH-RESPONSIVE PEPTIDE AND LIPOSOME CONTAINING SAME [Right-click to bookmark this link]
Former [2015/35]WEAKLY ACIDIC pH-RESPONSIVE PEPTIDE AND LIPOSOME CONTAINING SAME
[2016/45]
StatusNo opposition filed within time limit
Status updated on  26.01.2018
Database last updated on 29.06.2024
FormerThe patent has been granted
Status updated on  17.02.2017
FormerGrant of patent is intended
Status updated on  13.02.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Taiho Pharmaceutical Co., Ltd.
1-27, Kandanishiki-cho
Chiyoda-ku, Tokyo 101-8444 / JP
[2015/35]
Inventor(s)01 / KOGURE, Kentaro
3-5-7 Niono-hama
Otsu-shi Shiga 520-0801 / JP
02 / HAMA, Susumu
14-14 Youmei-cho
Otsu-shi Shiga 520-0226 / JP
 [2015/36]
Former [2015/35]01 / KOGURE, Kentaro
5-7 Niono-hama 3-chome
Otsu-shi Shiga 520-0801 / JP
02 / HAMA, Susumu
14-14 Youmei-cho
Otsu-shi Shiga 520-0226 / JP
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2015/35]
Application number, filing date13848530.521.10.2013
[2015/35]
WO2013JP78497
Priority number, dateJP2012023301122.10.2012         Original published format: JP 2012233011
[2015/35]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014065245
Date:01.05.2014
Language:JA
[2014/18]
Type: A1 Application with search report 
No.:EP2910564
Date:26.08.2015
Language:EN
[2015/35]
Type: B1 Patent specification 
No.:EP2910564
Date:22.03.2017
Language:EN
[2017/12]
Search report(s)International search report - published on:JP01.05.2014
(Supplementary) European search report - dispatched on:EP02.03.2016
ClassificationIPC:C07K14/00, A61K9/127, A61K47/42, A61P35/00, A61K9/00
[2016/13]
CPC:
A61K47/42 (EP,US); A61K9/0019 (EP,US); A61K9/127 (EP,US);
A61P35/00 (EP); C07K14/00 (EP,US); C07K14/001 (US)
Former IPC [2015/35]C07K14/00, A61K9/127, A61K47/42, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/35]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:SCHWACH SAURES PH-REAKTIVES PEPTID UND LIPOSOM DAMIT[2015/35]
English:WEAKLY ACIDIC PH-RESPONSIVE PEPTIDE AND LIPOSOME CONTAINING SAME[2016/45]
French:PEPTIDE SENSIBLE AU PH FAIBLEMENT ACIDE ET LIPOSOME LE CONTENANT[2016/45]
Former [2015/35]WEAKLY ACIDIC pH-RESPONSIVE PEPTIDE AND LIPOSOME CONTAINING SAME
Former [2015/35]PEPTIDE SENSIBLE AU pH FAIBLEMENT ACIDE ET LIPOSOME LE CONTENANT
Entry into regional phase09.04.2015Translation filed 
09.04.2015National basic fee paid 
09.04.2015Search fee paid 
09.04.2015Designation fee(s) paid 
09.04.2015Examination fee paid 
Examination procedure09.04.2015Examination requested  [2015/35]
23.09.2016Amendment by applicant (claims and/or description)
31.10.2016Communication of intention to grant the patent
07.02.2017Fee for grant paid
07.02.2017Fee for publishing/printing paid
07.02.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  31.10.2016
Opposition(s)02.01.2018No opposition filed within time limit [2018/09]
Fees paidRenewal fee
26.10.2015Renewal fee patent year 03
27.10.2016Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU21.10.2013
AL22.03.2017
AT22.03.2017
CY22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
MK22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
TR22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
IE21.10.2017
LU21.10.2017
MT21.10.2017
BE31.10.2017
CH31.10.2017
LI31.10.2017
[2020/34]
Former [2020/15]HU21.10.2013
AT22.03.2017
CY22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
MK22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
TR22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
IE21.10.2017
LU21.10.2017
MT21.10.2017
BE31.10.2017
CH31.10.2017
LI31.10.2017
Former [2019/52]HU21.10.2013
AT22.03.2017
CY22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
MK22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
IE21.10.2017
LU21.10.2017
MT21.10.2017
BE31.10.2017
CH31.10.2017
LI31.10.2017
Former [2019/47]HU21.10.2013
AT22.03.2017
CY22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
IE21.10.2017
LU21.10.2017
MT21.10.2017
BE31.10.2017
CH31.10.2017
LI31.10.2017
Former [2019/31]HU21.10.2013
AT22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
IE21.10.2017
LU21.10.2017
MT21.10.2017
BE31.10.2017
CH31.10.2017
LI31.10.2017
Former [2018/45]AT22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
IE21.10.2017
LU21.10.2017
MT21.10.2017
BE31.10.2017
CH31.10.2017
LI31.10.2017
Former [2018/43]AT22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
LU21.10.2017
MT21.10.2017
BE31.10.2017
CH31.10.2017
LI31.10.2017
Former [2018/36]AT22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
LU21.10.2017
BE31.10.2017
CH31.10.2017
LI31.10.2017
Former [2018/30]AT22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
MC22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
Former [2018/14]AT22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SI22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
Former [2018/09]AT22.03.2017
CZ22.03.2017
DK22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
Former [2017/51]AT22.03.2017
CZ22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SK22.03.2017
SM22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
PT24.07.2017
Former [2017/50]AT22.03.2017
CZ22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
NL22.03.2017
PL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SK22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
Former [2017/49]AT22.03.2017
CZ22.03.2017
EE22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
NL22.03.2017
RO22.03.2017
RS22.03.2017
SE22.03.2017
SK22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
IS22.07.2017
Former [2017/48]CZ22.03.2017
FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
NL22.03.2017
RS22.03.2017
SE22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
Former [2017/41]FI22.03.2017
HR22.03.2017
LT22.03.2017
LV22.03.2017
NL22.03.2017
RS22.03.2017
SE22.03.2017
BG22.06.2017
NO22.06.2017
GR23.06.2017
Documents cited:Search[I]  - W ZHANG ET AL., "Design of acid-activated cell-penetrating peptide for delivery of active molecules into cancer cells", BIOCONJUGATE CHEMISTRY., ACS, WASHINGTON, DC., (2011), vol. 22, ISSN 1043-1802, pages 1410 - 1415, XP002754612 [I] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1021/bc200138d
International search[A]JP2008214324  (UNIV HOKKAIDO, et al);
 [AP]WO2012147714  (TAIHO PHARMACEUTICAL CO LTD [JP], et al)
 [A]  - SATOSHI MORIMOTO ET AL., "Gan Chiryo no Tameno Bijaku pH Henka Otosei Yakubutsu Carrier no Kaihatsu", ANNUAL CONFERENCE OF THE JAPAN DRUG DELIVERY SYSTEM RESEARCH SOCIETY GAKUJUTSU SHUKAI PROGRAM YOKOSHU, 28TH, (20120605), page 135, XP008178630
 [A]  - GUO, X.D. ET AL., "Core/Shell pH-Sensitive Micelles Self-Assembled from Cholesterol Conjugated Oligopeptides for Anticancer Drug Delivery", AICHE JOURNAL, (2010), vol. 56, no. 7, pages 1922 - 1931, XP055119564

