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Extract from the Register of European Patents

EP About this file: EP3026109

EP3026109 - IMPROVED PRODUCTION OF GLYCOPROTEINS USING MANGANESE [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  04.02.2022
Database last updated on 14.09.2024
FormerGrant of patent is intended
Status updated on  24.09.2021
FormerExamination is in progress
Status updated on  20.08.2021
FormerGrant of patent is intended
Status updated on  15.04.2021
FormerExamination is in progress
Status updated on  23.02.2018
FormerRequest for examination was made
Status updated on  09.12.2016
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): MC, TR		published on 17.07.2024  [2024/29]
Applicant(s)For all designated states
Amgen Inc.
One Amgen Center Drive
Thousand Oaks, California 91320-1799 / US
[2016/22]
Inventor(s)01 / CROWELL, Christopher K.
1061 Wildwood Ave
Thousand Oaks, CA 91360 / US
02 / GRAMPP, Gustavo
8329 Pawnee Lane
Niwot, CO 80503 / US
 [2016/32]
Former [2016/22]01 / CROWELL, Christopher K.
1836 Mallard Dr.
Superior, CO 80027 / US
02 / GRAMPP, Gustavo
5363 Muirfield Ct.
Boulder, CO 80301 / US
Representative(s)Uexküll & Stolberg
Partnerschaft von
Patent- und Rechtsanwälten mbB
Beselerstraße 4
22607 Hamburg / DE
[2016/22]
Application number, filing date15198171.906.12.2006
[2016/22]
Priority number, dateUS20050748880P08.12.2005         Original published format: US 748880 P
[2016/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3026109
Date:01.06.2016
Language:EN
[2016/22]
Type: B1 Patent specification 
No.:EP3026109
Date:09.03.2022
Language:EN
[2022/10]
Search report(s)(Supplementary) European search report - dispatched on:EP28.04.2016
ClassificationIPC:C12N5/02, C07K14/505, C12P21/02, C12N5/10
[2016/22]
CPC:
C07K14/505 (EP,US); C07K14/575 (US); C12N5/0018 (EP,US);
C12P21/005 (EP,US); C12N2500/20 (EP,US); C12N2500/32 (EP,US);
C12N2510/02 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/02]
Former [2016/22]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:VERBESSERTE HERSTELLUNG VON GLYKOPROTEINEN UNTER VERWENDUNG VON MANGAN[2016/22]
English:IMPROVED PRODUCTION OF GLYCOPROTEINS USING MANGANESE[2016/22]
French:PRODUCTION AMELIOREE DE GLYCOPROTEINES UTILISANT LE MANGANESE[2016/22]
Examination procedure07.12.2015Date on which the examining division has become responsible
01.12.2016Examination requested  [2017/02]
21.03.2017Amendment by applicant (claims and/or description)
26.02.2018Despatch of a communication from the examining division (Time limit: M08)
23.07.2018Observations by third parties
14.02.2019Reply to a communication from the examining division
15.05.2019Despatch of a communication from the examining division (Time limit: M06)
07.01.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
17.03.2020Reply to a communication from the examining division
10.07.2020Despatch of a communication from the examining division (Time limit: M04)
20.11.2020Reply to a communication from the examining division
16.04.2021Communication of intention to grant the patent
18.08.2021Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
18.08.2021Fee for grant paid
18.08.2021Fee for publishing/printing paid
01.10.2021Communication of intention to grant the patent
27.01.2022Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP06847508.6  / EP1957630
Divisional application(s)EP22159008.6  / EP4155385
Opposition(s)Opponent(s)01  07.12.2022  08.12.2022  ADMISSIBLE
STRAWMAN LIMITED
Orchard Lea
Horns Lane
Combe
Witney, Oxfordshire OX29 8NH / GB
Opponent's representative
Potter Clarkson
Chapel Quarter
Mount Street
Nottingham NG1 6HQ / GB
 [N/P]
Former [2023/02]
Opponent(s)01  07.12.2022  08.12.2022  ADMISSIBLE
STRAWMAN LIMITED
