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Extract from the Register of European Patents

EP About this file: EP3102036

EP3102036 - 3-SUBSTITUTED CARBONYL-NAPHTHO[2,3-B]FURANE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  23.08.2019
Database last updated on 15.06.2024
FormerExamination is in progress
Status updated on  14.12.2018
FormerRequest for examination was made
Status updated on  11.11.2016
Most recent event   Tooltip23.08.2019Application deemed to be withdrawnpublished on 25.09.2019  [2019/39]
Applicant(s)For all designated states
Boston Biomedical, Inc.
640 Memorial Drive
Cambridge, MA 02139 / US
[2016/50]
Inventor(s)01 / SONE, Toshihiko
33-94 Enoki-cho
Suita
Osaka 564-0053 / JP
02 / HIROSE, Wataru
33-94 Enoki-cho
Suita
Osaka 564-0053 / JP
03 / SHIMADA, Naoaki
33-94 Enoki-cho
Suita
Osaka 564-0053 / JP
04 / LI, Chiang J.
8 Museum Way
Unit 1606
Cambridge, MA 02141 / US
05 / LI, Wei
19 Black Oak Road
Wayland, MA 01778 / US
06 / LEGGETT, David
5 Lincoln Street
Milton, MA 02186 / US
 [2016/50]
Representative(s)Haseltine Lake Kempner LLP
Cheapside House
138 Cheapside
London EC2V 6BJ / GB
[N/P]
Former [2016/50]Kelly, Donal Morgan
FRKelly
27 Clyde Road
Dublin D04 F838 / IE
Application number, filing date15746714.306.02.2015
[2016/50]
WO2015US14865
Priority number, dateUS201461936925P07.02.2014         Original published format: US 201461936925 P
[2016/50]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015120304
Date:13.08.2015
Language:EN
[2015/32]
Type: A1 Application with search report 
No.:EP3102036
Date:14.12.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 13.08.2015 takes the place of the publication of the European patent application.
[2016/50]
Search report(s)International search report - published on:US13.08.2015
(Supplementary) European search report - dispatched on:EP18.08.2017
ClassificationIPC:A01N47/10
[2016/50]
CPC:
C07D307/92 (EP,US); A61K31/343 (EP,US); A61K31/443 (EP,US);
A61K31/497 (EP,US); A61P35/00 (EP); A61P35/02 (EP);
C07D405/04 (EP,US); C07D405/12 (EP,US); C07D413/06 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/50]
TitleGerman:3-SUBSTITUIERTE CARBONYL-NAPHTHO[2,3-B]FURAN-DERIVATE ODER PHARMAZEUTISCH UNBEDENKLICHES SALZ DAVON[2016/50]
English:3-SUBSTITUTED CARBONYL-NAPHTHO[2,3-B]FURANE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF[2016/50]
French:DÉRIVÉ DE CARBONYLE -NAPHTO [2,3-B]FURANE 3-SUBSTITUÉ DÉRIVÉ OU SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI[2016/50]
Entry into regional phase21.06.2016National basic fee paid 
21.06.2016Search fee paid 
21.06.2016Designation fee(s) paid 
21.06.2016Examination fee paid 
Examination procedure21.06.2016Examination requested  [2016/50]
21.06.2016Date on which the examining division has become responsible
22.06.2018Amendment by applicant (claims and/or description)
14.12.2018Despatch of a communication from the examining division (Time limit: M04)
25.04.2019Application deemed to be withdrawn, date of legal effect  [2019/39]
21.05.2019Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2019/39]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
22.06.2018Request for further processing filed
22.06.2018Full payment received (date of receipt of payment)
Request granted
04.07.2018Decision despatched
Fees paidRenewal fee
10.02.2017Renewal fee patent year 03
14.02.2018Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
28.02.201905   M06   Not yet paid
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Documents cited:Search[XI]WO2004087153  (CHIRON CORP [US], et al) [X] 1-6,8-12 * page 1, paragraph 1; example 29 * [I] 1-12;
 [X]  - JIN-WEI SUN ET AL, "Copper(II)-Catalyzed Sequential C,N-Difunctionalization of 1,4-Naphthoquinone for the Synthesis of Benzo[ f ]indole-4,9-diones under Base-Free Condition", THE JOURNAL OF ORGANIC CHEMISTRY, (20131018), vol. 78, no. 20, doi:10.1021/jo401842d, ISSN 0022-3263, pages 10560 - 10566, XP055396331 [X] 1,3-6 * table 3; compounds 4a-4p *

DOI:   http://dx.doi.org/10.1021/jo401842d
 [X]  - Gaurav Shukla ET AL, "Supporting Information DMAP mediated one-pot domino thienannulation: A versatile, regioselective and green mechanochemical route to naphtho[2,3-b]thiophenes", (20130101), URL: http://www.rsc.org/suppdata/ra/c3/c3ra41100a/c3ra41100a.pdf, (20170804), XP055396333 [X] 1,3-6 * compounds in chapter 1.3 and 3 *
 [X]  - WEI WANG ET AL, "Photoinduced Reactions of para -Quinones with Bicyclopropylidene Leading to Diverse Polycyclic Compounds with Spirocyclopropanes", THE JOURNAL OF ORGANIC CHEMISTRY, (20130621), vol. 78, no. 12, doi:10.1021/jo4008767, ISSN 0022-3263, pages 6211 - 6222, XP055396336 [X] 1-6 * compound 19a *

DOI:   http://dx.doi.org/10.1021/jo4008767
 [X]  - M. V. STASEVYCH ET AL2-ARYL-4H-NAPHTHO[2',3':4,5]THIENO+-[2,3-D][1,3]OXAZINE-4,5,10-TRIONES, CHEMISTRY OF HETEROCYCLIC COMPOUNDS, (2008), vol. 44, no. 7, pages 897 - 898, XP009195164 [X] 1,3-6 * compounds 1,2a,2b *

