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Extract from the Register of European Patents

EP About this file: EP2938351

EP2938351 - SHORT-ACTING FACTOR VII POLYPEPTIDES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.07.2020
Database last updated on 10.08.2024
FormerThe patent has been granted
Status updated on  24.05.2019
FormerGrant of patent is intended
Status updated on  07.01.2019
FormerExamination is in progress
Status updated on  09.06.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Coagulant Therapeutics Corporation
48-6, Gangnam-daero
5F, Hansock Building, Yangjae-dong
Seocho-gu
Seoul / KR
[2019/28]
Former [2019/25]For all designated states
Bayer Healthcare LLC
100 Bayer Boulevard
Whippany, NJ 07981-0915 / US
Former [2015/45]For all designated states
Bayer Healthcare LLC
555 White Plains Road, 5th Floor
Tarrytown, NY 10591-5097 / US
Inventor(s)01 / BAUZON, Maxine
1033 Park Street
Hercules, California 94547 / US
02 / HERMISTON, Terry
305 E. Strawberry Drive
Mill Valley, California 94941 / US
 [2015/45]
Representative(s)Greaves Brewster LLP
Copa House
Station Road
Cheddar, Somerset BS27 3AH / GB
[N/P]
Former [2019/26]Greaves Brewster LLP
Copa House
Station Road
Cheddar, Somerset BS27 3AH / GB
Former [2015/45]BIP Patents
c/o Bayer Intellectual Property GmbH
Alfred-Nobel-Straße 10
40789 Monheim am Rhein / DE
Application number, filing date13867801.623.12.2013
[2015/45]
WO2013US77405
Priority number, dateUS201261745674P24.12.2012         Original published format: US 201261745674 P
US201361787026P15.03.2013         Original published format: US 201361787026 P
[2015/45]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014105784
Date:03.07.2014
Language:EN
[2014/27]
Type: A1 Application with search report 
No.:EP2938351
Date:04.11.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 03.07.2014 takes the place of the publication of the European patent application.
[2015/45]
Type: B1 Patent specification 
No.:EP2938351
Date:26.06.2019
Language:EN
[2019/26]
Type: B8 Corrected title page of specification 
No.:EP2938351
Date:31.07.2019
[2019/31]
Search report(s)International search report - published on:US03.07.2014
(Supplementary) European search report - dispatched on:EP25.07.2016
ClassificationIPC:A61K38/00, A61K38/48, C12N9/64
[2016/34]
CPC:
C12N9/6437 (EP,CN,IL,KR,US); A61K38/00 (EP,CN,IL,KR,US); A61K38/4846 (EP,IL,KR,US);
A61P7/00 (EP,IL); A61P7/04 (EP,IL); C12Y304/21021 (EP,CN,IL,KR,US)
Former IPC [2015/45]A61K38/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/45]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:KURZFRISTIG WIRKENDE FAKTOR-VII-POLYPEPTIDE[2015/45]
English:SHORT-ACTING FACTOR VII POLYPEPTIDES[2015/45]
French:POLYPEPTIDES DE FACTEUR VII À COURTE ACTION[2015/45]
Entry into regional phase24.07.2015National basic fee paid 
24.07.2015Search fee paid 
24.07.2015Designation fee(s) paid 
24.07.2015Examination fee paid 
Examination procedure24.07.2015Examination requested  [2015/45]
31.01.2017Amendment by applicant (claims and/or description)
13.06.2017Despatch of a communication from the examining division (Time limit: M06)
13.12.2017Reply to a communication from the examining division
16.03.2018Despatch of a communication from the examining division (Time limit: M04)
17.07.2018Reply to a communication from the examining division
08.01.2019Communication of intention to grant the patent
13.05.2019Fee for grant paid
13.05.2019Fee for publishing/printing paid
13.05.2019Receipt of the translation of the claim(s)
Divisional application(s)EP16196780.7  / EP3165232
EP19181784.0  / EP3572090
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  13.06.2017
Opposition(s)03.06.2020No opposition filed within time limit [2020/32]
Fees paidRenewal fee
04.01.2016Renewal fee patent year 03
27.12.2016Renewal fee patent year 04
12.12.2017Renewal fee patent year 05
12.12.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU23.12.2013
AL26.06.2019
CY26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
MK26.06.2019
MT26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
LU23.12.2019
[2022/31]
Former [2021/34]HU23.12.2013
AL26.06.2019
CY26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
MT26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
LU23.12.2019
Former [2021/32]HU23.12.2013
AL26.06.2019
CY26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
LU23.12.2019
Former [2021/26]AL26.06.2019
CY26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
LU23.12.2019
Former [2020/46]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
LU23.12.2019
Former [2020/39]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
MC26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/37]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SI26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/36]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/24]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
PT28.10.2019
IS24.02.2020
Former [2020/17]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SK26.06.2019
SM26.06.2019
TR26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/14]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SK26.06.2019
SM26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/12]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
IT26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SK26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
IS26.10.2019
PT28.10.2019
Former [2020/11]AL26.06.2019
CZ26.06.2019
EE26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
SK26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
PT28.10.2019
Former [2020/10]AL26.06.2019
CZ26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RO26.06.2019
RS26.06.2019
SE26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
PT28.10.2019
Former [2020/09]AL26.06.2019
CZ26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RS26.06.2019
SE26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
Former [2019/51]AL26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RS26.06.2019
SE26.06.2019
BG26.09.2019
NO26.09.2019
GR27.09.2019
Former [2019/50]AL26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
LV26.06.2019
RS26.06.2019
SE26.06.2019
NO26.09.2019
GR27.09.2019
Former [2019/49]AL26.06.2019
FI26.06.2019
HR26.06.2019
LT26.06.2019
SE26.06.2019
NO26.09.2019
Former [2019/48]FI26.06.2019
LT26.06.2019
SE26.06.2019
NO26.09.2019
Former [2019/47]FI26.06.2019
LT26.06.2019
NO26.09.2019
Documents cited:Search[X]  - SEESTED TORBEN ET AL, "The unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytes", THROMBOSIS AND HAEMOSTASIS, SCHATTAUER GMBH, DE, (20101210), vol. 104, no. 6, doi:10.1160/TH10-06-0356, ISSN 0340-6245, pages 1166 - 1173, XP008139984 [X] 1-7 * abstract * * Introduction *

