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Extract from the Register of European Patents

EP About this file: EP3097079

EP3097079 - PROCESS FOR THE CYCLOADDITION OF A HETERO(ARYL) 1,3-DIPOLE COMPOUND WITH A (HETERO)CYCLOALKYNE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.03.2022
Database last updated on 27.07.2024
FormerThe patent has been granted
Status updated on  09.04.2021
FormerGrant of patent is intended
Status updated on  22.11.2020
FormerExamination is in progress
Status updated on  16.06.2017
Most recent event   Tooltip27.04.2024Lapse of the patent in a contracting state
New state(s): MK
published on 29.05.2024  [2024/22]
Applicant(s)For all designated states
SynAffix B.V.
Molenstraat 110
5342 CC Oss / NL
[2016/48]
Inventor(s)01 / VAN DELFT, Floris Louis
Bandoengstraat 13
NL-6524 KZ Nijmegen / NL
02 / DOMMERHOLT, Frederik Jan
Nervalaan 1
NL-6642 AK Beuningen / NL
 [2016/48]
Representative(s)Nederlandsch Octrooibureau
P.O. Box 29720
2502 LS The Hague / NL
[2016/48]
Application number, filing date15703639.326.01.2015
[2016/48]
WO2015NL50045
Priority number, dateEP2014015242024.01.2014         Original published format: EP 14152420
[2016/48]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015112014
Date:30.07.2015
Language:EN
[2015/30]
Type: A1 Application with search report 
No.:EP3097079
Date:30.11.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 30.07.2015 takes the place of the publication of the European patent application.
[2016/48]
Type: B1 Patent specification 
No.:EP3097079
Date:12.05.2021
Language:EN
[2021/19]
Search report(s)International search report - published on:EP30.07.2015
ClassificationIPC:C07D261/20, C07D225/02, C07D225/08, C07D231/54, C07D249/16
[2020/48]
CPC:
C07D487/04 (EP,US); A61K47/545 (EP,US); A61K47/60 (EP,US);
A61K47/6855 (EP,US); C07C269/06 (US); C07C271/18 (US);
C07D225/02 (EP,US); C07D225/08 (EP,US); C07D231/54 (EP,US);
C07D249/16 (EP,US); C07D261/20 (EP,US); C07H19/10 (EP,US);
C07K14/473 (US); C07C2602/22 (EP,US); C07C2603/50 (EP,US) (-)
Former IPC [2016/48]C07D225/02, C07D225/08, C07D231/54, C07D249/16, C07D261/20, C07H19/10, A61K47/48
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/48]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR CYCLOADDITION EINER HETERO(ARYL)-1,3-DIPOL-VERBINDUNG MIT EINEM (HETERO)CYCLOALKYN[2016/48]
English:PROCESS FOR THE CYCLOADDITION OF A HETERO(ARYL) 1,3-DIPOLE COMPOUND WITH A (HETERO)CYCLOALKYNE[2016/48]
French:PROCÉDÉ DE CYCLOADDITION D'UN COMPOSÉ HÉTÉRO(ARYL) 1,3-DIPÔLE AVEC UN (HÉTÉRO)CYCLOALCYNE[2020/48]
Former [2016/48]PROCÉDÉ DE CYCLOADDITION D'UN COMPOSÉ HÉTÉRO(ARYL) 1,3-DIPOLE AVEC UN (HÉTÉRO)CYCLOALKYNE
Entry into regional phase23.08.2016National basic fee paid 
23.08.2016Designation fee(s) paid 
23.08.2016Examination fee paid 
Examination procedure23.08.2016Amendment by applicant (claims and/or description)
23.08.2016Examination requested  [2016/48]
16.06.2017Despatch of a communication from the examining division (Time limit: M04)
26.10.2017Reply to a communication from the examining division
26.03.2018Despatch of a communication from the examining division (Time limit: M06)
05.10.2018Reply to a communication from the examining division
14.02.2019Despatch of a communication from the examining division (Time limit: M06)
20.09.2019Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
02.12.2019Reply to a communication from the examining division
29.09.2020Cancellation of oral proceeding that was planned for 30.09.2020
30.09.2020Date of oral proceedings (cancelled)
23.11.2020Communication of intention to grant the patent
02.04.2021Fee for grant paid
02.04.2021Fee for publishing/printing paid
02.04.2021Receipt of the translation of the claim(s)
Divisional application(s)EP21173350.6  / EP3925951
Opposition(s)15.02.2022No opposition filed within time limit [2022/16]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
02.12.2019Request for further processing filed
02.12.2019Full payment received (date of receipt of payment)
Request granted
16.12.2019Decision despatched
Fees paidRenewal fee
10.01.2017Renewal fee patent year 03
