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Extract from the Register of European Patents

EP About this file: EP3126357

EP3126357 - SMALL MOLECULAR PROBES, PROCESSES AND USE THEREOF [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  19.02.2021
Database last updated on 19.10.2024
FormerExamination is in progress
Status updated on  26.08.2019
FormerRequest for examination was made
Status updated on  06.01.2017
FormerThe international publication has been made
Status updated on  04.11.2016
Most recent event   Tooltip19.02.2021Application deemed to be withdrawnpublished on 24.03.2021  [2021/12]
Applicant(s)For all designated states
Jawaharlal Nehru Centre For Advanced Scientific Research
Jakkur
Bangalore, Karnataka 560 064 / IN
[2017/06]
Inventor(s)01 / THIMMAIAH, Govindaraju
Bioorganic Chemistry Laboratory
New Chemistry Unit
Jawaharlal Nehru Centre For Advanced Scientific
Research, Jakkur P.O.
Bangalore 560064 / IN
02 / NARAYANASWAMY, Nagarjun
Bioorganic Chemistry Laboratory
New Chemistry Unit
Jawaharlal Nehru Centre For Advanced Scientific
Research, Jakkur P.O.
Bangalore 560064 / IN
03 / RAJASEKHAR, Kolla
Bioorganic Chemistry Laboratory
New chemistry Unit
Jawaharlal Nehru Centre for Advanced Scientific
Research, Jakkur P.O.
Bangalore 560064 / IN
 [2017/06]
Representative(s)Fairbairn, Angus Chisholm, et al
Marks & Clerk LLP
15 Fetter Lane
London EC4A 1BW / GB
[N/P]
Former [2017/06]Lumsden, Stuart Edward Henry
Marks & Clerk LLP
90 Long Acre
London WC2E 9RA / GB
Application number, filing date15723043.403.04.2015
[2017/06]
WO2015IB52463
Priority number, dateIN2014CHE181904.04.2014         Original published format: IN 1819CH2014
[2017/06]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2015151071
Date:08.10.2015
Language:EN
[2015/40]
Type: A2 Application without search report 
No.:EP3126357
Date:08.02.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 08.10.2015 takes the place of the publication of the European patent application.
[2017/06]
Search report(s)International search report - published on:EP07.01.2016
ClassificationIPC:C07D405/06, C07D413/06, C07D417/06, C07D421/06, C07D277/64
[2017/06]
CPC:
C07D417/14 (EP,US); C07D277/64 (EP,US); C07D405/06 (EP,US);
C07D413/06 (EP,US); C07D417/06 (EP,US); C07D421/06 (EP,US);
C09B23/105 (EP,US); C12Q1/6818 (US); C12Q1/6883 (US);
G01N21/6428 (US); G01N33/582 (US); G01N33/6896 (US);
G01N2021/6439 (US); G01N2333/4709 (US); G01N2800/2821 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/06]
TitleGerman:KLEINMOLEKULARE SONDEN, VERFAHREN UND DEREN VERWENDUNG[2017/06]
English:SMALL MOLECULAR PROBES, PROCESSES AND USE THEREOF[2017/06]
French:PETITES SONDES MOLÉCULAIRES, PROCÉDÉS ASSOCIÉS ET UTILISATION DE CELLES-CI[2017/06]
Entry into regional phase03.11.2016National basic fee paid 
03.11.2016Designation fee(s) paid 
03.11.2016Examination fee paid 
Examination procedure02.02.2016Request for preliminary examination filed
International Preliminary Examining Authority: EP
03.11.2016Amendment by applicant (claims and/or description)
03.11.2016Examination requested  [2017/06]
03.11.2016Date on which the examining division has become responsible
29.08.2019Despatch of a communication from the examining division (Time limit: M06)
09.03.2020Reply to a communication from the examining division
18.06.2020Despatch of a communication from the examining division (Time limit: M04)
29.10.2020Application deemed to be withdrawn, date of legal effect  [2021/12]
17.11.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2021/12]
Fees paidRenewal fee
24.04.2017Renewal fee patent year 03
30.03.2018Renewal fee patent year 04
15.04.2019Renewal fee patent year 05
30.03.2020Renewal fee patent year 06
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[XA]EP0047881  (BAYER AG [DE]) [X] 1,3,7-19 * examples 1-9,38,41,44a,45,46 * [A] 2,4-6,20-33;
 [XA]US5223382  (OHNO SHIGERU [JP]) [X] 1,3 * columns 7,8; compounds I-11 *[A] 2,4-33;
 [XA]US2004260093  (CZERNEY PETER [DE], et al) [X] 1,3,7-19 * paragraph [0011]; compound I * * example 8 * [A] 2,4-6,20-33;
 [XA]WO2006025887  (BECTON DICKINSON CO [US], et al) [X] 1-3,7-33 * page 13; compounds XI,XIa * * pages 23,24; compounds 10,10g,10h' * * page 30, line 7 - page 34, line 15 * [A] 4-6;
 [XA]US2006166368  (BERKELMAN THOMAS R [US]) [X] 1,3,7-33 * page 4; compound 2 * [A] 2,4-6;
 [XA]US2008305489  (THOMAS JOSEPH [US], et al) [X] 1,3 * paragraph [0072] * * figure 4; compound COBzT * [A] 2,4-33;
 [XA]  - HARA K ET AL, "MOLECULAR DESIGN OF COUMARIN DYES FOR EFFICIENT DYE-SENSITIZED SOLAR CELLS", JOURNAL OF PHYSICAL CHEMISTRY. B (ONLINE), AMERICAN CHEMICAL SOCIETY, COLUMBUS, OH, US, (20030116), vol. 107, doi:10.1021/jp026963x, ISSN 1520-5207, pages 597 - 606, XP002435448 [X] 1,3 * page 598; compounds NKX-2460, NKX-2475 * [A] 2,4-33

