EP3003315 - A QUINOLINE INHIBITOR OF THE MACROPHAGE STIMULATING 1 RECEPTOR MST1R [Right-click to bookmark this link] | |||
Former [2016/15] | A QUINOLINE INHIBITOR OF THE MACROPHAGE STIMULATING 1 RECEPTOR MST1 R | ||
[2017/27] | Status | No opposition filed within time limit Status updated on 23.11.2018 Database last updated on 12.07.2024 | |
Former | The patent has been granted Status updated on 15.12.2017 | ||
Former | Grant of patent is intended Status updated on 04.07.2017 | ||
Former | Examination is in progress Status updated on 13.01.2017 | Most recent event Tooltip | 26.06.2020 | Lapse of the patent in a contracting state New state(s): MK | published on 29.07.2020 [2020/31] | Applicant(s) | For all designated states Lead Discovery Center GmbH Otto-Hahn-Strasse 15 44227 Dortmund / DE | [2018/03] |
Former [2016/15] | For all designated states Merck Patent GmbH Frankfurter Strasse 250 64293 Darmstadt / DE | Inventor(s) | 01 /
SCHADT, Oliver Forststrasse 4 63517 Rodenbach / DE | 02 /
ESDAR, Christina Albanusstrasse 82a 55128 Mainz / DE | 03 /
SCHULTZ-FADEMRECHT, Carsten Hollandstrasse 77 c 44309 Dortmund / DE | 04 /
EICKHOFF, Jan Siepen 35 58313 Herdecke / DE | [2018/03] |
Former [2016/15] | 01 /
SCHADT, Oliver Forststrasse 4 63517 Rodenbach / DE | ||
02 /
ESDAR, Christina Albanusstrasse 82a 55128 Mainz / DE | |||
03 /
SCHULTZ-FADEMRECHT, Carsten Scherrweg 37 44309 Dortmund / DE | |||
04 /
EICKHOFF, Jan Am Zickenkamp 6 58313 Heerdecke / DE | Representative(s) | Arth, Hans-Lothar ABK Patent Attorneys Jasminweg 9 14052 Berlin / DE | [2018/03] | Application number, filing date | 14722116.2 | 07.05.2014 | [2016/15] | WO2014EP01231 | Priority number, date | EP20130002926 | 06.06.2013 Original published format: EP 13002926 | [2016/15] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2014194975 | Date: | 11.12.2014 | Language: | EN | [2014/50] | Type: | A1 Application with search report | No.: | EP3003315 | Date: | 13.04.2016 | Language: | EN | The application published by WIPO in one of the EPO official languages on 11.12.2014 takes the place of the publication of the European patent application. | [2016/15] | Type: | B1 Patent specification | No.: | EP3003315 | Date: | 17.01.2018 | Language: | EN | [2018/03] | Search report(s) | International search report - published on: | EP | 11.12.2014 | Classification | IPC: | A61K31/506, A61K31/4709, A61K45/06, A61P35/00, A61P31/00, A61P29/00, A61P27/06, A61P25/28, A61P19/02, A61P17/06, A61P15/00, A61P9/10, C07D401/14 | [2017/27] | CPC: |
C07D401/14 (EP,US);
A61K31/4709 (EP,US);
A61K31/506 (EP,US);
A61K45/06 (US);
A61P15/00 (EP);
A61P17/06 (EP);
A61P19/02 (EP);
A61P25/28 (EP);
A61P27/02 (EP);
A61P27/06 (EP);
A61P29/00 (EP);
A61P31/00 (EP);
A61P31/04 (EP);
A61P35/00 (EP);
A61P43/00 (EP);
A61P9/10 (EP)
(-)
| C-Set: |
A61K31/4709, A61K2300/00 (US,EP);
A61K31/506, A61K2300/00 (EP,US) |
Former IPC [2016/15] | A61K31/506, A61K31/4709, A61K45/06, A61P35/00, A61P31/00, A61P29/00, A61P27/06, A61P25/28, A61P19/02, A61P17/06, A61P15/00, A61P9/10 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2016/15] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | CHINOLIN-DERIVAT ALS INHIBITOR VOM MAKROPHAGEN STIMMULIERENDEN 1 REZEPTOR MST1R | [2017/27] | English: | A QUINOLINE INHIBITOR OF THE MACROPHAGE STIMULATING 1 RECEPTOR MST1R | [2017/27] | French: | DÉRIVÉ DE QUINOLINE EN TANT QU'INHIBITEURS DE RÉCEPTEUR DE STIMULATION DE MACROPHAGES 1 | [2017/27] |
Former [2016/15] | CHINOLININHIBITOR DES MAKROPHAGENSTIMULIERENDEN 1-REZEPTORS MST1-R | ||
Former [2016/15] | A QUINOLINE INHIBITOR OF THE MACROPHAGE STIMULATING 1 RECEPTOR MST1 R | ||
