blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2966069

EP2966069 - PREPARATION OF 3-[(S)-7-BROMO-2-(2-HYDROXY-PROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONIC ACID METHYL ESTER WITH A WORK-UP METHOD WITHOUT AMMONIUM CONTAINING SOLUTIONS [Right-click to bookmark this link]
Former [2016/02]OXIDATION REACTION WITH EXCELLENT CONVERSION RATE
[2019/32]
StatusNo opposition filed within time limit
Status updated on  13.11.2020
Database last updated on 06.07.2024
FormerThe patent has been granted
Status updated on  06.12.2019
FormerGrant of patent is intended
Status updated on  23.07.2019
FormerExamination is in progress
Status updated on  19.01.2018
FormerRequest for examination was made
Status updated on  10.07.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Paion UK Limited
Chivers Way
Histon, Cambridge CB24 9ZR / GB
[2016/02]
Inventor(s)01 / KAWAKAMI, Yuji
c/o ONO PHARMACEUTICAL CO. LTD.
50-10 Yamagishi
Mikuni-cho
Sakai-shi Fukui 913-8538 / JP
02 / MURASE, Tatsushi
c/o ONO PHARMACEUTICAL CO. LTD.
50-10 Yamagishi
Mikuni-cho
Sakai-shi Fukui 913-8538 / JP
03 / TANAKA, Daisuke
c/o ONO PHARMACEUTICAL CO. LTD.
50-10 Yamagishi
Mikuni-cho
Sakai-shi Fukui 913-8538 / JP
04 / YOSHIYAMA, Hideyuki
c/o ONO PHARMACEUTICAL CO. LTD.
50-10 Yamagishi
Mikuni-cho
Sakai-shi Fukui 913-8538 / JP
05 / KUWABE, Shinitsu
c/o ONO PHARMACEUTICAL CO. LTD.
50-10 Yamagishi
Mikuni-cho
Sakai-shi Fukui 913-8538 / JP
 [2016/02]
Representative(s)König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB München
Mönchenwerther Straße 11
40545 Düsseldorf / DE
[N/P]
Former [2016/02]König Szynka Tilmann von Renesse Patentanwälte Partnerschaft mbB
Mönchenwerther Straße 11
40545 Düsseldorf / DE
Application number, filing date14759551.603.03.2014
[2016/02]
WO2014JP55329
Priority number, dateJP2013004149204.03.2013         Original published format: JP 2013041492
[2016/02]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014136730
Date:12.09.2014
Language:JA
[2014/37]
Type: A1 Application with search report 
No.:EP2966069
Date:13.01.2016
Language:EN
[2016/02]
Type: B1 Patent specification 
No.:EP2966069
Date:08.01.2020
Language:EN
[2020/02]
Search report(s)International search report - published on:JP12.09.2014
(Supplementary) European search report - dispatched on:EP03.11.2016
ClassificationIPC:C07D401/04, B01J31/02, C07D487/04, A61K31/5517, A61P25/02, A61P25/20, C07B61/00
[2016/02]
CPC:
C07D401/04 (EP,EA,US); A61K31/5517 (EP,EA,US); A61P25/02 (EP);
A61P25/20 (EP); B01J31/0235 (EP,EA,US); C07D487/04 (EP,EA,US);
B01J2231/763 (EP,EA,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/02]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:HERSTELLUNG VON 3-[(S)-7-BROMO-2-(2-HYDROXY-PROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONSÄUREMETHYLESTER MIT EINER AUFARBEITUNGSMETHODE OHNE AMMONIUM-ENTHALTENDEN LÖSUNGEN[2019/32]
English:PREPARATION OF 3-[(S)-7-BROMO-2-(2-HYDROXY-PROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONIC ACID METHYL ESTER WITH A WORK-UP METHOD WITHOUT AMMONIUM CONTAINING SOLUTIONS[2019/32]
French:PRÉPARATION DE .... 3-[(S)-7-BROMO-2-(2-HYDROXY-PROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONIC ACID METHYL ESTER WITH A WORK-UP METHOD WITHOUT AMMONIUM CONTAINING SOLUTIONS[2019/32]
Former [2016/02]OXIDATIONSREAKTION MIT HERVORRAGENDER UMWANDLUNGSRATE
Former [2016/02]OXIDATION REACTION WITH EXCELLENT CONVERSION RATE
Former [2016/02]RÉACTION D'OXYDATION À UN EXCELLENT TAUX DE CONVERSION
Entry into regional phase02.10.2015Translation filed 
02.10.2015National basic fee paid 
02.10.2015Search fee paid 
02.10.2015Designation fee(s) paid 
02.10.2015Examination fee paid 
Examination procedure02.10.2015Examination requested  [2016/02]
11.07.2017Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
15.09.2017Amendment by applicant (claims and/or description)
23.01.2018Despatch of a communication from the examining division (Time limit: M06)
02.08.2018Reply to a communication from the examining division
21.11.2018Despatch of a communication from the examining division (Time limit: M04)
01.04.2019Reply to a communication from the examining division
24.07.2019Communication of intention to grant the patent
28.11.2019Fee for grant paid
28.11.2019Fee for publishing/printing paid
28.11.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.01.2018
Opposition(s)09.10.2020No opposition filed within time limit [2020/51]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
15.09.2017Request for further processing filed
15.09.2017Full payment received (date of receipt of payment)
Request granted
27.09.2017Decision despatched
Fees paidRenewal fee
30.03.2016Renewal fee patent year 03
30.03.2017Renewal fee patent year 04
28.03.2018Renewal fee patent year 05
27.03.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.03.2014
AL08.01.2020
AT08.01.2020
CY08.01.2020
CZ08.01.2020
DK08.01.2020
EE08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
