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Extract from the Register of European Patents

EP About this file: EP2988826

EP2988826 - IL4 CONJUGATED TO ANTIBODIES AGAINST EXTRACELLULAR MATRIX COMPONENTS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  04.01.2019
Database last updated on 14.06.2024
FormerExamination is in progress
Status updated on  23.06.2017
Most recent event   Tooltip04.01.2019Application deemed to be withdrawnpublished on 06.02.2019  [2019/06]
Applicant(s)For all designated states
Philogen S.p.A.
Piazza La Lizza, 7
53100 Siena / IT
[2016/09]
Inventor(s)01 / HEMMERLE, Teresa
Lettgräbli 1
CH-9490 Vaduz / LI
02 / NERI, Dario
Zihl Strasse 35
CH-8107 Buchs / CH
 [2016/09]
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[N/P]
Former [2016/09]Keirstead, Tanis Evelyne, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
Application number, filing date14708835.528.02.2014
[2016/09]
WO2014EP53998
Priority number, dateGB2013000759926.04.2013         Original published format: GB 201307599
GB2013001804311.10.2013         Original published format: GB 201318043
GB2013002064722.11.2013         Original published format: GB 201320647
[2016/09]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014173570
Date:30.10.2014
Language:EN
[2014/44]
Type: A1 Application with search report 
No.:EP2988826
Date:02.03.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 30.10.2014 takes the place of the publication of the European patent application.
[2016/09]
Search report(s)International search report - published on:EP30.10.2014
ClassificationIPC:A61P37/00, A61P19/02, A61P17/06, A61P3/10, A61K47/48
[2016/09]
CPC:
A61K38/2026 (EP,US); C07K14/5406 (EP,US); A61K31/573 (US);
A61K39/3955 (EP,US); A61K39/39558 (EP); A61K47/6813 (EP,US);
A61K47/6851 (EP,US); A61P15/00 (EP); A61P17/06 (EP);
A61P19/02 (EP); A61P35/00 (EP); C07K14/5428 (EP);
C07K14/5434 (EP); C07K14/55 (EP); C07K14/70578 (EP);
C07K16/18 (EP,US); C07K16/40 (EP); A61K2039/505 (EP,US);
A61K2039/545 (EP); A61K38/00 (EP); C07K2317/21 (US);
C07K2317/565 (US); C07K2317/626 (EP,US); C07K2317/76 (US);
C07K2317/92 (US); C07K2319/035 (EP,US); C07K2319/30 (EP,US) (-)
C-Set:
A61K39/3955, A61K2300/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/09]
TitleGerman:ZU ANTIKÖRPERN GEGEN EXTRAZELLULÄRE MATRIXKOMPONENTEN KONJUGIERTES IL4[2016/09]
English:IL4 CONJUGATED TO ANTIBODIES AGAINST EXTRACELLULAR MATRIX COMPONENTS[2016/09]
French:IL-4 CONJUGUÉE À DES ANTICORPS CONTRE DES COMPOSANTS DE LA MATRICE EXTRACELLULAIRE[2016/09]
Entry into regional phase13.11.2015National basic fee paid 
13.11.2015Designation fee(s) paid 
13.11.2015Examination fee paid 
Examination procedure11.12.2014Request for preliminary examination filed
International Preliminary Examining Authority: EP
13.11.2015Examination requested  [2016/09]
14.06.2016Amendment by applicant (claims and/or description)
22.06.2017Despatch of a communication from the examining division (Time limit: M04)
25.10.2017Reply to a communication from the examining division
01.09.2018Application deemed to be withdrawn, date of legal effect  [2019/06]
27.09.2018Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2019/06]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  22.06.2017
Fees paidRenewal fee
24.02.2016Renewal fee patent year 03
27.01.2017Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
28.02.201805   M06   Not yet paid
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Cited inInternational search[A]WO0110912  (LEXIGEN PHARM CORP [US]) [A] 1-9,18-25,56-60 * page 16, line 14 - line 16; example 17 *;
 [A]WO2010011697  (IMMUNOMEDICS INC [US], et al) [A] 1-9,18-25,56-60 * claims 31,45 *;
 [Y]WO2013014149  (PHILOGEN SPA [IT], et al) [Y] 3,9,18-20 * claim 12; sequence 32 *;
 [XAY]  - Teresa Hemmerle ET AL, "Doktorandentag -Spring Session 2013 2", Zürich, (20130208), pages 1 - 6, URL: http://www.pharma.ethz.ch/box_feeder/Doktorandentag2013.pdf, (20140602), XP055121083 [X] 1,2,4-8,21-25,56-60 * the whole document * [A] 85-89 [Y] 3,9,18-20
 [Y]  - N. PASCHE ET AL, "The Antibody-Based Delivery of Interleukin-12 to the Tumor Neovasculature Eradicates Murine Models of Cancer in Combination with Paclitaxel", CLINICAL CANCER RESEARCH, (20120612), vol. 18, no. 15, doi:10.1158/1078-0432.CCR-12-0282, ISSN 1078-0432, pages 4092 - 4103, XP055039930 [Y] 3,9,18-20 * the whole document *