DOI:   http://dx.doi.org/10.1007/s10593-008-0131-4
 [XI]  - PARK H J ET AL, "Inhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 527, no. 1-3, ISSN 0014-2999, (20051219), pages 31 - 36, (20051219), XP027695489 [X] 1,3-6,8-12 * compound in figure 1; abstract * [I] 1-12
 [XI]  - Choi, "correlation between the binding mode and inhibitory actvity of benz[f]indole-4,9,dione analogs with human topoisomerase I-DNA", (20050101), URL: http://ocean.kisti.re.kr/downfile/volume/chemical/JCGMDC/2005/v49n5/JCGMDC_2005_v49n5_449.pdf, (20170804), XP055396366 [X] 1,3-6,8-12 * abstract;; compounds 1-9 * [I] 1-12
 [X]  - HUA-YOU HU ET AL, "Direct One-pot synthesis of naphtho[2,3-b]furan-4,9-dione Derivatives via C,O-Dialkylation of [beta]-Dicarbonyl Compounds by 2,3-Dichloro-1,4-naphthoquinones", SYNTHESIS, STUTTGART, DE., (20050101), no. 10, doi:10.1055/s-2005-865305, ISSN 0039-7881, pages 1605 - 1610, XP055396375 [X] 1-6 * compounds 4d,4e,6d,6e *

DOI:   http://dx.doi.org/10.1055/s-2005-865305
 [X]  - HYUNG-WOO YI ET AL, "A simple synthesis of 4-chloro-5-hydroxy-1 H -benzo[g]indoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, US, (20050101), vol. 42, no. 1, doi:10.1002/jhet.5570420123, ISSN 0022-152X, pages 147 - 151, XP055396377 [X] 1,3-6 * compounds 5a-5c *

DOI:   http://dx.doi.org/10.1002/jhet.5570420123
 [X]  - TSENG C-M ET AL, "Solvent effects on the oxidative free radical reactions of 2-amino-1,4-naphthoquinones", TETRAHE, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20041220), vol. 60, no. 52, doi:10.1016/J.TET.2004.10.029, ISSN 0040-4020, pages 12249 - 12260, XP004768184 [X] 1,3-6 * compounds 3a-3e,11a-11e,12a-12e *

DOI:   http://dx.doi.org/10.1016/j.tet.2004.10.029
 [XI]  - LEE HYUN-JUNG ET AL, Synthesis and cytotoxicity evaluation of 2-amino- and 2-hydroxy-3-ethoxycarbonyl-N-substituted-benzo[f]indole-4,9-dione derivatives, BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, PAGE(S) 1511 - 1519, (20030306), vol. 11, pages 1511 - 1519, ISSN 0968-0896, XP085050916 [X] 1,3-6,8-12 * abstract;; compounds A1-A10, B1-B12 * [I] 1-12

DOI:   http://dx.doi.org/10.1016/S0968-0896(03)00062-2
 [X]  - TSENG C-C ET AL, "Cerium salts in the oxidative free radical reactions between 2-amino-1,4-naphthoquinones and @b-dicarbonyl compounds", TETRAHE, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20020916), vol. 58, no. 38, doi:10.1016/S0040-4020(02)00864-5, ISSN 0040-4020, pages 7625 - 7633, XP004379385 [X] 1,3-6 * compounds 3a-3t *

DOI:   http://dx.doi.org/10.1016/S0040-4020(02)00864-5
 [X]  - WU Y-L ET AL, "Oxidative free radical reactions between 2-amino-1,4-naphthoquinones and carbonyl compounds", TETRAHE, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20010625), vol. 57, no. 26, doi:10.1016/S0040-4020(01)00480-X, ISSN 0040-4020, pages 5543 - 5549, XP004247090 [X] 1,3-6 * compound 11f *

DOI:   http://dx.doi.org/10.1016/S0040-4020(01)00480-X
 [X]  - CHUANG C-P ET AL, "Manganese(III) Acetate Initiated Oxidative Free Radical Reaction Between 1,4-Naphthoquinones And @a-Alkylmalonates", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (19980820), vol. 54, no. 34, doi:10.1016/S0040-4020(98)00622-X, ISSN 0040-4020, pages 10043 - 10052, XP004129982 [X] 1-6 * compounds 2a,2g *

DOI:   http://dx.doi.org/10.1016/S0040-4020(98)00622-X
 [X]  - E. GHERA ET AL, "Synthesis of maturone", TETRAHEDRON LETTERS, (19860101), vol. 27, no. 33, doi:10.1016/S0040-4039(00)83921-0, ISSN 0040-4039, pages 3935 - 3938, XP055205640 [X] 1-6 * compound 15 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)83921-0
 [X]  - MARTIN E. KUEHNE ET AL, "Photochemical and thermal reactions of naphthoquinones and ynamines. Formations of intermediate cyclobutadienes", THE JOURNAL OF ORGANIC CHEMISTRY, (19721201), vol. 37, no. 25, doi:10.1021/jo00798a013, ISSN 0022-3263, pages 4031 - 4036, XP055396691 [X] 1,3-6 * compound 22 *

DOI:   http://dx.doi.org/10.1021/jo00798a013
International search[Y]US2013345176  (JIANG ZHIWEI [CN], et al) [Y] 5 * para [0004];[0005]; [0066] *;
 [XY]  - PubChem, (20061016), Database accession no. 11002488, XP055218191 [X] 1-4 * ; pg 2 * [Y] 5, 14
 [Y]  - PubChem, (20050915), Database accession no. 4493092, XP055218193 [Y] 14 * ; pg 2 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.