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Extract from the Register of European Patents

EP About this file: EP3062783

EP3062783 - IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.06.2021
Database last updated on 26.06.2024
FormerThe patent has been granted
Status updated on  10.07.2020
FormerGrant of patent is intended
Status updated on  18.04.2020
FormerExamination is in progress
Status updated on  05.04.2020
FormerGrant of patent is intended
Status updated on  21.11.2019
FormerExamination is in progress
Status updated on  11.05.2018
Most recent event   Tooltip15.07.2022Lapse of the patent in a contracting state
New state(s): MK, PT		published on 17.08.2022  [2022/33]
Applicant(s)For all designated states
The General Hospital Corporation
55 Fruit Street
Boston, MA 02114 / US
[2019/51]
Former [2016/36]For all designated states
The General Hospital Corporation DBA Massachusetts
55 Fruit Street
Boston, MA 02114 / US
Inventor(s)01 / HOOKER, Jacob, M.
149 13th Street
Charlestown, MA 02129 / US
02 / WANG, Changning
1 Town House Lane
Unit 1
Acton, MA 01720 / US
03 / SCHROEDER, Frederick, Albert
2426 Brambleton Rd.
Baltimore, MD 21209 / US
 [2016/36]
Representative(s)Samson & Partner Patentanwälte mbB
Widenmayerstraße 6
80538 München / DE
[2016/36]
Application number, filing date14853451.417.10.2014
[2016/36]
WO2014US61179
Priority number, dateUS201361892966P18.10.2013         Original published format: US 201361892966 P
[2016/36]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015058106
Date:23.04.2015
Language:EN
[2015/16]
Type: A1 Application with search report 
No.:EP3062783
Date:07.09.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 23.04.2015 takes the place of the publication of the European patent application.
[2016/36]
Type: B1 Patent specification 
No.:EP3062783
Date:12.08.2020
Language:EN
[2020/33]
Search report(s)International search report - published on:US23.04.2015
(Supplementary) European search report - dispatched on:EP05.07.2017
ClassificationIPC:A61K31/16, C07C259/06
[2016/36]
CPC:
C07C259/06 (EP,US); A61K51/04 (US); C07C259/08 (EP,US);
C07C275/34 (EP,US); C07C311/16 (EP,US); C07C311/21 (EP,US);
C07D209/08 (US); C07D209/14 (US); C07D235/08 (US);
C07D267/16 (US); C07D281/12 (US); C07B2200/05 (EP,US);
C07C2601/14 (EP,US); C07C2602/10 (EP,US); C07C2603/74 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/36]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:BILDGEBUNG VON HISTONDEACETYLASEN MIT EINEM RADIOTRACER MITTELS POSITRONENEMISSIONSTOMOGRAFIE[2016/36]
English:IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY[2016/36]
French:IMAGERIE D'HISTONE DÉSACÉTYLASES AU MOYEN D'UN RADIOTRACEUR À L'AIDE DE LA TOMOGRAPHIE PAR ÉMISSION DE POSITRONS[2016/36]
Entry into regional phase18.05.2016National basic fee paid 
25.07.2016Search fee paid 
18.05.2016Designation fee(s) paid 
18.05.2016Examination fee paid 
Examination proceduredeletedDeletion: Application deemed to be withdrawn, date of legal effect  [2016/36]
18.05.2016Examination requested  [2016/36]
24.06.2016Despatch of communication that the application is deemed to be withdrawn, reason: filing fee / search fee not paid in time  [2016/36]
19.01.2018Amendment by applicant (claims and/or description)
14.05.2018Despatch of a communication from the examining division (Time limit: M06)
06.11.2018Reply to a communication from the examining division
07.03.2019Despatch of a communication from the examining division (Time limit: M04)
02.07.2019Reply to a communication from the examining division
22.11.2019Communication of intention to grant the patent
02.04.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
02.04.2020Fee for grant paid
02.04.2020Fee for publishing/printing paid
28.04.2020Communication of intention to grant the patent
08.07.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20190478.6  / EP3769757
Opposition(s)14.05.2021No opposition filed within time limit [2021/29]
Request for further processing for:The application is deemed to be withdrawn due to non-payment of the search fee
25.07.2016Request for further processing filed
25.07.2016Full payment received (date of receipt of payment)
Request granted
10.08.2016Decision despatched
Fees paidRenewal fee
27.10.2016Renewal fee patent year 03
27.10.2017Renewal fee patent year 04
29.10.2018Renewal fee patent year 05
28.10.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU17.10.2014
AL12.08.2020
AT12.08.2020
CY12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
MK12.08.2020
MT12.08.2020
NL12.08.2020
PL12.08.2020
PT12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
TR12.08.2020
IE17.10.2020
LU17.10.2020
BE31.10.2020
CH31.10.2020
LI31.10.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
[2022/32]
Former [2022/27]HU17.10.2014
AL12.08.2020
AT12.08.2020
CY12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
MT12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
TR12.08.2020
IE17.10.2020
LU17.10.2020
BE31.10.2020
CH31.10.2020
LI31.10.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/46]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
IE17.10.2020
LU17.10.2020
BE31.10.2020
CH31.10.2020
LI31.10.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/37]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
LU17.10.2020
BE31.10.2020
CH31.10.2020
LI31.10.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/36]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SI12.08.2020
SK12.08.2020
SM12.08.2020
LU17.10.2020
BE31.10.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/34]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
IT12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SK12.08.2020
SM12.08.2020
LU17.10.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/31]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
MC12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SK12.08.2020
SM12.08.2020
LU17.10.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/28]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SK12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/25]AL12.08.2020
AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
ES12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/23]AT12.08.2020
CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
SM12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/22]CZ12.08.2020
DK12.08.2020
EE12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RO12.08.2020
RS12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/20]DK12.08.2020
FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RS12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/12]FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
NL12.08.2020
PL12.08.2020
RS12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/10]FI12.08.2020
HR12.08.2020
LT12.08.2020
LV12.08.2020
PL12.08.2020
RS12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
IS12.12.2020
Former [2021/09]FI12.08.2020
LT12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
GR13.11.2020
Former [2021/08]FI12.08.2020
LT12.08.2020
SE12.08.2020
BG12.11.2020
NO12.11.2020
Former [2021/07]FI12.08.2020
LT12.08.2020
NO12.11.2020
Documents cited:Search   [ ] - No further relevant documents disclosed
International search[X]US2004106599  (DELORME DANIEL [CA], et al);
 [Y]US2008103391  (DOS SANTOS VARELA JOAO MANUEL [PT]);
 [Y]US2010249197  (WATKINS CLARE J [GB], et al);
 [Y]US2010317739  (BROWN MILTON L [US], et al);
 [X]US2011212943  (BALASUBRAMANIAN GOPALAN [IN], et al);
 [X]  - WANG ET AL., "Visualizing Epigenetics: Current Advances and Advantages in HDAC PET Imaging techniques in Neuroscience", (2014), vol. 264, pages 186 - 197 . PAGES 187-193, XP028637612

