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Extract from the Register of European Patents

EP About this file: EP3105216

EP3105216 - PYRAZINE MODULATORS OF GPR6 [Right-click to bookmark this link]
Former [2016/51]	PYRAZINES MODULATORS OF GPR6
	[2018/39]
Status	No opposition filed within time limit Status updated on 16.08.2019 Database last updated on 09.04.2026
Former	The patent has been granted Status updated on 07.09.2018
Former	Grant of patent is intended Status updated on 22.08.2018
Former	Examination is in progress Status updated on 17.08.2018
Former	Grant of patent is intended Status updated on 05.04.2018
Former	Examination is in progress Status updated on 13.10.2017
Former	Request for examination was made Status updated on 18.11.2016
Most recent event Tooltip	01.07.2022	Lapse of the patent in a contracting state New state(s): MK	published on 03.08.2022 [2022/31]
Applicant(s)	For all designated states Takeda Pharmaceutical Company Limited 1-1 Doshomachi 4-chome Chuo-ku Osaka-shi, Osaka 541-0045 / JP
	[2018/41]
Former [2016/51]	For all designated states Takeda Pharmaceutical Company Limited 1-1 Doshomachi 4-chome Chuo-ku Osaka-shi, Osaka 541-0045 / JP
Inventor(s)	01 / REICHARD, Holly Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	02 / ADAMS, Mark E. Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	03 / BROWN, Jason W. Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	04 / HITCHCOCK, Stephen Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	05 / KIKUCHI, Shota Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	06 / LAM, Betty Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	07 / MONENSCHEIN, Holger Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	08 / SUN, Huikai Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	09 / HOPKINS, Maria Takeda California, Inc. 10410 Science Center Drive San Diego, CA 92121 / US
	[2018/18]
Former [2016/51]	01 / REICHARD, Holly c/o Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	02 / ADAMS, Mark E. Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	03 / BROWN, Jason W. Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	04 / HITCHCOCK, Stephen Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	05 / KIKUCHI, Shota Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	06 / LAM, Betty Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	07 / MONENSCHEIN, Holger Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	08 / SUN, Huikai c/o Takeda California Inc. 10410 Science Center Drive San Diego, California 92121 / US
	09 / HOPKINS, Maria c/o Takeda California, Inc. 10410 Science Center Drive San Diego, CA 92121 / US
Representative(s)	Elend, Almut Susanne, et al Venner Shipley LLP 406 Cambridge Science Park Milton Road Cambridge CB4 0WW / GB
	[N/P]
Former [2018/41]	Elend, Almut Susanne, et al Venner Shipley LLP Byron House Cambridge Business Park Cowley Road Cambridge, Cambridgeshire CB4 0WZ / GB
Former [2016/51]	Wrobel, Olaf, et al Takeda GmbH Postfach 10 03 10 78403 Konstanz / DE
Application number, filing date	15707836.1	13.02.2015
	[2016/51]
	WO2015US15841
Priority number, date	US201461940294P	14.02.2014 Original published format: US 201461940294 P
	[2016/51]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2015123533
	Date:	20.08.2015
	Language:	EN
	[2015/33]
	Type:	A1 Application with search report
	No.:	EP3105216
	Date:	21.12.2016
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 20.08.2015 takes the place of the publication of the European patent application.
	[2016/51]
	Type:	B1 Patent specification
	No.:	EP3105216
	Date:	10.10.2018
	Language:	EN
	[2018/41]
Search report(s)	International search report - published on:	EP	20.08.2015
Classification	IPC:	C07D401/04, C07D241/26, C07D241/28, A61K31/497, A61K31/5377, A61P25/00	[2016/51]
	CPC:	C07D401/14 (EP,KR,US); A61K31/497 (EP,KR,US); A61K31/506 (EP,KR,US); A61K31/551 (EP,KR,US); A61P1/00 (EP); A61P25/00 (EP); (+) A61P25/14 (EP); A61P25/16 (EP,KR); A61P25/18 (EP,KR); A61P25/24 (EP,KR); A61P25/28 (EP,KR); A61P25/30 (EP); A61P25/36 (EP,KR); A61P43/00 (EP,KR); C07D241/26 (EP,US); C07D241/28 (EP,KR,US); C07D401/04 (EP,KR,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2016/51]
Extension states	BA	14.09.2016
	ME	14.09.2016
Title	German:	PYRAZINMODULATOREN VON GPR6	[2016/51]
	English:	PYRAZINE MODULATORS OF GPR6	[2018/39]
	French:	MODULATEURS PYRAZINIQUES DE GPR6	[2018/14]
	Former [2016/51]	PYRAZINES MODULATORS OF GPR6
	Former [2016/51]	MODULATEURS DE PYRAZINES DE GPR6
Entry into regional phase	14.09.2016	National basic fee paid
	14.09.2016	Designation fee(s) paid
	14.09.2016	Examination fee paid
Examination procedure	09.09.2016	Date on which the examining division has become responsible
	14.09.2016	Examination requested [2016/51]
