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Extract from the Register of European Patents

EP About this file: EP2970877

EP2970877 - NEURAL PROGENITOR CELL DIFFERENTIATION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  31.05.2019
Database last updated on 15.06.2024
FormerThe patent has been granted
Status updated on  22.06.2018
FormerGrant of patent is intended
Status updated on  04.03.2018
FormerExamination is in progress
Status updated on  31.03.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Wake Forest University Health Sciences
Medical Center Boulevard
Winston-Salem, NC 27157 / US
[2016/08]
Former [2016/03]For all designated states
Wake Forest University Health Sciences
391 Technology Way, Suite 199
Winston-Salem, NC 27101 / US
Inventor(s)01 / Bitar, Khalil
634 Gramercy Street
Winston Salem, NC 27104 / US
 [2016/08]
Former [2016/04]01 / Bitar, Khalil
Medical Center Boulevard
Winston Salem North Carolina 27157 / US
Former [2016/03]01 / Bitar, Khalil
634 Gramercy Street
Winston-Salem North Carolina 27104 / US
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2018/30]J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2016/03]Tuxworth, Pamela M.
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date14763675.717.03.2014
[2016/03]
WO2014US30456
Priority number, dateUS201361788285P15.03.2013         Original published format: US 201361788285 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2014145653
Date:18.09.2014
Language:EN
[2014/38]
Type: A2 Application without search report 
No.:EP2970877
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 18.09.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2970877
Date:25.07.2018
Language:EN
[2018/30]
Search report(s)International search report - published on:US13.11.2014
(Supplementary) European search report - dispatched on:EP12.08.2016
ClassificationIPC:C12N5/0793, C12N5/079, C12N5/071, C12N5/077, A61K35/30, A61K35/34
[2018/12]
CPC:
C12N5/0619 (EP,US); A61K35/30 (US); A61K35/34 (US);
C12N5/0622 (EP,US); C12N2502/1347 (EP,US); C12N2533/52 (EP,US);
C12N2533/54 (EP,US); C12N2533/90 (EP,US) (-)
Former IPC [2016/37]C12N5/0793, C12N5/079, C12N5/071, C12N5/077
Former IPC [2016/03]C12N5/00, C12N5/071, C12N5/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:DIFFERENZIERUNG NEURONALER VORLÄUFERZELLEN[2016/03]
English:NEURAL PROGENITOR CELL DIFFERENTIATION[2016/03]
French:DIFFÉRENCIATION DE CELLULES PROGÉNITRICES NEURALES[2016/03]
Entry into regional phase14.10.2015National basic fee paid 
14.10.2015Search fee paid 
14.10.2015Designation fee(s) paid 
14.10.2015Examination fee paid 
Examination procedure14.10.2015Examination requested  [2016/03]
03.03.2017Amendment by applicant (claims and/or description)
29.03.2017Despatch of a communication from the examining division (Time limit: M04)
06.07.2017Reply to a communication from the examining division
05.03.2018Communication of intention to grant the patent
08.06.2018Fee for grant paid
08.06.2018Fee for publishing/printing paid
08.06.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  29.03.2017
Opposition(s)26.04.2019No opposition filed within time limit [2019/27]
Fees paidRenewal fee
31.03.2016Renewal fee patent year 03
27.03.2017Renewal fee patent year 04
27.03.2018Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU17.03.2014
AL25.07.2018
AT25.07.2018
CY25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
MK25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
PT25.11.2018
IE17.03.2019
LU17.03.2019
MT17.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
[2022/31]
Former [2021/32]HU17.03.2014
AL25.07.2018
AT25.07.2018
CY25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
PT25.11.2018
IE17.03.2019
LU17.03.2019
MT17.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2021/26]AL25.07.2018
AT25.07.2018
CY25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
PT25.11.2018
IE17.03.2019
LU17.03.2019
MT17.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2020/29]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
PT25.11.2018
IE17.03.2019
LU17.03.2019
MT17.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2020/16]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
IE17.03.2019
LU17.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2020/11]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
IE17.03.2019
LU17.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2020/09]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
IE17.03.2019
LU17.03.2019
Former [2020/01]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
LU17.03.2019
Former [2019/46]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/37]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/26]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/23]AL25.07.2018
AT25.07.2018
CZ25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SK25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/22]AL25.07.2018
AT25.07.2018
CZ25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/21]AL25.07.2018
AT25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/12]AL25.07.2018
AT25.07.2018
FI25.07.2018
HR25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/11]AT25.07.2018
FI25.07.2018
HR25.07.2018
LT25.07.2018
NL25.07.2018
PL25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/10]AT25.07.2018
FI25.07.2018
LT25.07.2018
NL25.07.2018
PL25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/08]FI25.07.2018
LT25.07.2018
NL25.07.2018
NO25.10.2018
IS25.11.2018
Former [2019/07]LT25.07.2018
NL25.07.2018
Former [2019/04]NL25.07.2018
Documents cited:Search[A]WO0149827  (CHILDRENS MEDICAL CENTER [US]) [A] 1-15 * claims 1,8 * * page 10, lines 13-20 *;
 [A]WO03029418  (BECTON DICKINSON CO [US], et al) [A] 1-15 * example 1 *;
 [A]WO2011059920  (DAVID GLADSTONE INST [US], et al) [A] 1-15 * example 1; claims 1,7 *;
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DOI:   http://dx.doi.org/10.4172/2157-7013.1000103
 [A]  - SHREYA RAGHAVAN ET AL, "Bioengineered Three-Dimensional Physiological Model of Colonic Longitudinal Smooth Muscle In Vitro Background", TISSUE ENGINEERING PART C: METHODS, (20100901), vol. 999, no. 1009, pages 16 - 5, XP055281051 [A] 1-15 * abstract *
 [A]  - GIUSEPPE ORLANDO ET AL, "Regenerative medicine as applied to solid organ transplantation: current status and future challenges", TRANSPLANT INTERNATIONAL., GB, (20101110), vol. 24, no. 3, doi:10.1111/j.1432-2277.2010.01182.x, ISSN 0934-0874, pages 223 - 232, XP055293163 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1432-2277.2010.01182.x
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DOI:   http://dx.doi.org/10.1016/j.biomaterials.2013.05.023
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DOI:   http://dx.doi.org/10.1016/j.biomaterials.2014.05.037
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DOI:   http://dx.doi.org/10.4172/2157-7013.1000103
 [Y]  - RAGHAVAN, S. ET AL., "Bioengineered Three-Dimensional Physiological Model Of Colonic Longitudinal Smooth Muscle In Vitro.", TISSUE ENGINEERING: PART C: METHODS., (201010), vol. 16, no. 5, pages 999 - 1009, XP055281051
 [Y]  - WARD, S.M. ET AL., "Interstitial Cells Of Cajal Mediate Cholinergic Neurotransmission From Enteric Motor Neurons.", THE JOURNAL OF NEUROSCIENCE., (20000215), vol. 20, no. 4, pages 1393 - 1403, XP055281061
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DOI:   http://dx.doi.org/10.1021/la2023727
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DOI:   http://dx.doi.org/10.4239/wjd.v3.i5.80
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DOI:   http://dx.doi.org/10.1016/j.biomaterials.2014.05.037
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.