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Extract from the Register of European Patents

EP About this file: EP3030905

EP3030905 - BOTULINUM TOXIN ASSAY WITH IMPROVED SENSITIVITY [Right-click to bookmark this link]
StatusPatent maintained as amended
Status updated on  08.12.2023
Database last updated on 14.05.2024
FormerThe patent has been granted
Status updated on  01.09.2017
FormerGrant of patent is intended
Status updated on  27.03.2017
Most recent event   Tooltip01.03.2024Correction of patent specificationpublished on 03.04.2024  [2024/14]
Applicant(s)For all designated states
Biomadison, Inc.
1568 Luneta Drive
Del Mar, CA 92014 / US
[2016/24]
Inventor(s)01 / TUCKER, Ward C.
501 Moygara
Monona, Wisconsin 53716 / US
02 / PIAZZA, Tim
6110 Spring Pond Ct
McFarland, Wisconsin 53558 / US
 [2017/40]
Former [2016/24]01 / TUCKER, Ward C.
501 Moygara
Monona, Wisconsin 53716 / US
02 / PIAZZA, Tim
6110 Spring Pond Court
McFarland, Wisconsin 53558 / US
Representative(s)Zaccaro, Elisabetta, et al
Notarbartolo & Gervasi S.p.A.
Viale Achille Papa, 30
20149 Milano / IT
[2024/02]
Former [2016/24]Pallini Gervasi, Diego, et al
Notarbartolo & Gervasi GmbH
Bavariaring 21
80336 Munich / DE
Application number, filing date14761444.008.08.2014
[2016/24]
WO2014US50424
Priority number, dateUS201361864436P09.08.2013         Original published format: US 201361864436 P
[2016/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015021433
Date:12.02.2015
Language:EN
[2015/06]
Type: A1 Application with search report 
No.:EP3030905
Date:15.06.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 12.02.2015 takes the place of the publication of the European patent application.
[2016/24]
Type: B1 Patent specification 
No.:EP3030905
Date:04.10.2017
Language:EN
[2017/40]
Type: B2 New European patent specification 
No.:EP3030905
Date:10.01.2024
Language:EN
[2024/02]
Type: B9 Corrected patent specification 
No.:EP3030905
Date:03.04.2024
[2024/14]
Search report(s)International search report - published on:EP12.02.2015
ClassificationIPC:G01N33/569
[2016/24]
CPC:
C12Q1/6897 (EP,KR,US); G01N33/56911 (KR,US); A47C15/006 (US);
C12Q1/37 (KR,US); G01N21/6408 (EP,KR,US); G01N21/6428 (EP,KR,US);
G01N33/582 (KR); G01N2333/33 (KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/24]
TitleGerman:BOTULINUMTOXIN-ASSAY MIT ERHÖHTER EMPFINDLICHKEIT[2016/24]
English:BOTULINUM TOXIN ASSAY WITH IMPROVED SENSITIVITY[2016/24]
French:DOSAGE DE TOXINE BOTULIQUE À SENSIBILITÉ AMÉLIORÉE[2016/24]
Entry into regional phase07.03.2016National basic fee paid 
07.03.2016Designation fee(s) paid 
07.03.2016Examination fee paid 
Examination procedure09.02.2016Amendment by applicant (claims and/or description)
07.03.2016Examination requested  [2016/24]
28.03.2017Communication of intention to grant the patent
17.07.2017Fee for grant paid
17.07.2017Fee for publishing/printing paid
17.07.2017Receipt of the translation of the claim(s)
Divisional application(s)EP17183975.6  / EP3270162
EP20182832.4  / EP3742165
Opposition(s)Opponent(s)01  28.06.2018    ADMISSIBLE
Merz Pharma GmbH & Co. KGaA
Eckenheimer Landstrasse 100
60318 Frankfurt/Main / DE
Opponent's representative
Altmann Stößel Dick Patentanwälte PartG mbB
Theodor-Heuss-Anlage 2
68165 Mannheim / DE
 [N/P]
Former [2018/32]
Opponent(s)01  28.06.2018    ADMISSIBLE
Merz Pharma GmbH & Co. KGaA
Eckenheimer Landstrasse 100
60318 Frankfurt/Main / DE
Opponent's representative
Herzog, Fiesser & Partner Patentanwälte PartG mbB
Dudenstrasse 46
68167 Mannheim / DE
18.07.2018Invitation to proprietor to file observations on the notice of opposition
19.11.2018Reply of patent proprietor to notice(s) of opposition
17.10.2019Date of oral proceedings
29.11.2019Despatch of interlocutory decision in opposition
29.11.2019Despatch of minutes of oral proceedings
04.04.2023Legal effect of interlocutory decision in opposition
03.07.2023Despatch of communication that the patent will be maintained as amended
03.10.2023Fee for printing new specification paid
Appeal following opposition23.01.2020Appeal received No.  T0235/20
27.03.2020Statement of grounds filed
04.04.2023Result of appeal procedure: appeal of the proprietor was rejected
29.06.2023Despatch of the decision of the Board of Appeal
16.01.2020Appeal received No.  T0235/20
17.03.2020Statement of grounds filed
04.04.2023Result of appeal procedure: appeal of the proprietor was rejected
29.06.2023Despatch of the decision of the Board of Appeal
04.04.2023Date of oral proceedings
Fees paidRenewal fee
22.08.2016Renewal fee patent year 03
