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Extract from the Register of European Patents

EP About this file: EP2968264

EP2968264 - INHIBITORS OF LEUKOTRIENE A4 HYDROLASE [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  09.10.2020
Database last updated on 31.05.2024
FormerGrant of patent is intended
Status updated on  23.01.2020
FormerExamination is in progress
Status updated on  29.09.2017
Most recent event   Tooltip13.10.2020New entry: Additional fee for renewal fee: despatch of communication + time limit 
Applicant(s)For all designated states
Celtaxsys Inc.
201 17th Street NW
Suite 530
Atlanta, GA 30363 / US
[2016/03]
Inventor(s)01 / GUILFORD, William
1881 Robin Whipple Way
Belmont, CA 94002 / US
 [2016/03]
Representative(s)Harris, Jennifer Lucy, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[N/P]
Former [2016/03]Harris, Jennifer Lucy, et al
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Application number, filing date14768642.214.03.2014
[2016/03]
WO2014US27097
Priority number, dateUS201361781181P14.03.2013         Original published format: US 201361781181 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2014152229
Date:25.09.2014
Language:EN
[2014/39]
Type: A2 Application without search report 
No.:EP2968264
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 25.09.2014 takes the place of the publication of the European patent application.
[2016/03]
Search report(s)International search report - published on:US04.12.2014
(Supplementary) European search report - dispatched on:EP06.10.2016
ClassificationIPC:C07D413/12, C07D451/02, C07D471/08, C07D205/04, C07D207/09, C07D211/26, A61K31/395, A61P25/28, A61P29/00, A61P35/00
[2020/07]
CPC:
C07D451/02 (EP,US); C07D205/04 (EP,MX,US); A61K31/395 (MX);
A61P1/00 (EP); A61P1/02 (EP); A61P1/04 (EP);
A61P11/00 (EP); A61P11/02 (EP); A61P11/06 (EP);
A61P11/08 (EP); A61P13/08 (EP); A61P13/12 (EP);
A61P17/00 (EP); A61P17/02 (EP); A61P17/04 (EP);
A61P17/06 (EP); A61P19/02 (EP); A61P25/00 (EP);
A61P25/02 (EP); A61P25/04 (EP); A61P25/06 (EP);
A61P25/14 (EP); A61P25/16 (EP); A61P27/02 (EP);
A61P29/00 (EP); A61P3/10 (EP); A61P31/00 (EP);
A61P31/04 (EP); A61P35/00 (EP); A61P35/02 (EP);
A61P37/00 (EP); A61P37/02 (EP); A61P37/06 (EP);
A61P37/08 (EP); A61P9/00 (EP); A61P9/10 (EP);
C07D207/09 (EP,MX,US); C07D211/26 (EP,MX,US); C07D413/12 (EP,US);
C07D471/08 (EP,MX,US) (-)
Former IPC [2016/31]A61K31/395, C07D413/12, C07D451/02, C07D471/08, C07D205/04, C07D207/09, C07D211/26
Former IPC [2016/03]A61K31/395
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBA15.09.2015
ME15.09.2015
TitleGerman:INHIBITOREN DER LEUKOTRIEN-A4-HYDROLASE[2016/03]
English:INHIBITORS OF LEUKOTRIENE A4 HYDROLASE[2016/03]
French:INHIBITEURS DE LA LEUCOTRIÈNE A4 HYDROLASE[2016/03]
Entry into regional phase15.09.2015National basic fee paid 
15.09.2015Search fee paid 
15.09.2015Designation fee(s) paid 
15.09.2015Examination fee paid 
Examination procedure15.09.2015Examination requested  [2016/03]
02.05.2017Amendment by applicant (claims and/or description)
29.09.2017Despatch of a communication from the examining division (Time limit: M04)
31.01.2018Reply to a communication from the examining division
03.05.2018Despatch of a communication from the examining division (Time limit: M06)
13.11.2018Reply to a communication from the examining division
28.02.2019Despatch of a communication from the examining division (Time limit: M06)
