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Extract from the Register of European Patents

EP About this file: EP2956175

EP2956175 - CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.08.2018
Database last updated on 06.07.2024
FormerThe patent has been granted
Status updated on  01.09.2017
FormerGrant of patent is intended
Status updated on  08.05.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
The Regents of the University of California
1111 Franklin Street, 12th Floor
Oakland, CA 94607-5200 / US
[2015/52]
Inventor(s)01 / WU, Chia-Yung
1 Hawthorne Street
Unit 4F
San Francisco California 94105 / US
02 / ONUFFER, James
1032 Fountain Street
Alameda California 94501 / US
03 / LIM, Wendell A.
149 Collins Street
San Francisco California 94118 / US
 [2015/52]
Representative(s)Brasnett, Adrian Hugh, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[2015/52]
Application number, filing date14751227.114.02.2014
[2015/52]
WO2014US16527
Priority number, dateUS201361765585P15.02.2013         Original published format: US 201361765585 P
[2015/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014127261
Date:21.08.2014
Language:EN
[2014/34]
Type: A1 Application with search report 
No.:EP2956175
Date:23.12.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 21.08.2014 takes the place of the publication of the European patent application.
[2015/52]
Type: B1 Patent specification 
No.:EP2956175
Date:04.10.2017
Language:EN
[2017/40]
Search report(s)International search report - published on:US21.08.2014
(Supplementary) European search report - dispatched on:EP25.07.2016
ClassificationIPC:A61K48/00, C07K14/705, C07K16/28, C12N5/0783, A61K35/17, C07K14/725, C07K16/18, C12N9/14, C12N9/90, A61K39/00
[2017/19]
CPC:
A61P35/00 (EP,IL,KR); C07K14/7051 (EP,IL,KR,US); C07K14/705 (EP,IL,KR,US);
A61K35/17 (US); A61K39/4611 (EP,IL,KR); A61K39/4631 (EP,IL,KR);
A61K39/464412 (EP,IL,KR); A61K39/464468 (EP,IL,KR); A61K47/6891 (EP,IL,US);
A61P37/04 (EP,IL); A61P43/00 (EP,IL); C07K14/70517 (IL,KR);
C07K14/70521 (IL,US); C07K14/70575 (IL,US); C07K14/70578 (EP,IL,KR,US);
C07K16/18 (EP,IL,US); C07K16/2803 (IL,KR,US); C07K16/2866 (EP,IL,US);
C07K16/2878 (EP,IL); C07K16/30 (IL,KR); C12N5/0636 (EP,IL,KR,US);
C12N9/14 (EP,IL,US); C12N9/90 (EP,IL,KR,US); C12Y502/01008 (EP,IL,KR,US);
A61K2039/505 (EP,IL,US); A61K2239/23 (EP,IL,KR); A61K2239/24 (EP,IL,KR);
A61K2239/31 (EP,IL,KR); A61K2239/38 (EP,IL,KR); C07K2317/622 (EP,IL,KR,US);
C07K2319/00 (EP,IL,US); C07K2319/03 (EP,IL,KR,US); C07K2319/20 (EP,IL,KR,US);
C07K2319/33 (EP,IL,US); C07K2319/70 (EP,IL); C07K2319/74 (EP,IL,US);
C12N2510/00 (IL,KR,US) (-)
Former IPC [2016/34]A61K48/00, C07K14/705, C07K16/28, C12N5/0783, A61K47/48, A61K35/17, C07K14/725, C07K16/18, C12N9/14, C12N9/90, A61K39/00
Former IPC [2015/52]A61K48/00, C07K14/705, C07K16/28, C12N5/0783
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/52]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:CHIMÄRER ANTIGEN-REZEPTOR UND VERFAHREN ZUR VERWENDUNG DAVON[2015/52]
English:CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF[2015/52]
French:RÉCEPTEUR D'ANTIGÈNE CHIMÈRE ET PROCÉDÉS D'UTILISATION DE CELUI-CI[2015/52]
Entry into regional phase19.08.2015National basic fee paid 
19.08.2015Search fee paid 
19.08.2015Designation fee(s) paid 
19.08.2015Examination fee paid 
Examination procedure19.08.2015Examination requested  [2015/52]
27.10.2016Amendment by applicant (claims and/or description)
09.05.2017Communication of intention to grant the patent
23.08.2017Fee for grant paid
23.08.2017Fee for publishing/printing paid
23.08.2017Receipt of the translation of the claim(s)
Divisional application(s)EP17187293.0  / EP3300745
EP19188398.2  / EP3613439
EP21158396.8  / EP3881868
EP23198143.2
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  09.05.2017
Opposition(s)05.07.2018No opposition filed within time limit [2018/37]
Fees paidRenewal fee
26.02.2016Renewal fee patent year 03
27.02.2017Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL04.10.2017
CY04.10.2017
EE04.10.2017
HR04.10.2017
LV04.10.2017
MK04.10.2017
RO04.10.2017
RS04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
MT14.02.2018
[2020/34]
Former [2020/31]CY04.10.2017
EE04.10.2017
HR04.10.2017
LV04.10.2017
MK04.10.2017
RO04.10.2017
RS04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
MT14.02.2018
Former [2020/08]EE04.10.2017
HR04.10.2017
LV04.10.2017
RO04.10.2017
RS04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
MT14.02.2018
Former [2018/52]EE04.10.2017
HR04.10.2017
LV04.10.2017
RO04.10.2017
RS04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
Former [2018/40]EE04.10.2017
HR04.10.2017
LV04.10.2017
RO04.10.2017
RS04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
Former [2018/37]EE04.10.2017
HR04.10.2017
LV04.10.2017
RS04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
Former [2018/25]HR04.10.2017
LV04.10.2017
RS04.10.2017
BG04.01.2018
Documents cited:Search[E]WO2015057852  (CALIFORNIA INST BIOMEDICAL RES [US], et al) [E] 1-19* the whole document *;
 [E]WO2015142661  (NOVARTIS AG [CH], et al) [E] 1-19 * the whole document *;
 [A]  - SADELAIN M ET AL, "The promise and potential pitfalls of chimeric antigen receptors", CURRENT OPINION IN IMMUNOLOGY, ELSEVIER, OXFORD, GB, vol. 21, no. 2, doi:10.1016/J.COI.2009.02.009, ISSN 0952-7915, (20090401), pages 215 - 223, (20090325), XP026058399 [A] 1-19 * abstract * * page 218; table 2 * * page 219, column r, paragraph 2 - paragraph 4 *