22.08.2017Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU08.08.2014
AL04.10.2017
CY04.10.2017
CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
MK04.10.2017
NL04.10.2017
PL04.10.2017
PT04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
TR04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
IE08.08.2018
LU08.08.2018
MT08.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
[2020/34]
Former [2020/31]HU08.08.2014
CY04.10.2017
CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
MK04.10.2017
NL04.10.2017
PL04.10.2017
PT04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
TR04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
IE08.08.2018
LU08.08.2018
MT08.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2020/30]HU08.08.2014
CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
NL04.10.2017
PL04.10.2017
PT04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
TR04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
IE08.08.2018
LU08.08.2018
MT08.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2020/28]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
NL04.10.2017
PL04.10.2017
PT04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
TR04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
IE08.08.2018
LU08.08.2018
MT08.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2020/16]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
NL04.10.2017
PL04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
TR04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
IE08.08.2018
LU08.08.2018
MT08.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2020/08]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
NL04.10.2017
PL04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
IE08.08.2018
LU08.08.2018
MT08.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2019/38]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
NL04.10.2017
PL04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
IE08.08.2018
LU08.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
Former [2019/33]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
NL04.10.2017
PL04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
IE08.08.2018
LU08.08.2018
CH31.08.2018
LI31.08.2018
Former [2019/21]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
NL04.10.2017
PL04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
LU08.08.2018
CH31.08.2018
LI31.08.2018
Former [2019/15]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
MC04.10.2017
NL04.10.2017
PL04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
Former [2018/52]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
NL04.10.2017
PL04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SI04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
Former [2018/40]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
NL04.10.2017
PL04.10.2017
RO04.10.2017
RS04.10.2017
SE04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
Former [2018/39]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
IT04.10.2017
LV04.10.2017
NL04.10.2017
PL04.10.2017
RS04.10.2017
SE04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
Former [2018/37]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
LV04.10.2017
NL04.10.2017
PL04.10.2017
RS04.10.2017
SE04.10.2017
SK04.10.2017
SM04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
Former [2018/35]CZ04.10.2017
DK04.10.2017
EE04.10.2017
ES04.10.2017
FI04.10.2017
HR04.10.2017
LV04.10.2017
NL04.10.2017
RS04.10.2017
SE04.10.2017
SK04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
Former [2018/24]ES04.10.2017
FI04.10.2017
HR04.10.2017
LV04.10.2017
NL04.10.2017
RS04.10.2017
SE04.10.2017
BG04.01.2018
NO04.01.2018
GR05.01.2018
IS04.02.2018
Former [2018/23]ES04.10.2017
FI04.10.2017
HR04.10.2017
NL04.10.2017
RS04.10.2017
SE04.10.2017
NO04.01.2018
GR05.01.2018
IS04.02.2018
Former [2018/22]ES04.10.2017
FI04.10.2017
NL04.10.2017
NO04.01.2018
Former [2018/17]NL04.10.2017
Cited inInternational search[A]WO2009014854  (ALLERGAN INC [US], et al) [A] 1-21 * paragraphs 219-221 *;
 [A]WO2009035476  (BIOSENTINEL LLC [US], et al) [A] 1-21 * claim 18; example 5 page 37 *;
 [A]WO2013103737  (BIOMADISON INC [US]) [A] 1-21 * claims; page 11, [0050] *;
 [A]  - NUSS JONATHAN E ET AL, "Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies", JOURNAL OF BIOMOLECULAR SCREENING, SAGE; LIEBERT, US, (20100101), vol. 15, no. 1, doi:10.1177/1087057109354779, ISSN 1087-0571, pages 42 - 51, XP008124093 [A] 1-21 * page 43, column 2 first line; page 44 first passage. *

