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Extract from the Register of European Patents

EP About this file: EP3115457

EP3115457 - GENOMIC SEQUENCE MODIFICATION METHOD FOR SPECIFICALLY CONVERTING NUCLEIC ACID BASES OF TARGETED DNA SEQUENCE, AND MOLECULAR COMPLEX FOR USE IN SAME [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  03.01.2025
Database last updated on 03.04.2025
FormerThe patent has been granted
Status updated on  30.08.2019
FormerGrant of patent is intended
Status updated on  30.05.2019
FormerExamination is in progress
Status updated on  04.05.2018
FormerRequest for examination was made
Status updated on  09.12.2016
FormerThe international publication has been made
Status updated on  09.11.2016
Most recent event   Tooltip10.01.2025Revocation of patentpublished on 12.02.2025  [2025/07]
Applicant(s)For all designated states
National University Corporation Kobe University
1-1 Rokkodai-cho Nada-ku
Kobe-shi, Hyogo 657-8501 / JP
[2017/02]
Inventor(s)01 / NISHIDA, Keiji
c/o National University Corporation
Kobe University
1-1 Rokkodai-cho
Nada-ku
Kobe-shi Hyogo 657-8501 / JP
02 / KONDO, Akihiko
c/o National University Corporation
Kobe University
1-1 Rokkodai-cho
Nada-ku
Kobe-shi Hyogo 657-8501 / JP
03 / KOJIMA, Satomi
c/o National University Corporation
Kobe University
1-1 Rokkodai-cho
Nada-ku
Kobe-shi Hyogo 657-8501 / JP
 [2017/02]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2017/02]
Application number, filing date15758734.604.03.2015
[2017/02]
WO2015JP56436
Priority number, dateJP2014004334805.03.2014         Original published format: JP 2014043348
JP2014020185930.09.2014         Original published format: JP 2014201859
[2017/02]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015133554
Date:11.09.2015
Language:JA
[2015/36]
Type: A1 Application with search report 
No.:EP3115457
Date:11.01.2017
Language:EN
[2017/02]
Type: B1 Patent specification 
No.:EP3115457
Date:02.10.2019
Language:EN
[2019/40]
Search report(s)International search report - published on:JP11.09.2015
(Supplementary) European search report - dispatched on:EP07.07.2017
ClassificationIPC:C12N15/09, C07K19/00, C12N9/78
[2017/02]
CPC:
C12N15/102 (EP,US); C12N15/1024 (US); C12N15/11 (US);
C12N9/22 (EP,US); C12N9/78 (EP,US); C12Y305/04005 (EP,US);
C07K2319/00 (EP,US); C07K2319/81 (EP,US); C12N2310/3513 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/02]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:GENOMSEQUENZMODIFIZIERUNGSVERFAHREN ZUR SPEZIFISCHEN UMWANDLUNG VON NUKLEINSÄUREBASEN EINER GEZIELTEN DNA-SEQUENZ UND MOLEKULARKOMPLEX ZUR VERWENDUNG DARIN[2017/02]
English:GENOMIC SEQUENCE MODIFICATION METHOD FOR SPECIFICALLY CONVERTING NUCLEIC ACID BASES OF TARGETED DNA SEQUENCE, AND MOLECULAR COMPLEX FOR USE IN SAME[2017/02]
French:PROCÉDÉ DE MODIFICATION DE SÉQUENCE GÉNOMIQUE PERMETTANT LA CONVERSION DE FAÇON SPÉCIFIQUE DE BASES D'ACIDE NUCLÉIQUE DE SÉQUENCES D'ADN CIBLÉES ET COMPLEXE MOLÉCULAIRE DESTINÉ À ÊTRE UTILISÉE DANS CE DERNIER[2017/02]
Entry into regional phase05.10.2016Translation filed 
05.10.2016National basic fee paid 
05.10.2016Search fee paid 
05.10.2016Designation fee(s) paid 
05.10.2016Examination fee paid 
Examination procedure08.09.2015Request for preliminary examination filed
International Preliminary Examining Authority: JP
05.10.2016Examination requested  [2017/02]
05.10.2016Date on which the examining division has become responsible
02.02.2018Amendment by applicant (claims and/or description)
04.05.2018Despatch of a communication from the examining division (Time limit: M04)
03.09.2018Reply to a communication from the examining division
28.09.2018Despatch of a communication from the examining division (Time limit: M04)
31.10.2018Reply to a communication from the examining division
13.11.2018Despatch of a communication from the examining division (Time limit: M04)
19.11.2018Reply to a communication from the examining division
04.04.2019Despatch of a communication from the examining division (Time limit: M01)
