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EP About this file: EP3099706

EP3099706 - PEPTIDE MIMOTOPES OF CLAUDIN 18.2 AND USES THEREOF [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 06.09.2019 Database last updated on 22.05.2024
Former	The patent has been granted Status updated on 28.09.2018
Former	Grant of patent is intended Status updated on 17.05.2018
Former	Examination is in progress Status updated on 08.09.2017
Former	Request for examination was made Status updated on 04.11.2016
Most recent event Tooltip	01.07.2022	Lapse of the patent in a contracting state New state(s): MK	published on 03.08.2022 [2022/31]
Applicant(s)	For all designated states BioNTech AG An der Goldgrube 12 55131 Mainz / DE
	For all designated states TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH Freiligrathstrasse 12 55131 Mainz / DE
	For all designated states JPT Peptide Technologies GmbH Volmerstrasse (UTZ) 5 12489 Berlin / DE
	[2017/20]
Former [2016/49]	For all designated states BioNTech AG An der Goldgrube 12 55131 Mainz / DE
	For all designated states TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH Freiligrathstrasse 12 55131 Mainz / DE
	For all designated states Universitätsmedizin der Johannes Gutenberg-Universität Mainz Langenbeckstrasse 1 55131 Mainz / DE
	For all designated states JPT Peptide Technologies GmbH Volmerstrasse (UTZ) 5 12489 Berlin / DE
Inventor(s)	01 / SAHIN, Ugur Philipp-von-Zabern-Platz 1 55116 Mainz / DE
	02 / DANESCHDAR, Matin Heinrich-Gärtner-Strasse 8 55257 Budenheim / DE
	03 / SCHMOLDT, Hans-Ulrich Akazienstrasse 53 55270 Klein-Winternheim / DE
	04 / PLUM, Laura-Marie Tumblinger Strasse 12 80337 München / DE
	05 / FIEDLER, Markus Kreuzvorwerk 60 06120 Halle an der Saale / DE
	06 / REIMER, Ulf Dunckerstrasse 25 10437 Berlin / DE
	07 / SCHNATBAUM, Karsten Kreutzigerstrasse 26 10247 Berlin / DE
	[2018/44]
Former [2016/49]	01 / SAHIN, Ugur Philipp-von-Zabern-Platz 1 55116 Mainz / DE
	02 / DANESCHDAR, Matin Heinrich-Gärtner-Strasse 8 55257 Budenheim / DE
	03 / SCHMOLDT, Hans-Ulrich Akazienstrasse 53 55270 Klein-Winternheim / DE
	04 / PLUM, Laura-Marie Fritz-Kohl-Strasse 3d 55122 Mainz / DE
	05 / FIEDLER, Markus Kreuzvorwerk 60 06120 Halle an der Saale / DE
	06 / REIMER, Ulf Dunckerstrasse 25 10437 Berlin / DE
	07 / SCHNATBAUM, Karsten Kreutzigerstrasse 26 10247 Berlin / DE
Representative(s)	Schnappauf, Georg ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
	[2018/44]
Former [2016/49]	Schnappauf, Georg ZSP Patentanwälte PartG mbB Radlkoferstrasse 2 81373 München / DE
Application number, filing date	14701918.6	29.01.2014
	[2016/49]
	WO2014EP00244
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2015113576
	Date:	06.08.2015
	Language:	EN
	[2015/31]
	Type:	A1 Application with search report
	No.:	EP3099706
	Date:	07.12.2016
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 06.08.2015 takes the place of the publication of the European patent application.
