EP2976076 - TRAIL ENHANCERS FOR THE SELECTIVE KILLING OF CANCER CELLS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 08.01.2021 Database last updated on 31.08.2024 | |
Former | The patent has been granted Status updated on 31.01.2020 | ||
Former | Grant of patent is intended Status updated on 17.09.2019 | ||
Former | Examination is in progress Status updated on 28.09.2018 | Most recent event Tooltip | 08.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 10.08.2022 [2022/32] | Applicant(s) | For all designated states The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 / US | [2016/04] | Inventor(s) | 01 /
KRAVCHENKO, Vladimir 7192 Whipple Avenue San Diego, California 92122 / US | 02 /
ULEVITCH, Richard J. 1001 Genter Street Apt. 7F La Jolla, California 92037 / US | 03 /
JANDA, Kim D. 5787 La Jolla Corona Drive La Jolla, California 92037 / US | [2016/04] | Representative(s) | Steffan & Kiehne Patentanwälte PartG mbB Patentanwälte Postfach 10 40 09 40031 Düsseldorf / DE | [N/P] |
Former [2020/10] | Leifert & Steffan Patentanwälte PartG mbB Patentanwälte Postfach 10 40 09 40031 Düsseldorf / DE | ||
Former [2016/04] | Leifert & Steffan Patentanwälte Postfach 10 40 09 40031 Düsseldorf / DE | Application number, filing date | 14770705.3 | 19.03.2014 | [2016/04] | WO2014US31235 | Priority number, date | US201361803177P | 19.03.2013 Original published format: US 201361803177 P | [2016/04] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2014153415 | Date: | 25.09.2014 | Language: | EN | [2014/39] | Type: | A2 Application without search report | No.: | EP2976076 | Date: | 27.01.2016 | Language: | EN | The application published by WIPO in one of the EPO official languages on 25.09.2014 takes the place of the publication of the European patent application. | [2016/04] | Type: | B1 Patent specification | No.: | EP2976076 | Date: | 04.03.2020 | Language: | EN | [2020/10] | Search report(s) | International search report - published on: | US | 08.01.2015 | (Supplementary) European search report - dispatched on: | EP | 17.10.2016 | Classification | IPC: | A61K31/402, A61P35/00, C07D405/12, C07D307/33 | [2016/46] | CPC: |
C07D405/12 (EP,KR,US);
A61K31/365 (EP,KR,US);
A61K31/336 (EP,US);
A61K31/337 (EP,US);
A61K31/341 (EP,US);
A61K31/396 (EP,KR,US);
A61K38/1761 (EP,US);
A61K38/177 (EP,KR,US);
A61K38/19 (EP,US);
A61P35/00 (EP);
A61P43/00 (EP);
C07D305/12 (EP,US);
C07D307/33 (EP,KR,US)
(-)
| C-Set: |
A61K31/365, A61K2300/00 (EP,US);
A61K31/396, A61K2300/00 (US,EP);
A61K38/177, A61K2300/00 (US,EP)
|
Former IPC [2016/04] | A61K31/402 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2016/04] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | MODULATOREN VON TRAIL ZUR SELEKTIVEN TÖTUNG VON KREBSZELLEN | [2019/41] | English: | TRAIL ENHANCERS FOR THE SELECTIVE KILLING OF CANCER CELLS | [2016/04] | French: | AMPLIFICATEURS DE TRAIL POUR TUER SÉLECTIVEMENT DES CELLULES CANCÉREUSES | [2016/04] |
Former [2016/04] | SPURVERSTÄRKER ZUR SELEKTIVEN TÖTUNG VON KREBSZELLEN | Entry into regional phase | 19.10.2015 | National basic fee paid | 19.10.2015 | Search fee paid | 19.10.2015 | Designation fee(s) paid | 19.10.2015 | Examination fee paid | Examination procedure | 19.10.2015 | Examination requested [2016/04] | 03.05.2017 | Amendment by applicant (claims and/or description) | 01.10.2018 | Despatch of a communication from the examining division (Time limit: M04) | 14.03.2019 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 09.05.2019 | Reply to a communication from the examining division | 18.09.2019 | Communication of intention to grant the patent | 22.01.2020 | Fee for grant paid | 22.01.2020 | Fee for publishing/printing paid | 22.01.2020 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 01.10.2018 | Opposition(s) | 07.12.2020 | No