blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3183236

EP3183236 - METHOD FOR THE PRODUCTION OF 18F-LABELED ACTIVE ESTERS AND THEIR APPLICATION EXEMPLIFIED BY THE PREPARATION OF A PSMA-SPECIFIC PET-TRACER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.02.2023
Database last updated on 06.07.2024
FormerThe patent has been granted
Status updated on  18.03.2022
FormerGrant of patent is intended
Status updated on  19.10.2021
FormerExamination is in progress
Status updated on  29.09.2020
FormerGrant of patent is intended
Status updated on  24.05.2020
FormerExamination is in progress
Status updated on  16.03.2018
FormerRequest for examination was made
Status updated on  26.05.2017
FormerThe international publication has been made
Status updated on  20.03.2017
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): TR		published on 17.07.2024 [2024/29]
Applicant(s)For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften
Hofgartenstrasse 8
80539 Munich / DE
For all designated states
Universität zu Köln
Albertus-Magnus-Platz
50923 Köln / DE
[2018/12]
Former [2017/26]For all designated states
Max-Planck-Gesellschaft zur Förderung der Wissenschaften
Hofgartenstrasse 8
80539 Munich / DE
Inventor(s)01 / NEUMAIER, Bernd
Josef-Löcher-Str. 25
50354 Hürth / DE
02 / ZLATOPOLSKIY, Boris
Andreaestr. 29
51063 Köln / DE
03 / RICHARZ, Raphael
Alte Garten 29
51371 Leverkusen / DE
04 / KRAPF, Phillip
Dörrenbitze 12
53804 Much / DE
 [2017/26]
Representative(s)Kilger, Ute
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Pettenkoferstrasse 22
80336 München / DE
[2022/16]
Former [2017/26]Kilger, Ute
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Patentanwälte Rechtsanwälte
Pettenkoferstrasse 20-22
80336 München / DE
Application number, filing date15753692.124.08.2015
[2017/26]
WO2015EP69356
Priority number, dateEP2014018205324.08.2014         Original published format: EP 14182053
EP2014018363504.09.2014         Original published format: EP 14183635
[2017/26]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016030329
Date:03.03.2016
Language:EN
[2016/09]
Type: A1 Application with search report 
No.:EP3183236
Date:28.06.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 03.03.2016 takes the place of the publication of the European patent application.
[2017/26]
Type: B1 Patent specification 
No.:EP3183236
Date:20.04.2022
Language:EN
[2022/16]
Search report(s)International search report - published on:EP03.03.2016
ClassificationIPC:C07D213/81, C07D213/82, C07C275/16, C07D231/14, C07D241/24, C07C231/02, A61K31/44, A61P35/00
[2017/26]
CPC:
C07K5/06026 (EP,US); A61P35/00 (EP); C07B59/002 (US);
C07C275/16 (EP,US); C07D213/82 (EP,US); C07D237/24 (EP,US);
C07D241/24 (EP,US); C07K1/13 (EP,US); C07K5/06078 (EP,US);
C07B2200/05 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/26]
Extension statesBA20.03.2017
ME20.03.2017
Validation statesMANot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON 18F-MARKIERTEN AKTIVEN ESTERN UND DEREN VERWENDUNG AM BEISPIEL DER HERSTELLUNG EINES PSMA-SPEZIFISCHEN PET-TRACERS[2017/26]
English:METHOD FOR THE PRODUCTION OF 18F-LABELED ACTIVE ESTERS AND THEIR APPLICATION EXEMPLIFIED BY THE PREPARATION OF A PSMA-SPECIFIC PET-TRACER[2017/26]
French:PROCÉDÉ DE PRODUCTION D'ESTERS ACTIFS MARQUÉS AU 18F ET LEUR APPLICATION ILLUSTRÉE PAR LA PRÉPARATION D'UN TRACEUR POUR PET SPÉCIFIQUE DE L'ANTIGÈNE MEMBRANAIRE SPÉCIFIQUE DE LA PROSTATE (PSMA)[2017/26]
Entry into regional phase20.03.2017National basic fee paid 
20.03.2017Designation fee(s) paid 
20.03.2017Examination fee paid 
Examination procedure20.03.2017Examination requested  [2017/26]
20.03.2017Date on which the examining division has become responsible
29.09.2017Amendment by applicant (claims and/or description)
16.03.2018Despatch of a communication from the examining division (Time limit: M04)
19.07.2018Reply to a communication from the examining division
12.10.2018Despatch of a communication from the examining division (Time limit: M06)
17.04.2019Reply to a communication from the examining division
21.04.2020Cancellation of oral proceeding that was planned for 04.05.2020
04.05.2020Date of oral proceedings (cancelled)
25.05.2020Communication of intention to grant the patent
25.09.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
08.10.2020Despatch of a communication from the examining division (Time limit: M04)
08.12.2020Reply to a communication from the examining division
18.03.2021Despatch of a communication from the examining division (Time limit: M04)
02.07.2021Reply to a communication from the examining division
02.11.2021Communication of intention to grant the patent
11.03.2022Fee for grant paid
11.03.2022Fee for publishing/printing paid
11.03.2022Receipt of the translation of the claim(s)
Opposition(s)23.01.2023No opposition filed within time limit [2023/13]
Fees paidRenewal fee
25.08.2017Renewal fee patent year 03
11.06.2018Renewal fee patent year 04
15.08.2019Renewal fee patent year 05
13.08.2020Renewal fee patent year 06
24.08.2021Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU24.08.2015
AL20.04.2022
AT20.04.2022
CY20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
MK20.04.2022
RS20.04.2022
SE20.04.2022
SI20.04.2022
SK20.04.2022
SM20.04.2022
TR20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
IE24.08.2022
LU24.08.2022
BE31.08.2022
CH31.08.2022
LI31.08.2022
[2024/29]
Former [2024/27]HU24.08.2015
AL20.04.2022
AT20.04.2022
CY20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
MK20.04.2022
RS20.04.2022
SE20.04.2022
SI20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
IE24.08.2022
LU24.08.2022
BE31.08.2022
CH31.08.2022
LI31.08.2022
Former [2024/21]HU24.08.2015
AL20.04.2022
AT20.04.2022
CY20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
RS20.04.2022
SE20.04.2022
SI20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
IE24.08.2022
LU24.08.2022
BE31.08.2022
CH31.08.2022
LI31.08.2022
Former [2024/18]HU24.08.2015
AL20.04.2022
AT20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
RS20.04.2022
SE20.04.2022
SI20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
IE24.08.2022
LU24.08.2022
BE31.08.2022
CH31.08.2022
LI31.08.2022
Former [2023/42]AL20.04.2022
AT20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
RS20.04.2022
SE20.04.2022
SI20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
IE24.08.2022
LU24.08.2022
BE31.08.2022
CH31.08.2022
LI31.08.2022
Former [2023/33]AL20.04.2022
AT20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
RS20.04.2022
SE20.04.2022
SI20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
IE24.08.2022
LU24.08.2022
CH31.08.2022
LI31.08.2022
Former [2023/25]AL20.04.2022
AT20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
RS20.04.2022
SE20.04.2022
SI20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
LU24.08.2022
CH31.08.2022
LI31.08.2022
Former [2023/21]AL20.04.2022
AT20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
RS20.04.2022
SE20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
LU24.08.2022
CH31.08.2022
LI31.08.2022
Former [2023/17]AL20.04.2022
AT20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
RS20.04.2022
SE20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
Former [2023/16]AT20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
MC20.04.2022
RS20.04.2022
SE20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
Former [2023/09]AT20.04.2022
CZ20.04.2022
DK20.04.2022
EE20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
RS20.04.2022
SE20.04.2022
SK20.04.2022
SM20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
Former [2023/07]AT20.04.2022
DK20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
RS20.04.2022
SE20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
Former [2022/51]AT20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
RS20.04.2022
SE20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
IS20.08.2022
PT22.08.2022
Former [2022/50]AT20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
RS20.04.2022
SE20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
PT22.08.2022
Former [2022/49]AT20.04.2022
FI20.04.2022
HR20.04.2022
LT20.04.2022
LV20.04.2022
SE20.04.2022
BG20.07.2022
NO20.07.2022
GR21.07.2022
PT22.08.2022
Former [2022/47]AT20.04.2022
FI20.04.2022
LT20.04.2022
SE20.04.2022
NO20.07.2022
PT22.08.2022
Cited inInternational search[XI]WO2008058192  (MOLECULAR INSIGHT PHARM INC [US], et al) [X] 11-15 * claims 1, 11 * [I] 31,32;
 [I]WO2009002529  (UNIV JOHNS HOPKINS [US], et al) [I] 1-15,31,32 * claim 4 * * product after step ii, step iii; pages 35-36 *;
 [Y]WO2009003251  (TRASIS S A [BE], et al) [Y] 16* page 6, paragraph 24 *;
 [XI]WO2010014933  (UNIV JOHNS HOPKINS [US], et al) [X] 1-15,32 * claims 16, 18, 21-23 * * page 20, paragraphs 66, 67 * [I] 31;
 [XYI]WO2010108125  (UNIV JOHNS HOPKINS [US], et al) [X] 1-15,17 * claim 1 * * page 74; compounds YC-VIII-24 * * page 79; compounds Lys-Urea-Glu * [Y] 18-30 [I] 31,32;
 [XY]  - HASSAN M. SHALLAL ET AL, "Heterobivalent Agents Targeting PSMA and Integrin-[alpha] v [beta] 3", BIOCONJUGATE CHEMISTRY, (20140219), vol. 25, no. 2, doi:10.1021/bc4005377, ISSN 1043-1802, pages 393 - 405, XP055214872 [X] 1-9,11,12,14,15,17 * page 397; compound 2 * * scheme 1 * [Y] 18-30

