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Extract from the Register of European Patents

EP About this file: EP3036256

EP3036256 - MODULATION OF TUMOR IMMUNITY [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  27.10.2023
Database last updated on 11.09.2024
FormerThe patent has been granted
Status updated on  25.09.2020
FormerGrant of patent is intended
Status updated on  05.05.2020
FormerExamination is in progress
Status updated on  10.02.2017
Most recent event   Tooltip27.10.2023Revocation of patentpublished on 29.11.2023  [2023/48]
Applicant(s)For all designated states
Merck Sharp & Dohme LLC
126 East Lincoln Avenue
Rahway, New Jersey 07065 / US
[2022/42]
Former [2016/26]For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
Inventor(s)01 / GU, Danling
901 S. California Avenue
Palo Alto, California 94304 / US
02 / BEEBE, Amy M.
901 S. California Avenue
Palo Alto, California 94304 / US
 [2016/26]
Representative(s)Merck Sharp & Dohme LLC
120 Moorgate
London EC2M 6UR / GB
[N/P]
Former [2020/44]Böhles, Elena, et al
Merck Sharp & Dohme Limited
Hertford Road
Hoddesdon, Herts EN11 9BU / GB
Former [2016/26]Buchan, Gavin MacNicol
Merck Sharp & Dohme Limited
European Patent Department
Hertford Road
Hoddesdon
Hertfordshire EN11 9BU / GB
Application number, filing date14761460.618.08.2014
[2016/26]
WO2014US51402
Priority number, dateUS201361867976P20.08.2013         Original published format: US 201361867976 P
[2016/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015026684
Date:26.02.2015
Language:EN
[2015/08]
Type: A1 Application with search report 
No.:EP3036256
Date:29.06.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 26.02.2015 takes the place of the publication of the European patent application.
[2016/26]
Type: B1 Patent specification 
No.:EP3036256
Date:28.10.2020
Language:EN
[2020/44]
Search report(s)International search report - published on:EP26.02.2015
ClassificationIPC:C07K16/28, A61P35/00, A61K39/395
[2016/26]
CPC:
A61P35/00 (EP); A61K39/3955 (IL,US); A61K39/395 (KR);
A61K39/39558 (KR); A61P43/00 (EP); C07K16/2818 (EP,IL,KR,US);
C07K16/2878 (EP,IL,KR,US); A61K2039/505 (EP,IL,KR,US); A61K2039/507 (EP,IL,KR,US);
A61K2039/545 (EP,IL,KR,US); C07K2317/24 (KR); C07K2317/565 (KR);
C07K2317/75 (EP,IL,KR,US); C07K2317/76 (EP,IL,KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/26]
Extension statesBA21.03.2016
ME21.03.2016
TitleGerman:MODULATION DER TUMORIMMUNITÄT[2016/26]
English:MODULATION OF TUMOR IMMUNITY[2016/26]
French:MODULATION D'IMMUNITÉ TUMORALE[2016/26]
Entry into regional phase21.03.2016National basic fee paid 
21.03.2016Designation fee(s) paid 
21.03.2016Examination fee paid 
Examination procedure21.03.2016Examination requested  [2016/26]
12.10.2016Amendment by applicant (claims and/or description)
10.02.2017Despatch of a communication from the examining division (Time limit: M06)
28.11.2017Reply to a communication from the examining division
16.02.2018Despatch of a communication from the examining division (Time limit: M06)
24.08.2018Reply to a communication from the examining division
14.12.2018Despatch of a communication from the examining division (Time limit: M06)
26.07.2019Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
25.09.2019Reply to a communication from the examining division
06.05.2020Communication of intention to grant the patent
11.09.2020Fee for grant paid
11.09.2020Fee for publishing/printing paid
11.09.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20190848.0  / EP3770175
Opposition(s)Opponent(s)01  27.07.2021  30.07.2021  ADMISSIBLE
Regeneron Pharmaceuticals, Inc.
777 Old Saw Mill River Road
Tarrytown NY 10591 / US
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 02  28.07.2021  30.07.2021  ADMISSIBLE
Pajaro Limited
12 New Fetter Lane
London
EC4A 1JP / GB
Opponent's representative
Alt, Michael
Bird & Bird LLP
Maximiliansplatz 22
80333 München / DE
 [2022/31]
Former [2021/35]
Opponent(s)01  27.07.2021   
Regeneron Pharmaceuticals, Inc.
777 Old Saw Mill River Road
Tarrytown NY 10591 / US
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 02  28.07.2021   
Pajaro Limited
12 New Fetter Lane
London
EC4A 1JP / GB
Opponent's representative
Höpfner, Sebastian
Bird & Bird LLP
Maximiliansplatz 22
DE-80333 München / DE
11.08.2021Invitation to proprietor to file observations on the notice of opposition
16.12.2021Reply of patent proprietor to notice(s) of opposition
13.06.2023Date of oral proceedings
13.06.2023Legal effect of revocation of patent [2023/48]
12.07.2023Despatch of minutes of oral proceedings
12.07.2023Despatch of communication that the patent will be revoked
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
25.09.2019Request for further processing filed
25.09.2019Full payment received (date of receipt of payment)
Request granted
10.10.2019Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
28.11.2017Request for further processing filed
28.11.2017Full payment received (date of receipt of payment)
Request granted
08.12.2017Decision despatched
Fees paidRenewal fee
05.08.2016Renewal fee patent year 03
10.08.2017Renewal fee patent year 04
10.08.2018Renewal fee patent year 05
08.08.2019Renewal fee patent year 06
17.08.2020Renewal fee patent year 07
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Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipMC28.10.2020
SM28.10.2020
[2022/18]
Former [2021/32]SM28.10.2020
Cited inInternational search[XD]WO2011028683  (SCHERING CORP [US], et al) [XD] 18 * paragraph [0196]; example 5; table 8 *;
 [YD]WO2013019906  (GENENTECH INC [US], et al) [YD] 1-7,10,11,18,19 * claims 1-50 *;
 [Y]  - I. MELERO ET AL, "Clinical Development of Immunostimulatory Monoclonal Antibodies and Opportunities for Combination", CLINICAL CANCER RESEARCH, (20130301), vol. 19, no. 5, doi:10.1158/1078-0432.CCR-12-2214, ISSN 1078-0432, pages 997 - 1008, XP055151065 [Y] 1-7,10,11,18,19 * abstract * * page 1000, column l, paragraph 1 - page 1002, column r, paragraph 1 * * page 1004, column l, paragraph 2 * * page 1004, column r, paragraph l - page 1005, column l, paragraph 1 *

