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Extract from the Register of European Patents

EP About this file: EP3122742

EP3122742 - QUINOXALINE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.07.2019
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  17.08.2018
FormerGrant of patent is intended
Status updated on  04.08.2018
FormerRequest for examination was made
Status updated on  13.07.2018
FormerGrant of patent is intended
Status updated on  01.03.2018
FormerRequest for examination was made
Status updated on  26.01.2018
FormerGrant of patent is intended
Status updated on  18.09.2017
FormerRequest for examination was made
Status updated on  30.12.2016
FormerThe international publication has been made
Status updated on  23.11.2016
Most recent event   Tooltip29.07.2022Change - lapse in a contracting state
State(s) deleted from list of lapses: AL
published on 31.08.2022  [2022/35]
Applicant(s)For all designated states
Astex Therapeutics Ltd
436 Cambridge Science Park
Milton Road
Cambridge
Cambridgeshire CB4 0QA / GB
[2017/05]
Inventor(s)01 / VERMEULEN, Wim
Janssen Pharmaceutica NV
Turnhoutseweg 30
2340 Beerse / BE
02 / HOSTYN, Steven Anna
Janssen Pharmaceutica NV
Turnhoutseweg 30
2340 Beerse / BE
03 / CUYCKENS, Filip Albert Celine
Janssen Pharmaceutica NV
Turnhoutseweg 30
2340 Beerse / BE
04 / JONES, Russell Mark
Bruderholzstrasse 38
4102 Binningen / CH
05 / BROGGINI, Diego Fernando Domenico
Cilag AG
Hochstrasse 201
8200 Schaffhausen / CH
 [2018/38]
Former [2017/05]01 / VERMEULEN, Wim
Janssen Pharmaceutica NV
Turnhoutseweg 30
B-2340 Beerse / BE
02 / HOSTYN, Steven Anna
Janssen Pharmaceutica NV
Turnhoutseweg 30
B-2340 Beerse / BE
03 / CUYCKENS, Filip Albert Celine
Janssen Pharmaceutica NV
Turnhoutseweg 30
B-2340 Beerse / BE
04 / JONES, Russell Mark
Bruderholzstrasse 38
CH-4102 Binningen / CH
05 / BROGGINI, Diego Fernando Domenico
Cilag AG
Hochstrasse 201
CH-8200 Schaffhausen / CH
Representative(s)Barker Brettell LLP
100 Hagley Road
Edgbaston
Birmingham B16 8QQ / GB
[2018/38]
Former [2017/05]Trueman, Lucy Petra
Barker Brettell LLP
100 Hagley Road
Edgbaston
Birmingham B16 8QQ / GB
Application number, filing date15720269.826.03.2015
[2017/05]
WO2015EP56507
Priority number, dateEP2014016182026.03.2014         Original published format: EP 14161820
[2017/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015144803
Date:01.10.2015
Language:EN
[2015/39]
Type: A1 Application with search report 
No.:EP3122742
Date:01.02.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 01.10.2015 takes the place of the publication of the European patent application.
[2017/05]
Type: B1 Patent specification 
No.:EP3122742
Date:19.09.2018
Language:EN
[2018/38]
Search report(s)International search report - published on:EP01.10.2015
ClassificationIPC:C07D403/14, A61K31/4985, A61P35/00
[2017/05]
CPC:
C07D403/14 (EP,CN,EA,KR,US); A61K31/4985 (EP,EA,US); A61K31/498 (KR);
A61K31/5513 (EP,EA,KR,US); A61P35/00 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/05]
Extension statesBA25.10.2016
ME25.10.2016
Validation statesMA25.10.2016
TitleGerman:CHINOXALINDERIVATE ALS FGFR KINASE MODULATOREN[2017/40]
English:QUINOXALINE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS[2017/05]
French:DÉRIVÉS DE QUINOXALINE UTILES EN TANT QUE MODULATEURS DE LA FGFR KINASE[2017/40]
Former [2017/05]CHINOXALINDERIVATE ALS FGFR-KINASEMODULATOREN
Former [2017/05]DÉRIVÉS DE QUINOXALINE UTILES EN TANT QUE MODULATEURS DE LA KINASE FGFR
Entry into regional phase25.10.2016National basic fee paid 
25.10.2016Designation fee(s) paid 
25.10.2016Examination fee paid 
Examination procedure25.10.2016Amendment by applicant (claims and/or description)
25.10.2016Examination requested  [2017/05]
25.10.2016Date on which the examining division has become responsible
19.09.2017Communication of intention to grant the patent
24.01.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
02.03.2018Communication of intention to grant the patent
12.07.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
12.07.2018Fee for grant paid
12.07.2018Fee for publishing/printing paid
03.08.2018Information about intention to grant a patent
03.08.2018Receipt of the translation of the claim(s)
Opposition(s)20.06.2019No opposition filed within time limit [2019/35]
Fees paidRenewal fee
16.02.2017Renewal fee patent year 03
15.02.2018Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  Tooltipdeleted
[2022/35]
Former [2022/31]AL19.09.2018
Cited inInternational search[AD]WO2011135376  (ASTEX THERAPEUTICS LTD [GB], et al) [AD] 1-29* claims 1-25 *;
 [AD]WO2012073017  (ASTEX THERAPEUTICS LTD [GB], et al) [AD] 1-29 * claims 1-21 *
by applicantUS4166117
 US4666828
 US4683202
 US4801531
 US5192659
 EP0548934
 US5272057
 US5882864
 WO0042026
 WO0055153
 US6218529
 WO0168047
 WO02096873
 WO03076416
 WO2004030635
 WO2004098494
 WO2005007099
 WO2006092430
 WO2007003419
 WO2008003702
 WO2008141065
 WO2009141386
 WO2011026579
 WO2011028947
 WO2011047129
 WO2011135376
 WO2012073017
 WO2012154760
 WO2013061074
 WO2013061081
 WO2013061077
 WO2013061080
 WO2013179034
 WO2013179033
 WO2014174307
    - BERGE ET AL., "Pharmaceutically Acceptable Salts", J. PHARM. SCI., (1977), vol. 66, pages 1 - 19
    - Pharmaceutical Salts: Properties, Selection, and Use, (200208), page 388
    - JERRY MARCH, Advanced Organic Chemistry, WILEY INTERSCIENCE
    - L. W. DEADY, SYN. COMM., (1977), vol. 7, pages 509 - 514
    - JERRY MARCH, Advanced Organic Chemistry, JOHN WILEY & SONS, (1992), pages 109 - 114
    - CAHN; INGOLD; PRELOG, ANGEW. CHEM. INT. ED. ENGL., (1966), vol. 5, pages 385 - 415
    - KNIGHTS ET AL., PHARMACOLOGY AND THERAPEUTICS, (2010), vol. 125, no. 1, pages 105 - 117
    - KORC M. ET AL., CURRENT CANCER DRUG TARGETS, (2009), vol. 9, no. 5, pages 639 - 651
    - ANGERER, Meth. Enzymol., (1987), vol. 152, page 649
    - "Fluorescence In Situ Hybridization: Technical Overview", JOHN M. S. BARTLETT, Molecular Diagnosis of Cancer, Methods and Protocols, 2nd ed.;, (200403), pages 077 - 088, ISBN 1-59259-760-2
    - DEPRIMO ET AL., BMC CANCER, (2003), vol. 3, page 3
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.