blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2941247

EP2941247 - BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  07.01.2022
Database last updated on 21.05.2024
FormerGrant of patent is intended
Status updated on  11.04.2021
FormerExamination is in progress
Status updated on  24.11.2017
Most recent event   Tooltip07.01.2022Application deemed to be withdrawnpublished on 09.02.2022  [2022/06]
Applicant(s)For all designated states
Rempex Pharmaceuticals, Inc.
3033 Science Park Road
Suite 200
San Diego, CA 92121 / US
[2015/46]
Inventor(s)01 / REDDY, Raja
5507 Mill Creek Road
San Diego, CA 92130 / US
02 / GLINKA, Tomasz
2112 Patriot Way
Cupertino, CA 95014 / US
03 / TOTROV, Maxim
3310 1st Avenue
3D
San Diego, CA 92103 / US
04 / HECKER, Scott
4802 Rancho Viego Dr.
Del Mar, CA 92014 / US
 [2015/46]
Representative(s)Plougmann Vingtoft a/s
Strandvejen 70
2900 Hellerup / DK
[N/P]
Former [2015/46]Plougmann & Vingtoft A/S
Rued Langgaards Vej 8
2300 Copenhagen S / DK
Application number, filing date14735389.002.01.2014
[2015/46]
WO2014US10107
Priority number, dateUS201361749204P04.01.2013         Original published format: US 201361749204 P
US201361780855P13.03.2013         Original published format: US 201361780855 P
[2015/46]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014107536
Date:10.07.2014
Language:EN
[2014/28]
Type: A1 Application with search report 
No.:EP2941247
Date:11.11.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 10.07.2014 takes the place of the publication of the European patent application.
[2015/46]
Search report(s)International search report - published on:AU10.07.2014
(Supplementary) European search report - dispatched on:EP09.01.2017
ClassificationIPC:A61K31/00, A61K31/69, C07F5/02, A61P31/04, A61K45/06, A61K31/407, A61K31/4196, A61K31/427, A61K31/546, A61P29/00, A61P31/06, A61P31/10, A61P31/12, A61P37/08
[2021/14]
CPC:
A61K31/69 (EP,US); A61K31/407 (EP,US); A61K31/4196 (EP,US);
A61K31/427 (EP,US); A61K31/546 (EP,US); A61K45/06 (EP,US);
A61P29/00 (EP); A61P31/04 (EP); A61P31/06 (EP);
A61P31/10 (EP); A61P31/12 (EP); A61P37/08 (EP);
C07F5/025 (EP,US); Y02A50/30 (EP,US) (-)
C-Set:
A61K31/407, A61K2300/00 (US,EP);
A61K31/4196, A61K2300/00 (US,EP);
A61K31/427, A61K2300/00 (US,EP);
A61K31/546, A61K2300/00 (EP,US);
A61K31/69, A61K2300/00 (EP,US)
(-)
Former IPC [2016/37]A61K31/00, A61K31/69, C07F5/02, A61P31/04, A61K45/06, A61K31/407, A61K31/4196, A61K31/427, A61K31/546
Former IPC [2015/46]A61K31/00, A61K31/69, C07F5/02, A61P31/04
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/46]
TitleGerman:BORSÄUREDERIVATE UND THERAPEUTISCHE VERWENDUNGEN DAVON[2015/46]
English:BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF[2015/46]
French:DÉRIVÉS D'ACIDE BORONIQUE ET LEURS UTILISATIONS THÉRAPEUTIQUES[2015/46]
Entry into regional phase10.07.2015National basic fee paid 
10.07.2015Search fee paid 
10.07.2015Designation fee(s) paid 
10.07.2015Examination fee paid 
Examination procedure03.11.2014Request for preliminary examination filed
International Preliminary Examining Authority: AU
10.07.2015Examination requested  [2015/46]
27.07.2017Amendment by applicant (claims and/or description)
23.11.2017Despatch of a communication from the examining division (Time limit: M06)
31.05.2018Reply to a communication from the examining division
11.03.2020Despatch of a communication from the examining division (Time limit: M06)
18.09.2020Reply to a communication from the examining division
12.04.2021Communication of intention to grant the patent
24.08.2021Application deemed to be withdrawn, date of legal effect  [2022/06]
22.09.2021Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2022/06]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.11.2017
Fees paidRenewal fee
11.01.2016Renewal fee patent year 03
11.01.2017Renewal fee patent year 04
15.01.2018Renewal fee patent year 05
15.01.2019Renewal fee patent year 06
14.01.2020Renewal fee patent year 07
13.01.2021Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO2010130708  (NOVARTIS INT PHARM LTD, et al) [Y] 4,9 * the whole document *;
 [X]EP2508506  (LEK PHARMACEUTICALS [SI]) [X] 1 * page 36; compound IIIc and IIId *;
 [XP]WO2013104897  (UNIV TROMSOE [NO], et al) [XP] 1-3,5,6,8,10,11,13-15 * Compounds of table 1 such as compound 40, page 3 or compound 48, page 36 * * Pharmaceutical compositions with such compounds: claim 20 * * Use of compounds to treat bacterial infections: claims 16-18 *;
 [XY]  - GOROVOY A S ET AL, "Boron-Containing Peptidomimetics - A Novel Class of Selective Anti-tubercular Drugs", CHEMICAL BIOLOGY & DRUG DESIGN (ONLINE), WILEY-BLACKWELL MUNKSGAARD, MUNKSGAARD ? DENMARK, UNITED KINGDOM, UNITED STATES, NETHERLANDS, vol. 81, no. 3, doi:10.1111/CBDD.12091, ISSN 1747-0285, (20121226), pages 408 - 413, (20121226), XP002694240 [X] 1-3,5,6,8,10,11,13-15 * compounds 6g - 7s of table 2 of the general formula 6 and 7 in figure 1, featuring a (optionally substituted) benzyl group for R1 and an amino acid residue for R2 * * Use of such compounds as antibiotic against bacterial infections: see table 1 and 2 * [Y] 4,9