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-12-0282
 [XPI]  - TERESA HEMMERLE ET AL, "The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer", INTERNATIONAL JOURNAL OF CANCER, (20130702), vol. 134, no. 2, doi:10.1002/ijc.28359, ISSN 0020-7136, pages 467 - 477, XP055121200 [XP] 1-9,18-25,56-60 * the whole document * [I] 26-51,85-95

DOI:   http://dx.doi.org/10.1002/ijc.28359
 [Y]  - ROLAND E. KONTERMANN, "Antibody-cytokine fusion proteins", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, (20121001), vol. 526, no. 2, doi:10.1016/j.abb.2012.03.001, ISSN 0003-9861, pages 194 - 205, XP055121202 [Y] 3,9,18-20 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.abb.2012.03.001
 [A]  - TRZPIS MONIKA ET AL, "Epithelial cell adhesion molecule - More than a carcinoma marker and adhesion molecule", AMERICAN JOURNAL OF PATHOLOGY; [10640], ELSEVIER INC, US, vol. 171, no. 2, doi:10.2353/AJPATH.2007.070152, ISSN 0002-9440, (20070801), pages 386 - 395, (20070628), XP002581967 [A] 1-9,18-25,56-60 * the whole document *

DOI:   http://dx.doi.org/10.2353/AJPATH.2007.070152
 [A]  - SABINE DENZEL ET AL, "MMP7 is a target of the tumour-associated antigen EpCAM", INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, (20120913), vol. 93, no. 5, doi:10.1111/j.1365-2613.2012.00826.x, ISSN 0959-9673, pages 341 - 353, XP055121392 [A] 1-9,18-25,56-60 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1365-2613.2012.00826.x
 [IAY]  - FONS A VAN DE LOO ET AL, "Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis?", ARTHRITIS RESEARCH & THERAPY, England, (20091106), vol. 11, no. 6, doi:10.1186/ar2835, ISSN 1478-6362, pages 1 - 2, XP055121193 [I] 1-9,18-21,26-44 * the whole document * [A] 85-89 [Y] 1-9,18-21,26-29

DOI:   http://dx.doi.org/10.1186/ar2835
 [IA]  - SCHWAGER KATHRIN ET AL, "Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis", ARTHRITIS RESEARCH AND THERAPY, BIOMED CENTRAL, LONDON, GB, (20090925), vol. 11, no. 5, doi:10.1186/AR2814, ISSN 1478-6354, page R142, XP021065243 [I] 1-9,18-21,26-43 * the whole document * [A] 85-89

DOI:   http://dx.doi.org/10.1186/ar2814
 [YA]  - Kathrin Annina Schwager, "Recombinant antibodies for the imaging and treatment of rheumatoid arthritis and endometriosis", (20100101), pages 1 - 106, URL: http://e-collection.library.ethz.ch/eserv/eth:1816/eth-1816-02.pdf, (20140603), XP055121189 [Y] 1-9,18-21,26-29,44-51 * pages 6,7,34 * * pages 37-42 * * pages 44-51 * * pages 74,93 * [A] 85-89
 [Y]  - MARTIN R, "Interleukin 4 treatment of psoriasis: are pleiotropic cytokines suitable therapies for autoimmune diseases?", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, (20031201), vol. 24, no. 12, doi:10.1016/J.TIPS.2003.10.006, ISSN 0165-6147, pages 613 - 616, XP004476611 [Y] 44-47 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.tips.2003.10.006
 [A]  - LOO VAN DE F A J ET AL, "Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators", RHEUMATIC DISEASES CLINICS OF NORTH AMERICA, W.B. SAUNDERS, PHILADELPHIA, PA, US, (20020201), vol. 28, no. 1, doi:10.1016/S0889-857X(03)00073-5, ISSN 0889-857X, pages 127 - 149, XP009028686 [A] 85-89 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0889-857X(03)00073-5
 [A]  - ARREAZA G A ET AL, "Interleukin-4: Potential immunoregulatory agent in therapy of insulin-dependent diabetes mellitus", EMBASE, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (1996), Database accession no. EMB-1996306612, XP002729061 [A] 34,90-95 * abstract *
    [ ] - ARREAZA G A ET AL, "Interleukin-4: Potential immunoregulatory agent in therapy of insulin-dependent diabetes mellitus", CLINICAL IMMUNOTHERAPEUTICS 1996 NZ, (1996), vol. 6, no. 4, ISSN 1172-7039, pages 251 - 260, XP002086507
 [Y]  - URCELAY E ET AL, "Role of interleukin 4 in Spanish multiple sclerosis patients", JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 168, no. 1-2, ISSN 0165-5728, (20051101), pages 164 - 167, (20051101), XP027673107 [Y] 48-51 * the whole document *
Examination   - Leo A. B. Joosten ET AL, "Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction", Arthritis & Rheumatism, (19970201), vol. 40, no. 2, doi:10.1002/art.1780400209, ISSN 0004-3591, pages 249 - 260, XP055033715

DOI:   http://dx.doi.org/10.1002/art.1780400209
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