DOI:   http://dx.doi.org/10.1177/1087057109354779
 [A]  - F. M. DUNNING ET AL, "Detection of Botulinum Neurotoxin Serotype A, B, and F Proteolytic Activity in Complex Matrices with Picomolar to Femtomolar Sensitivity", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, (20120824), vol. 78, no. 21, doi:10.1128/AEM.01664-12, ISSN 0099-2240, pages 7687 - 7697, XP055151398 [A] 1-21 * page 7689, figure 1 and column 1, last paragraph *

DOI:   http://dx.doi.org/10.1128/AEM.01664-12
by applicantUS2004191887
 US2006134722
 US7183066
 US7208285
 US2011033866
 WO2014060373
    - FOSTER; STRINGER, GENETIC REGULATORY ELEMENTS INTRODUCED INTO NEURAL STEM AND PROGENITOR CELL POPULATIONS, BRAIN PATHOLOGY, (1999), vol. 9, pages 547 - 567
OppositionUS2006134722
 WO2007001358
 US2008064054
 WO2009035476
 WO2009114748
 US2010209955
 WO2012166943
 WO2013103737
 WO2013131991
 WO2014060373
    - DONG et al., "Using fluorescent sensors to detect botulinium neurotoxin activity in vitro and in living cells", PNAS, (20040000), vol. 101, pages 14701 - 14706, XP008156528

DOI:   http://dx.doi.org/10.1073/pnas.0404107101
    - PELLET, "Progress in cell based assays for botulinum neurotoxin detection", Curr. Top. Microbiol. Immunol., (20130000), vol. 364, pages 257 - 285, XP055111189

DOI:   http://dx.doi.org/10.1007/978-3-642-33570-9_12
    - RUGE et al., Anal. Biochem., (20110000), vol. 411, pages 200 - 209, XP028171767

DOI:   http://dx.doi.org/10.1016/j.ab.2011.01.002
    - PIRAZZINI et al., Biochemical and Biophysical Research Com- munications, (20130000), vol. 430, pages 38 - 42, XP028962880

DOI:   http://dx.doi.org/10.1016/j.bbrc.2012.11.048
    - POULAIN et al., "Differences in the temperature dependencies of uptake of botulinum and tetanus toxins in Aplysia neurons.", Neuroscience Letters, (19920000), vol. 139, pages 289 - 292, XP024162799

DOI:   http://dx.doi.org/10.1016/0304-3940(92)90573-P
    - BLACK et al., "Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis.", The Journal of Cell Biology, (19860000), vol. 103, pages 535 - 544, XP055514881
    - PIER et al., FEBS Lett., (20110000), vol. 585, pages 199 - 206, XP055012305

DOI:   http://dx.doi.org/10.1016/j.febslet.2010.11.045
    - "Media formulation Neurobasal medium", Technical Resources , thermo fisher scientific, URL: https://www.thermofisher.com/us/en/home/technical-resources/media-formulation.251.html
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