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-12-2214
 [IA]  - DAVID A SCHAER ET AL, "Modulation of GITR for cancer immunotherapy", CURRENT OPINION IN IMMUNOLOGY, (20120401), vol. 24, no. 2, doi:10.1016/j.coi.2011.12.011, ISSN 0952-7915, pages 217 - 224, XP055150991 [I] 1-7,10,11,18,19 * paragraph [introduction] * * page 220, column r, paragraph l * [A] 8,9,12-17

DOI:   http://dx.doi.org/10.1016/j.coi.2011.12.011
 [Y]  - KO K ET AL, "TREATMENT OF ADVANCED TUMORS WITH AGONISTIC ANTI-GITR MAB AND ITS EFFECTS ON TUMOR-INFILTRATING FOXP3(+)CD25(+)CD4(+) REGULATORY T CELLS", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, (20051003), vol. 202, no. 7, doi:10.1084/JEM.20050940, ISSN 0022-1007, pages 885 - 891, XP009076415 [Y] 1-7,10,11,18,19 * abstract * * paragraph [results]; figure 4 *
 [XP]  - LEI LU ET AL, "Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, (20140207), vol. 12, no. 1, doi:10.1186/1479-5876-12-36, ISSN 1479-5876, page 36, XP021176018 [XP] 1-19 * the whole document *

DOI:   http://dx.doi.org/10.1186/1479-5876-12-36
by applicantUS4683195
 US4816567
 EP0404097
 WO9311161
 WO9404678
 WO9425591
 US5624821
 US6005079
 US6150584
 US6326482
 US6329511
 US6420140
 US6458592
 WO03086310
 WO2005047326
 WO2005120571
 WO2006005770
 US2006014225
 WO2006105021
 WO2008156712
 US7521051
 WO2010077634
 WO2011028683
 US8008449
 US8354509
 WO2013019906
 US8383796
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OppositionWO2011028683
 WO2012145493
 WO2015026684
 WO2004107618
 WO2006105021
 WO2013019906
 WO2017214548
 EP3036256
    - "FDA Approves New Immunotherapy for Metastatic Melanoma", FDA Approves New Immunotherapy for Metastatic Melanoma, (20110325), XP055831681
    - "Phase I study of MK -3475 (anti-PD-i monoclonal antibody) in patients with advanced solid tumors", Journal of Clinical Oncology, (20120520), vol. 30, no. 15, pages 2512 - 2512, XP055831683
    - DAVID A SCHAER et al., "Modulation of GITR for cancer immunotherapy", Curr Opin Immunol, (20120400), vol. 24, no. 2, pages 217 - 224, XP055150991

DOI:   http://dx.doi.org/10.1016/j.coi.2011.12.011
    - MIKAYEL MKRTICHYAN et al., "Anti-PD-1 synergizes with cyclophosphamide to inducepotent anti-tumor vaccine effects through novelmechanisms", Eur. J. Immunol., (20110000), vol. 41, pages 2977 - 2986, XP055831685
    - ADEEGBE et al., "Natural and induced! regulatory cells in cancer", Frontiers in Immunology, (20130700), vol. 4, no. Article 190, page 9, XP055831686
    - GENEVIEVE M. WEI et al., "Immune Modulation by Chemotherapy or Immunotherapy to Enhance Cancer Vaccines", Cancers, (20110000), vol. 3, pages 3114 - 3142, XP055184265

DOI:   http://dx.doi.org/10.3390/cancers3033114
    - ANGELA D. PARDEE, "CANCER IMMUNOTHERAPY TARGETING T CELL COSTIMULATORY MOLECULES", Dissertation, (20100000), XP055831689
    - ASAD JAVED et al., "PD-L1 expression in tumor metastasis isdifferent between uveal melanoma and cutaneous melanoma", Immunotherapy, (20170000), vol. 9, no. 16, pages 1323 - 1330, XP055750914

DOI:   http://dx.doi.org/10.2217/imt-2017-0066
    - MUSTAFA KHASRAW et al., "PD-1 Inhibitors: Do they have a Future in the Treatment of (g)Glioblastoma?", Clin Cancer Res, (20201015), vol. 26, no. 20, pages 5287 - 5296, XP055750968

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-20-1135
    - IGNACIO MELERO et al., "Clinical Development of Immunostimulatory Monoclonal Antibodies and Opportunities for Combination", Clin Cancer Res, (20130301), vol. 19, no. 5, pages 997 - 1108, XP055151065

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-12-2214
    - I. Melero, A. M. Grimaldi, J. L. Perez-Gracia, P. A. Ascierto, "Clinical Development of Immunostimulatory Monoclonal Antibodies and Opportunities for Combination", Clinical Cancer Research, Association for Cancer Research, (20130301), vol. 19, no. 5, doi:10.1158/1078-0432.CCR-12-2214, ISSN 10780432, pages 997 - 1008, XP055151065

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-12-2214
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