DOI:   http://dx.doi.org/10.1111/CBDD.12091
 [X]  - WEBB ET AL, "Metal catalysed hydroboration of vinyl sulfides, sulfoxides, sulfones, and sulfonates", JOURNAL OF MOLECULAR CATALYSIS A: CHEMICAL, ELSEVIER, AMSTERDAM, NL, (20070829), vol. 275, no. 1-2, doi:10.1016/J.MOLCATA.2007.05.026, ISSN 1381-1169, pages 91 - 100, XP022219963 [X] 1 * compound 3 *

DOI:   http://dx.doi.org/10.1016/j.molcata.2007.05.026
 [A]  - VAULTIER, M. ET AL, "Product subclass 28: vinylboranes", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2005:329437, URL: STN, XP002764965 [A] 1-15 * abstract *
International search[X]WO2010056827  (PROTEZ PHARMACEUTICALS INC [US], et al);
 [X]WO2010130708  (NOVARTIS INT PHARM LTD, et al);
 [XP]WO2013056163  (UNIV CALIFORNIA [US], et al);
 [XP]WO2013092979  (ARES TRADING SA [CH]);
 [X]  - EIDAM O. ET AL., "Design, Synthesis, Crystal Structures and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-lactamase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, (2010), vol. 53, no. 21, pages 7852 - 7863, XP055259885

DOI:   http://dx.doi.org/10.1021/jm101015z
by applicantWO8705297
 US6586615
 WO2004058679
 WO2004064755
 EP1550657
 WO2009046098
 WO2009064414
 WO2009064413
 WO2010130708
 WO2012067664
 WO2012106995
 EP2508506
 WO2013056163
 WO2013104897
    - MONTEFOUR, K. et al., Crit. Care Nurse, (20080000), vol. 28, page 15
    - PEREZ, F. et al., Expert Rev. Anti Infect. Ther., (20080000), vol. 6, page 269
    - BOU, G.MARTINEZ-BELTRAN, J. Antimicrob. Agents Chemother., (20000000), vol. 44, page 1556
    - J. ANTIMICROB. AGENTS CHEMOTHER., (20060000), vol. 50, page 2280
    - GOROVOY, A. S. et al., "Boron-containing Peptidomimetics - A Novel Class of Selectiove Anti-tubercular Drugs", Chemic al Biology & Drug Design (online, (20121226), vol. 81, no. 3, doi:10.1111/CBDD.12091, pages 408 - 413, XP002694240

DOI:   http://dx.doi.org/10.1111/CBDD.12091
    - WEBB, "Metal-catalysed hydroboration of vinyl sulfides", Journal o molecular catalysis, vol. 275, no. 1-2, doi:10.1016/j.molcata.2007.05.026, pages 91 - 100, XP022219963

DOI:   http://dx.doi.org/10.1016/j.molcata.2007.05.026
    - Biochemistry, (20000000), vol. 39, pages 5312 - 21
    - J. Am. Chem. Soc., (19900000), vol. 112, pages 3964 - 969
    - Bioorg. Med.Chem. Lett., (19990000), vol. 9, pages 34 - 346
    - MATTESON, D. S., Tetrahedron, (19890000), vol. 45, no. 7, pages 1859 - 1885
    - MATTESON, D. S., "Asymmetric synthesis with boronic esters", Accounts of Chemical Research, (19880000), vol. 21, no. 8, pages 294 - 300
    - YUEN, A. K. L.HUTTON, C. A., Tetrahedron Letters, (20050000), vol. 46, no. 46, pages 7899 - 7903
    - COUTTS, S. J. et al., Tetrahedron Letters, (19940000), vol. 35, no. 29, pages 5109 - 5112
    - J. Organomet. Chem., (19790000), vol. 170, pages 259 - 64
    - Tetrahedron, (20050000), vol. 61, pages 4427 - 4536
    - J. Am. Chem. Soc., (20110000), vol. 133, pages 409 - 411
    - Tetrahedron Letters, (20030000), vol. 44, pages 233 - 235
    - J. Am. Chem. Soc., (20100000), vol. 132, pages 11825 - 11827
    - J. Org. Chem., (20100000), vol. 75, pages 468 - 471
    - Tetrahedron Lett., (20030000), vol. 44, pages 233 - 235
    - J. Org. Chem., (20130000), vol. 78, pages 8250 - 8266
    - Chem Lett., (19930000), pages 845 - 848
    - Org. Lett., (20110000), vol. 13, pages 3368 - 3371
    - Journal of Medicinal Chemistry, (20080000), vol. 51, pages 1925 - 1944
    - Tetrahedron Lett., (19840000), vol. 25, pages 1103 - 1104
    - J. Med. Chem., (20030000), vol. 46, pages 3437 - 3440
    - Org. React., (19750000), vol. 22, pages 1 - 252
    - POWELL et al., "Compendium of Excipients for Parenteral Formulations", PDA J Pharm Sci and Tech, (19980000), vol. 52, pages 238 - 311, XP009119027
    - NEMA et al., "Excipients and Their Role in Approved Injectable Products: Current Usage and Future Directions", PDA J Pharm Sci and Tech, (20110000), vol. 65, doi:10.5731/pdajpst.2011.00634, pages 287 - 332, XP009166667

DOI:   http://dx.doi.org/10.5731/pdajpst.2011.00634
    - WALEY SG, Biochem J., (19820901), vol. 205, no. 3, pages 631 - 3
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.