16.04.2019Reply to a communication from the examining division
31.05.2019Communication of intention to grant the patent
23.08.2019Fee for grant paid
23.08.2019Fee for publishing/printing paid
23.08.2019Receipt of the translation of the claim(s)
Divisional application(s)EP19196085.5  / EP3613854
Opposition(s)Opponent(s)01  02.07.2020  06.07.2020  ADMISSIBLE
James Poole Limited
One Southampton Row
London WC1B 5HA / GB
Opponent's representative
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
 [2021/37]
Former [2020/33]
Opponent(s)01  02.07.2020  06.07.2020  ADMISSIBLE
James Poole Limited
One Southampton Row
London WC1B 5HA / GB
Opponent's representative
Chapman, Desmond Mark
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
17.07.2020Invitation to proprietor to file observations on the notice of opposition
26.11.2020Reply of patent proprietor to notice(s) of opposition
28.04.2022Date of oral proceedings
22.07.2022Despatch of interlocutory decision in opposition
22.07.2022Despatch of minutes of oral proceedings
19.12.2024Legal effect of revocation of patent [2025/07]
23.12.2024Despatch of communication that the patent will be revoked
Appeal following opposition30.09.2022Appeal received No.  T2235/22
30.09.2022Payment of appeal fee
01.12.2022Statement of grounds filed
19.12.2024Result of appeal procedure: REVOCATION OF PATENT AT PROPRIETOR'S REQUEST
23.12.2024Despatch of the decision of the Board of Appeal
19.12.2024Date of oral proceedings
Fees paidRenewal fee
13.03.2017Renewal fee patent year 03
26.01.2018Renewal fee patent year 04
31.01.2019Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU04.03.2015
AL02.10.2019
CY02.10.2019
HR02.10.2019
LT02.10.2019
LV02.10.2019
MC02.10.2019
MK02.10.2019
MT02.10.2019
RO02.10.2019
RS02.10.2019
SI02.10.2019
SM02.10.2019
BG02.01.2020
GR03.01.2020
[2023/10]
Former [2022/32]HU04.03.2015
AL02.10.2019
CY02.10.2019
HR02.10.2019
LT02.10.2019
LV02.10.2019
MC02.10.2019
MK02.10.2019
MT02.10.2019
RO02.10.2019
RS02.10.2019
SI02.10.2019
SM02.10.2019
BG02.01.2020
GR03.01.2020
IT04.03.2020
Former [2022/28]HU04.03.2015
AL02.10.2019
CY02.10.2019
HR02.10.2019
LT02.10.2019
LV02.10.2019
MC02.10.2019
MT02.10.2019
RO02.10.2019
RS02.10.2019
SI02.10.2019
SM02.10.2019
BG02.01.2020
GR03.01.2020
IT04.03.2020
Former [2021/48]AL02.10.2019
HR02.10.2019
LT02.10.2019
LV02.10.2019
MC02.10.2019
RO02.10.2019
RS02.10.2019
SI02.10.2019
SM02.10.2019
BG02.01.2020
GR03.01.2020
IT04.03.2020
Former [2020/50]AL02.10.2019
HR02.10.2019
LT02.10.2019
LV02.10.2019
MC02.10.2019
RO02.10.2019
RS02.10.2019
SI02.10.2019
SM02.10.2019
BG02.01.2020
GR03.01.2020
Former [2020/38]AL02.10.2019
HR02.10.2019
LT02.10.2019
LV02.10.2019
RO02.10.2019
RS02.10.2019
SM02.10.2019
BG02.01.2020
GR03.01.2020
Former [2020/35]AL02.10.2019
HR02.10.2019
LT02.10.2019
LV02.10.2019
RO02.10.2019
RS02.10.2019
BG02.01.2020
GR03.01.2020
Former [2020/32]AL02.10.2019
HR02.10.2019
LT02.10.2019
LV02.10.2019
RS02.10.2019
BG02.01.2020
GR03.01.2020
Former [2020/26]HR02.10.2019
LT02.10.2019
LV02.10.2019
RS02.10.2019
BG02.01.2020
GR03.01.2020
Former [2020/24]LT02.10.2019
LV02.10.2019
BG02.01.2020
GR03.01.2020
Former [2020/22]LT02.10.2019
BG02.01.2020
Documents cited:Search[Y]WO2010132092  (SCRIPPS RESEARCH INST [US], et al) [Y] 1-15 * claims 1-46 *;
 [E]WO2015089406  (HARVARD COLLEGE [US]) [E] 1,2,5,6,12,14,15 * claims 1-23 *;
 [Y]  - RAN F ANN ET AL, "Genome engineering using the CRISPR-Cas9 system", NATURE PROTO, NATURE PUBLISHING GROUP, GB, (20131101), vol. 8, no. 11, doi:10.1038/NPROT.2013.143, ISSN 1750-2799, pages 2281 - 2308, XP009174668 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1038/nprot.2013.143
 [Y]  - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055299674 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1126/science.1225829
 [T]  - K. NISHIDA ET AL, "Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems", SCIENCE, (20160804), vol. 353, doi:10.1126/science.aaf8729, ISSN 0036-8075, pages 1 - 14, XP055367833

