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Extract from the Register of European Patents

EP About this file: EP3074770

EP3074770 - IMMUNE MONITORING TO PREDICT AND PREVENT INFECTION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  05.03.2021
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  27.03.2020
FormerGrant of patent is intended
Status updated on  14.11.2019
FormerExamination is in progress
Status updated on  30.03.2018
Most recent event   Tooltip15.07.2022Lapse of the patent in a contracting state
New state(s): BE		published on 17.08.2022  [2022/33]
Applicant(s)For all designated states
Duke University
2812 Erwin Road
Durham, NC 27705 / US
[2016/40]
Inventor(s)01 / PALMER, Scott, M.
Duke University Medical Center
Department of Medicine - Pulmonary
Box 103002
Durham, NC 27710 / US
02 / WEINHOLD, Kent, J.
Duke University - Division of Surgical Sciences
204 Surg Oncol Res Fac
Durham, NC 27710 / US
03 / CHAN, Chi Wei, Cliburn
Duke University
Dept. of Statistical Science
2424 Erwin Road Ste. 1102
11078 Hock Plaza, Duke Box 2721
Durham, NC 27705 / US
04 / SNYDER, Laurie, D.
Duke University Medical Center
Department of Medicine - Pulmonary
Box 103002
Durham, NC 27705 / US
 [2016/40]
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[2020/18]
Former [2016/40]Kremer, Simon Mark, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
Application number, filing date14866032.726.11.2014
[2016/40]
WO2014US67726
Priority number, dateUS201361908890P26.11.2013         Original published format: US 201361908890 P
US201462014906P20.06.2014         Original published format: US 201462014906 P
[2016/40]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015081267
Date:04.06.2015
Language:EN
[2015/22]
Type: A1 Application with search report 
No.:EP3074770
Date:05.10.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 04.06.2015 takes the place of the publication of the European patent application.
[2016/40]
Type: B1 Patent specification 
No.:EP3074770
Date:29.04.2020
Language:EN
[2020/18]
Search report(s)International search report - published on:US04.06.2015
(Supplementary) European search report - dispatched on:EP20.03.2017
ClassificationIPC:G01N33/50
[2016/40]
CPC:
G01N33/5091 (EP,US); G01N2333/525 (EP,US); G01N2333/55 (EP,US);
G01N2333/57 (EP,US); G01N2333/70596 (EP,US); G01N2800/50 (EP,US);
G01N2800/52 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/40]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:IMMUNÜBERWACHUNG ZUR VORHERSAGE UND VERHINDERUNG VON INFEKTIONEN[2016/40]
English:IMMUNE MONITORING TO PREDICT AND PREVENT INFECTION[2016/40]
French:SURVEILLANCE IMMUNITAIRE POUR PRÉDIRE ET PRÉVENIR LES INFECTIONS[2016/40]
Entry into regional phase14.06.2016National basic fee paid 
14.06.2016Search fee paid 
14.06.2016Designation fee(s) paid 
14.06.2016Examination fee paid 
Examination procedure14.06.2016Examination requested  [2016/40]
12.10.2017Amendment by applicant (claims and/or description)
04.04.2018Despatch of a communication from the examining division (Time limit: M04)
13.08.2018Reply to a communication from the examining division
15.11.2019Communication of intention to grant the patent
23.03.2020Fee for grant paid
23.03.2020Fee for publishing/printing paid
23.03.2020Receipt of the translation of the claim(s)
Opposition(s)01.02.2021No opposition filed within time limit [2021/14]
Fees paidRenewal fee
07.11.2016Renewal fee patent year 03
27.11.2017Renewal fee patent year 04
27.11.2018Renewal fee patent year 05
27.11.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.11.2014
AL29.04.2020
AT29.04.2020
CY29.04.2020
CZ29.04.2020
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EE29.04.2020
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TR29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
PT31.08.2020
GB26.11.2020
IE26.11.2020
LU26.11.2020
BE30.11.2020
CH30.11.2020
FR30.11.2020
LI30.11.2020
[2022/33]
Former [2022/32]HU26.11.2014
AL29.04.2020
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BG29.07.2020
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GR30.07.2020
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Former [2022/27]HU26.11.2014
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PT31.08.2020
GB26.11.2020
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FR30.11.2020
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PL29.04.2020
RO29.04.2020
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SI29.04.2020
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SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
PT31.08.2020
GB26.11.2020
IE26.11.2020
LU26.11.2020
CH30.11.2020
FR30.11.2020
LI30.11.2020
Former [2021/49]AL29.04.2020
AT29.04.2020
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IT29.04.2020
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MC29.04.2020
NL29.04.2020
PL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SI29.04.2020
SK29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
GB26.11.2020
IE26.11.2020
LU26.11.2020
CH30.11.2020
FR30.11.2020
LI30.11.2020
Former [2021/48]AL29.04.2020
AT29.04.2020
CZ29.04.2020
DK29.04.2020
EE29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
IT29.04.2020
LT29.04.2020
LV29.04.2020
MC29.04.2020
NL29.04.2020
PL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SI29.04.2020
SK29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
IE26.11.2020
LU26.11.2020
CH30.11.2020
FR30.11.2020
LI30.11.2020
Former [2021/46]AL29.04.2020
AT29.04.2020
CZ29.04.2020
DK29.04.2020
EE29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
IT29.04.2020
LT29.04.2020
LV29.04.2020
MC29.04.2020
NL29.04.2020
PL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SI29.04.2020
SK29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
IE26.11.2020
LU26.11.2020
CH30.11.2020
LI30.11.2020
Former [2021/37]AL29.04.2020
AT29.04.2020
CZ29.04.2020
DK29.04.2020
EE29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
IT29.04.2020
LT29.04.2020
LV29.04.2020
MC29.04.2020
NL29.04.2020
PL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SI29.04.2020
SK29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
LU26.11.2020
CH30.11.2020
LI30.11.2020
Former [2021/33]AL29.04.2020
AT29.04.2020
CZ29.04.2020
DK29.04.2020
EE29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
IT29.04.2020
LT29.04.2020
LV29.04.2020
MC29.04.2020
NL29.04.2020
PL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SI29.04.2020
SK29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
LU26.11.2020
Former [2021/31]AL29.04.2020
AT29.04.2020
CZ29.04.2020
DK29.04.2020
EE29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
IT29.04.2020
LT29.04.2020
LV29.04.2020
MC29.04.2020
NL29.04.2020
PL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SI29.04.2020
SK29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2021/24]AL29.04.2020
AT29.04.2020
CZ29.04.2020
DK29.04.2020
EE29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
IT29.04.2020
LT29.04.2020
LV29.04.2020
NL29.04.2020
PL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SI29.04.2020
SK29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2021/10]AL29.04.2020
AT29.04.2020
CZ29.04.2020
DK29.04.2020
EE29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
IT29.04.2020
LT29.04.2020
LV29.04.2020
NL29.04.2020
PL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SK29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2021/09]AL29.04.2020
AT29.04.2020
CZ29.04.2020
DK29.04.2020
EE29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
IT29.04.2020
LT29.04.2020
LV29.04.2020
NL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2021/08]AL29.04.2020
DK29.04.2020
ES29.04.2020
FI29.04.2020
HR29.04.2020
LT29.04.2020
LV29.04.2020
NL29.04.2020
RO29.04.2020
RS29.04.2020
SE29.04.2020
SM29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2021/04]AL29.04.2020
FI29.04.2020
HR29.04.2020
LT29.04.2020
LV29.04.2020
NL29.04.2020
RS29.04.2020
SE29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2021/01]FI29.04.2020
HR29.04.2020
LT29.04.2020
LV29.04.2020
RS29.04.2020
SE29.04.2020
BG29.07.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2020/51]FI29.04.2020
HR29.04.2020
LT29.04.2020
LV29.04.2020
RS29.04.2020
SE29.04.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2020/50]FI29.04.2020
HR29.04.2020
LT29.04.2020
LV29.04.2020
SE29.04.2020
NO29.07.2020
GR30.07.2020
IS29.08.2020
PT31.08.2020
Former [2020/48]FI29.04.2020
LT29.04.2020
SE29.04.2020
NO29.07.2020
IS29.08.2020
PT31.08.2020
Former [2020/47]LT29.04.2020
NO29.07.2020
IS29.08.2020
Former [2020/46]IS29.08.2020
Documents cited:Search[XI]  - FUHRMANN S. ET AL., "Cyclosporin A and tacrolimus reduce T-cell polyfunctionality but not interferon-gamma responses directed at cytomegalovirus", IMMUNOL., (201208), vol. 136, no. 4, pages 408 - 413, XP055352509 [X] 1,3-8,10-13 * abstract * * page 408, column 1 - page 409, column 2 * * page 411, column 2, paragraph 2 * [I] 2,9,14,15