DOI:   http://dx.doi.org/10.1021/jp026963x
 [XA]  - HYUN JUNG KIM ET AL, "KCN sensor: unique chromogenic and turn-on fluorescent Chemodosimeter: rapid Response and high Selectivity", CHEMICAL COMMUNICATIONS > CHEMICAL COMMUNICATIONS - CHEMCOM; [6015D], ROYAL SOCIETY OF CHEMISTRY, GB, vol. 47, no. 10, doi:10.1039/C0CC05018K, ISSN 1359-7345, (20110101), pages 2886 - 2888, (20110117), XP002668246 [X] 1,3 * page 2886; compound 1 * [A] 2,4-33

DOI:   http://dx.doi.org/10.1039/C0CC05018K
 [XPA]  - AN, KYOUNG LYONG ET AL, "The synthesis and light absorption behavior of novel coumarin chromophores", JOURNAL OF THE KOREAN CHEMICAL SOCIETY, (201406), vol. 58, no. 3, doi:10.5012/JKCS.2014.58.3.297, ISSN 1017-2548, pages 297 - 302, XP002742868 [XP] 1-3,7-19 * page 299; table 1; compounds 1-7 * [A] 4-6,20-33

DOI:   http://dx.doi.org/10.5012/JKCS.2014.58.3.297
 [XA]  - MCCALLUM, MEGAN M. ET AL, "A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, (20140105), vol. 406, no. 7, doi:10.1007/S00216-013-7560-3, ISSN 1618-2642, pages 1867 - 1875, XP002742869 [X] 1,3 * page 1869; figure 1a * [A] 2,4-33

DOI:   http://dx.doi.org/10.1007/S00216-013-7560-3
 [XA]  - LIU, JING ET AL, "Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20131223), vol. 136, no. 2, doi:10.1021/JA409578W, ISSN 0002-7863, pages 574 - 577, XP002742870 [X] 1,3 * page 575; compounds 1, C7 * [A] 2,4-33

DOI:   http://dx.doi.org/10.1021/J 10.1021/JA409578W
 [XA]  - LIU, XIAO-DONG ET AL, "A coumarin-indole-based near-infrared ratiometric pH probe for intracellular fluorescence imaging", ANALYST, CAMBRIDGE, UNITED KINGDOM, (20130808), vol. 138, no. 21, doi:10.1039/C3AN01033C, ISSN 0003-2654, pages 6542 - 6550, XP002742871 [X] 1,3,7-33 * page 6543; compounds 1-3 * [A] 2,4-6

