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Extract from the Register of European Patents

EP About this file: EP2976076

EP2976076 - TRAIL ENHANCERS FOR THE SELECTIVE KILLING OF CANCER CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  08.01.2021
Database last updated on 31.08.2024
FormerThe patent has been granted
Status updated on  31.01.2020
FormerGrant of patent is intended
Status updated on  17.09.2019
FormerExamination is in progress
Status updated on  28.09.2018
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA 92037 / US
[2016/04]
Inventor(s)01 / KRAVCHENKO, Vladimir
7192 Whipple Avenue
San Diego, California 92122 / US
02 / ULEVITCH, Richard J.
1001 Genter Street Apt. 7F
La Jolla, California 92037 / US
03 / JANDA, Kim D.
5787 La Jolla Corona Drive
La Jolla, California 92037 / US
 [2016/04]
Representative(s)Steffan & Kiehne Patentanwälte PartG mbB
Patentanwälte
Postfach 10 40 09
40031 Düsseldorf / DE
[N/P]
Former [2020/10]Leifert & Steffan Patentanwälte PartG mbB
Patentanwälte
Postfach 10 40 09
40031 Düsseldorf / DE
Former [2016/04]Leifert & Steffan
Patentanwälte Postfach 10 40 09
40031 Düsseldorf / DE
Application number, filing date14770705.319.03.2014
[2016/04]
WO2014US31235
Priority number, dateUS201361803177P19.03.2013         Original published format: US 201361803177 P
[2016/04]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2014153415
Date:25.09.2014
Language:EN
[2014/39]
Type: A2 Application without search report 
No.:EP2976076
Date:27.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 25.09.2014 takes the place of the publication of the European patent application.
[2016/04]
Type: B1 Patent specification 
No.:EP2976076
Date:04.03.2020
Language:EN
[2020/10]
Search report(s)International search report - published on:US08.01.2015
(Supplementary) European search report - dispatched on:EP17.10.2016
ClassificationIPC:A61K31/402, A61P35/00, C07D405/12, C07D307/33
[2016/46]
CPC:
C07D405/12 (EP,KR,US); A61K31/365 (EP,KR,US); A61K31/336 (EP,US);
A61K31/337 (EP,US); A61K31/341 (EP,US); A61K31/396 (EP,KR,US);
A61K38/1761 (EP,US); A61K38/177 (EP,KR,US); A61K38/19 (EP,US);
A61P35/00 (EP); A61P43/00 (EP); C07D305/12 (EP,US);
C07D307/33 (EP,KR,US) (-)
C-Set:
A61K31/365, A61K2300/00 (EP,US);
A61K31/396, A61K2300/00 (US,EP);
A61K38/177, A61K2300/00 (US,EP)
Former IPC [2016/04]A61K31/402
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/04]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MODULATOREN VON TRAIL ZUR SELEKTIVEN TÖTUNG VON KREBSZELLEN[2019/41]
English:TRAIL ENHANCERS FOR THE SELECTIVE KILLING OF CANCER CELLS[2016/04]
French:AMPLIFICATEURS DE TRAIL POUR TUER SÉLECTIVEMENT DES CELLULES CANCÉREUSES[2016/04]
Former [2016/04]SPURVERSTÄRKER ZUR SELEKTIVEN TÖTUNG VON KREBSZELLEN
Entry into regional phase19.10.2015National basic fee paid 
19.10.2015Search fee paid 
19.10.2015Designation fee(s) paid 
19.10.2015Examination fee paid 
Examination procedure19.10.2015Examination requested  [2016/04]
03.05.2017Amendment by applicant (claims and/or description)
01.10.2018Despatch of a communication from the examining division (Time limit: M04)
14.03.2019Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
09.05.2019Reply to a communication from the examining division
18.09.2019Communication of intention to grant the patent
22.01.2020Fee for grant paid
22.01.2020Fee for publishing/printing paid
22.01.2020Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  01.10.2018
Opposition(s)07.12.2020No opposition filed within time limit [2021/06]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
09.05.2019Request for further processing filed
09.05.2019Full payment received (date of receipt of payment)
Request granted
21.05.2019Decision despatched
Fees paidRenewal fee
10.03.2016Renewal fee patent year 03
10.03.2017Renewal fee patent year 04
13.03.2018Renewal fee patent year 05
31.05.2019Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.03.201906   M06   Fee paid on   31.05.2019
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.03.2014
AL04.03.2020
AT04.03.2020
CY04.03.2020
CZ04.03.2020
DK04.03.2020
EE04.03.2020
ES04.03.2020
FI04.03.2020
HR04.03.2020
IT04.03.2020
LT04.03.2020
LV04.03.2020
MC04.03.2020
MK04.03.2020
MT04.03.2020
NL04.03.2020
PL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SI04.03.2020
SK04.03.2020
SM04.03.2020
TR04.03.2020
IE19.03.2020
LU19.03.2020
BE31.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
[2022/31]
Former [2022/30]HU19.03.2014
AL04.03.2020
AT04.03.2020
CY04.03.2020
CZ04.03.2020
DK04.03.2020
EE04.03.2020
ES04.03.2020
FI04.03.2020
HR04.03.2020
IT04.03.2020
LT04.03.2020
LV04.03.2020
MC04.03.2020
MT04.03.2020
NL04.03.2020
PL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SI04.03.2020
SK04.03.2020
SM04.03.2020
TR04.03.2020
IE19.03.2020
LU19.03.2020