DOI:   http://dx.doi.org/10.1002/aic.12119
 [A]  - TURK, M.J. ET AL., "Characterization of a novel pH-sensitive peptide that enhances drug release from folate-targeted liposomes at endosomal pHs", BIOCHIMICA ET BIOPHYSICA ACTA, (2002), vol. 1559, pages 56 - 68, XP004334733

DOI:   http://dx.doi.org/10.1016/S0005-2736(01)00441-2
 [A]  - YU, W. ET AL., "Enhanced transfection efficiency of a systemically delivered tumor- targeting immunolipoplex by inclusion of a pH- sensitive histidylated oligolysine peptide", NUCLEIC ACIDS RESEARCH, (2004), vol. 32, no. 5, page E48, XP008129590

DOI:   http://dx.doi.org/10.1093/nar/gnh049
 [A]  - KYTE, J. ET AL., "A Simple Method for Displaying the Hydropathic Character of a Protein", J. MOL. BIOL., (1982), vol. 157, pages 105 - 132, XP024014365

DOI:   http://dx.doi.org/10.1016/0022-2836(82)90515-0
by applicantJP2004010481
 JP2004523531
    - AICHE JOURNAL, (2010), vol. 56, no. 7, pages 1922 - 1931
    - INTERNATIONAL JOURNAL OF PHARMACEUTICS, (2009), vol. 376, pages 134 - 140
    - J. MOL. BIOL., (1982), vol. 157, pages 105 - 132
    - MOLECULAR MEDICINE, (1998), vol. 4, pages 240 - 257
    - MARTINEZ ET AL., CELL, (2002), vol. 110, pages 563 - 574
    - SCHWARZ ET AL., MOLEC. CELL, (2002), vol. 10, pages 537 - 568
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.