	[2016/49]
	Type:	B1 Patent specification
	No.:	EP3099706
	Date:	31.10.2018
	Language:	EN
	[2018/44]
Search report(s)	International search report - published on:	EP	06.08.2015
Classification	IPC:	C07K14/705	[2016/49]
	CPC:	C07K14/705 (EP,US); A61K38/08 (US); A61K38/12 (US); A61K39/0005 (US); C07K7/64 (US); G01N33/5308 (EP,US); (+) G01N33/57492 (US); G01N2333/705 (US); G01N2500/02 (US); G01N2500/04 (EP,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2016/49]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	PEPTID-MIMOTOPE VON CLAUDIN 18.2 UND VERWENDUNGEN DAVON	[2016/49]
	English:	PEPTIDE MIMOTOPES OF CLAUDIN 18.2 AND USES THEREOF	[2016/49]
	French:	MIMOTOPES PEPTIDIQUES DE CLAUDINE 18.2 ET LEURS UTILISATIONS	[2016/49]
Entry into regional phase	18.07.2016	National basic fee paid
	18.07.2016	Designation fee(s) paid
	18.07.2016	Examination fee paid
Examination procedure	18.07.2016	Examination requested [2016/49]
	18.07.2016	Date on which the examining division has become responsible
	13.02.2017	Amendment by applicant (claims and/or description)
	08.09.2017	Despatch of a communication from the examining division (Time limit: M04)
	19.12.2017	Reply to a communication from the examining division
	10.01.2018	Despatch of a communication from the examining division (Time limit: M04)
	14.02.2018	Reply to a communication from the examining division
	18.05.2018	Communication of intention to grant the patent
	18.09.2018	Fee for grant paid
	18.09.2018	Fee for publishing/printing paid
	18.09.2018	Receipt of the translation of the claim(s)
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 08.09.2017
Opposition(s)	01.08.2019	No opposition filed within time limit [2019/41]
Fees paid	Renewal fee
	18.07.2016	Renewal fee patent year 03
	25.01.2017	Renewal fee patent year 04
	31.01.2018	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	29.01.2014
	AL	31.10.2018
	AT	31.10.2018
	CY	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	MK	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SI	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	TR	31.10.2018
	IE	29.01.2019
	LU	29.01.2019
	MT	29.01.2019
	BE	31.01.2019
	BG	31.01.2019
	CH	31.01.2019
	LI	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
	[2022/31]
Former [2021/32]	HU	29.01.2014
	AL	31.10.2018
	AT	31.10.2018
	CY	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SI	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	TR	31.10.2018
	IE	29.01.2019
	LU	29.01.2019
	MT	29.01.2019
	BE	31.01.2019
	BG	31.01.2019
	CH	31.01.2019
	LI	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2021/26]	AL	31.10.2018
	AT	31.10.2018
	CY	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SI	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	TR	31.10.2018
	IE	29.01.2019
	LU	29.01.2019
	MT	29.01.2019
	BE	31.01.2019
	BG	31.01.2019
	CH	31.01.2019
	LI	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2020/29]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SI	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	TR	31.10.2018
	IE	29.01.2019
	LU	29.01.2019
	MT	29.01.2019
	BE	31.01.2019
	BG	31.01.2019
	CH	31.01.2019
	LI	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2020/17]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SI	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	TR	31.10.2018
	IE	29.01.2019
	LU	29.01.2019
	BE	31.01.2019
	BG	31.01.2019
	CH	31.01.2019
	LI	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2020/09]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SI	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	IE	29.01.2019
	LU	29.01.2019
	BE	31.01.2019
	BG	31.01.2019
	CH	31.01.2019
	LI	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2020/04]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SI	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	LU	29.01.2019
	BE	31.01.2019
	BG	31.01.2019
	CH	31.01.2019
	LI	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2019/50]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SI	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	LU	29.01.2019
	BE	31.01.2019
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2019/44]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	LU	29.01.2019
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2019/40]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	MC	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SK	31.10.2018
	SM	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2019/37]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	EE	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RO	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	SM	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2019/35]	AL	31.10.2018
	AT	31.10.2018
	CZ	31.10.2018
	DK	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2019/34]	AL	31.10.2018
	AT	31.10.2018
	DK	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2019/26]	AL	31.10.2018
	AT	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
	PT	01.03.2019
Former [2019/25]	AT	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	RS	31.10.2018
	SE	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