BE31.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
Former [2022/27]HU19.03.2014
AT04.03.2020
CY04.03.2020
CZ04.03.2020
DK04.03.2020
EE04.03.2020
ES04.03.2020
FI04.03.2020
HR04.03.2020
IT04.03.2020
LT04.03.2020
LV04.03.2020
MC04.03.2020
MT04.03.2020
NL04.03.2020
PL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SI04.03.2020
SK04.03.2020
SM04.03.2020
TR04.03.2020
IE19.03.2020
LU19.03.2020
BE31.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
Former [2021/10]AT04.03.2020
CZ04.03.2020
DK04.03.2020
EE04.03.2020
ES04.03.2020
FI04.03.2020
HR04.03.2020
IT04.03.2020
LT04.03.2020
LV04.03.2020
MC04.03.2020
NL04.03.2020
PL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SI04.03.2020
SK04.03.2020
SM04.03.2020
IE19.03.2020
LU19.03.2020
BE31.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
Former [2021/08]CZ04.03.2020
DK04.03.2020
EE04.03.2020
ES04.03.2020
FI04.03.2020
HR04.03.2020
LT04.03.2020
LV04.03.2020
MC04.03.2020
NL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SK04.03.2020
SM04.03.2020
IE19.03.2020
LU19.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
Former [2021/04]CZ04.03.2020
EE04.03.2020
ES04.03.2020
FI04.03.2020
HR04.03.2020
LT04.03.2020
LV04.03.2020
MC04.03.2020
NL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SK04.03.2020
SM04.03.2020
LU19.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
Former [2020/50]CZ04.03.2020
EE04.03.2020
ES04.03.2020
FI04.03.2020
HR04.03.2020
LT04.03.2020
LV04.03.2020
NL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SK04.03.2020
SM04.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
Former [2020/49]CZ04.03.2020
ES04.03.2020
FI04.03.2020
HR04.03.2020
LT04.03.2020
LV04.03.2020
NL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SK04.03.2020
SM04.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
Former [2020/48]ES04.03.2020
FI04.03.2020
HR04.03.2020
LT04.03.2020
LV04.03.2020
NL04.03.2020
RO04.03.2020
RS04.03.2020
SE04.03.2020
SM04.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
PT29.07.2020
Former [2020/47]ES04.03.2020
FI04.03.2020
HR04.03.2020
LT04.03.2020
LV04.03.2020
NL04.03.2020
RS04.03.2020
SE04.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
Former [2020/46]FI04.03.2020
HR04.03.2020
LV04.03.2020
NL04.03.2020
RS04.03.2020
SE04.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
IS04.07.2020
Former [2020/45]FI04.03.2020
HR04.03.2020
LV04.03.2020
NL04.03.2020
RS04.03.2020
SE04.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
Former [2020/39]FI04.03.2020
HR04.03.2020
LV04.03.2020
RS04.03.2020
SE04.03.2020
BG04.06.2020
NO04.06.2020
GR05.06.2020
Former [2020/38]FI04.03.2020
HR04.03.2020
LV04.03.2020
RS04.03.2020
SE04.03.2020
NO04.06.2020
GR05.06.2020
Former [2020/37]FI04.03.2020
HR04.03.2020
LV04.03.2020
RS04.03.2020
SE04.03.2020
NO04.06.2020
Former [2020/35]FI04.03.2020
NO04.06.2020
Documents cited:Search[XY]  - DUBINSKY LUBA ET AL, "Synthesis and validation of a probe to identify quorum sensing receptors.", CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND) 21 DEC 2009, (20091221), no. 47, ISSN 1364-548X, pages 7378 - 7380, XP002759598 [X] 1,10 * figures 1,2 * [Y] 1-4,10,11
 [Y]  - GARNER AMANDA L ET AL, "Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (201105), vol. 21, no. 9, pages 2702 - 2705, XP002759599 [Y] 1-4,10,11 * Schemes 1 and 2 *
International search[A]US6602905  (GARDINER SHEILA MARGARET [GB], et al);
 [A]US2005003387  (AZA-BLANC PEDRO [US], et al);
 [A]US2007010477  (DOLNICK BRUCE J [US], et al);
 [A]US2010286261  (PRITCHARD DAVID IDRIS [GB], et al);
 [A]  - PRANEENARARAT ET AL., "Chemical methods to interrogate bacterial quorum sensing pathways.", ORG BIOMOL CHEM., vol. 10, no. 41, (2012), pages 8189 - 8199, URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480174/pdf/nihms409202.pdf, (20140718), XP055281448

DOI:   http://dx.doi.org/10.1039/c2ob26353j
 [A]  - KARLSSON ET AL., "The Pseudomonas aeruginosa N-Acylhomoserine Lactone Quorum Sensing Molecules Target IQGAP1 and Modulate Epithelial Cell Migration.", PLOS PATHOGEN, (2012), vol. 8, no. 10, pages 1 - 17, XP055281451

DOI:   http://dx.doi.org/10.1371/journal.ppat.1002953
 [AP]  - DUBINSKY ET AL., "Species selective diazirine positioning in tag-free photoactive quorum sensing probes.", CHEM COMMUN, vol. 49, no. 52, (2013), pages 5826 - 5828, URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723129/pdf/nihms485740.pdf, (20141007), XP055281457

DOI:   http://dx.doi.org/10.1039/c3cc43092h
 [XP]  - KRAVCHENKO ET AL., "Facilitating Cytokine-Mediated Cancer Cell Death by Proteobacterial N-Acylhomoserine Lactones.", ACS CHEM. BIOL., vol. 8, no. 6, (2013), pages 1117 - 1120, URL: http://pubs.acs.org/doi/abs/10.1021/cb4000184, (20141008), XP055281459

DOI:   http://dx.doi.org/10.1021/cb4000184
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