IT08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
MK08.01.2020
MT08.01.2020
NL08.01.2020
PL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SI08.01.2020
SK08.01.2020
SM08.01.2020
IE03.03.2020
LU03.03.2020
FR08.03.2020
BE31.03.2020
CH31.03.2020
LI31.03.2020
BG08.04.2020
GB08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
DE01.10.2020
[2022/31]
Former [2022/30]HU03.03.2014
AL08.01.2020
AT08.01.2020
CY08.01.2020
CZ08.01.2020
DK08.01.2020
EE08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
IT08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
MT08.01.2020
NL08.01.2020
PL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SI08.01.2020
SK08.01.2020
SM08.01.2020
IE03.03.2020
LU03.03.2020
FR08.03.2020
BE31.03.2020
CH31.03.2020
LI31.03.2020
BG08.04.2020
GB08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
DE01.10.2020
Former [2022/27]HU03.03.2014
AT08.01.2020
CY08.01.2020
CZ08.01.2020
DK08.01.2020
EE08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
IT08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
MT08.01.2020
NL08.01.2020
PL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SI08.01.2020
SK08.01.2020
SM08.01.2020
IE03.03.2020
LU03.03.2020
FR08.03.2020
BE31.03.2020
CH31.03.2020
LI31.03.2020
BG08.04.2020
GB08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
DE01.10.2020
Former [2021/22]AT08.01.2020
CZ08.01.2020
DK08.01.2020
EE08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
IT08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
NL08.01.2020
PL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SI08.01.2020
SK08.01.2020
SM08.01.2020
IE03.03.2020
LU03.03.2020
FR08.03.2020
BE31.03.2020
CH31.03.2020
LI31.03.2020
BG08.04.2020
GB08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
DE01.10.2020
Former [2021/10]AT08.01.2020
CZ08.01.2020
DK08.01.2020
EE08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
IT08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
NL08.01.2020
PL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SI08.01.2020
SK08.01.2020
SM08.01.2020
IE03.03.2020
LU03.03.2020
FR08.03.2020
BE31.03.2020
CH31.03.2020
LI31.03.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
DE01.10.2020
Former [2021/07]CZ08.01.2020
DK08.01.2020
EE08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
NL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SK08.01.2020
SM08.01.2020
IE03.03.2020
LU03.03.2020
FR08.03.2020
CH31.03.2020
LI31.03.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
DE01.10.2020
Former [2021/04]CZ08.01.2020
DK08.01.2020
EE08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
NL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SK08.01.2020
SM08.01.2020
LU03.03.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
Former [2020/50]CZ08.01.2020
DK08.01.2020
EE08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
NL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SK08.01.2020
SM08.01.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
Former [2020/49]CZ08.01.2020
DK08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
MC08.01.2020
NL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SK08.01.2020
SM08.01.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
Former [2020/48]DK08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
NL08.01.2020
RO08.01.2020
RS08.01.2020
SE08.01.2020
SM08.01.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
Former [2020/47]DK08.01.2020
ES08.01.2020
FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
NL08.01.2020
RS08.01.2020
SE08.01.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
Former [2020/40]FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
NL08.01.2020
RS08.01.2020
SE08.01.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
IS08.05.2020
PT31.05.2020
Former [2020/39]FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
NL08.01.2020
RS08.01.2020
SE08.01.2020
BG08.04.2020
NO08.04.2020
GR09.04.2020
PT31.05.2020
Former [2020/38]FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
NL08.01.2020
RS08.01.2020
SE08.01.2020
NO08.04.2020
GR09.04.2020
PT31.05.2020
Former [2020/37]FI08.01.2020
HR08.01.2020
LT08.01.2020
LV08.01.2020
NL08.01.2020
RS08.01.2020
SE08.01.2020
NO08.04.2020
PT31.05.2020
Former [2020/36]FI08.01.2020
LT08.01.2020
NL08.01.2020
RS08.01.2020
NO08.04.2020
PT31.05.2020
Former [2020/35]FI08.01.2020
LT08.01.2020
NL08.01.2020
NO08.04.2020
Former [2020/33]NL08.01.2020
Documents cited:Search   [ ] - No further relevant documents disclosed
International search[A]JP2002544266  (GLAXO GROUP LTD.);
 [Y]WO2009145323  (NISSAN CHEMICAL IND LTD [JP], et al);
 [A]JP2009542787  (PAION UK LTD.);
 [Y]WO2010116794  (JUJO PAPER CO LTD [JP], et al);
 [X]WO2011032692  (PAION UK LTD [GB], et al);
 [Y]JP2011153104  (NISSHINBO HOLDINGS INC, et al);
 [Y]  - SHIBUYA MASATOSHI ET AL., "Oxidation of nitroxyl radicals: electrochemical and computational studies", TETRAHEDRON LETTERS, (20120418), vol. 53, no. 16, doi:10.1016/J.TETLET.2012.02.033, pages 2070 - 2073, XP028468903

