EP3110972 - PREDICTION OF PREECLAMPSIA USING MICRORNA [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 12.04.2019 Database last updated on 30.10.2024 | |
Former | Grant of patent is intended Status updated on 04.07.2018 | ||
Former | Examination is in progress Status updated on 03.11.2017 | ||
Former | Request for examination was made Status updated on 02.12.2016 | Most recent event Tooltip | 12.04.2019 | Application deemed to be withdrawn | published on 15.05.2019 [2019/20] | Applicant(s) | For all designated states Friedrich Miescher Institute for Biomedical Research Maulbeerstrasse 66 4058 Basel / CH | For all designated states University Hospital Basel Hebelstrasse 32 4031 Basel / CH | [2017/01] | Inventor(s) | 01 /
BUEHLER, Marc Bettingerstrasse 279 4125 Riehen / CH | 02 /
LALEVÉE, Sébastien 535 Rue de l'Espinouse Appartement 203 34090 Montpellier / FR | 03 /
LAPAIRE, Olav Neubadrain 92 4102 Binningen / CH | [2017/01] | Representative(s) | Favre, Nicolas, et al Friedrich Miescher Institute for Biomedical Research Maulbeerstrasse 66 4058 Basel / CH | [2017/01] | Application number, filing date | 15714022.9 | 26.02.2015 | [2017/01] | WO2015IB51442 | Priority number, date | EP20140157298 | 28.02.2014 Original published format: EP 14157298 | [2017/01] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2015128836 | Date: | 03.09.2015 | Language: | EN | [2015/35] | Type: | A1 Application with search report | No.: | EP3110972 | Date: | 04.01.2017 | Language: | EN | The application published by WIPO in one of the EPO official languages on 03.09.2015 takes the place of the publication of the European patent application. | [2017/01] | Search report(s) | International search report - published on: | EP | 03.09.2015 | Classification | IPC: | C12Q1/68 | [2017/01] | CPC: |
C12Q1/6883 (EP,US);
G01N33/689 (US);
G01N33/6893 (EP,US);
C12Q2600/158 (EP,US);
C12Q2600/178 (EP,US);
G01N2800/368 (US);
G01N2800/50 (US)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/01] | Title | German: | VORHERSAGE VON PRÄEKLAMPSIE MITTELS MICRORNA | [2017/01] | English: | PREDICTION OF PREECLAMPSIA USING MICRORNA | [2017/01] | French: | PRÉDICTION DE LA PRÉÉCLAMPSIE À L'AIDE DE MICRO-ARN | [2018/29] |
Former [2017/01] | PRÉDICTION DE PRÉÉCLAMPSIE À L'AIDE DE MICROARN | Entry into regional phase | 28.09.2016 | National basic fee paid | 28.09.2016 | Designation fee(s) paid | 28.09.2016 | Examination fee paid | Examination procedure | 10.08.2016 | Date on which the examining division has become responsible | 28.09.2016 | Examination requested [2017/01] | 10.04.2017 | Amendment by applicant (claims and/or description) | 03.11.2017 | Despatch of a communication from the examining division (Time limit: M04) | 22.02.2018 | Reply to a communication from the examining division | 05.07.2018 | Communication of intention to grant the patent | 15.11.2018 | Fee for grant paid | 15.11.2018 | Fee for publishing/printing paid | 16.11.2018 | Application deemed to be withdrawn, date of legal effect [2019/20] | 02.01.2019 | Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time [2019/20] | Fees paid | Renewal fee | 10.02.2017 | Renewal fee patent year 03 | 14.02.2018 | Renewal fee patent year 04 | 28.02.2019 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [Y]WO2009093254 (ROSETTA GENOMICS LTD [IL], et al) [Y] 2-10 * pg 5, l 16-20; Fig 4; cl 5, 7, 9, 18. *; | [XYI] - ROMAN A ET AL, "237: Microrna expression in placenta of patients with preeclampsia", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 199, no. 6, doi:10.1016/J.AJOG.2008.09.265, ISSN 