DOI:   http://dx.doi.org/10.1111/j.1365-2567.2012.03594.x
    [XDYI] - SNYDER L. D. ET AL., "Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis", AM. J. TRANSPLANT., (20110110), vol. 11, no. 3, pages 553 - 560, XP055352162 [XD] 1,3-8,10 * abstract * * page 554 * * page 557 * [Y] 15 [I] 2,9

DOI:   http://dx.doi.org/10.1111/j.1600-6143.2010.03405.x
 [XYI]  - HOEGH-PETERSEN M. ET AL., "Low cytomegalovirus-specific T-cell counts at reactivation are associated with progression to high-level viremia or disease in seropositive recipients of hematopoietic cell grafts from seropositive but not seronegative donors", CYTOTHERAPY, (201202), vol. 14, no. 2, pages 194 - 204, XP055352516 [X] 1,3-8,10 * abstract * [Y] 15 [I] 2,9

DOI:   http://dx.doi.org/10.3109/14653249.2011.634402
 [XYI]  - ZHOU W. ET AL., "Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients", BLOOD, (20090618), vol. 113, no. 25, pages 6465 - 6476, XP055045483 [X] 1,3-8,10,13 * abstract * * page 6466, column 1 * [Y] 15 [I] 2,9

DOI:   http://dx.doi.org/10.1182/blood-2009-02-203307
 [XYI]  - LACEY S.F. ET AL., "Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ transplant recipients", J. INFECT. DIS., (2006), vol. 194, pages 1410 - 1421, XP055352515 [X] 1-8,10 * abstract * * page 1411 * * page 1420, column 1, paragraph l - column 2, paragraph l * [Y] 15 [I] 2,9

DOI:   http://dx.doi.org/10.1086/508495
 [T]  - SNYDER L.D. ET AL., "Polyfunctional T-cell signatures to predict protection from cytomegalovirus after lung transplantation", AM. J. RESPIR. CRIT. CARE MED., (20150916), vol. 193, no. 1, pages 78 - 85, XP055352165 [T] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1164/rccm.201504-0733OC
International search[Y]US2008112949  (WINSOR-HINES DAWN [US], et al);
 [X]CN102297968  (CHENG ET AL);
 [Y]US2012093848  (LIAN YIN [TW], et al);
 [A]US2012288850  (SOETHOUT ERNST CHRISTIAAN [NL], et al);
 [A]US8425898  (SAMPSON JOHN H [US], et al);
 [X]  - SCHEINBERG ET AL., "The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor", BLOOD, (20090923), vol. 114, pages 5071 - 5080, XP055345922

DOI:   http://dx.doi.org/10.1182/blood-2009-04-214684
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