16.01.2018Renewal fee patent year 04
16.01.2019Renewal fee patent year 05
31.01.2020Renewal fee patent year 06
29.01.2021Renewal fee patent year 07
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.01.2015
AL12.05.2021
AT12.05.2021
CY12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
ES12.05.2021
FI12.05.2021
HR12.05.2021
IT12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
MK12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
IE26.01.2022
LU26.01.2022
BE31.01.2022
[2024/22]
Former [2024/20]HU26.01.2015
AL12.05.2021
AT12.05.2021
CY12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
ES12.05.2021
FI12.05.2021
HR12.05.2021
IT12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
IE26.01.2022
LU26.01.2022
BE31.01.2022
Former [2024/18]HU26.01.2015
AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
ES12.05.2021
FI12.05.2021
HR12.05.2021
IT12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
IE26.01.2022
LU26.01.2022
BE31.01.2022
Former [2023/09]AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
ES12.05.2021
FI12.05.2021
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IT12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
IE26.01.2022
LU26.01.2022
BE31.01.2022
Former [2023/01]AL12.05.2021
AT12.05.2021
CZ12.05.2021
DK12.05.2021
EE12.05.2021
ES12.05.2021
FI12.05.2021
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IT12.05.2021
LT12.05.2021
LV12.05.2021
MC12.05.2021
PL12.05.2021
RO12.05.2021
RS12.05.2021
SE12.05.2021
SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU26.01.2022
BE31.01.2022
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SE12.05.2021
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SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
LU26.01.2022
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CZ12.05.2021
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SI12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
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SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
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SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
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CZ12.05.2021
DK12.05.2021
EE12.05.2021
ES12.05.2021
FI12.05.2021
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SE12.05.2021
SK12.05.2021
SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
IS12.09.2021
PT13.09.2021
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EE12.05.2021
ES12.05.2021
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BG12.08.2021
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GR13.08.2021
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PT13.09.2021
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CZ12.05.2021
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EE12.05.2021
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SM12.05.2021
BG12.08.2021
NO12.08.2021
GR13.08.2021
PT13.09.2021
IS22.12.2021
Former [2022/09]AT12.05.2021
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GR13.08.2021
IS12.09.2021
PT13.09.2021
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FI12.05.2021
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PL12.05.2021
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NO12.08.2021
GR13.08.2021
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Cited inInternational search[XI]WO2012047663  (UNIV GEORGIA REASERCH FOUNDATION INC [US], et al) [X] 1-6,9,10,13,15-17,19 * compounds 6b-6f from pages 28-29;; figures 1, 5 * [I] 7,8,11,12,14,20;
 [XI]US2013011901  (HOSOYA TAKAMITSU [JP], et al) [X] 1-6,9,15,16 * examples 6-14 * [I] 7,8,10-14,17-20;
 [XI]WO2013132268  (UCL BUSINESS PLC [GB]) [X] 1-7,9,10,13-17,19 * the whole document * [I] 8,11,12,18,20;
 [XP]WO2014065661  (SYNAFFIX BV [NL]) [XP] 1-20* the whole document *;
 [XI]  - ISHWAR SINGH ET AL, "Fast RNA conjugations on solid phase by strain-promoted cycloadditions", ORGANIC & BIOMOLECULAR CHEMISTRY, (19220222), vol. 10, no. 33, doi:10.1039/c2ob25628b, ISSN 1477-0520, page 6633, XP055057358 [X] 1-7,9,10,13,15-17,19,20 * the whole document * [I] 8,11,12,14,18

