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Extract from the Register of European Patents

EP About this file: EP3003348

EP3003348 - CHIMERAS OF BRUCELLA LUMAZINE SYNTHASE AND BETA SUBUNIT OF AB5 TOXINS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.07.2020
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  07.06.2019
FormerGrant of patent is intended
Status updated on  03.12.2018
FormerExamination is in progress
Status updated on  06.01.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Inmunova S.A.
25 de mayo 574 Piso 2 Of. 12
1642 San Isidro - Pcia. de Buenos Aires / AR
For all designated states
Consejo Nacional De Investigaciones Cientificas Y Tecnicas
Avda. Rivadavia 1917
C1033AAJ Buenos Aires / AR
[2019/22]
Former [2019/21]For all designated states
Inmunova S.A.
25 de mayo 574 Piso 2 Of. 12
1642 San Isidro - Pcia. de Buenos Aires / AR
Former [2016/15]For all designated states
Inmunova S.A.
25 de mayo 574 Piso 2 Of. 12
1642 San Isidro - Pcia. de Buenos Aires / AR
For all designated states
Spatz, Martín, Diego, Linus
Dorrego 1441
B1644BSC Victoria - Pcia. de Buenos Aires / AR
Inventor(s)01 / SPATZ, Martín, Diego, Linus
Dorrego 1441
B1644BSC Victoria - Pcia. de Buenos Aires / AR
02 / GOLDBAUM, Fernando, Alberto
Araoz 2719 piso 8
1425 Ciudad Autónoma de Buenos Aires / AR
03 / ZYLBERMAN, Vanesa
Zarraga 3779 piso 1
1427 Ciudad Autónoma de Buenos Aires / AR
04 / CRAIG, Patricio, Oliver
Olazabal 1447 - 6A
1428 Ciudad Autónoma de Buenos Aires / AR
05 / GHERSI, Giselle
Quintino Bocayuva 1171
1257 Ciudad Autónoma de Buenos Aires / AR
06 / PALERMO, Marina, Sandra
Udet 435 - Ciudad Jardin
1684 Palomar - Pcia. de Buenos Aires / AR
07 / MEJIAS, Maria, Pilar
Mitre 667 Dto. 16A
1878 Quilmes - Pcia. de Buenos Aires / AR
08 / BENTANCOR, Leticia, Veronica
Necochea 1307
1888 Florencio Varela - Pcia. de Buenos Aires / AR
 [2016/15]
Representative(s)Hoffmann Eitle
Hoffmann Eitle S.L.U.
Paseo de la Castellana 140, 3a planta
Edificio LIMA
28046 Madrid / ES
[2019/28]
Former [2016/15]Høiberg A/S
St. Kongensgade 59 A
1264 Copenhagen K / DK
Application number, filing date14736442.626.05.2014
[2016/15]
WO2014IB61731
Priority number, dateUS201361827713P27.05.2013         Original published format: US 201361827713 P
[2016/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014191903
Date:04.12.2014
Language:EN
[2014/49]
Type: A1 Application with search report 
No.:EP3003348
Date:13.04.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 04.12.2014 takes the place of the publication of the European patent application.
[2016/15]
Type: B1 Patent specification 
No.:EP3003348
Date:10.07.2019
Language:EN
[2019/28]
Search report(s)International search report - published on:EP04.12.2014
ClassificationIPC:A61K38/16, A61K39/02, A61K39/108
[2016/15]
CPC:
C12N9/1085 (EP,US); A61K38/45 (EP,MX,US); A61K39/0258 (EP,MX,US);
A61K39/098 (EP,MX,US); A61P13/12 (EP); A61P31/04 (EP);
A61P37/04 (EP); A61P7/00 (EP); C07K14/245 (US);
C07K16/1232 (EP,US); C07K16/18 (EP,US); C07K16/40 (US);
A61K2039/505 (EP,US); A61K2039/523 (EP,US); A61K2039/545 (EP,US);
A61K2039/55505 (EP,US); A61K2039/55566 (EP,US); A61K2039/575 (US);
A61K2039/6037 (US); A61K2039/6068 (EP,US); A61K38/00 (EP,US);
C07K2317/20 (US); C07K2317/22 (EP,US); C07K2317/31 (EP,US);
C07K2317/565 (EP,US); C07K2317/569 (EP,US); C07K2317/76 (EP,US);
C07K2319/55 (EP,US); C12Y205/01078 (EP,US); Y02A50/30 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/15]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:CHIMÄREN AUS BRUCELLA-LUMAZIN-SYNTHASE UND BETA-UNTEREINHEIT VON AB5-TOXINEN[2016/15]
English:CHIMERAS OF BRUCELLA LUMAZINE SYNTHASE AND BETA SUBUNIT OF AB5 TOXINS[2016/15]
French:CHIMÈRES DE LUMAZINE SYNTHASE DE BRUCELLA ET SOUS-UNITÉ BÊTA DES TOXINES AB5[2016/15]
Entry into regional phase04.01.2016National basic fee paid 
04.01.2016Designation fee(s) paid 
04.01.2016Examination fee paid 
Examination procedure27.03.2015Request for preliminary examination filed
International Preliminary Examining Authority: EP
18.12.2015Amendment by applicant (claims and/or description)
04.01.2016Examination requested  [2016/15]
11.01.2017Invitation to indicate the basis for amendments (Time limit: M01)
14.02.2017Reply to an invitation to indicate the basis for amendments
23.02.2017Despatch of a communication from the examining division (Time limit: M02)
28.04.2017Reply to a communication from the examining division
04.09.2017Despatch of a communication from the examining division (Time limit: M04)
05.01.2018Reply to a communication from the examining division
10.09.2018Despatch of a communication from the examining division (Time limit: M02)
29.10.2018Reply to a communication from the examining division
04.12.2018Communication of intention to grant the patent
12.04.2019Fee for grant paid
12.04.2019Fee for publishing/printing paid
12.04.2019Receipt of the translation of the claim(s)
Opposition(s)03.06.2020No opposition filed within time limit [2020/32]
Fees paidRenewal fee
23.05.2016Renewal fee patent year 03
26.05.2017Renewal fee patent year 04
23.05.2018Renewal fee patent year 05
28.05.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.05.2014
AL10.07.2019
AT10.07.2019
CY10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
MC10.07.2019
MK10.07.2019
MT10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SI10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
IE26.05.2020
LU26.05.2020
BE31.05.2020
CH31.05.2020
LI31.05.2020
[2022/32]
Former [2022/27]HU26.05.2014
AL10.07.2019
AT10.07.2019
