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Extract from the Register of European Patents

EP About this file: EP3055409

EP3055409 - METABOLICALLY OPTIMIZED CELL CULTURE [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  23.03.2018
Database last updated on 14.09.2024
FormerExamination is in progress
Status updated on  01.03.2018
FormerGrant of patent is intended
Status updated on  20.12.2017
FormerExamination is in progress
Status updated on  26.05.2017
Most recent event   Tooltip06.08.2024New entry: Date of oral proceedings 
Applicant(s)For all designated states
Regeneron Pharmaceuticals, Inc.
777 Old Saw Mill River Road
Tarrytown, NY 10591 / US
[2016/33]
Inventor(s)01 / LAWRENCE, Shawn
371 Kings Highway
Valley Cottage New York 10989 / US
02 / KIM, Ann
300 Mamaroneck Ave, No. 434
White Plains, NY 10605 / US
03 / JOHNSON, Amy
953 Long Hill Road W
Briarcliff Manor New York 10510 / US
 [2016/36]
Former [2016/33]01 / LAWRENCE, Shawn
371 Kings Highway
Valley Cottage New York 10989 / US
02 / KIM, Ann
181 Chatterton Parkway
White Plains New York 10606 / US
03 / JOHNSON, Amy
953 Long Hill Road W
Briarcliff Manor New York 10510 / US
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2018/17]J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2016/33]Nicholls, James Ronald
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date14851841.810.10.2014
[2016/33]
WO2014US59993
Priority number, dateUS201361889815P11.10.2013         Original published format: US 201361889815 P
[2016/33]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015054554
Date:16.04.2015
Language:EN
[2015/15]
Type: A1 Application with search report 
No.:EP3055409
Date:17.08.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 16.04.2015 takes the place of the publication of the European patent application.
[2016/33]
Type: B1 Patent specification 
No.:EP3055409
Date:25.04.2018
Language:EN
[2018/17]
Search report(s)International search report - published on:AU16.04.2015
(Supplementary) European search report - dispatched on:EP29.08.2016
ClassificationIPC:C12N5/02, C12N5/16
[2016/33]
CPC:
C07K16/00 (EP,EA,KR,MX,US); C12N5/06 (EA,KR); C12N5/0682 (EA,US);
C12N5/00 (EP,EA,MX,US); C12P21/02 (EP,EA,KR,MX,US); C07K2317/14 (EP,EA,KR,MX,US);
C12N2500/60 (EP,EA,KR,MX,US); C12N2511/00 (EP,EA,KR,MX,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/33]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:METABOLISCH OPTIMIERTE ZELLKULTUR[2016/33]
English:METABOLICALLY OPTIMIZED CELL CULTURE[2016/33]
French:CULTURE CELLULAIRE À MÉTABOLISME OPTIMISÉ[2016/33]
Entry into regional phase22.03.2016National basic fee paid 
22.03.2016Search fee paid 
22.03.2016Designation fee(s) paid 
22.03.2016Examination fee paid 
Examination procedure22.03.2016Examination requested  [2016/33]
01.02.2017Amendment by applicant (claims and/or description)
29.05.2017Despatch of a communication from the examining division (Time limit: M02)
21.07.2017Reply to a communication from the examining division
21.12.2017Communication of intention to grant the patent
22.02.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
22.02.2018Fee for grant paid
22.02.2018Fee for publishing/printing paid
19.03.2018Information about intention to grant a patent
19.03.2018Receipt of the translation of the claim(s)
Divisional application(s)EP18161278.9  / EP3351620
EP20193898.2  / EP3812453
Opposition(s)Opponent(s)01  25.01.2019  31.01.2019  ADMISSIBLE
Neuefeind, Regina
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
Opponent's representative
Maiwald GmbH, et al, et al
Elisenhof
Elisenstraße 3
80335 München / DE
 [N/P]
Former [2019/10]
Opponent(s)01  25.01.2019  31.01.2019  ADMISSIBLE
Neuefeind, Regina
Maiwald Patentanwalts - und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH, et al, et al
Elisenhof
Elisenstraße 3
80335 München / DE
08.02.2019Invitation to proprietor to file observations on the notice of opposition
18.06.2019Reply of patent proprietor to notice(s) of opposition
03.09.2020Cancellation of oral proceeding that was planned for 01.10.2020
01.10.2020Date of oral proceedings
16.03.2021Cancellation of oral proceeding that was planned for 10.06.2021
10.06.2021Date of oral proceedings
01.07.2021Date of oral proceedings
04.10.2021Despatch of interlocutory decision in opposition
04.10.2021Despatch of minutes of oral proceedings
Appeal following opposition13.12.2021Appeal received No.  T2226/21
13.12.2021Payment of appeal fee
14.02.2022Statement of grounds filed
17.09.2024Date of oral proceedings
Fees paidRenewal fee
25.10.2016Renewal fee patent year 03
23.10.2017Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL25.04.2018
AT25.04.2018
CY25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
MC25.04.2018
MK25.04.2018
RO25.04.2018
RS25.04.2018
SI25.04.2018
SK25.04.2018
SM25.04.2018
TR25.04.2018
BG25.07.2018
GR26.07.2018
IS25.08.2018
PT27.08.2018
LU10.10.2018
MT10.10.2018
[2020/32]
Former [2020/31]AL25.04.2018
AT25.04.2018
CY25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
MC25.04.2018
MK25.04.2018
RO25.04.2018
RS25.04.2018
SI25.04.2018
SK25.04.2018
SM25.04.2018
TR25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
LU10.10.2018
MT10.10.2018
Former [2020/16]AL25.04.2018
AT25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
MC25.04.2018
RO25.04.2018
RS25.04.2018
SI25.04.2018
SK25.04.2018
SM25.04.2018
TR25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
LU10.10.2018
MT10.10.2018
Former [2020/08]AL25.04.2018
AT25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
MC25.04.2018
RO25.04.2018
RS25.04.2018
SI25.04.2018
SK25.04.2018
SM25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
LU10.10.2018
MT10.10.2018
Former [2019/51]AL25.04.2018
AT25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
MC25.04.2018
RO25.04.2018
RS25.04.2018
SI25.04.2018
SK25.04.2018
SM25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
LU10.10.2018
Former [2019/30]AT25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
MC25.04.2018
RO25.04.2018
RS25.04.2018
SI25.04.2018
SK25.04.2018
SM25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
LU10.10.2018
Former [2019/28]AT25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
MC25.04.2018
RO25.04.2018
RS25.04.2018
SI25.04.2018
SK25.04.2018
SM25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
Former [2019/26]AT25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
RO25.04.2018
RS25.04.2018
SI25.04.2018
SK25.04.2018
SM25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
Former [2019/11]AT25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
RO25.04.2018
RS25.04.2018
SK25.04.2018
SM25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
Former [2019/10]AT25.04.2018
CZ25.04.2018
EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
RO25.04.2018
RS25.04.2018
SK25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
Former [2019/09]EE25.04.2018
HR25.04.2018
LT25.04.2018
LV25.04.2018
RS25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
Former [2019/03]HR25.04.2018
LT25.04.2018
LV25.04.2018
RS25.04.2018
BG25.07.2018
GR26.07.2018
PT27.08.2018
Former [2018/52]HR25.04.2018
LT25.04.2018
LV25.04.2018
RS25.04.2018
BG25.07.2018
GR26.07.2018
Former [2018/51]HR25.04.2018
LT25.04.2018
LV25.04.2018
RS25.04.2018
BG25.07.2018
Former [2018/50]HR25.04.2018
LT25.04.2018
BG25.07.2018
Former [2018/47]LT25.04.2018
Documents cited:Search[A]  - BHANU CHANDRA MULUKUTLA ET AL, "On metabolic shift to lactate consumption in fed-batch culture of mammalian cells", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 14, no. 2, doi:10.1016/J.YMBEN.2011.12.006, ISSN 1096-7176, (20111216), pages 138 - 149, (20120108), XP028466094 [A] 1-18 * page 139, column l, lines 2-10 * * page 147, column r, lines 5-8 * * page 148, column l, paragraph last - column r, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/j.ymben.2011.12.006
 [A]  - FRANCESCA ZAGARI ET AL, "Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity", NEW BIOTECHNOLOGY, NL, (20130101), vol. 30, no. 2, doi:10.1016/j.nbt.2012.05.021, ISSN 1871-6784, pages 238 - 245, XP055295213 [A] 1-18 * page 239, column l, paragraph 2 - column r, paragraph last *