opposition filed within time limit [2021/06] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 09.05.2019 | Request for further processing filed | 09.05.2019 | Full payment received (date of receipt of payment) Request granted | 21.05.2019 | Decision despatched | Fees paid | Renewal fee | 10.03.2016 | Renewal fee patent year 03 | 10.03.2017 | Renewal fee patent year 04 | 13.03.2018 | Renewal fee patent year 05 | 31.05.2019 | Renewal fee patent year 06 | Penalty fee | Additional fee for renewal fee | 31.03.2019 | 06   M06   Fee paid on   31.05.2019 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 19.03.2014 | AL | 04.03.2020 | AT | 04.03.2020 | CY | 04.03.2020 | CZ | 04.03.2020 | DK | 04.03.2020 | EE | 04.03.2020 | ES | 04.03.2020 | FI | 04.03.2020 | HR | 04.03.2020 | IT | 04.03.2020 | LT | 04.03.2020 | LV | 04.03.2020 | MC | 04.03.2020 | MK | 04.03.2020 | MT | 04.03.2020 | NL | 04.03.2020 | PL | 04.03.2020 | RO | 04.03.2020 | RS | 04.03.2020 | SE | 04.03.2020 | SI | 04.03.2020 | SK | 04.03.2020 | SM | 04.03.2020 | TR | 04.03.2020 | IE | 19.03.2020 | LU | 19.03.2020 | BE | 31.03.2020 | BG | 04.06.2020 | NO | 04.06.2020 | GR | 05.06.2020 | IS | 04.07.2020 | PT | 29.07.2020 | [2022/31] |
Former [2022/30] | HU | 19.03.2014 | |
AL | 04.03.2020 | ||
AT | 04.03.2020 | ||
CY | 04.03.2020 | ||
CZ | 04.03.2020 | ||
DK | 04.03.2020 | ||
EE | 04.03.2020 | ||
ES | 04.03.2020 | ||
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
IT | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
MC | 04.03.2020 | ||
MT | 04.03.2020 | ||
NL | 04.03.2020 | ||
PL | 04.03.2020 | ||
RO | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
SI | 04.03.2020 | ||
SK | 04.03.2020 | ||
SM | 04.03.2020 | ||
TR | 04.03.2020 | ||
IE | 19.03.2020 | ||
LU | 19.03.2020 | ||
BE | 31.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
PT | 29.07.2020 | ||
Former [2022/27] | HU | 19.03.2014 | |
AT | 04.03.2020 | ||
CY | 04.03.2020 | ||
CZ | 04.03.2020 | ||
DK | 04.03.2020 | ||
EE | 04.03.2020 | ||
ES | 04.03.2020 | ||
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
IT | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
MC | 04.03.2020 | ||
MT | 04.03.2020 | ||
NL | 04.03.2020 | ||
PL | 04.03.2020 | ||
RO | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
SI | 04.03.2020 | ||
SK | 04.03.2020 | ||
SM | 04.03.2020 | ||
TR | 04.03.2020 | ||
IE | 19.03.2020 | ||
LU | 19.03.2020 | ||
BE | 31.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
PT | 29.07.2020 | ||
Former [2021/10] | AT | 04.03.2020 | |
CZ | 04.03.2020 | ||
DK | 04.03.2020 | ||
EE | 04.03.2020 | ||
ES | 04.03.2020 | ||
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
IT | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
MC | 04.03.2020 | ||
NL | 04.03.2020 | ||
PL | 04.03.2020 | ||
RO | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
SI | 04.03.2020 | ||
SK | 04.03.2020 | ||
SM | 04.03.2020 | ||
IE | 19.03.2020 | ||
LU | 19.03.2020 | ||
BE | 31.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
PT | 29.07.2020 | ||
Former [2021/08] | CZ | 04.03.2020 | |
DK | 04.03.2020 | ||
EE | 04.03.2020 | ||
ES | 04.03.2020 | ||
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
MC | 04.03.2020 | ||
NL | 04.03.2020 | ||
RO | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
SK | 04.03.2020 | ||
SM | 04.03.2020 | ||
IE | 19.03.2020 | ||
LU | 19.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
PT | 29.07.2020 | ||
Former [2021/04] | CZ | 04.03.2020 | |
EE | 04.03.2020 | ||
ES | 04.03.2020 | ||
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
MC | 04.03.2020 | ||
NL | 04.03.2020 | ||
RO | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
SK | 04.03.2020 | ||
SM | 04.03.2020 | ||
LU | 19.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
PT | 29.07.2020 | ||