DOI:   http://dx.doi.org/10.1160/TH10-06-0356
 [X]  - APPA RUPA S ET AL, "Investigating clearance mechanisms for recombinant activated factor VII in a perfused liver model", THROMBOSIS AND HAEMOSTASIS, SCHATTAUER GMBH, DE, (20100801), vol. 104, no. 2, ISSN 0340-6245, pages 243 - 251, XP009156273 [X] 1-7 * abstract * * the whole document * * Especially * * page 247; figure 3 *

DOI:   http://dx.doi.org/10.1160/TH09-10-0723
International search[Y]WO03093465  (MAXYGEN APS [DK], et al);
 [A]WO2006114105  (MAXYGEN HOLDINGS LTD, et al);
 [A]WO2007013993  (MAXYGEN HOLDINGS LTD, et al);
 [X]US2010028939  (BEHRENS CARSTEN [DK], et al)
by applicantUS5180583
 US2008058255
 US8008252
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    - IWANAGA et al., Thromb. Haemost., (19990800), page 466
    - TOSO et al., "Lack of Heavy Chain Glycosylation in Patient with Factor VII Deficiency Not Responsible for Mutant FVIIa Activity", Blood, (20001116), vol. 96, no. 11, page 79b
    - FEBS Lett., (19880000), vol. 238, no. 1, pages 31 - 34
    - CALICETI P; VERONESE FM, "Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates", Adv Drug Deliv Rev., (20030000), vol. 55, no. 10, doi:doi:10.1016/S0169-409X(03)00108-X, pages 1261 - 77, XP003001867

DOI:   http://dx.doi.org/10.1016/S0169-409X(03)00108-X
    - WEINSTEIN T et al., "Distribution of glycosaminoglycans in rat renal tubular epithelium", J Am Soc Nephrol., (19970000), vol. 8, no. 4, pages 586 - 95
    - CHOI HS et al., "Renal clearance of quantum dots", Nat Biotechnol., (20070000), vol. 25, no. 10, pages 1165 - 70
    - BYRNE B. et al., "Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells", Drug Discovery Today, (20070000), vol. 12, no. 7-8, doi:doi:10.1016/j.drudis.2007.02.010, page 319, XP022003236

DOI:   http://dx.doi.org/10.1016/j.drudis.2007.02.010
    - SAMBROOK et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor
    - GRAHAM et al., J. Gen. Virol., (19770000), vol. 36, pages 59 - 72
    - WAECHTER; BASERGA, Proc. Natl. Acad. Sci. USA, (19820000), vol. 79, pages 1106 - 1110
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