CY10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
MC10.07.2019
MT10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SI10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
IE26.05.2020
LU26.05.2020
BE31.05.2020
CH31.05.2020
LI31.05.2020
Former [2021/24]AL10.07.2019
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FI10.07.2019
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LV10.07.2019
MC10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SI10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
IE26.05.2020
LU26.05.2020
BE31.05.2020
CH31.05.2020
LI31.05.2020
Former [2021/20]AL10.07.2019
AT10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
MC10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SI10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
IE26.05.2020
LU26.05.2020
CH31.05.2020
LI31.05.2020
Former [2021/15]AL10.07.2019
AT10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
MC10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SI10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
LU26.05.2020
CH31.05.2020
LI31.05.2020
Former [2021/12]AL10.07.2019
AT10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
MC10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SI10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
CH31.05.2020
LI31.05.2020
Former [2021/07]AL10.07.2019
AT10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SI10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
CH31.05.2020
LI31.05.2020
Former [2020/37]AL10.07.2019
AT10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
PL10.07.2019
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RS10.07.2019
SI10.07.2019
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SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
Former [2020/36]AL10.07.2019
AT10.07.2019
CZ10.07.2019
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EE10.07.2019
FI10.07.2019
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LV10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
Former [2020/27]AL10.07.2019
AT10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
PL10.07.2019
RO10.07.2019
RS10.07.2019
SK10.07.2019
SM10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
PT11.11.2019
IS24.02.2020
Former [2020/25]AL10.07.2019
AT10.07.2019
CZ10.07.2019
DK10.07.2019
EE10.07.2019
FI10.07.2019
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RO10.07.2019
RS10.07.2019
SK10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
PT11.11.2019
IS24.02.2020
Former [2020/24]AL10.07.2019
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DK10.07.2019
EE10.07.2019
FI10.07.2019
HR10.07.2019
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PL10.07.2019
RO10.07.2019
RS10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
PT11.11.2019
IS24.02.2020
Former [2020/23]AL10.07.2019
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EE10.07.2019
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PL10.07.2019
RO10.07.2019
RS10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
Former [2020/22]AL10.07.2019
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DK10.07.2019
EE10.07.2019
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RS10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
Former [2020/17]AL10.07.2019
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FI10.07.2019
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RS10.07.2019
TR10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
Former [2020/15]AL10.07.2019
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FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
RS10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
Former [2020/12]AT10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
RS10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
IS10.11.2019
PT11.11.2019
Former [2020/11]AT10.07.2019
FI10.07.2019
HR10.07.2019
LT10.07.2019
LV10.07.2019
RS10.07.2019
BG10.10.2019
NO10.10.2019
GR11.10.2019
PT11.11.2019
Former [2020/10]AT10.07.2019
FI10.07.2019
LT10.07.2019
BG10.10.2019
NO10.10.2019
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Former [2020/09]FI10.07.2019
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NO10.10.2019
Cited inInternational search[Y]WO2005121330  (GOLDGENE LLC [AR]) [Y] 1-42 * The whole document, in particular, Example 13, Fig.28 (peptides with >95% identity to SEQ ID NO:3 and 5) *;
 [Y]CN102532324  (QINGDAO BAOMAIDE BIOLOG MEDICAL TECHNOLOGY CO LTD) [Y] 1-42 * The whole document, in particular, SEQ ID NO: 2 and 12 (>95% identity to SEQ ID NO:3,5,7,9 of present application) *;
 [Y]  - PAULA ALVAREZ ET AL, "Tandem repeats of the extracellular domain of Matrix 2 influenza protein exposed in Brucella lumazine synthase decameric carrier molecule induce protection in mice", VACCINE, (20130101), vol. 31, no. 5, doi:10.1016/j.vaccine.2012.11.072, ISSN 0264-410X, pages 806 - 812, XP055138225 [Y] 1-42 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.vaccine.2012.11.072
 [Y]  - BELLIDO D ET AL, "Brucella spp. lumazine synthase as a bovine rotavirus antigen delivery system", VACCINE, ELSEVIER LTD, GB, vol. 27, no. 1, doi:10.1016/J.VACCINE.2008.10.018, ISSN 0264-410X, (20090101), pages 136 - 145, (20081028), XP025714119 [Y] 1-42 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.vaccine.2008.10.018
 [Y]  - PAOLA MARCATO ET AL, "Immunoprophylactic Potential of Cloned Shiga Toxin 2 B Subunit", THE JOURNAL OF INFECTIOUS DISEASES, (20000330), vol. 183, no. 3, doi:10.1086/318080, ISSN 0022-1899, pages 435 - 443, XP055138263 [Y] 1-42 * the whole document *

