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EP About this file: EP3000468

EP3000468 - SMALL MOLECULE INHIBITORS OF NECROPTOSIS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 05.10.2018 Database last updated on 19.10.2024
Former	Examination is in progress Status updated on 19.01.2018
Former	Request for examination was made Status updated on 16.12.2016
Most recent event Tooltip	05.10.2018	Application deemed to be withdrawn	published on 07.11.2018 [2018/45]
Applicant(s)	For all designated states President and Fellows of Harvard College 17 Quincy Street Cambridge, MA 02138 / US
	[2016/13]
Inventor(s)	01 / YUAN, Junying 22 Fairlee Road Newton MA 02468 / US
	02 / HSU, Emily, P. Schwanthalerstr. 113, App. 405 80339 Munich / DE
	[2016/13]
Representative(s)	Lahrtz, Fritz Patentanwälte Isenbruck Bösl Hörschler PartG mbB Prinzregentenstraße 68 81675 München / DE
	[N/P]
Former [2016/13]	Lahrtz, Fritz Isenbruck Bösl Hörschler LLP Patentanwälte Prinzregentenstrasse 68 81675 München / DE
Application number, filing date	15001699.6	23.12.2009
	[2016/13]
Priority number, date	US20080140615P	23.12.2008 Original published format: US 140615 P
	[2016/13]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP3000468
	Date:	30.03.2016
	Language:	EN
	[2016/13]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	05.02.2016
Classification	IPC:	A61K31/519, C07D495/04, C07D498/08, A61P35/00, A61K31/045, A61K31/415, A61K31/4178, A61K31/429, A61K31/496, A61K31/517, C07D231/06, C07D231/12, C07D231/56, C07D277/46, C07D403/12, C07D417/12, C07D209/08	[2016/13]
	CPC:	C07D209/08 (EP,US); C07D403/06 (EP,CN,US); C07C35/37 (US); A61P1/00 (EP); A61P1/04 (EP); A61P1/14 (EP); (+) A61P1/16 (EP); A61P1/18 (EP); A61P11/00 (EP); A61P11/06 (EP); A61P13/12 (EP); A61P19/08 (EP); A61P21/00 (EP); A61P21/04 (EP); A61P25/00 (EP); A61P25/02 (EP); A61P25/28 (EP); A61P27/00 (EP); A61P27/02 (EP); A61P29/00 (EP); A61P3/10 (EP); A61P31/04 (EP); A61P31/06 (EP); A61P31/12 (EP); A61P35/00 (EP); A61P37/00 (EP); A61P37/02 (EP); A61P37/06 (EP); A61P7/00 (EP); A61P9/00 (EP); A61P9/10 (EP); C07C33/38 (US); C07D211/78 (EP,US); C07D211/90 (EP,US); C07D215/08 (EP,US); C07D231/06 (EP,US); C07D231/12 (EP,US); C07D231/56 (EP,US); C07D233/02 (EP,US); C07D277/18 (EP,US); C07D277/46 (EP,US); C07D307/52 (EP,US); C07D333/20 (EP,US); C07D403/12 (EP,US); C07D405/06 (EP,US); C07D417/12 (EP,US); C07D495/04 (EP,US); C07D498/08 (EP,US) (-)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2016/45]
Former [2016/13]	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR
Title	German:	KLEINMOLEKULARE HEMMER VON NEKROPTOSE	[2016/13]
	English:	SMALL MOLECULE INHIBITORS OF NECROPTOSIS	[2016/13]
	French:	INHIBITEURS À PETITE MOLÉCULE DE LA NÉCROPTOSE	[2016/13]
Examination procedure	29.09.2016	Amendment by applicant (claims and/or description)
	29.09.2016	Examination requested [2016/45]
	22.01.2018	Despatch of a communication from the examining division (Time limit: M04)
	02.06.2018	Application deemed to be withdrawn, date of legal effect [2018/45]
	28.06.2018	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2018/45]
Parent application(s) Tooltip	EP09835866.6 / EP2381775
Fees paid	Renewal fee
	08.06.2015	Renewal fee patent year 03
	08.06.2015	Renewal fee patent year 04
	08.06.2015	Renewal fee patent year 05
	08.06.2015	Renewal fee patent year 06
	28.12.2015	Renewal fee patent year 07
	27.12.2016	Renewal fee patent year 08
	27.12.2017	Renewal fee patent year 09
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[XY]US4110536 (HAVERA HERBERT J, et al) [X] 1,5,14,15 * column 1, paragraph 1 * * examples 5-7,9,11 * * claims 8-10 * [Y] 1-15;
		[XY]US6355664 (KELLY TERENCE A [US], et al) [X] 1,5-7,14,15 * abstract * * claim 8 * * column 43; compound 23 * * column 45; compound 28 * * column 51; compound 42 * * column 151; table 14 * [Y] 1-15;
		[XY]WO2004093871 (LANKENAU INST MEDICAL RES [US], et al) [X] 3,5,14,15 * abstract * * figures 8-9; compounds PTH-DL-trp, * [Y] 1-15;
		[IY]WO2005077344 (BRIGHAM & WOMENS HOSPITAL [US], et al) [I] 1-15 * the whole document * * example 10 * [Y] 1-15;
		[XY]US2007037752 (ANSORGE SIEGFRIED [DE], et al) [X] 3,5,14,15 * abstract * * claims 83-84 * * pages 113-114; compounds A7.006, A8.009 * [Y] 1-15;
		[XY]WO2007047146 (INTERMUNE INC [US], et al) [X] 1,2,5-10,14,15 * abstract * * paragraphs [0163] - [0167] * * page 29; compounds I-52 * * page 30; compounds I-56 * * page 32; compounds I-71 * * page 34; compounds I-84 * * page 35; compounds I-90, I-91 * * page 44; compounds I-147, I-153 * * page 94; compound 13 * * paragraph [0074] * * claim 1 * [Y] 1-15;
		[X] - OOMS F ET AL, "Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB1 Cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity and molecular modeling", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (20020101), vol. 45, doi:10.1021/JM010896Y, ISSN 0022-2623, pages 1748 - 1756, XP002259830 [X] 1,2,10,14,15 * page 1749; table 2; compounds 27-29 * DOI: http://dx.doi.org/10.1021/jm010896y
		[IY] - TENG X ET AL, "Structure-activity relationship study of novel necroptosis inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 15, no. 22, ISSN 0960-894X, (20051115), pages 5039 - 5044, (20051115), XP027801287 [I] 1-15 * abstract * * page 5042; table 1 * * page 5043; table 2 * [Y] 1-15
		[T] - JENNY L MAKI ET AL, "Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC, NEW YORK, vol. 427, no. 2, doi:10.1016/J.AB.2012.05.019, ISSN 0003-2697, (20120521), pages 164 - 174, (20120529), XP028405139 [T] 1-15 * the whole document * DOI: http://dx.doi.org/10.1016/j.ab.2012.05.019
	by applicant	US6756394
		US2005119260
		WO2005115147
		US7253201
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		US20080086792
		US20080077320

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