Former [2019/24]	AT	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	SE	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	GR	01.02.2019
	IS	28.02.2019
Former [2019/23]	AT	31.10.2018
	FI	31.10.2018
	HR	31.10.2018
	LT	31.10.2018
	LV	31.10.2018
	NL	31.10.2018
	PL	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	IS	28.02.2019
Former [2019/22]	FI	31.10.2018
	LT	31.10.2018
	PL	31.10.2018
	BG	31.01.2019
	NO	31.01.2019
	IS	28.02.2019
Former [2019/21]	FI	31.10.2018
	LT	31.10.2018
	NO	31.01.2019
	IS	28.02.2019
Former [2019/20]	LT	31.10.2018
	NO	31.01.2019
Cited in	International search	[X]WO9816549 (PENCE INC [CA], et al) [X] 1-11,17-23,34,42-44,46 * Abstract; compounds GS14inv, GS14invK1, GS14invV2 (table 7) and GS12 (table 10) *;
		[X] - Masood Jelokhani-Niaraki ET AL, "Diastereoisomeric analogues of gramicidin S: structure, biological activityand interaction with lipid bilayers", Biochem. J, (20000101), pages 747 - 755, URL: http://www.biochemj.org/bj/349/0747/3490747.pdf, (20140303), XP055105044 [X] 1-11,17-23,34,42-44,46 * Abstract; compounds 6-8 (table 1) *
		[X] - ALAN C. GIBBS ET AL, "Unusual [beta]-sheet periodicity in small cyclic peptides", NATURE STRUCTURAL BIOLOGY, (19980401), vol. 5, no. 4, doi:10.1038/nsb0498-284, ISSN 1072-8368, pages 284 - 288, XP055105060 [X] 1-11,17-23,34,42-44,46 * Abstract; peptide 12-mer (table 1) * DOI: http://dx.doi.org/10.1038/nsb0498-284
		[X] - FRECER ET AL, "QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from protegrin-1", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 14, no. 17, ISSN 0968-0896, (20060901), pages 6065 - 6074, (20060901), XP027992880 [X] 1-11,17-23,34,42-44,46 * Abstract; peptide NR1 (table 1) *
		[X] - "SubName: Full=Uncharacterized protein;", UniProt, (20050719), Database accession no. Q4QAP3, XP002721329 [X] 1-12,17-23,34,43,46 * sequence . *
		[X] - "SubName: Full=Uncharacterized protein;", UniProt, (20050719), Database accession no. Q4QIG7, XP002721330 [X] 1-12,17-23,34,43,46 * sequence . *
		[X] - "SubName: Full=Metallo-beta-lactamase superfamily:Flavin reductase-like domain;", UniProt, (20031001), Database accession no. Q7TUJ5, XP002721331 [X] 1-12,17-23,34,43,46 * sequence . *
		[X] - "SubName: Full=Putative uncharacterized protein PF14_0731;", UniProt, (20030301), Database accession no. Q8IK76, XP002721332 [X] 1-12,17-23,34,43,46 * sequence . *
		[X] - "Poribacteria bacterium WGA-3G", UniParc, (20131024), Database accession no. UPI0003B732C0, URL: Uniprot, XP002721333 [X] 1-11,16-23,34,43,46 * sequence . *
		[X] - "Marine metagenome", UniParc, (20070411), Database accession no. UPI00011491B9, URL: Uniprot, XP002721334 [X] 1-11,13,14,16-23,34,43,46 * sequence . *
		[X] - "Tepidanaerobacter acetatoxydans (strain DSM 21804 /JCM 16047 / Ref1)", UniParc, (20130318), Database accession no. UPI0003019F0D, URL: Uniprot, XP002721335 [X] 1-11,13,14,16-23,34,43,46 * sequence . *
		[X] - "Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)", UniParc, (20111027), Database accession no. UPI00022F4FBB, URL: Uniprot, XP002721336 [X] 1-11,13,14,16-23,34,43,46 * sequence . *
		[X] - "SubName: Full=Uncharacterized protein;", UniProt, (20130724), Database accession no. R9K409, XP002721337 [X] 1-11,13,14,16-23,34,43,46 * sequence . *
		[X] - "SubName: Full=Uncharacterized protein;", UniProt, (20120613), Database accession no. I0XL36, XP002721338 [X] 1-11,13,14,16-23,34,43,46 * sequence . *
		[X] - "SubName: Full=Putative uncharacterized protein;", UniProt, (20111019), Database accession no. G0PHM1, XP002721339 [X] 1-11,13,14,16-23,34,43,46 * sequence . *
		[Y] - CASEY JOANNE L ET AL, "Phage display of peptides in ligand selection for use in affinity chromatography", METHODS IN MOLECULAR BIOLOGY, HUMANA PRESS INC, NJ, US, (20080101), vol. 421, ISSN 1064-3745, pages 111 - 124, XP009176648 [Y] 1-47 * the whole document *
		[Y] - DAMEN CAROLA W N ET AL, "Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies", HUMAN ANTIBODIES, IOS PRESS, AMSTERDAM, NL, (20090101), vol. 18, no. 3, doi:10.3233/HAB-2009-0206, ISSN 1093-2607, pages 47 - 73, XP009176631 [Y] 1-47 * the whole document * DOI: http://dx.doi.org/10.3233/HAB-2009-0206
		[YD] - STEFAN WÖLL ET AL, "Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms", INTERNATIONAL JOURNAL OF CANCER, (20130916), doi:10.1002/ijc.28400, ISSN 0020-7136, pages 1 - 9, XP055084209 [YD] 1-47 * the whole document * DOI: http://dx.doi.org/10.1002/ijc.28400
		[YD] - SAHIN UGUR ET AL, "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20081201), vol. 14, no. 23, doi:10.1158/1078-0432.CCR-08-1547, ISSN 1078-0432, pages 7624 - 7634, XP002588324 [YD] 1-47 * the whole document * DOI: http://dx.doi.org/10.1158/1078-0432.CCR-08-1547
		[T] - KARSTEN SCHNATBAUM ET AL, "Peptide microarrays enable rapid mimotope optimization for pharmacokinetic analysis of the novel therapeutic antibody IMAB362", BIOTECHNOLOGY JOURNAL, (20140204), doi:10.1002/biot.201300456, ISSN 1860-6768, pages 1 - 19, XP055105133 [T] 1-47 * the whole document * DOI: http://dx.doi.org/10.1002/biot.201300456
	Examination	US2005214852
		WO2007007116
		WO2012068236
	by applicant	US2003118592
		US2003133939
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