Orchard Lea
Horns Lane
Combe
Witney, Oxfordshire OX29 8NH / GB
Opponent's representative
Potter Clarkson
The Belgrave Centre
Talbot Street
Nottingham NG1 5GG / GB
21.12.2022Invitation to proprietor to file observations on the notice of opposition
02.05.2023Reply of patent proprietor to notice(s) of opposition
13.11.2024Date of oral proceedings
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
17.03.2020Request for further processing filed
17.03.2020Full payment received (date of receipt of payment)
Request granted
26.03.2020Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
14.02.2019Request for further processing filed
14.02.2019Full payment received (date of receipt of payment)
Request granted
25.02.2019Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
21.03.2017Request for further processing filed
21.03.2017Full payment received (date of receipt of payment)
Request granted
05.04.2017Decision despatched
Fees paidRenewal fee
07.12.2015Renewal fee patent year 03
07.12.2015Renewal fee patent year 04
07.12.2015Renewal fee patent year 05
07.12.2015Renewal fee patent year 06
07.12.2015Renewal fee patent year 07
07.12.2015Renewal fee patent year 08
07.12.2015Renewal fee patent year 09
07.12.2015Renewal fee patent year 10
13.12.2016Renewal fee patent year 11
12.12.2017Renewal fee patent year 12
12.12.2018Renewal fee patent year 13
13.12.2019Renewal fee patent year 14
14.12.2020Renewal fee patent year 15
10.11.2021Renewal fee patent year 16
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU06.12.2006
AT09.03.2022
CY09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
TR09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE06.12.2022
LU06.12.2022
BE31.12.2022
[2024/29]
Former [2024/21]HU06.12.2006
AT09.03.2022
CY09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE06.12.2022
LU06.12.2022
BE31.12.2022
Former [2024/18]HU06.12.2006
AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE06.12.2022
LU06.12.2022
BE31.12.2022
Former [2023/49]AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE06.12.2022
LU06.12.2022
BE31.12.2022
Former [2023/48]AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE06.12.2022
LU06.12.2022
Former [2023/38]AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
LU06.12.2022
Former [2023/10]AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
Former [2023/07]AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
Former [2022/51]AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
Former [2022/50]AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
PL09.03.2022
RO09.03.2022
SE09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
PT11.07.2022
Former [2022/49]AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
RO09.03.2022
SE09.03.2022
SK09.03.2022
BG09.06.2022
GR10.06.2022
PT11.07.2022
Former [2022/48]AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
RO09.03.2022
SE09.03.2022
BG09.06.2022
GR10.06.2022
PT11.07.2022
Former [2022/47]AT09.03.2022
FI09.03.2022
LT09.03.2022
LV09.03.2022
RO09.03.2022
SE09.03.2022
BG09.06.2022
GR10.06.2022
PT11.07.2022
Former [2022/39]FI09.03.2022
LT09.03.2022
LV09.03.2022
SE09.03.2022
BG09.06.2022
GR10.06.2022
Former [2022/36]LT09.03.2022
LV09.03.2022
SE09.03.2022
BG09.06.2022
GR10.06.2022
Former [2022/35]LT09.03.2022
SE09.03.2022
BG09.06.2022
Former [2022/33]LT09.03.2022
Documents cited:Search[X]WO9808934  (LIFE TECHNOLOGIES INC [US], et al) [X] 14 * claim 14 *;
 [X]EP1085083  (CHUGAI PHARMACEUTICAL CO LTD [JP]) [X] 14-15 * paragraphs [0020] , [0029] *;
 [X]  - KAUFMAN RANDAL J ET AL, "Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells", BIOCHEMISTRY, (1994), vol. 33, no. 33, ISSN 0006-2960, pages 9813 - 9819, XP002454613 [X] 14-15 * the whole document *