DOI:   http://dx.doi.org/10.1016/j.tetlet.2012.02.033
 [Y]  - HAYASHI MASAKI ET AL., "Oxidative Conversion of Silyl Enol Ethers to alpha, beta-Unsaturated Ketones Employing Oxoammonium Salts", ORGANIC LETTERS, (20120101), vol. 14, no. 1, doi:10.1021/OL2029417, pages 154 - 157, XP055183107

DOI:   http://dx.doi.org/10.1021/ol2029417
 [Y]  - MASAKI HAYASHI ET AL., "9-Azanoradamantane N- Oxyl (Nor-AZADO): A Highly Active Organocatalyst for Alcohol Oxidation", CHEM. PHARM. BULL., (20110101), vol. 59, no. 12, doi:10.1248/CPB.59.1570, pages 1570 - 1573, XP055183110

DOI:   http://dx.doi.org/10.1248/cpb.59.1570
 [Y]  - MASATOSHI SHIBUYA ET AL., "Highly Efficient, Organocatalytic Aerobic Alcohol Oxidation", JOURNAL OF AMERICAN CHEMICAL SOCIETY, (20110101), vol. 133, no. 17, doi:10.1021/JA110940C, pages 6497 - 6500, XP055285577

DOI:   http://dx.doi.org/10.1021/ja110940c
by applicantWO0069836
 WO2011032692
    - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2006), vol. 128, pages 8412 - 8413
    - JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2011), vol. 133, pages 6497 - 6500
    - CHEMICAL & PHARMACEUTICAL BULLETIN, (2011), vol. 59, pages 1570 - 1573
    - SYNTHESIS, (2010), vol. 20, pages 3545 - 3555
    - JOURNAL OF ORGANIC CHEMISTRY, (1999), vol. 64, pages 2564 - 2566
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.