Former [2016/15] | INHIBITEUR QUINOLÉIQUE DU RÉCEPTEUR D'ORIGINE NANTAISE MST1R | Entry into regional phase | 26.10.2015 | National basic fee paid | 26.10.2015 | Designation fee(s) paid | 26.10.2015 | Examination fee paid | Examination procedure | 26.10.2015 | Examination requested [2016/15] | 14.04.2016 | Amendment by applicant (claims and/or description) | 13.01.2017 | Despatch of a communication from the examining division (Time limit: M04) | 07.03.2017 | Reply to a communication from the examining division | 05.07.2017 | Communication of intention to grant the patent | 01.11.2017 | Fee for grant paid | 01.11.2017 | Fee for publishing/printing paid | 06.11.2017 | Receipt of the translation of the claim(s) | Opposition(s) | 18.10.2018 | No opposition filed within time limit [2018/52] | Fees paid | Renewal fee | 10.05.2016 | Renewal fee patent year 03 | 10.05.2017 | Renewal fee patent year 04 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 07.05.2014 | AL | 17.01.2018 | AT | 17.01.2018 | CY | 17.01.2018 | CZ | 17.01.2018 | EE | 17.01.2018 | HR | 17.01.2018 | LT | 17.01.2018 | LV | 17.01.2018 | MC | 17.01.2018 | MK | 17.01.2018 | PL | 17.01.2018 | PT | 17.01.2018 | RO | 17.01.2018 | RS | 17.01.2018 | SI | 17.01.2018 | SK | 17.01.2018 | SM | 17.01.2018 | BG | 17.04.2018 | GR | 18.04.2018 | IE | 07.05.2018 | LU | 07.05.2018 | MT | 07.05.2018 | IS | 17.05.2018 | [2020/31] |
Former [2020/30] | HU | 07.05.2014 | |
AL | 17.01.2018 | ||
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
MC | 17.01.2018 | ||
PL | 17.01.2018 | ||
PT | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SI | 17.01.2018 | ||
SK | 17.01.2018 | ||
SM | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IE | 07.05.2018 | ||
LU | 07.05.2018 | ||
MT | 07.05.2018 | ||
IS | 17.05.2018 | ||
Former [2020/28] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
MC | 17.01.2018 | ||
PL | 17.01.2018 | ||
PT | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SI | 17.01.2018 | ||
SK | 17.01.2018 | ||
SM | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IE | 07.05.2018 | ||
LU | 07.05.2018 | ||
MT | 07.05.2018 | ||
IS | 17.05.2018 | ||
Former [2020/08] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
MC | 17.01.2018 | ||
PL | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SI | 17.01.2018 | ||
SK | 17.01.2018 | ||
SM | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IE | 07.05.2018 | ||
LU | 07.05.2018 | ||
MT | 07.05.2018 | ||
IS | 17.05.2018 | ||
Former [2019/19] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
MC | 17.01.2018 | ||
PL | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SI | 17.01.2018 | ||
SK | 17.01.2018 | ||
SM | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IE | 07.05.2018 | ||
LU | 07.05.2018 | ||
IS | 17.05.2018 | ||
Former [2019/17] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
MC | 17.01.2018 | ||
PL | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SI | 17.01.2018 | ||
SK | 17.01.2018 | ||
SM | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
LU | 07.05.2018 | ||
IS | 17.05.2018 | ||
Former [2019/13] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
MC | 17.01.2018 | ||
PL | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SI | 17.01.2018 | ||
SK | 17.01.2018 | ||
SM | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IS | 17.05.2018 | ||
Former [2019/06] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
MC | 17.01.2018 | ||
PL | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SK | 17.01.2018 | ||
SM | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IS | 17.05.2018 | ||
Former [2018/52] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
PL | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SK | 17.01.2018 | ||
SM | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IS | 17.05.2018 | ||
Former [2018/50] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
CZ | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
PL | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
SK | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IS | 17.05.2018 | ||
Former [2018/49] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
EE | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
PL | 17.01.2018 | ||
RO | 17.01.2018 | ||
RS | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IS | 17.05.2018 | ||
Former [2018/46] | AL | 17.01.2018 | |
AT | 17.01.2018 | ||
CY | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
PL | 17.01.2018 | ||
RS | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IS | 17.05.2018 | ||
Former [2018/40] | AT | 17.01.2018 | |
CY | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
PL | 17.01.2018 | ||
RS | 17.01.2018 | ||