DOI:   http://dx.doi.org/10.1016/j.neuroscience.2013.09.018
 [Y]  - HOOKER ET AL., "Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [11C]MS-275 using Positron Emission Tomography in ACS Chem.", NEUROSCIENCE, (2010), vol. 1, pages 65 - 73, XP055338825

DOI:   http://dx.doi.org/10.1021/cn9000268
 [Y]  - WILSON ET AL., "Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography: Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of 11C-Labeled 2-(Phenylthio)araalkylamines", JOURNAL OF MEDICINAL CHEMISTRY, (2000), vol. 43, pages 3103 - 3110, XP002971679

DOI:   http://dx.doi.org/10.1021/jm000079i
 [Y]  - MEIKLE ET AL., "Complementary molecular imaging technologies: High resolution SPECT, PET and MRI in Drug Discovery Today", TECHNOLOGIES, (2006), vol. 3, pages 187 - 194, XP005575176

DOI:   http://dx.doi.org/10.1016/j.ddtec.2006.05.001
Examination   - GOPALAN BALASUBRAMANIAN ET AL, "Discovery of adamantane based highly potent HDAC inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, (20130314), vol. 23, no. 9, doi:10.1016/J.BMCL.2013.03.002, ISSN 0960-894X, pages 2532 - 2537, XP028546972

DOI:   http://dx.doi.org/10.1016/j.bmcl.2013.03.002
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.