	19.04.2017	Amendment by applicant (claims and/or description)
	17.10.2017	Despatch of a communication from the examining division (Time limit: M04)
	22.02.2018	Reply to a communication from the examining division
	06.04.2018	Communication of intention to grant the patent
	15.08.2018	Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
	15.08.2018	Fee for grant paid
	15.08.2018	Fee for publishing/printing paid
	30.08.2018	Communication of intention to grant the patent
	30.08.2018	Receipt of the translation of the claim(s)
Opposition(s)	11.07.2019	No opposition filed within time limit [2019/38]
Fees paid	Renewal fee
	27.02.2017	Renewal fee patent year 03
	27.02.2018	Renewal fee patent year 04
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	13.02.2015
	AL	10.10.2018
	AT	10.10.2018
	CY	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	MK	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SI	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	TR	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	IE	13.02.2019
	LU	13.02.2019
	MT	13.02.2019
	BE	28.02.2019
	[2022/31]
Former [2021/33]	HU	13.02.2015
	AL	10.10.2018
	AT	10.10.2018
	CY	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SI	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	TR	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	IE	13.02.2019
	LU	13.02.2019
	MT	13.02.2019
	BE	28.02.2019
Former [2021/26]	AL	10.10.2018
	AT	10.10.2018
	CY	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SI	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	TR	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	IE	13.02.2019
	LU	13.02.2019
	MT	13.02.2019
	BE	28.02.2019
Former [2020/29]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SI	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	TR	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	IE	13.02.2019
	LU	13.02.2019
	MT	13.02.2019
	BE	28.02.2019
Former [2020/17]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SI	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	TR	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	IE	13.02.2019
	LU	13.02.2019
	BE	28.02.2019
Former [2020/12]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SI	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	IE	13.02.2019
	LU	13.02.2019
	BE	28.02.2019
Former [2020/09]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SI	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	IE	13.02.2019
	LU	13.02.2019
Former [2019/50]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SI	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	LU	13.02.2019
Former [2019/47]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
	LU	13.02.2019
Former [2019/45]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	MC	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
Former [2019/40]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SK	10.10.2018
	SM	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
Former [2019/37]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	EE	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RO	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	SM	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
Former [2019/35]	AL	10.10.2018
	AT	10.10.2018
	CZ	10.10.2018
	DK	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
Former [2019/34]	AL	10.10.2018
	AT	10.10.2018
	DK	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
Former [2019/26]	AL	10.10.2018
	AT	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
	PT	10.02.2019
Former [2019/25]	AT	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	RS	10.10.2018
	SE	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
Former [2019/24]	AT	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	SE	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	GR	11.01.2019
	IS	10.02.2019
Former [2019/23]	AT	10.10.2018
	FI	10.10.2018
	HR	10.10.2018
	LT	10.10.2018
	LV	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	IS	10.02.2019
Former [2019/22]	FI	10.10.2018
	LT	10.10.2018
	NL	10.10.2018
	PL	10.10.2018
	BG	10.01.2019
	NO	10.01.2019
	IS	10.02.2019
Former [2019/21]	FI	10.10.2018
	LT	10.10.2018
	NL	10.10.2018
	NO	10.01.2019
	IS	10.02.2019
Former [2019/20]	LT	10.10.2018
	NL	10.10.2018
	NO	10.01.2019
Former [2019/17]	NL	10.10.2018
Cited in	International search	[A] LACIVITA ENZA ET AL: "SELECTIVE AGENTS FOR SEROTONIN(2C)(5-HT2C) RECEPTOR", CURRENT TOPICS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS LTD, HILVERSUM; NL, vol. 6, no. 18, 1 January 2006 (2006-01-01), pages 1927 - 1970, XP009085750, ISSN: 1568-0266, DOI: 10.2174/156802606778522168 [A] 1-12 * tables 42, 43 * DOI: http://dx.doi.org/10.2174/156802606778522168

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