0002-9378, (20081201), page S78, (20081201), XP025766764 [X] 8 * the whole document * [Y] 2-10 [I] 1 DOI: http://dx.doi.org/10.1016/j.ajog.2008.09.265 | [Y] - LAUREN ANTON ET AL, "miR-210 inhibits trophoblast invasion and is a serum biomarker for preeclampsia", AMERICAN JOURNAL OF PATHOLOGY; [10640], ELSEVIER INC, US, vol. 183, no. 5, ISSN 0002-9440, (20131101), pages 1437 - 1445, (20130910), XP009179018 [Y] 2-10 * pg 1437, 1441. * DOI: http://dx.doi.org/10.1016/j.ajpath.2013.07.021 | [Y] - ZHU X M ET AL, "Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 200, no. 6, doi:10.1016/J.AJOG.2008.12.045, ISSN 0002-9378, (20090601), pages 661.e1 - 661.e7, (20090314), XP026142518 [Y] 2-10 * pg 661e4-661e5. * DOI: http://dx.doi.org/10.1016/j.ajog.2008.12.045 | [XY] - O. ISHIBASHI ET AL, "Hydroxysteroid (17- ) Dehydrogenase 1 Is Dysregulated by Mir-210 and Mir-518c That Are Aberrantly Expressed in Preeclamptic Placentas: A Novel Marker for Predicting Preeclampsia", HYPERTENSION, (20111227), vol. 59, no. 2, doi:10.1161/HYPERTENSIONAHA.111.180232, ISSN 0194-911X, pages 265 - 273, XP055188493 [X] 7 * abstract, pg 268, right col, second par; table S1, table S2. * [Y] 2-6,8-10 DOI: http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.180232 | [T] - S LALEVÉE ET AL, "miR455 is linked to hypoxia signaling and is deregulated in preeclampsia", CELL DEATH AND DISEASE, (20140904), vol. 5, no. 9, doi:10.1038/cddis.2014.368, page e1408, XP055188495 [T] 1-10 DOI: http://dx.doi.org/10.1038/cddis.2014.368 | by applicant | US4683195 | US4683202 | - MURPHY ET AL., ENDOCR REV., (200604), vol. 27, no. 2, pages 141 - 69 | - STEEGERS ET AL., LANCET, (20100821), vol. 376, no. 9741, pages 631 - 44 | - ROBERTS ET AL., PLACENTA, (200903), vol. 30, no. A, pages 32 - 7 | - VERLOHREN, S.; H. STEPAN ET AL., "Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia", CLINICAL SCIENCE, (2012), vol. 122, no. 2, doi:doi:10.1042/cs20110097, pages 43 - 52, XP002688317 DOI: http://dx.doi.org/10.1042/cs20110097 | - YOUNG, B. C.; R. J. LEVINE ET AL., "Pathogenesis of preeclampsia", ANNUAL REVIEW OF PATHOLOGY, (2010), vol. 5, doi:doi:10.1146/annurev-pathol-121808-102149, pages 173 - 192, XP055021569 DOI: http://dx.doi.org/10.1146/annurev-pathol-121808-102149 | - REDMAN, C. W., "Preeclampsia: a multi-stress disorder", LA REVUE DE MEDECINE INTERNE / FONDEE ..., (2011), vol. 32, no. 1, pages 41 - 44 | - WANG, A.; S. RANA ET AL., "Preeclampsia: the role of angiogenic factors in its pathogenesis", PHYSIOLOGY, (2009), vol. 24, pages 147 - 158 | - GEORGE, E. M.; J. P. GRANGER, "Recent insights into the pathophysiology of preeclampsia", EXPERT REVIEW OF OBSTETRICS & GYNECOLOGY, (2010), vol. 5, no. 5, pages 557 - 566 | - KROL J ET AL., NAT REV GENET, (201009), vol. 11, no. 9, pages 597 - 610 | - CHIANG, H. R.; L. W. SCHOENFELD ET AL., "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes", GENES & DEVELOPMENT, (2010), vol. 24, no. 10, doi:doi:10.1101/gad.1884710, pages 992 - 1009, XP055019380 DOI: http://dx.doi.org/10.1101/gad.1884710 | - GRIFFITHS-JONES, S., "The microRNA Registry", NUCLEIC ACIDS RESEARCH, (2004), vol. 32, doi:doi:10.1093/nar/gkh023, pages D109 - 11, XP002392427 DOI: http://dx.doi.org/10.1093/nar/gkh023 | - KROL J ET AL., NAT REV GENET., (201009), vol. 11, no. 9, pages 597 - 610 | - BARTEL DP, CELL, (20090123), vol. 136, no. 2, pages 215 - 33 | - LIANG, Y.; D. RIDZON ET AL., "Characterization of microRNA expression profiles in normal human tissues", BMC GENOMICS, (2007), vol. 8, doi:doi:10.1186/1471-2164-8-166, page 166, XP021027980 