DOI:   http://dx.doi.org/10.1021/bi00199a001
 [DA]  - WITSELL D L ET AL, "DIVALENT CATION ACTIVATION OF GALACTOSYLTRANSFERASE IN NATIVE MAMMARY GOLGI VESICLES", JOURNAL OF BIOLOGICAL CHEMISTRY, (1990), vol. 265, no. 26, ISSN 0021-9258, pages 15731 - 15737, XP002454614 [DA] 1-15 * the whole document *
    [ ] - CROWELL CHRISTOPHER K ET AL, "Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system", BIOTECHNOLOGY AND BIOENGINEERING, (200702), vol. 96, no. 3, ISSN 0006-3592, pages 538 - 549, XP002454615 [ ] * the whole document *

DOI:   http://dx.doi.org/10.1002/bit.21141
ExaminationWO8502610
 US4703008
 WO9505465
 WO0065070
 EP1298217
 WO2005121173
    - Michael H. Rayner ET AL, "A simple and effective method for the removal of trace metal cations from a mammalian culture medium supplemented with 10% fetal calf serum", BioMetals, (19950101), vol. 8, pages 188 - 192, XP055378079

DOI:   http://dx.doi.org/10.1007/BF00143374
    - SHANTHA RAJU T ET AL, "Glycoengineering of Therapeutic Glycoproteins: In Vitro Galactosylation and Sialylation of Glycoproteins with Terminal N-Acetylglucosamine and Galactose Residues", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 40, no. 30, doi:10.1021/BI010475I, ISSN 0006-2960, (20010101), pages 8868 - 8876, (20010706), XP008153602

DOI:   http://dx.doi.org/10.1021/bi010475i
by applicantUS4667016
 US4703008
 WO9105867
 WO9505465
 US5459031
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 WO0181405
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    - KAUFMAN ET AL., BIOCHEMISTRY, (1994), vol. 33, no. 33, pages 9813 - 9
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otherWO8502610
 EP0148605
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 EP1298217
 WO2005121173
 EP1957630
    - LAI et al., "Structural Characterization of Human Erythropoietin", J. Biol. Chem., (19860305), vol. 261, no. 7, pages 3116 - 3121, XP000857434
    - "Cell Culture Catalogue 2004", BioConcept, (20040000), pages 1 - 82, XP055468535
OppositionWO8502610
 US4667016
 US4703008
 EP0513738
 WO9505465
 WO9619573
 EP0428267
 WO9911781
 WO0065070
 WO0181405
 EP1298217
 EP1394179
 WO2005080545
 WO2007045453
 WO2007070315
 EP3026109
 US2016222075
    - ELLIOTT STEVE ET AL, "Enhancement of therapeutic protein in vivo activities through glycoengineering.", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20030401), vol. 21, no. 4, doi:10.1038/nbt799, ISSN 1087-0156, pages 414 - 421, XP002354911

DOI:   http://dx.doi.org/10.1038/nbt799
    - RAJU T SHANTHA ET AL, "Glycoengineering of therapeutic glycoproteins: In vitro galactosylation and sialylation of glycoproteins with terminal N-acetylglucosamine and galactose residues", Biochemistry, (20010731), vol. 40, no. 30, doi:10.1021/bi010475i, ISSN 0006-2960, pages 8868 - 8876, XP002461128

DOI:   http://dx.doi.org/10.1021/bi010475i
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DOI:   http://dx.doi.org/10.1021/bi00199a001
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    - Christopher K. Crowell et al, "Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20060825), vol. 96, no. 3, doi:10.1002/bit.21141, ISSN 0006-3592, pages 538 - 549, XP071134465

DOI:   http://dx.doi.org/10.1002/bit.21141
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DOI:   http://dx.doi.org/10.1007/BF01209934
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DOI:   http://dx.doi.org/10.1007/BF00143374
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DOI:   http://dx.doi.org/10.1016/0014-4827(68)90489-8
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