DOI:   http://dx.doi.org/10.1016/j.coi.2009.02.009
 [A]  - ROBERT DEROSE ET AL, "Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology", PFLUEGERS ARCHIV: EUROPEAN JOURNAL OF PHYSIOLOGY, DE, (20130109), vol. 465, no. 3, doi:10.1007/s00424-012-1208-6, ISSN 0031-6768, pages 409 - 417, XP055221913 [A] 1-19 * abstract * * page 410, paragraph 1 * * figure 1 *

DOI:   http://dx.doi.org/10.1007/s00424-012-1208-6
International search[Y]WO2011119773  (ROETH JEREMIAH F [US], et al);
 [Y]WO2012099973  (UNIV PENNSYLVANIA [US], et al);
 [Y]  - FEGAN ET AL., "Chemically controlled protein assembly: techniques and applications.", CHEM REV, (20100609), vol. 110, no. 6, pages 3315 - 36, XP055221903

DOI:   http://dx.doi.org/10.1021/cr8002888
 [A]  - PORTER ET AL., "Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.", N ENGL J MED, (20110825), vol. 365, no. 8, pages 725 - 733, XP055052475

DOI:   http://dx.doi.org/10.1056/NEJMoa1103849
 [A]  - DEROSE ET AL., "Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology.", PFLUGERS ARCH, (201303), vol. 465, no. 3, pages 409 - 417, XP055221913

DOI:   http://dx.doi.org/10.1007/s00424-012-1208-6
 [A]  - DI STASI ET AL., "Inducible apoptosis as a safety switch for adoptive cell therapy.", N ENGL J MED, (20111103), vol. 365, no. 18, pages 1673 - 83, XP055181696

DOI:   http://dx.doi.org/10.1056/NEJMoa1106152
 [A]  - GRAEF ET AL., "Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70.", EMBO J, (19970915), vol. 16, no. 18, pages 5618 - 2628, XP055263591

DOI:   http://dx.doi.org/10.1093/emboj/16.18.5618
 [A]  - KLOSS ET AL., "Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells", NAT BIOTECHNOL, (20121216), vol. 31, no. 1, pages 71 - 75, XP055130697

DOI:   http://dx.doi.org/10.1038/nbt.2459
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