DOI:   http://dx.doi.org/10.1039/c2ob25628b
 [XI]  - CRAIG S. MCKAY ET AL, "Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes", CHEMICAL COMMUNICATIONS, (20100101), vol. 46, no. 6, doi:10.1039/b921630h, ISSN 1359-7345, page 931, XP055105232 [X] 1-6,9,10,13,16 * the whole document * [I] 7,8,11,12,14-20

DOI:   http://dx.doi.org/10.1039/B921630H
 [XI]  - BRIAN C. SANDERS ET AL, "Metal-Free Sequential [3 + 2]-Dipolar Cycloadditions using Cyclooctynes and 1,3-Dipoles of Different Reactivity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20110202), vol. 133, no. 4, doi:10.1021/ja1081519, ISSN 0002-7863, pages 949 - 957, XP055114630 [X] 1-7,9,10,13,15-17 * the whole document * [I] 8,11,12,14,18-20

DOI:   http://dx.doi.org/10.1021/ja1081519
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DOI:   http://dx.doi.org/10.1039/c2ob07165g
 [XI]  - ANUP M. JAWALEKAR ET AL, "Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes", CHEMICAL COMMUNICATIONS, (20110101), vol. 47, no. 11, doi:10.1039/c0cc04646a, ISSN 1359-7345, page 3198, XP055105185 [X] 1-5,9,10,13,16 * figure 1; tables 1,2 * [I] 6-8,11,12,14,15,17-20

DOI:   http://dx.doi.org/10.1039/c0cc04646a
 [XI]  - BORIS D. ZLATOPOLSKIY ET AL, "Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions", CHEMICAL COMMUNICATIONS, (20120101), vol. 48, no. 57, doi:10.1039/c2cc31335a, ISSN 1359-7345, page 7134, XP055057375 [X] 1-5,9,10,13,16 * table 1 * [I] 6-8,11,12,14,15,17-20

DOI:   http://dx.doi.org/10.1039/c2cc31335a
 [XI]  - FRÉDÉRIC FRISCOURT ET AL, "A Fluorogenic Probe for the Catalyst-Free Detection of Azide-Tagged Molecules", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20121114), vol. 134, no. 45, doi:10.1021/ja309000s, ISSN 0002-7863, pages 18809 - 18815, XP055114632 [X] 1-7,9,10,15-17,19 * figure 1 * [I] 7,8,11-14,18,20

DOI:   http://dx.doi.org/10.1021/ja309000s
 [XI]  - AUDREY HOSPITAL ET AL, "Access to functionalised silver(i) and gold(i) N-heterocyclic carbenes by [2 + 3] dipolar cycloadditions", DALTON TRANSACTIONS, (20120101), vol. 41, no. 22, doi:10.1039/c2dt30249g, ISSN 1477-9226, page 6803, XP055114633 [X] 1-6,9-13,16-19 * the whole document * [I] 7,8,14,15,20

DOI:   http://dx.doi.org/10.1039/c2dt30249g
 [XI]  - NATALIA MERCER ET AL, "Use of Novel Mutant Galactosyltransferase for the Bioconjugation of Terminal N -Acetylglucosamine (GlcNAc) Residues on Live Cell Surface", BIOCONJUGATE CHEMISTRY, (20130116), vol. 24, no. 1, doi:10.1021/bc300542z, ISSN 1043-1802, pages 144 - 152, XP055061203 [X] 1-7,9,10,13,15-17,19 * the whole document * [I] 8,11,12,14,18,20

DOI:   http://dx.doi.org/10.1021/bc300542z
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DOI:   http://dx.doi.org/10.1038/nnano.2013.23
 [I]  - QASBA PRADMAN K ET AL, "Site-specific linking of biomolecules via glycan residues using glycosyltransferases", BIOTECHNOLOGY PROGRESS,, (20080422), vol. 24, no. 3, doi:10.1021/BP0704034, ISSN 1520-6033, pages 520 - 526, XP009107098 [I] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1021/bp0704034
 [XP]  - P. SHIEH ET AL, "Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20140331), vol. 111, no. 15, doi:10.1073/pnas.1322727111, ISSN 0027-8424, pages 5456 - 5461, XP055129077 [XP] 1-20 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.1322727111
 [XP]  - LUCIE PLOUGASTEL ET AL, "4-Halogeno-sydnones for fast strain promoted cycloaddition with bicyclo-[6.1.0]-nonyne", CHEMICAL COMMUNICATIONS, (20140501), vol. 50, no. 66, doi:10.1039/C4CC03816A, ISSN 1359-7345, page 9376, XP055143131 [XP] 1-20 * the whole document *

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