DOI:   http://dx.doi.org/10.1126/science.aaf8729
 [T]  - ALEXIS C. KOMOR ET AL, "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage", NATURE, (20160420), vol. 533, no. 7603, doi:10.1038/nature17946, ISSN 0028-0836, pages 420 - 424, XP055343871

DOI:   http://dx.doi.org/10.1038/nature17946
 [T]  - PLOSKY BRIAN S, "CRISPR-Mediated Base Editing without DNA Double-Strand Breaks", MOLECULAR CELL, (20160519), vol. 62, no. 4, doi:10.1016/J.MOLCEL.2016.05.006, ISSN 1097-2765, pages 477 - 478, XP029552452

DOI:   http://dx.doi.org/10.1016/j.molcel.2016.05.006
 [T]  - DAESIK KIM ET AL, "Genome-wide target specificities of CRISPR RNA-guided programmable deaminases", NATURE BIOTECHNOLOGY, US, (20170410), vol. 35, no. 5, doi:10.1038/nbt.3852, ISSN 1087-0156, pages 475 - 480, XP055383071

DOI:   http://dx.doi.org/10.1038/nbt.3852
International search[XY]US2011104787  (CHURCH GEORGE M [US], et al) [X] 1, 2, 6-18, 20, 21 * , claims 1 to 24 (Family: none) * [Y] 1-21;
 [Y]WO2013058404  (UNIV KYUSHU NAT UNIV CORP [JP]) [Y] 1-21* , claims 7, 8; paragraphs [0038] to [0049] & US 2014/0335521 A1 & EP 2784157 A1 *;
 [Y]  - MALI P. et al., "Cas9 as a versatile tool for engineering biology", Nat Methods, (20131010), pages 957 - 963, XP002718606 [Y] 1-21

DOI:   http://dx.doi.org/10.1038/nmeth.2649
 [Y]  - CERMAK T. et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Res., (20110700), vol. 39, no. 12, page e82, XP055130093 [Y] 1-21

DOI:   http://dx.doi.org/10.1093/nar/gkr218
OppositionWO2010132092
 US2011104787
 WO2013176772
 JP2014043348
 JP2014201859
 WO2014186686
 WO2015089406
 WO2015133554
 EP3241902
    - RAN F ANN et al., "Genome engineering using the CRISPR-Cas9 system", NATURE PROTO, (20130000), vol. 8, no. 11, doi:10.1038/nprot.2013.143, pages 2281 - 2308, XP009174668

DOI:   http://dx.doi.org/10.1038/nprot.2013.143
    - JINEK et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120000), vol. 337, no. 6096, doi:10.1126/science.1225829, pages 816 - 821, XP055549487

DOI:   http://dx.doi.org/10.1126/science.1225829
    - MALI P et al., "Cas9 as a versatile tool for engineering biology", Nat Methods, (20130000), vol. 10, no. 10, doi:10.1038/nmeth.2649, pages 957 - 963, XP002718606

DOI:   http://dx.doi.org/10.1038/nmeth.2649
    - FU, B et al., "Target-dependent nickase activities of CRISPR-Cas nucleases Cpf1 and Cas9", Nat Microbiol., (20190000), vol. 4, no. 5, doi:10.1038/s41564-019-0382-0, pages 888 - 897, XP036764450

DOI:   http://dx.doi.org/10.1038/s41564-019-0382-0
    - YAN W. et al., "Functionally diverse type V CRISPR-Cas systems", Science, (20190000), vol. 363, doi:10.1126/science.aav7271, pages 88 - 91, XP055594948

DOI:   http://dx.doi.org/10.1126/science.aav7271
    - PEREZ-PINERA, P. et al., "RNA-guided gene activation by CRISPR-Cas9-based transcription factors", Nat Methods, (20130000), vol. 10, no. 10, doi:10.1038/nmeth.2600, pages 973 - 976, XP055181249

DOI:   http://dx.doi.org/10.1038/nmeth.2600
    - GILBERT, L. et al., "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", Cell, (20130000), vol. 154, no. 2, doi:10.1016/j.cell.2013.06.044, pages 442 - 451, XP055115843

DOI:   http://dx.doi.org/10.1016/j.cell.2013.06.044
    - STAFFORST, T. et al., "An RNA-Deaminase Conjugate Selectively Repairs Point Mutations", Angew. Chem. Int. Ed., (20120000), vol. 51, pages 11166 - 11169, XP002765253
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.