DOI:   http://dx.doi.org/10.1021/bc4005377
 [XYI]  - R. RICHARZ ET AL, "Neither azeotropic drying, nor base nor other additives: a minimalist approach to 18 F-labeling", ORGANIC & BIOMOLECULAR CHEMISTRY, GB, (20140101), vol. 12, no. 40, doi:10.1039/C4OB01336K, ISSN 1477-0520, pages 8094 - 8099, XP055229136 [X] 31 * footnotes;; tables 2, 4 * * scheme 1 * [Y] 16 [I] 16

DOI:   http://dx.doi.org/10.1039/C4OB01336K
ExaminationWO2010114723
    - NOEEN MALIK ET AL, "Radiosynthesis of a new PSMA targeting ligand ([F]FPy-DUPA-Pep)", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD, GB, vol. 69, no. 7, doi:10.1016/J.APRADISO.2011.03.041, ISSN 0969-8043, (20110329), pages 1014 - 1018, (20110408), XP028384396

DOI:   http://dx.doi.org/10.1016/j.apradiso.2011.03.041
    - KIM SERDONS ET AL, "The Prescence of Ethanol in Radiopharmaceutical Injections", JOURNAL OF NUCLEAR MEDICINE, (20080101), vol. 49, doi:10.2967/jnumed.108.057026, page 2071, XP055481242

DOI:   http://dx.doi.org/10.2967/jnumed.108.057026
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.