DOI:   http://dx.doi.org/10.1086/318080
 [Y]  - L. V. BENTANCOR ET AL, "A DNA Vaccine Encoding the Enterohemorragic Escherichia coli Shiga-Like Toxin 2 A2 and B Subunits Confers Protective Immunity to Shiga Toxin Challenge in the Murine Model", CLINICAL AND VACCINE IMMUNOLOGY, (20090501), vol. 16, no. 5, doi:10.1128/CVI.00328-08, ISSN 1556-6811, pages 712 - 718, XP055138258 [Y] 1-42 * the whole document *

DOI:   http://dx.doi.org/10.1128/CVI.00328-08
 [XP]  - L. V. BENTANCOR ET AL, "Promoter Sequence of Shiga Toxin 2 (Stx2) Is Recognized In Vivo, Leading to Production of Biologically Active Stx2", MBIO, (20131001), vol. 4, no. 5, doi:10.1128/mBio.00501-13, ISSN 2150-7511, pages e00501 - 13, XP055138223 [XP] 1-42 * The whole document, in particular, p.5, col.1, §2 *

DOI:   http://dx.doi.org/10.1128/mBio.00501-13
 [XP]  - M. P. MEJIAS ET AL, "Immunization with a Chimera Consisting of the B Subunit of Shiga Toxin Type 2 and Brucella Lumazine Synthase Confers Total Protection against Shiga Toxins in Mice", THE JOURNAL OF IMMUNOLOGY, (20130805), vol. 191, no. 5, doi:10.4049/jimmunol.1300999, ISSN 0022-1767, pages 2403 - 2411, XP055138224 [XP] 1-42 * the whole document *

DOI:   http://dx.doi.org/10.4049/jimmunol.1300999
Examination   - PILAR MEJIAS MARIA ET AL, "Protection of Mice against Shiga Toxin 2 (Stx2)-Associated Damage by Maternal Immunization with a Brucella Lumazine Synthase-Stx2 B Subunit Chimera", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, (20140401), vol. 82, no. 4, doi:10.1128/IAI.00027-14, ISSN 0019-9567, pages 1491 - 1499, XP009179980

DOI:   http://dx.doi.org/10.1128/IAI.00027-14
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