BG | 17.04.2018 | ||
GR | 18.04.2018 | ||
IS | 17.05.2018 | ||
Former [2018/39] | AT | 17.01.2018 | |
CY | 17.01.2018 | ||
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
LV | 17.01.2018 | ||
PL | 17.01.2018 | ||
RS | 17.01.2018 | ||
GR | 18.04.2018 | ||
IS | 17.05.2018 | ||
Former [2018/37] | CY | 17.01.2018 | |
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
PL | 17.01.2018 | ||
GR | 18.04.2018 | ||
Former [2018/36] | CY | 17.01.2018 | |
HR | 17.01.2018 | ||
LT | 17.01.2018 | ||
PL | 17.01.2018 | ||
Former [2018/35] | CY | 17.01.2018 | |
HR | 17.01.2018 | ||
LT | 17.01.2018 | Cited in | International search | [AD]WO2006116713 (AMGEN INC [US], et al) [AD] 1-6 * the whole document ** examples 1-239 *; | [A]WO2007146824 (ARRAY BIOPHARMA INC [US], et al) [A] 1-6 * the whole document * * examples 1-106 *; | [A]EP2423208 (LEAD DISCOVERY CENTER GMBH [DE], et al) [A] 1-6 * the whole document * * examples 1-87 *; | [AD] - TED UNDERINER ET AL, "Discovery of Small Molecule c-Met Inhibitors: Evolution and Profiles of Clinical Candidates", ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, (20100101), vol. 10, no. 1, doi:10.2174/1871520611009010007, ISSN 1871-5206, pages 7 - 27, XP055136161 [AD] 1-6 * the whole document * * tables 12,13,17 * DOI: http://dx.doi.org/10.2174/1871520611009010007 | [AD] - PORTER J, "Small molecule c-Met kinase inhibitors: A review of recent patents", EXPERT OPINION ON THERAPEUTIC PATENTS, INFORMA HEALTHCARE, GB, (20100201), vol. 20, no. 2, ISSN 1354-3776, pages 159 - 177, XP009147272 [AD] 1-6 * the whole document * | [AD] - RAEPPEL S ET AL, "Identification of a novel series of potent RON receptor tyrosine kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 20, no. 9, ISSN 0960-894X, (20100501), pages 2745 - 2749, (20100319), XP027012825 [AD] 1-6 * the whole document * | [AD] - LONGBIN LIU ET AL, "Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (20080701), vol. 51, doi:10.1021/JM800401T, ISSN 0022-2623, pages 3688 - 3691, XP008140337 [AD] 1-6 * the whole document * DOI: http://dx.doi.org/10.1021/jm800401t | by applicant | US6069134 | WO0050032 | WO2006116713 | - WEINSTEIN-OPPENHEIMER ET AL., PHARMA. &. THERAP., (2000), vol. 88, pages 229 - 279 | - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2010), vol. 20, pages 2745 - 2749 | - J.M. O'TOOLE ET AL., CANCER RES., (2006), vol. 66, page 9162 | - P.C. MA; G. MAULIK; J. CHRISTENSEN; R. SALGIA, CANCER METASTASIS REV, (2003), vol. 22, page 309 | - C.W. BIRCHMEIER; W. BIRCHMEIER; E. GHERARDI; G.F. VANDE WOUDE, NAT. REV. MOL. CELL BIOL., (2003), vol. 4, page 915 | - J.G. CHRISTENSEN; J. BURROWS; R. SALGIA, CANCER LETT, (2005), vol. 225, page 1 | - S. CORSO; P.M. COMOGLIO; S. GIORDANO, TRENDS MOL. MED., (2005), vol. 11, page 284 | - C. BOCCACCIO; P.M. COMOGLIO, NAT. REV. CANCER, (2006), vol. 6, page 637 | - B. PERUZZI; D.P. BOTTARO, CLIN. CANCER RES., (2006), vol. 12, page 3657 | - B.S. KNUDSEN; G. VANDE WOUDE, CUR. OPIN. GEN. DEV., (2008), vol. 18, page 87 | - L. TOSCHI; P.A. JANNE, CLIN. CANCER RES., (2008), vol. 14, page 5941 | - I. DUSSAULT; S.F. BELLON, ANTI-CANCER AGENTS MED. CHEM., (2009), vol. 9, page 221 | - N.A. CIPRIANI; 0.0. ABIDOYE; E. VOKES; R. SALGIA, LUNG CANCER, (2009), vol. 63, page 169 | - J. PORTER, EXPERT OPIN. THER. PATENTS, (2010), vol. 20, page 159 | - T.L. UNDERINER; T. HERBERTZ; S.J. MIKNYOCZKI, ANTI-CANCER AGENTS MED. CHEM., (2010), vol. 10, page 7 | - J.ZHANG ET AL., CANCER RES., (2008), vol. 68, page 6680 | - L.LIU ET AL., J. MED. CHEM., (2008), vol. 51, page 3688 | - G.M. SCHROEDER ET AL., J. MED. CHEM., (2009), vol. 52, page 1251 | - INT. J. PHARM., (1995), vol. 115, pages 61 - 67 | - KHWAJA ET AL., EMBO, (1997), vol. 16, pages 2783 - 93 | - WHITE ET AL., ONCOGENE, (2001), vol. 20, pages 7064 - 7072 | - STEPHENS ET AL., BIOCHEMICAL J., (2000), vol. 351, pages 95 - 105 | - ALESSI ET AL., FEBS LETT, (1996), vol. 399, no. 3, pages 333 - 338 | - CAMPOS-GONZAIEZ, R.; GLENNEY, JR., J.R, J. BIOL. CHEM., (1992), vol. 267, page 14535 | - SORG ET AL., J. OF. BIOMOLECULAR SCREENING, (2002), vol. 7, pages 11 - 19 | - SILLS ET AL., J. OF BIOMOLECULAR SCREENING, (2002), pages 191 - 214 |