Former [2020/50] | CZ | 04.03.2020 | |
EE | 04.03.2020 | ||
ES | 04.03.2020 | ||
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
NL | 04.03.2020 | ||
RO | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
SK | 04.03.2020 | ||
SM | 04.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
PT | 29.07.2020 | ||
Former [2020/49] | CZ | 04.03.2020 | |
ES | 04.03.2020 | ||
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
NL | 04.03.2020 | ||
RO | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
SK | 04.03.2020 | ||
SM | 04.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
PT | 29.07.2020 | ||
Former [2020/48] | ES | 04.03.2020 | |
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
NL | 04.03.2020 | ||
RO | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
SM | 04.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
PT | 29.07.2020 | ||
Former [2020/47] | ES | 04.03.2020 | |
FI | 04.03.2020 | ||
HR | 04.03.2020 | ||
LT | 04.03.2020 | ||
LV | 04.03.2020 | ||
NL | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
Former [2020/46] | FI | 04.03.2020 | |
HR | 04.03.2020 | ||
LV | 04.03.2020 | ||
NL | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
IS | 04.07.2020 | ||
Former [2020/45] | FI | 04.03.2020 | |
HR | 04.03.2020 | ||
LV | 04.03.2020 | ||
NL | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
Former [2020/39] | FI | 04.03.2020 | |
HR | 04.03.2020 | ||
LV | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
BG | 04.06.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
Former [2020/38] | FI | 04.03.2020 | |
HR | 04.03.2020 | ||
LV | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
NO | 04.06.2020 | ||
GR | 05.06.2020 | ||
Former [2020/37] | FI | 04.03.2020 | |
HR | 04.03.2020 | ||
LV | 04.03.2020 | ||
RS | 04.03.2020 | ||
SE | 04.03.2020 | ||
NO | 04.06.2020 | ||
Former [2020/35] | FI | 04.03.2020 | |
NO | 04.06.2020 | Documents cited: | Search | [XY] - DUBINSKY LUBA ET AL, "Synthesis and validation of a probe to identify quorum sensing receptors.", CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND) 21 DEC 2009, (20091221), no. 47, ISSN 1364-548X, pages 7378 - 7380, XP002759598 [X] 1,10 * figures 1,2 * [Y] 1-4,10,11 | [Y] - GARNER AMANDA L ET AL, "Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (201105), vol. 21, no. 9, pages 2702 - 2705, XP002759599 [Y] 1-4,10,11 * Schemes 1 and 2 * | International search | [A]US6602905 (GARDINER SHEILA MARGARET [GB], et al); | [A]US2005003387 (AZA-BLANC PEDRO [US], et al); | [A]US2007010477 (DOLNICK BRUCE J [US], et al); | [A]US2010286261 (PRITCHARD DAVID IDRIS [GB], et al); | [A] - PRANEENARARAT ET AL., "Chemical methods to interrogate bacterial quorum sensing pathways.", ORG BIOMOL CHEM., vol. 10, no. 41, (2012), pages 8189 - 8199, URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480174/pdf/nihms409202.pdf, (20140718), XP055281448 DOI: http://dx.doi.org/10.1039/c2ob26353j | [A] - KARLSSON ET AL., "The Pseudomonas aeruginosa N-Acylhomoserine Lactone Quorum Sensing Molecules Target IQGAP1 and Modulate Epithelial Cell Migration.", PLOS PATHOGEN, (2012), vol. 8, no. 10, pages 1 - 17, XP055281451 DOI: http://dx.doi.org/10.1371/journal.ppat.1002953 | [AP] - DUBINSKY ET AL., "Species selective diazirine positioning in tag-free photoactive quorum sensing probes.", CHEM COMMUN, vol. 49, no. 52, (2013), pages 5826 - 5828, URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723129/pdf/nihms485740.pdf, (20141007), XP055281457 DOI: http://dx.doi.org/10.1039/c3cc43092h | [XP] - KRAVCHENKO ET AL., "Facilitating Cytokine-Mediated Cancer Cell Death by Proteobacterial N-Acylhomoserine Lactones.", ACS CHEM. BIOL., vol. 8, no. 6, (2013), pages 1117 - 1120, URL: http://pubs.acs.org/doi/abs/10.1021/cb4000184, (20141008), XP055281459 DOI: http://dx.doi.org/10.1021/cb4000184 |