29.08.2019Reply to a communication from the examining division
24.01.2020Communication of intention to grant the patent
04.06.2020Application deemed to be withdrawn, date of legal effect  [2020/46]
25.06.2020Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2020/46]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  29.09.2017
Fees paidRenewal fee
10.03.2016Renewal fee patent year 03
10.03.2017Renewal fee patent year 04
13.03.2018Renewal fee patent year 05
13.03.2019Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.03.202007   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[ID]US2007155726  (ARNAIZ DAMIAN [US], et al) [ID] 1-7,9,11-23 * paragraphs [0833] - [0836] - [ 844] - [0850] - [ 896] - [0901] - [ 912] - [0919]; claim - *;
 [XP]CN103159742  (BEIJING HANMEI PHARMACEUTICAL CO LTD) [XP] 1,5-7,9,11,15,16 * paragraphs [0161] - [0169]; claim 1 *
 [I]  - KHIM S K ET AL, "Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 18, no. 14, doi:10.1016/J.BMCL.2008.06.041, ISSN 0960-894X, (20080715), pages 3895 - 3898, (20080618), XP022852858 [I] 1-7,9,11-23 * tables 1, 2 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2008.06.041
International search[X]US2012028954  (GOFF DANE [US], et al);
 [A]US2008096906  (GALLEY GUIDO [DE], et al)
by applicantUS7737145
 US2010210630
 US2007155726
 US4886788
 US6355627
 US6288119
 US6110969
 US6235780
 US6262293
 US6225347
 US4935446
    - J. PALMBLAD, J. Rheumatol., (19840000), vol. 13, no. 2, pages 163 - 172
    - A.M. TAGER et al., J. Exp. Med., (20000000), vol. 192, no. 3, pages 439 - 446
    - N. DUGAS et al., Immunol., (19960000), vol. 88, no. 3, pages 384 - 388
    - L. GAGNON et al., Agents Actions, (19890000), vol. 34, no. 1-2, pages 172 - 174
    - H. MORITA et al., Biochem. Biophys. Res. Commun., (19990000), vol. 264, no. 2, pages 321 - 326
    - B. DUGAS et al., J. Immunol., (19900000), vol. 145, no. 10, pages 3405 - 3411
    - K. GOODARZI et al., Nat. Immunol., (20030000), vol. 4, pages 982 - 990
    - R.A. LEWIS et al., N. Engl. J. Med., (19900000), vol. 323, page 645
    - W.R. HENDERSON, Ann. Intern. Med., (19940000), vol. 121, page 684
    - D.A. MUNAFO et al., J. Clin. Invest., (19940000), vol. 93, no. 3, pages 1042 - 1050
    - P. SHARONW.F. STENSON, Gastroenterology, (19840000), vol. 86, no. 3, pages 453 - 460
    - P.J. BARNES, Respiration, (20010000), vol. 68, no. 5, pages 441 - 448
    - R.J. GRIFFITHS et al., Proc. Natl. Acad. Sci. U.S.A., (19950000), vol. 92, no. 2, pages 517 - 521
    - F. TSUJI et al., Life Sci., (19980000), vol. 64, no. 3, pages L51 - L56
    - K. IKAI, J. Dermatol. Sci., (19990000), vol. 21, no. 3, pages 135 - 146
    - Y.I. ZHUM.J. STILLER, Skin Pharmacol. Appl. Skin Physiol., (20000000), vol. 13, no. 5, pages 235 - 245
    - E.B. FRIEDRICH et al., Arterioscler. Thromb. Vase. Biol., (20030000), vol. 23, pages 1761 - 1767
    - K. SUBBARAO et al., Arterioscler. Thromb. Vase. Biol., (20040000), vol. 24, pages 369 - 375
    - A. HELGADOTTIR et al., Nat. Genet., (20040000), vol. 36, pages 233 - 239
    - V.R. JALA et al., Trends in Immun., (20040000), vol. 25, pages 315 - 322
    - A.W. FORD-HUTCHINSON, Immunology, (19900000), vol. 10, page 1
    - KOWAL-BIELECKA, O. et al., Arthritis Rheum., (20051130), vol. 52, no. 12, pages 3783 - 3791
    - A.W. FORD-HUTCHINSON et al., Annu. Rev. Biochem., (19940000), vol. 63, pages 383 - 347