DOI:   http://dx.doi.org/10.1039/C3AN01033C 10.1039/C3AN01033C
 [XA]  - DUBAR, FAUSTINE ET AL, "The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION , 5, (20130613), vol. 52, no. 30, doi:10.1002/anie.201303690, ISSN 1433-7851, pages 7690 - 7693, XP002742872 [X] 1,3 * page 7690; compound 2 * [A] 2,4-33

DOI:   http://dx.doi.org/10.1002/ANIE.201303690
 [XA]  - CHEN, YUNCONG ET AL, "A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, (20130103), vol. 52, no. 6, doi:10.1002/anie.201207701, ISSN 1433-7851, pages 1688 - 1691, XP002742873 [X] 1,3,20-33 * page 1688; compound CouMC * * page 1690; figure 3 * [A] 2,4-19

DOI:   http://dx.doi.org/10.1002/ANIE.201207701
 [XA]  - YANG, ZHENGHAO ET AL, "A new ratiometric and colorimetric chemosensor for cyanide anion based on Coumarin-hemicyanine hybrid", ORGANIC & BIOMOLECULAR CHEMISTRY, (20120514), vol. 10, no. 26, doi:10.1039/c2ob25516b, ISSN 1477-0520, pages 5073 - 5076, XP002742874 [X] 1,3 * page 5074; compounds Cou-BT * [A] 2,4-33

DOI:   http://dx.doi.org/10.1039/C2OB25516B
 [XA]  - LV, XIN ET AL, "Ratiometric fluorescence detection of cyanide based on a hybrid coumarin-hemicyanine dye: the large emission shift and the high selectivity", CHEMICAL COMMUNICATIONS, CAMBRIDGE, UNITED KINGDOM, (20111102), vol. 47, no. 48, doi:10.1039/c1cc15721c, ISSN 1359-7345, pages 12843 - 12845, XP002742875 [X] 1,3 * page 12843; compound 1 * [A] 2,4-33

DOI:   http://dx.doi.org/10.1039/C1CC15721C
 [XA]  - ENZA LACIVITA ET AL, "Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT1A receptors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (20101101), vol. 20, no. 22, doi:10.1016/j.bmcl.2010.09.027, ISSN 0960-894X, pages 6628 - 6632, XP055196122 [X] 1,3,7-33 * page 6629; compound 12 * [A] 2,4-6

DOI:   http://dx.doi.org/10.1016/j.bmcl.2010.09.027
 [XA]  - PROSTOTA, YA. O. ET AL, "Polymethine dyes - derivatives of the 7-N,N-dialkylaminocoumarins", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20070101), Database accession no. 2007:1480377, URL: STN, XP002742876 [X] 1,3 * abstract * * RN=1070967-02-0 * [A] 2,4-33
 [XA]  - BAHRA, G. S. ET AL, "Towards a structure-RSA relationship for non-linear optical materials", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (19940101), Database accession no. 1996:12710, URL: STN, XP002742877 [X] 1,3 * abstract * * RN= 168027-12-1 * [A] 2,4-33

DOI:   http://dx.doi.org/10.1557/PROC-374-33
ExaminationWO2006020156
    - VALENTYNA P TOKAR ET AL, "Styryl Dyes as Two-Photon Excited Fluorescent Probes for DNA Detection and Two-Photon Laser Scanning Fluorescence Microscopy of Living Cells", JOURNAL OF FLUORESCENCE, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, (20100303), vol. 20, no. 4, ISSN 1573-4994, pages 865 - 872, XP019822894
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DOI:   http://dx.doi.org/10.1016/j.ejphar.2007.01.005
    - Katryna Cisek ET AL, "QSAR studies for prediction of cross-[beta] sheet aggregate binding affinity and selectivity", Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, NL, (20120201), vol. 20, no. 4, doi:10.1016/j.bmc.2011.12.062, ISSN 0968-0896, pages 1434 - 1441, XP055614873

DOI:   http://dx.doi.org/10.1016/j.bmc.2011.12.062
    - Yuan-Qiang Sun ET AL, "Fluorescent probe for biological gas SO2 derivatives bisulfite and sulfite", Chemical Communications, (20130101), vol. 49, no. 26, doi:10.1039/c3cc39161b, ISSN 1359-7345, page 2637, XP055704702

DOI:   http://dx.doi.org/10.1039/c3cc39161b
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