DOI: http://dx.doi.org/10.1186/1471-2164-8-166 | - VENTURA, A.; T. JACKS, "MicroRNAs and cancer: short RNAs go a long way", CELL, (2009), vol. 136, no. 4, pages 586 - 591 | - HAMILTON, M. P.; M. O. GORE ET AL., "Adiponectin and cardiovascular risk profile in patients with type 2 diabetes mellitus: parameters associated with adiponectin complex distribution", DIABETES & VASCULAR DISEASE RESEARCH : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF DIABETES AND VASCULAR DISEASE, (2011), vol. 8, no. 3, pages 190 - 194 | - MORALES-PRIETO, D. M.; W. CHAIWANGYEN ET AL., "MicroRNA expression profiles of trophoblastic cells", PLACENTA, (2012), vol. 33, no. 9, doi:doi:10.1016/j.placenta.2012.05.009, pages 725 - 734, XP028935177 DOI: http://dx.doi.org/10.1016/j.placenta.2012.05.009 | - GIRARDOT, M; J. CAVAILLE ET AL., "Small regulatory RNAs controlled by genomic imprinting and their contribution to human disease", EPIGENETICS : OFFICIAL JOURNAL OF THE DNA METHYLATION SOCIETY, (2012), vol. 7, no. 12, pages 1341 - 1348 | - GIRARDOT, M.; J. CAVAILLE ET AL., "Small regulatory RNAs controlled by genomic imprinting and their contribution to human disease", EPIGENETICS : OFFICIAL JOURNAL OF THE DNA METHYLATION SOCIETY, (2012), vol. 7, no. 12, pages 1341 - 1348 | - LOUWEN, F.; C. MUSCHOL-STEINMETZ ET AL., "A lesson for cancer research: placental microarray gene analysis in preeclampsia", ONCOTARGET, (2012), vol. 3, no. 8, pages 759 - 773 | - DORIDOT, L.; F. MIRALLES ET AL., "Trophoblasts, invasion, and microRNA", FRONTIERS IN GENETICS, (2013), vol. 4, page 248 | - PINELES, B. L.; R. ROMERO ET AL., "Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, (2007), vol. 196, no. 3, doi:doi:10.1016/j.ajog.2007.01.008, pages 261 - 266, XP005913406 DOI: http://dx.doi.org/10.1016/j.ajog.2007.01.008 | - MAYOR-LYNN, K.; T. TOLOUBEYDOKHTI ET AL., "Expression Profile of MicroRNAs and mRNAs in Human Placentas From Pregnancies Complicated by Preeclampsia and Preterm Labor", REPRODUCTIVE SCIENCES, (2011), vol. 18, no. 1, doi:doi:10.1177/1933719110374115, pages 46 - 56, XP008171764 DOI: http://dx.doi.org/10.1177/1933719110374115 | - ENQUOBAHRIE, D. A.; D. F. ABETEW ET AL., "Placental microRNA expression in pregnancies complicated by preeclampsia", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, (2011), vol. 204, no. 2, pages 178 E112 - 121 | - ZHU, X. M.; T. HAN ET AL., "Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, (2009), vol. 200, no. 6, doi:doi:10.1016/j.ajog.2008.12.045, pages 661 E661 - 667, XP026142518 DOI: http://dx.doi.org/10.1016/j.ajog.2008.12.045 | - ISHIBASHI, O.; A. OHKUCHI ET AL., "Hydroxysteroid (17-beta) dehydrogenase 1 is dysregulated by miR-21 0 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia", HYPERTENSION, (2012), vol. 59, no. 2, doi:doi:10.1161/HYPERTENSIONAHA.111.180232, pages 265 - 273, XP055188493 DOI: http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.180232 | - JI, L.; J. BRKIC ET AL., "Placental trophoblast cell differentiation: Physiological regulation and pathological relevance to preeclampsia", MOLECULAR ASPECTS OF MEDICINE, (2013), vol. 34, no. 5, pages 981 - 1023 | - HUPPERTZ ET AL., HYPERTENSION, (200804), vol. 51, no. 4, pages 970 - 5 | - CHOMCZYNSKI, P.; SACCHI, N., "Single Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction", ANALYTICAL BIOCHEMISTRY, (1987), vol. 162, doi:doi:10.1016/0003-2697(87)90021-2, page 156, XP025650376 DOI: http://dx.doi.org/10.1016/0003-2697(87)90021-2 | - EMMERTH ET AL., DEV CELL, (20100119), vol. 18, no. 1, pages 102 - 13 | US20040575743 |