DOI:   http://dx.doi.org/10.1016/j.nbt.2012.05.021
 [A]  - JAMEY D YOUNG, "Metabolic flux rewiring in mammalian cell cultures", CURRENT OPINION IN BIOTECHNOLOGY., GB, (20130528), vol. 24, no. 6, doi:10.1016/j.copbio.2013.04.016, ISSN 0958-1669, pages 1108 - 1115, XP055295214 [A] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.copbio.2013.04.016
 [A]  - ZHOU W ET AL, "Fed-batch culture of recombinant NS0 myeloma cells with high monoclonal antibody production", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, (19970101), vol. 55, doi:10.1002/(SICI)1097-0290(19970905)55:5<783::AID-BIT8>3.0.CO;2-7, ISSN 0006-3592, pages 783 - 792, XP002170348 [A] 1-18 * abstract *

DOI:   http://dx.doi.org/10.1002/(SICI)1097-0290(19970905)55:5<783::AID-BIT8>3.0.CO;2-7
 [A]  - FENG LI ET AL, "Cell culture processes for monoclonal antibody production", MABS, (20100901), vol. 2, no. 5, doi:10.4161/mabs.2.5.12720, ISSN 1942-0862, pages 466 - 479, XP055166177 [A] 1-18 * figure 5 *

DOI:   http://dx.doi.org/10.4161/mabs.2.5.12720
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DOI:   http://dx.doi.org/10.1016/j.jbiotec.2012.08.021
 [X]  - SHEIKHOLESLAMI, Z. ET AL., "The impact of the timing of induction on the metabolism and productivity of CHO cells in culture", BIOCHEMICAL ENGINEERING JOURNAL, (2013), vol. 79, pages 162 - 171, XP028733030

DOI:   http://dx.doi.org/10.1016/j.bej.2013.07.015
 [X]  - MA, N. ET AL., "A single nutrient feed supports both chemically defined NSO and CHO fed-batch processes: improved productivity and lactate metabolism", BIOTECHNOLOGY PROGRESS, (2009), vol. 25, no. 5, pages 1353 - 1363, XP055287324

DOI:   http://dx.doi.org/10.1002/btpr.238
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 US6165741
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 US2009162901
 US7575890
 US2010291626
 US8192951
 US8470552
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DOI:   http://dx.doi.org/10.1016/j.nbt.2012.05.021
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DOI:   http://dx.doi.org/10.1016/j.copbio.2013.04.016
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DOI:   http://dx.doi.org/10.4161/mabs.2.5.12720
    - ZAGARI et al., "Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity", New Biotechnology, (20130100), vol. 30, no. 2, pages 238 - 245, XP055295213

DOI:   http://dx.doi.org/10.1016/j.nbt.2012.05.021
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.