    - AHARONY, D., Am. J. Respir. Crit. Care Med., (19980000), vol. 157, no. 6, pages S214 - S218
    - C.N. SERHAN, Prostaglandins, (19970000), vol. 53, pages 107 - 137
    - M.M. THUNISSEN et al., Nat Struct. Biol., (20010000), vol. 8, no. 2, pages 131 - 135
    - J.E. FABRE et al., J. Clin. Invest., (20020000), vol. 109, no. 10, pages 1373 - 1380
    - R.D.R. CAMP et al., Br. J. Pharmacol., (19830000), vol. 80, no. 3, pages 497 - 502
    - R. CAMP et al., J. Invest. Dermatol., (19840000), vol. 82, no. 2, pages 202 - 204
    - S.W. CROOKSR.S. STOCKLEY, Int. J. Biochem. Cell Biol., (19980000), vol. 30, no. 2, pages 173 - 178
    - R.S. BYRUM et al., J. Immunol., (19990000), vol. 163, no. 12, pages 6810 - 68129
    - J.K. KACHUR et al., J. Pharm,. Exp. Thr., (20020000), vol. 300, no. 2, pages 583 - 587
    - T.D. PENNING, Curr. Pharm. Des., (20010000), vol. 7, no. 3, pages 163 - 179
    - KHIM et al., Bioorg. Med. Chem. Lett., (20080000), vol. 18, no. 14, pages 3895 - 3898
    - GOLDBERG, I., "The Significance of Molecular Type, Shape and Complementarity in Clathrate Inclusion", Topics in Current Chemistry, (19880000), vol. 149, pages 2 - 44
    - WEBER, E. et al., "Functional Group Assisted Clathrate Formation--Scissor-Like and Roof-Shaped Host Molecules", Topics in Current Chemistry, (19880000), vol. 149, pages 45 - 135
    - MACNICOL, D. D. et al., "Clathrates and Molecular Inclusion Phenomena", Chemical Society Reviews, (19780000), vol. 7, no. 1, pages 65 - 87
    - SAENGER, W., "Cyclodextrin Inclusion Compounds in Research and Industry", Angew. Chem. Int. Ed. Engl., (19800000), vol. 19, doi:doi:10.1002/anie.198003441, pages 344 - 362, XP001121152

DOI:   http://dx.doi.org/10.1002/anie.198003441
    - BUNDGARD, H., Design of Prodrugs, Elsevier, (19850000), vol. 21-24, pages 7 - 9
    - HIGUCHI, T. et al., "Pro-drugs as Novel Delivery Systems", A.C.S. Symposium Series, vol. 14
    - KULL, F. et al., The Journal of Biological Chemistry, (19990000), vol. 274, no. 49, pages 34683 - 34690
    - Compendium of Organic Synthetic Methods, Wiley Interscience, (19740000), vol. 1-10
    - GRONERT, K. et al., Am. J. Pathol., (20010000), vol. 158, pages 3 - 9
    - RUDBERG, P. C. et al., J. Biol. Chem., (20020000), vol. 277, pages 1398 - 1404
    - ASKONAS, L. J. et al., The Journal of Pharmacology and Experimental Therapeutics, (20020000), vol. 300, no. 2, pages 577 - 582
    - PENNING, T. D. et al., J. Med. Chem., (20000000), vol. 43, no. 4, pages 721 - 735
    - COLGAN, S. P. et al., J. Clin. Invest, (19930000), vol. 92, no. 1, pages 75 - 82
    - SERHAN, C. N. et al., Biochemistry, (19950000), vol. 34, no. 44, pages 14609 - 14615
    - AJUEBOR, M. N. et al., Immunology, (19980000), vol. 95, pages 625 - 630
    - POULIOT, M. et al., Biochemistry, (20000000), vol. 39, pages 4761 - 4768
    - CLISH, C. B. et al., Proc. Natl. Acad. Sci. U.S.A., (19990000), vol. 96, pages 8247 - 8252
    - HACHICHA, M. et al., J. Exp. Med., (19990000), vol. 189, pages 1923 - 30
    - DE SANCTIS, G. T. et al., Journal of Clinical Investigation, (19990000), vol. 103, pages 507 - 515
    - CAMPBELL, E. M. et al., J. Immunol., (19980000), vol. 161, no. 12, pages 7047 - 7053
    - RUDBERG et al., J. Biol. Chem., (20040625), vol. 279, no. 26, pages 27376 - 27382
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.